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Search Results: 1 - 10 of 1298 matches for " Yvonne LB Klaver "
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Peritoneal carcinomatosis of colorectal origin: Incidence, prognosis and treatment options
Yvonne LB Klaver,Valery EPP Lemmens,Simon W Nienhuijs,Misha DP Luyer
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i39.5489
Abstract: Peritoneal carcinomatosis (PC) is one manifestation of metastatic colorectal cancer (CRC). Tumor growth on intestinal surfaces and associated fluid accumulation eventually result in bowel obstruction and incapacitating levels of ascites, which profoundly affect the quality of life for affected patients. PC appears resistant to traditional 5-fluorouracil-based chemotherapy, and surgery was formerly reserved for palliative purposes only. In the absence of effective treatment, the historical prognosis for these patients was extremely poor, with an invariably fatal outcome. These poor outcomes likely explain why PC secondary to CRC has received little attention from oncologic researchers. Thus, data are lacking regarding incidence, clinical disease course, and accurate treatment evaluation for patients with PC. Recently, population-based studies have revealed that PC occurs relatively frequently among patients with CRC. Risk factors for developing PC have been identified: right-sided tumor, advanced T-stage, advanced N-stage, poor differentiation grade, and younger age at diagnosis. During the past decade, both chemotherapeutical and surgical treatments have achieved promising results in these patients. A chance for long-term survival or even cure may now be offered to selected patients by combining radical surgical resection with intraperitoneal instillation of heated chemotherapy. This combined procedure has become known as hyperthermic intraperitoneal chemotherapy. This editorial outlines recent advancements in the medical and surgical treatment of PC and reviews the most recent information on incidence and prognosis of this disease. Given recent progress, treatment should now be considered in every patient presenting with PC.
Measuring Semileptonic Asymmetries in LHCb
Suzanne Klaver,for the LHCb Collaboration
Physics , 2015,
Abstract: The $C\!P$-violating flavour-specific asymmetry in neutral $b$ mesons provides a method for testing the Standard Model. The measurements from the D0 experiment yield values of this asymmetry that disagree with the Standard Model at a level of 3.6 $\sigma$. This contribution discusses the latest LHCb measurements in this sector both from $B^0$ mesons ($a_{\mathrm{sl}}^d$) and $B^0_s$ mesons ($a_{\mathrm{sl}}^s$). Using their 2011 dataset, corresponding to an integrated luminosity of 1.0 $\mathrm{fb}^{-1}$ obtained in 2011, LHCb measured a value of $a_{\mathrm{sl}}^s = (-0.06 \pm 0.50_{\text{stat}} \pm 0.36_{\text{syst}}) \%$. Combining the 2011 and 2012 datasets, with an integrated luminosity of 3 $\mathrm{fb}^{-1}$, LHCb measured $a_{\mathrm{sl}}^d = (-0.02 \pm 0.19_{\text{stat}} \pm 0.30_{\text{syst}}) \%$. These are the most precise measurements of the parameters $a_{\mathrm{sl}}^s$ and $a_{\mathrm{sl}}^d$ to date. Plans for an updated result for $a_{\mathrm{sl}}^s$ using the full 3 $\mathrm{fb}^{-1}$ dataset are discussed. This will include new methods to determine detection asymmetries which are the dominating systematic uncertainty of the 2011 measurement.
Ipads versus Books  [PDF]
Yvonne Shirley
Creative Education (CE) , 2018, DOI: 10.4236/ce.2018.91010
Abstract: During the past few years, technology such as iPads has been a growing trend in classrooms. Students are slowly being drawn away from text books and introduced to digital books on iPads. This study seeks to gain insights into the effectiveness of the implementation of technology in early childhood classrooms. To examine the effectiveness of using iPads for reading, this study addresses the following question: Do children comprehend more when reading from iPads? Ten kindergarten students participated in this study. Their reading comprehension scores when reading from iPads and books were collected within a two-week interval and then compared. After reading stories from iPads and books, students were asked comprehension questions from the DRA and their scores were recorded for each section of comprehension skills which included: previewing, retelling of events, character details, retelling using vocabulary, retelling with teacher’s support, reflections, and making connections. The data showed that nine out of ten students scored higher in reading comprehension when reading from iPads, and one student scored the same on both. This study suggests that more research on effective, appropriate, and intentional teaching with iPads and other technology in classrooms is needed to further examine the benefits and downfalls of using such devices in the field of education.
Experiences in New Public Management in Africa: The Case of Performance Management Systems in Botswana
LB Dzimbiri
Africa Development , 2008,
Abstract: In his 18-page paper entitled ‘The Challenges of Governance, Public Sector Reform and Public Administration in Africa: Some Research Issues’, Guy Mhone made central to public sector reforms the need to promote procedural rationality in the operation of the public sector and instrumental rationality in terms of economic, social and political outcomes. The present paper contributes to the debate on procedural rationality by focusing attention on performance management systems (PMS), which has emerged with the advent of New Public Management (NPM). It starts by providing the context of the changing role of the state since the 1980s as a background to public sector reforms in Africa. The paper further clarifies NPM and PMS as applied to the public sector before going on to discuss the experience of Botswana in public sector reforms, with particular emphasis on its performance management system. How PMS emerged, its implementation, its monitoring and evaluation are examined in this paper, along with an analysis of challenges and lessons learnt.
Adolescents' knowledge, beliefs and experiences regarding sexual practices: research
LB Khoza
Health SA Gesondheid , 2004,
Abstract: Unwanted or unprotected pregnancies and sexually transmitted infections among the youth are the result of engaging in unprotected sexual behaviour. The purpose of this qualitative study was to explore and describe what adolescents view as being safer or risky sex practice, and to differentiate between their sexual practice by gender and sexual experience. Non-probability purposive sampling was used to obtain a sample comprising of 12 females and 15 males of ages ranging between 15 and 18 years. Results indicated that the adolescents were able to identify what are regarded as safer or risky sexual practices. However, when expressing their lived experiences of sexual practices, the participants were still engaging in risky sexual behaviour. In conclusion there is a need to acknowledge that young people are sexual beings. The focus of sexuality education should shift from that of disease prevention instead to looking at the more socially-oriented health-enhancing behaviour such as teaching adolescents about sexual development, sexual behaviour and its possible negative outcomes, sexual abuse, gender issues and power relations and other nonsexual ways of showing affection. Key Words: Sexual practice; Adolescents; Condom use; Safer sex practice; Risky sex practice OPSOMMING Ongewenste of onbeskermde swangerskappe en seksueel-oorgedraagde infeksies onder die jeug is die gevolg van onbeskermde seksuele gedrag. Die doel van hierdie kwalitatiewe studie was om dit wat adolessente beskou as veiliger of meer gewaagde seksuele praktyk, te verken en te beskryf en om tussen seksuele praktyke volgens geslag en seksuele ondervinding te onderskei. Nie-waarskynlikheids, doelgerigte steekproeftrekking is gebruik om ‘n steekproef te bekom wat bestaan het uit 12 vroulike en 15 manlike deelnemers, tussen 15 en 18 jaar oud. Die resultate het getoon dat adolessente by magte was om dit te identifiseer wat as veiliger en meer riskante seksuele gedrag beskou kan word. Dit terwyl die deelnemers hulle beleefde ondervinding van seksuele praktyke beskryf het, het dit duidelik geblyk dat hulle steeds riskante seksuele gedrag beoefen het. Daar is tot die gevolgtrekking gekom dat daar erkenning gegee moet word aan die feit dat jong mense seksuele wesens is. Die fokus van seksualiteitsonderrig behoort te verskuif van siektevoorkoming, na gedrag wat meer sosiaal-geori nteerd is en wat op gesondheidsverbetering gerig is soos om adolessente te onderrig aangaande seksuele ontwikkeling, seksuele gedrag en die moontlike negatiewe gevolge daarvan, seksuele misbruik, geslagsvraagstukke en magsverhoudings, en nie-seksuele maniere om liefde en toegeneentheid te toon. Health SA Gesondheid Vol.9(3) 2004: 34-41
Complications of venepuncture  [PDF]
Omiepirisa Yvonne Buowari
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.41A018

Venepuncture is the commonest procedure performed in health care settings. A review of literature and search on complications of venepuncture and blood collection. This procedure is without complications, which sometime can be fatal. Complications that can arise from venepuncture include haematoma formation, nerve damage, pain, haemaconcentration, extravasation, iatrogenic anaemia, arterial puncture, petechiae, allergies, fear and phobia, infection, syncope and fainting, excessive bleeding, edema and thrombus.

Surveillance as an Option for the Treatment of Small Renal Masses
S. Klaver,S. Joniau,H. Van Poppel
Advances in Urology , 2008, DOI: 10.1155/2008/705958
Abstract: Objectives. To review the natural history and biological potential of small renal masses in order to evaluate surveillance as a treatment option. Methods. Literature search of Medline and additional references from non-Medline-indexed publications concerning surveillance of small renal masses. Results. The natural history and biological potential of small renal masses can still not be unambiguously predicted at present. There seems to be no clear correlation between tumour size and presence of benign histology. The majority of small renal masses grow and the majority are cancer, but one cannot safely assume that a lack of growth on serial CT scans is the confirmation of absence of malignancy. Needle core biopsies could be used to help in decision making. They show a high accuracy for histopathological tumour type but are less accurate in evaluating Fuhrman grade. Conclusions. At present, surveillance of small renal masses should only be considered in elderly and/or infirm patients with competing health risks, in those with a limited life expectancy, and in those for whom minimal invasive treatment or surgery is not an option. In all other patients, active surveillance should only be considered in the context of a study protocol. Long-term, prospective studies are needed to provide a more accurate assessment of the natural history and metastastic potential of small renal masses.
"Against the silence": Development and first results of a patient survey to assess experiences of safety-related events in hospital
David LB Schwappach
BMC Health Services Research , 2008, DOI: 10.1186/1472-6963-8-59
Abstract: A survey instrument was developed in an iterative procedure. The instrument asks patients to report whether they have experienced specific undesirable events during their hospital stay. The preliminary version was developed together with experts and tested in focus groups with patients. The adapted survey instrument was pilot-tested in random samples of patients of two Swiss hospitals (n = 400). Responders to the survey that had reported experience of any incident were sampled for qualitative interviews (n = 18). Based on the interview, the researcher classified the reported incidents as confirmed or discarded.The survey was generally well accepted in the focus groups and interviews. In the quantitative pilot test, 125 patients returned the survey (response rate: 31%). The mean age of responders was 55 years (range 17–91, SD 18 years) and 62.5% were female. The 125 participating patients reported 94 "definitive" and 34 "uncertain" events. 14% of the patients rated any of the experienced events as "serious". The definitive and uncertain events reported with highest frequency were phlebitis, missing hand hygiene, allergic drug reaction, unavailability of documents, and infection. 23% of patients reported some or serious concerns about their safety. The qualitative interviews indicate that both, the extent of patients' uncertainty in the classification of events and the likelihood of confirmation by the interviewer vary very much by type of incident. Unexpectedly, many patients reported problems and incidents related to food and dietary intake. Overall, the in-depth interviews confirmed experiences from the focus groups that many patients feel reluctant to report undesirable events without acknowledging the presence or absence of individual responsibility or failure. Many patients reported that they did not ask or communicate about errors or near misses with staff and some patients even develop strategies to improve their safety but do not disclose these to staff.Many
The equivalence of numbers: The social value of avoiding health decline: An experimental web-based study
David LB Schwappach
BMC Medical Informatics and Decision Making , 2002, DOI: 10.1186/1472-6947-2-3
Abstract: 127 individuals completed an interactive survey that was published in the World Wide Web. They were confronted with a standard gamble (SG) and three person trade-off tasks, either comparing improvements in health (PTO-Up), avoided decline (PTO-Down), or both, contrasting health changes of equal magnitude differing in the direction in which they are experienced (PTO-WAD). Finally, a direct priority ranking of various interventions was obtained.Participants strongly prioritized improving patients' health rather than avoiding decline. The mean substitution rate between health improvements and avoided decline (WAD) ranged between 0.47 and 0.64 dependent on the intervention. Weighting PTO values according to the direction in which changes in health are experienced improved their accuracy in predicting a direct prioritization ranking. Health state utilities obtained by the standard gamble method seem not to reflect social values in resource allocation contexts.Results suggest that the utility of being cured of a given health state might not be a good approximation for the societal value of avoiding this health state, especially in cases of competition between preventive and curative interventions.In the era of aging populations and rising incidence of progressive diseases in industrialized countries, health politicians in these countries are increasingly faced with the decision what fraction of their budgets to spend on treatment and cure or on avoiding (further) health decline. Therefore, health economic analysis aimed at informing policy makers and supporting resource allocation decisions has to evaluate not only improvements in health but also prevented decline. The benefit of these "upward-movements" on a health scale compared to avoided "downward-movements" is often calculated as the potential gain in QALYs ("quality-adjusted life years"). Traditionally the standard gamble (SG) or the time trade-off (TTO) method is used to determine the quality of life weights needed
Feeding and defaecation patterns in Triatoma sordida
Crocco, LB;Catalá, SS;
Memórias do Instituto Oswaldo Cruz , 1996, DOI: 10.1590/S0074-02761996000400004
Abstract: triatoma sordida is a peridomestic triatominae that could play an important role in the transmission of trypanosoma cruzi, although its vectorial competence is not well known. the aim of this work was to evaluate two aspects of the vectorial competence: the feeding behaviour and defaecation patterns, and to compare them with t. infestans. the feeding and defaecation patterns were studied in adults and fifth instar nymphs of t. sordida fed ad libitum on a restrained pigeon. the results showed how the blood meal size controls excretion behaviour. blood intake and time to first defaecation showed a significant negative correlation. adults and nymphs frequently defaecated during the blood meal, reaching the maximum frequency within the first 10 minutes.
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