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Search Results: 1 - 10 of 33253 matches for " Yuying Feng "
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Therapeutic effects of human umbilical cord-derived mesenchymal stem cells against acute tubular necrosis quantified through measures of iNOS, BMP-7 and Bcl-2  [PDF]
Fang Li, Feng Xiong, Yun Zhang, Yuying Li, Hongmei Zhao, S. Charles Cho, Thomas E. Ichim, Xiaofei Yang, Xiang Hu
Open Journal of Regenerative Medicine (OJRM) , 2013, DOI: 10.4236/ojrm.2013.22006

Introduction: Acute tubular necrosis (ATN) is the most prevalent cause of acute renal failure (ARF). Mesenchymal stem cell transplantation has been studied as a potential treatment for renal dysfunction due to ATN. Inducible nitric oxide synthase (iNOS), bone morphogenetic protein-7 (BMP-7) and B-cell lymphoma 2 (Bcl-2) are surrogate markers of renal tubular epithelial regeneration and subsequent recovery of renal function following ATN. Methods: Serum creatinine (Scr) and blood urea nitrogen (BUN), as well as expression of iNOS, BMP-7 and Bcl-2 in gentamycin-induced ATN rat kidneys was investigated after human umbilical cord-derived mesenchymal stem cell (HUC-MSC) transplantation. Immunohistochemical staining was performed in 3 groups of rats: gentamycin-induced ATN treated with HUC-MSC, gentamycin-induced ATN without HUC-MSC, and untreated rats not receiving any treatments. Results: HUC-MSC transplantation led to a reduction in Scr and BUN in the kidneys of rats with gentamycin-induced ATN. Expression of iNOS in the HUC-MSC treated group occurred later and the expression levels were much lower during gentamycin-induced ATN compared to rats with ATN that were not treated with HUC-MSC. The expression of BMP-7 and Bcl-2 in the MSC-transplanted group was significantly increased compared to both control groups of rats with injured and healthy renal tubules. Conclusions: HUC-MSCs induce renal protection in a rat model of gentamycin-induced ATN, which is associated with reduced iNOS expression and up-regulation of Bcl-2 and BMP-7.

Studies on the Photoinduced Interaction between Zn(II) Porphyrin and Colloidal TiO2
Heyong Huang,Jiahong Zhou,Yan Zhou,Yanhuai Zhou,Yuying Feng
International Journal of Photoenergy , 2010, DOI: 10.1155/2010/547135
Abstract: The interaction of Zn(II) porphyrin (ZnPP) with colloidal TiO2 was studied by absorption and fluorescence spectroscopy. The fluorescence emission of ZnPP was quenched by colloidal TiO2 upon excitation of its absorption band. The quenching rate constant ( ) is ?M?1?s?1. These data indicate that there is an interaction between ZnPP and colloidal TiO2 nanoparticle surface. The quenching mechanism is discussed on the basis of the quenching rate constant as well as the reduction potential of the colloidal TiO2. And the mechanism of electron transfer has been confirmed by the calculation of free energy change by applying Rehm-Weller equation as well as energy level diagram. 1. Introduction Wide-band gap semiconductor particles such as TiO2 have been widely used for different applications in photocatalysis and the environment [1, 2].Over the past decades, considerable interest has been shown in the modification of TiO2 semiconductors by organic dyes to extend the photoresponse to visible light owing to their potential application in solar energy conversion [3–5]. Dye sensitization is considered to be an efficient method to modify the photo response properties of TiO2 particles. The dyes used are erythrosine B [6], rose Bengal [7], metal porphyrin [8–10], and so forth. Porphyrins, (including metal-free porphyrins, metalloporphyrins and supramolecular porphyrins) [11] are recognized to be the most promising sensitizers [12]. The chemistry of porphyrin derivatives has played an important role especially during the past decade in particular branches of new materials science, and many researchers have undertaken projects on the synthesis of variously substituted compounds to obtain new functional materials [13–15]. Metalloporphyrin may be an appropriate candidate because of its high absorption coefficient within the solar spectrum and its good chemical stability in comparison to that of other dyes. They are highly effective photocatalysts due to their very strong absorption in the 400?nm–450?nm region (Soret band) and in the 500?nm–700?nm region (Q-bands) and, in fact, the presence of p-electrons affords the condition for electron transfer during the photoreaction. In the present work we have investigated the electron transfer from excited ZnPP (see Scheme 1) to the conduction band of TiO2 colloid by using absorption and fluorescence spectroscopy. Scheme 1: Structure of ZnPP. 2. Materials and Methods 2.1. Materials Zn(II) porphyrin and tetrabutyl titanate were purchased from Aldrich. The doubly distilled water was used for preparing the solutions. All measurements
Effect of Carotid Artery Stenting and Extracranial-Intracranial By-Pass on Cognitive Function: Preliminary Results  [PDF]
Li Liu, Yuying Zhou
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.66049
Background: To compare the neuropsychological consequences after carotid artery stenting (CAS) and extracranial-intracranial by-pass (EC-IC by-pass). Methods: A total of 43 patients referred to CAS, 32 patients referred to EC-IC by-pass and 43 control subjects were enrolled in the study. Neuropsychologic testing was performed before and three months after procedure. A paired Student t test was used to compare neuropsychologic test scores at baseline and three months after procedure in each group. Cognitive changes in a three-month follow-up were not normally distributed and compared among/between groups with Kruskal-Wallis test. Results: Three months after the treatment both the CAS and EC-IC by-pass groups showed improved cognitive performance compared to baseline, whereas the same improvement wasn’t seen in the control group. The scores from Activities of Daily Living also improved in all three groups in a three-month follow-up, and EC-IC group presented a more distinct increase in daily life abilities comparing to the other two groups. Conclusions: CAS and EC-IC by-pass in patients with a carotid or intracranial stenosis may result in cognitive improvement three months after surgery.
A Graduated Nonconvex Regularization for Sparse High Dimensional Model Estimation  [PDF]
Thomas F. Coleman, Yuying Li
Journal of Computer and Communications (JCC) , 2014, DOI: 10.4236/jcc.2014.211001

Many high dimensional data mining problems can be formulated as minimizing an empirical loss function with a penalty proportional to the number of variables required to describe a model. We propose a graduated non-convexification method to facilitate tracking of a global minimizer of this problem. We prove that under some conditions the proposed regularization problem using the continuous piecewise linear approximation is equivalent to the original lo  regularization problem. In addition, a family of graduated nonconvex approximations are proposed to approximate its l1  continuous approximation. Computational results are presented to illustrate the performance.

Affinity studies of hypocrellin B and mono-cysteine substituted hypocrellin B with CT-DNA using spectroscopic methods
Shaohua Wei,Jiahong Zhou,Yuying Feng,Deyin Huang,Xuesong Wang,Baowen Zhang,Jian Shen
Spectroscopy: An International Journal , 2005, DOI: 10.1155/2005/258617
Abstract: The interaction of anticancer drug hypocrellin B (HB) and mono-cysteine substituted hypocrellin B (MCHB) with calf thymus deoxyribonucleic acid (CT-DNA) has been investigated using spectral methods. The results of UV–visible spectra showed that the HB and MCHB can intercalate into the base-stacking domain of the CT-DNA double helix. Further studies based on fluorescence spectroscopy and circular dichroism (CD) spectroscopy also supported the intercalation mechanism.
Beam Collimation Using an Anisotropic Metamaterial Slab without Any Nanometer-sized Aperture
Shou Zhang,Guohui Li,Yanxia Cui,Feng Zhang,Sailing He,Yuying Hao,Furong Zhu
Physics , 2015,
Abstract: Plasmonic beam collimation effect has been thoroughly investigated based on the well-known nanometer-scale bull's eye structure formed by complex and high-cost fabrication processes. In this work, we report our effort for attaining beam collimation using an anisotropic metamaterial (AMM) slab that consists of a stack of alternating metal/dielectric layers and an integrated top metal grating. The results show that AMM slab allows creating the beam collimation effect similar to that of the bull's eye structure, an enabling technology for practical application due to its simple architecture and cost benefits. The excitation of surface plasmons at the AMM/air interface is derived. The structure of the AMM slab and its impact on beaming performance were analyzed using the effective medium theory and Finite Element Method.
Physical and numerical modelling of biomimetic approaches of natural hydrophobic surfaces
YuYing Yan
Chinese Science Bulletin , 2009, DOI: 10.1007/s11434-009-0015-8
Abstract: Physical and numerical models of the hydrophobic and self-cleaning characteristics of an object surface are developed, and a micro/meso scope numerical approach and simulation based on the lattice Boltzmann method (LBM) is achieved. The modelling focuses on surface tension dominated behaviour of water droplets in air spreading on hydrophilic surface with hydrophobic strips of different sizes and contact angles under different physical and interfacial conditions. Applying the LBM model, the droplets behaviours on heterogeneous partial wetting surfaces are studied and simulated. In the simulations, the interactions between the fluid-fluid interface and the partial wetting wall are typically considered; the phenomena of droplets spreading and breaking up, as well as the effect of hydrophobic strips on the surface wettability or self-cleaning characteristics are simulated and studied.
Targeting miRNAs in Osteoblast Differentiation under Malnutrition Conditions  [PDF]
Yuying Wang, Rui He, Liangjun Zhong
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.65012
Abstract: Aims: Previous studies reported that reduced bone formation was identified in fasting adult female mice compared with the ad libitum control group. An increasing number of studies have shown that miRNAs contribute to bone homeostasis. Unfortunately, there are minor concerns about the underlying mechanisms in osteoblastic differentiation under malnutrition conditions. Methods: We investigated microRNAs (miRNAs) in osteoblastic differentiation under malnutrition conditions using high-throughput bioinformatics approaches. To screen for targeted microRNAs, sequences were quantified by aligning reads to miRbase using miRDeep2 software. Unadjusted p-values were calculated using the Student’s t-test. Genes with a p-value of <0.05 and log 2FC (fold change) ≥ 1 were considered differentially expressed genes (DEGs). DEGs were submitted to Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, respectively. Results: They were mainly enriched in biological process terms type and biological pathways, respectively. Particularly, we evaluated seven microRNAs, mir-494 3p, mir-466, mir-455, mir-708, mir-298, mir-92 and mir-224, which likely play roles in osteoblastogenesis in fasting adult mice. Conclusion: To our knowledge, this is the first study on the expression pattern of miRNA in osteoblasts of malnourished adult mice. These targeting miRNAs may provide a potential therapeutic approach to treat osteoporosis.
Synchrotron radiation XRF microprobe investigation of elemental distribution in femoral head slice with osteoporosis
Zhang Yuanxun,Cheng Feng,Li Deyi,Wang Yinsong,Zhang Guilin,Xu Hongjie,Liao Wensheng,Tang Tingting,Huang Yuying,He Wei
Chinese Science Bulletin , 2001, DOI: 10.1007/BF02900696
Abstract: This note deals with the scanning of femoral head slices from both normal and osteoporosis subjects using synchrotron radiation X-ray fluorescence (SRXRF) microprobe technique. The sample preparation and experimental apparatus are described in detail. The quantitative computerized tomography (QCT) of elemental distribution, such as Ca, P, K, Fe, Zn, Sr and Pb in bone slice tissue including cartilage, substantial compact and substantial spongy, is investigated. Combined with the correlation between P, K, Zn, Sr and Ca, the loss way of minerals and the physiological functions of some metal elements in bone are also discussed.
Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Erα36 and the transformation of MCF10ACE
Shuang Feng,Yang Wang,Xi Wang,ZhaoYi Wang,YuYing Cui,Jing Liu,ChunHui Zhao,Mei Jin,Wei Zou
Science China Life Sciences , 2010, DOI: 10.1007/s11427-010-0100-x
Abstract: ERα36, a variant of estrogen receptor-α, acts as a dominant-negative factor in both estrogen-dependent and estrogenindependent transactivation signaling pathways, and is a key factor in the promotion, progression and prognosis of breast cancers. Caveolin-1, a 22- to 24-kD integral membrane protein, may function as a tumor suppressor in inhibiting of many growth-promoting signaling pathways. It was shown that downregulation of Caveolin-1 strengthens the interaction of ERα and Caveolin-1. In conclusion, Caveolin-1 gene silencing activated the PI3K/AKT signaling pathway in an ERα36-dependent way. Our finding may provide a promising therapeutic target of breast cancer.
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