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Search Results: 1 - 10 of 80832 matches for " Yuyan LIU "
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Analysis of Control Measures for Settlement of Differences on the Problems of Highway Subgrade Widening  [PDF]
Yuyan Wang
Open Journal of Civil Engineering (OJCE) , 2015, DOI: 10.4236/ojce.2015.52015
Abstract: The study mainly discusses the issues of the settlement of differences that occurs in the process of highway subgrade widening. Firstly, it briefly introduces the settlement of difference and its harms; then it analyzes the mechanism of settlement of differences in the process of difference widening, including four aspects: the new and old roadbeds themselves, design, construction and other links; finally, based on the above analysis of the mechanism, it discusses the corresponding control measures, mainly proposing these suggestions as followings: the use of lightweight materials, the foundation treatment, the cut slope excavation steps, and the strict control of the degree of compaction, etc. The paper is expected to provide some theoretical basis for the control measures of highway subgrade widening settlement of difference.
Linear Thanatin Is an Effective Antimicrobial Peptide against Colistin-Resistant Escherichia coli in Vitro  [PDF]
Quan Zhou, Huimin Fan, Peifeng Lu, Yuyan Zhou, Wei Li, Jianhua Liu
Advances in Microbiology (AiM) , 2018, DOI: 10.4236/aim.2018.87039
Abstract: Colistin has been regarded as the last line antibiotic for treatment of infections caused by multidrug resistant gram-negative bacteria. Therefore, the increasing emergence of colistin resistance among gram-negative bacteria represents a serious problem. The objective of this study was to characterize the effectiveness of the chemically synthesized thanatin in linear form against colistin-resistant E. coli isolated from a pig farm in China. Agar diffusion assay and broth microdilution test were employed to analyze the susceptibility of colistin-sensitive E. coli (ATCC25922) and colistin-resistant E. coli (SHP45) to linear thanatin (L-thanatin). Combinatory effect of linear thanatin and colistin against E. coli was also determined by fractional inhibition concentration index (FICI) analysis. The results showed that L-thanatin at a concentration of 1 mg/ml produced larger inhibition zone on agar against ATCC25922 than SHP45. In the quantitative microdilution test, L-thanatin had the same MIC of 3.2 μg/ml for ATCC25922 and SHP45. Based on the FICI analysis, additive effect was obtained with 1.56 μg/ml of L-thanatin and 0.125 μg/ml of colistin for ATCC25922; but with 1.56 μg/ml of L-thanatin and 0.25 μg/ml of colistin or with 2 μg/ml of colistin and 0.39 μg/ml of L-thanatin for SHP45. These data proved that L-thanatin is an effective antimicrobial peptide against colistin-resistant E. coli.
Pulse width effect on the dissociation probability of CH4 + in the intense femtosecond laser field
Cao Wang,Di Song,Yuyan Liu,Fan’ao Kong
Chinese Science Bulletin , 2006, DOI: 10.1007/s11434-006-1269-z
Abstract: The laser pulse width effect on the dissociation probability of CH4 + irradiated by an ultrafast laser has been investigated experimentally and theoretically. The femtosecond laser at 800 nm with an intensity of 8.0 × 1013 W/cm2 was used. The observed relative yield of the primary fragment ion CH3 + increases with increasing pulse width and tends to saturate when the pulse width is longer than 120 fs. The field-assisted dissociation (FAD) model and quasi-classical trajectory (QCT) calculation were applied to predicting the dissociation probability of CH4 +. The calculated probability is corrected with the molecular orientation effect and the spatial distribution of laser intensity. The modified results show that the dissociation requires at least 23 fs and saturates with long pulse widths ( 100 fs). The result is approximately consistent with the experimental observation.
Proline Accumulation in Leaves of Periploca sepium via Both Biosynthesis Up-Regulation and Transport during Recovery from Severe Drought
Yuyan An, Meixiang Zhang, Guobin Liu, Ruilian Han, Zongsuo Liang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069942
Abstract: Drought resistance and recovery ability are two important requisites for plant adaptation to drought environments. Proline (Pro) metabolism has been a major concern in plant drought tolerance. However, roles of Pro metabolism in plant recovery ability from severe drought stress are largely unexplored. Periploca sepium Bunge has gained increasing attention for its adaptation to dry environments. Here, we investigated Pro metabolism in different tissues of P. sepium seedlings in the course of drought stress and recovery. We found that leaf Pro metabolism response during post-drought recovery was dependant on drought severity. Pro biosynthesis was down-regulated during recovery from -0.4 MPa but increased continually and notably during recovery from -1.0 MPa. Significant correlation between Pro concentration and Δ1-pyrroline-5-carboxylate synthetase activity indicates that Glutamate pathway is the predominant synthesis route during both drought and re-watering periods. Ornithine δ-aminotransferase activity was up-regulated significantly only during recovery from ?1.0 MPa, suggesting positive contribution of ornithine pathway to improving plant recovery capacity from severe drought. In addition to up-regulation of biosynthesis, Pro transport from stems and roots also contributed to high Pro accumulation in leaves and new buds during recovery from ?1.0 MPa, as indicated by the combined analysis of Pro concentration and its biosynthesis in stems, roots and new buds. Except its known roles as energy, carbon and nitrogen sources for plant rapid recovery, significant positive correlation between Pro concentration and total antioxidant activity indicates that Pro accumulation can also promote plant damage repair ability by up-regulating antioxidant activity during recovery from severe drought stress.
The Effect on Proliferation and Differentiation of Cementoblast by Using Sclerostin as Inhibitor
Xingfu Bao,Yuyan Liu,Guanghong Han,Zhigang Zuo,Min Hu
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms141021140
Abstract: Cementogenesis is of great importance for normal teeth root development and is involved in the repair process of root resorption caused by orthodontic treatment. As highly differentiated mesenchymal cells, cementoblasts are responsible for this process under the regulation of many endogenous agents. Among these molecules, sclerostin has been much investigated recently for its distinct antagonism effect on bone metabolism. Encoded by the sost gene, sclerostin is expressed in osteocytes and cementocytes of cellular cementum. it is still unclear. In the current study, we investigated the effects of sclerostin on the processes of proliferation and differentiation; a series of experiments including MTT, apoptosis examination, alkaline phosphatase (ALP) activity, gene analysis, and alizarin red staining were carried out to evaluate the proliferation and differentiation of cementoblasts. Protein expression including osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) were also checked to analyze changes in osteoclastogenesis. Results show that sclerostin inhibits cementoblasts proliferation and differentiation, and promotes osteoclastogenesis. Interestingly, the monoclonal antibody for sclerostin has shown positive effects on osteoporosis, indicating that it may facilitate cementogenesis and benefit the treatment of cementum related diseases.
两岸保险法中“意外”构成要件与举证责任分配研究
Analysis of constitution of accidence and allocation of the burden of proof in compensation insurance in Mainland China and Taiwan

刘强,陈禹彦
LIU Qiang
, CHEN Yuyan

- , 2015, DOI: 1672-3104(2015)03-0058-07
Abstract: 摘 要: 对“意外”的认定是意外伤害保险理赔的首要问题。构成“意外”应当具有外来性、突发性和非自愿性等核心要素,此外还有偶然性和非疾病性等参考因素。就“意外”对象而言,应当采用结果说。两岸均将不同构成要件的举证责任分配给双方当事人,并适当地作有利于被保险人的解释。通过对两岸法律以及司法实务进行比较,可以完善“意外”的构成要件及举证责任分配制度,以维护被保险人一方的合法利益。
Abstract: The definition of accidence is the prior point in the insurance compensation, which should be external, sudden and involuntary as key factors, and probable and non-diseases as reference factors. The accident should refer to the result. In both sides of the strait, that is, in Mainland China and Taiwan, the burden of different proofs is allocated to both parties according to different components and proper interpretations are given in favor of the insurant. Through the comparison of the academic point of view and judicial practice between the two sides of the strait, the need is seen to improve “the accident” determination and the burden distribution system in the Insurance Law in Mainland China in order to protect the benefits of the insurant
Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms
Jia Liu, Ning Wu, Leina Ma, Ming Liu, Ge Liu, Yuyan Zhang, Xiukun Lin
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091606
Abstract: Warburg effect, one of the hallmarks for cancer cells, is characterized by metabolic switch from mitochondrial oxidative phosphorylation to aerobic glycolysis. In recent years, increased expression level of pyruvate kinase M2 (PKM2) has been found to be the culprit of enhanced aerobic glycolysis in cancer cells. However, there is no agent inhibiting aerobic glycolysis by targeting PKM2. In this study, we found that Oleanolic acid (OA) induced a switch from PKM2 to PKM1, and consistently, abrogated Warburg effect in cancer cells. Suppression of aerobic glycolysis by OA is mediated by PKM2/PKM1 switch. Furthermore, mTOR signaling was found to be inactivated in OA-treated cancer cells, and mTOR inhibition is required for the effect of OA on PKM2/PKM1 switch. Decreased expression of c-Myc-dependent hnRNPA1 and hnRNPA1 was responsible for OA-induced switch between PKM isoforms. Collectively, we identified that OA is an antitumor compound that suppresses aerobic glycolysis in cancer cells and there is potential that PKM2 may be developed as an important target in aerobic glycolysis pathway for developing novel anticancer agents.
CI431, an Aqueous Compound from Ciona intestinalis L., Induces Apoptosis through a Mitochondria-Mediated Pathway in Human Hepatocellular Carcinoma Cells
Linyou Cheng,Ming Liu,Cuicui Wang,Haizhou Liu,Yuyan Zhang,Xiukun Lin
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/292873
Abstract: In the present studies, a novel compound with potent anti-tumor activity from Ciona intestinalis L. was purified by acetone fractionation, ultrafiltration, gel chromatography and High Performance Liquid Chromatography. The molecular weight of the highly purified compound, designated CI431, was 431Da as determined by HPLC-MS analysis. CI431 exhibited significant cytotoxicity to several cancer cell types. However, only a slight inhibitory effect was found when treating the benign human liver cell line BEL-7702 with the compound. To explore its mechanism against hepatocellular carcinoma, BEL-7402 cells were treated with CI431 in vitro. We found that CI431 induced apoptotic death in BEL-7402 cells in a dose- and time-dependent manner. Cell cycle analysis demonstrated that CI431 caused cell cycle arrest at the G2/M phase, and a sub-G1 peak appeared after 24?h. The mitochondrial-mediated pathway was implicated in this CI431-induced apoptosis as evidenced by the disruption of mitochondrial membrane potential. The results suggest that the CI431 induces apoptosis in BEL-7402 human hepatoma cells by intrinsic mitochondrial pathway. 1. Introduction It is now clear that the oceans are not only home to a tremendous diversity of species but that their inhabitants produce also a wealth of natural products [1]. Since the 1950s, many structurally diverse natural products with astounding bioactivities have been discovered from marine organisms [2]. These compounds are mainly isolated from sessile animals, such as sponges, tunicates, corals, mollusks, and bryozoans [3, 4]. Among sessile animals, tunicates have received the most attention. More commonly known as Ascidiacea, members of the class Ascidiacea (Ascidians) are the most highly investigated tunicates, since they present a benthonic stage in their life, making their collection easier. The chemistry of ascidians has become one of the most active fields of marine natural products; it has been amply demonstrated that these sea creatures are prolific producers of unusual structures with significant bioactivities. Most of these products fall within the area of cancer therapy [5], and a significant number of ascidian-derived compounds have entered into preclinical and clinical trials as antitumor agents [3, 6]. Didemnin B, is perhaps the most studied marine natural product. This cyclic peptide was isolated from the Caribbean tunicate Trididemnum solidum [7]. Early investigation into the bioactivity of this compound revealed its strong antiproliferative effects in vitro against a variety of human tumor cell lines. It was
Role of MicroRNA-26b in Glioma Development and Its Mediated Regulation on EphA2
Ning Wu,Xiangzhong Zhao,Ming Liu,Haizhou Liu,Weicheng Yao,Yuyan Zhang,Shousong Cao,Xiukun Lin
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0016264
Abstract: MicroRNAs (miRNAs) are short, non-coding RNAs that regulate the expression of multiple target genes. Deregulation of miRNAs is common in human tumorigenesis. Low level expression of miR-26b has been found in glioma cells. However, its underlying mechanism of action has not been determined.
Morphometry Research of Deer, Sheep, and Human Lumbar Spine: Feasibility of Using Deerand Sheep in Spinal Animal Models
Bai,Xiaofan; Liu,Guomin; Xu,Chuanjie; Zhuang,Yingying; Zhang,Jinlong; Jia,Yuyan; Liu,Yi;
International Journal of Morphology , 2012, DOI: 10.4067/S0717-95022012000200025
Abstract: deer and sheep are used as spinal animal models in clinical and basic research. in this paper, the anatomical morphology, curvature, and morphology index parameters were investigated to assess the feasibility of using deer and sheep as animal models of the human spine. fresh adult male sheep, deer, and human spine specimens (n = 10 each) were screened and subjected to morphological analyses. the statistical software package spss (version 17.0) was used to analyze the statistical similarity and variability among the 3 species. deer displayed good similarity to human in terms of the vertebral transverse diameter, radius vector, spinal canal transverse diameter, radius vector, and vertebral upper and lower endplate curvature radii. sheep displayed good similarity to human in terms of the vertebral body height, pedicle height, vertebral mid-lever curvature radius, and vertebral positive curvature radius. human, deer, and sheep each displayed unique morphological characteristics and trends for the lumbar spine. these findings indicate that deer and sheep are good spinal animal models of human in morphometry, but with specific advantages in different research fields: deer are more suitable when studying vertebrae and endplate structures, while sheep are more suitable when referring to structures such as the vertebral walls.
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