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Search Results: 1 - 10 of 35491 matches for " Yunior Montaner Hernández "
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PRIMICIA, Plataforma de Televisión Informativa
Ruber Hernández García,Yunior Montaner Hernández,José Andrés Hernández Bustio,Jorge Daniel Olivares Tamayo
Ingenier?-a Electr?3nica, Autom??tica y Comunicaciones , 2010, DOI: 10.1234/rielac.v30i2.52
Abstract: Es una necesidad primaria de los seres humanos mantenerse informados. Sin embargo, en ocasiones existen situaciones especiales que imposibilitan la transmisión de informaciones en distintos formatos a una gran masa de personas. Dándole solución a la problemática planteada, en el presente trabajo se definen los conceptos que soportan el desarrollo de una Plataforma de Televisión Informativa con el uso de tecnologías informáticas, posibilitando de este modo la integración de informaciones textuales y audiovisuales capaces de actualizar informacionalmente a los usuarios de manera rápida y constante. Se describen además las características de la solución y finalmente se exponen los result
Demonstration by RNA interference of a new molecular mechanism for resistance to an oomycete in tobacco plants
Hernández,Ingrid; Borrás,Orlando; Chacón,Osmani; Pujol,Merardo; López,Yunior; Rodrígues,Raisa; Portieles,Roxana;
Biotecnolog?-a Aplicada , 2010,
Abstract: oomycetes constitute an important agricultural pathogen for plants of the solanaceae family. black shank, caused by phytophthora parasitica var. nicotianae, is one of the most important diseases affecting tobacco plantations in cuba and worldwide, constituting an occasional cause of major economic losses. we have constructed a subtractive library with the aim of identifying tobacco genes involved in the resistance to this oomycete. the analysis by realtime pcr confirmed, for the first time, the patterns of differential expression between resistance and susceptibility reactions for the identified genes. this constitutes the first report demonstrating the pattern of expression of the glutathione-s-transferase (gst) gene in varieties and species independently of the degree of resistance or susceptibility to the pathogen. the gene was cloned in a plant transformation vector for gene silencing, and transgenic n. tabacum plants with silenced gst were obtained. they significantly displayed increased resistance to the disease, in highly susceptible plants, in comparison to control plants. this work constitutes the first report on the role of gst as a negative regulator of the defensive response to oomycetes, as well as the first instance where rna interference technology has ever been used to obtain resistance to diseases produced by oomycetes.
La utilització de WebQuest i de Sistemes de Resposta Interactiva en l'assignatura Investigació de Mercats Use of WebQuest and Interactive Answer Systems in the Subject 'Marketing Research' La utilización de WebQuest y de Sistemas de Respuesta Interactiva en la asignatura Investigación de Mercados
Ma Dolores Delso Aranaz,Ana Garrido Rubio,Blanca Isabel Hernández Ortega,Teresa Montaner Gutiérrez
@tic : Revista d'Innovació Educativa , 2010, DOI: 10.7203/attic.5.236
Abstract: Aquest treball té com objectiu estudiar la importància d'implantar metodologies docents centrades en les noves tecnologies de la informació i comunicació (TIC), amb la finalitat de potenciar la participació de l'estudiant i de millorar els seus resultats d'aprenentatge. Concretament,aprofundirem en el disseny d'una WebQuest i en l'ús de Sistemes de Resposta Interactiva en l'assignatura Investigació de Mercats. Els resultats obtinguts serviran de base per a dissenyar les guies i metodologies docents de les assignatures de l'àrea de Comercialització i Investigació de Mercats en els nous estudis de grau. This paper aims to study the importance of implementing teaching methods focused on new information and communication technology (ICT), trying to enhance student participation and to improve his/her learning outcomes. Specifically, we deep into the design of a WebQuest and into the employment of Interactive Response System in the subject “Market Research”. The obtained results provide a basis for design guidelines and teaching methodologies in the subjects related to Marketing in the new degrees. Este trabajo tiene como objetivo estudiar la importancia de implantar metodologías docentes centradas en las nuevas tecnologías de la información y comunicación (TIC), tratando de potenciar la participación del estudiante y de mejorar sus resultados de aprendizaje. Concretamente, nos centraremos en el dise o de una WebQuest y en el empleo de Sistemas de Respuesta Interactiva en la asignatura “Investigación de Mercados”. Los resultados obtenidos servirán de base para dise ar las guías y metodologías docentes de las asignaturas del área de Comercialización e Investigación de Mercados en los nuevos estudios de grado.
On the zeros of orthogonal polynomials on the unit circle
María Pilar Alfaro,Manuel Bello-Hernández,Jesús María Montaner
Mathematics , 2011,
Abstract: Let ${z_n}$ be a sequence in the unit disk ${z\in\mathbb{C}:|z|<1}$. It is known that there exists a unique positive Borel measure in the unit circle ${z\in\mathbb{C}:|z|=1}$ such that the orthogonal polynomials ${\Phi_n}$ satisfy [\Phi_n(z_n)=0] for each $n=1,2,...$. Characteristics of the orthogonality measure and asymptotic properties of the orthogonal polynomial are given in terms of asymptotic behavior of the sequence ${z_n}$. Particular attention is paid to periodic sequence of zeros ${z_n}$ of period two and three.
Evidence for systems-level molecular mechanisms of tumorigenesis
Pilar Hernández, Jaime Huerta-Cepas, David Montaner, Fátima Al-Shahrour, Joan Valls, Laia Gómez, Gabriel Capellá, Joaquín Dopazo, Miguel Pujana
BMC Genomics , 2007, DOI: 10.1186/1471-2164-8-185
Abstract: Here, we determine the coordinated function of cancer gene products (i.e., proteins encoded by differentially expressed genes in tumors relative to healthy tissue counterparts, hereafter referred to as "CGPs") defined as their topological properties and organization in the interactome network. We show that CGPs are central to information exchange and propagation and that they are specifically organized to promote tumorigenesis. Centrality is identified by both local (degree) and global (betweenness and closeness) measures, and systematically appears in down-regulated CGPs. Up-regulated CGPs do not consistently exhibit centrality, but both types of cancer products determine the overall integrity of the network structure. In addition to centrality, down-regulated CGPs show topological association that correlates with common biological processes and pathways involved in tumorigenesis.Given the current limited coverage of the human interactome, this study proposes that tumorigenesis takes place in a specific and organized way at the molecular systems-level and suggests a model that comprises the precise down-regulation of groups of topologically-associated proteins involved in particular functions, orchestrated with the up-regulation of specific proteins.In recent years, functional genomic and proteomic approaches have generated a vast quantity of data through which cellular processes, pathways and pathologies can be deciphered. In particular, microarray-based studies have provided genome-wide expression data for almost every type of human cancer [1]. As a consequence of genetic and molecular analyses, the sequence of events that contributes to certain types of human cancer, for example colorectal cancer [2], is relatively well characterized.Although our understanding of the genetic determinants of tumorigenesis has been greatly enhanced by these approaches [3], other levels of molecular complexity have emerged [4-6]. Cancer arises from the consecutive acquisition of ge
Rat Middle Cerebral Artery Occlusion Is Not a Suitable Model for the Study of Stroke-Induced Spontaneous Infections
Mireia Campos-Martorell, M a ángeles Montero , Mar Hernández-Guillamón, Anna Rosell, Javier Gomis, David Salat, Lidia García-Bonilla, Joan Montaner
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099169
Abstract: Background Infections related to stroke-induced immunodepression are an important complication causing a high rate of death in patients. Several experimental studies in mouse stroke models have described this process but it has never been tested in other species such as rats. Methods Our study focused on the appearance of secondary systemic and pulmonary infections in ischemic rats, comparing with sham and naive animals. For that purpose, male Wistar rats were subjected to embolic middle cerebral artery occlusion (eMCAO) or to transient MCAO (tMCAO) inserting a nylon filament. Forty-eight hours after ischemia, blood and lung samples were evaluated. Results In eMCAO set, ischemic rats showed a significant decrease in blood-peripheral lymphocytes (naive = 58.8±18.1%, ischemic = 22.9±16.4%) together with an increase in polymorphonuclears (PMNs) (naive = 29.2±14.7%, ischemic = 71.7±19.5%), while no change in monocytes was observed. The increase in PMNs counts was positively correlated with worse neurological outcome 48 hours after eMCAO (r = 0.55, p = 0.043). However, sham animals showed similar changes in peripheral leukocytes as those seen in ischemic rats (lymphocytes: 40.1±19.7%; PMNs: 51.7±19.2%). Analysis of bacteriological lung growth showed clear differences between naive (0±0 CFU/mL; log10) and both sham (3.9±2.5 CFU/mL; log10) and ischemic (4.3±2.9 CFU/mL; log10) groups. Additionally, naive animals presented non-pathological lung histology, while both sham and ischemic showed congestion, edema or hemorrhage. Concordant results were found in the second set of animals submitted to a tMCAO. Conclusions Inflammatory and infection changes in Wistar rats subjected to MCAO models may be attributed not only to the brain ischemic injury but to the surgical aggression and/or anaesthetic stress. Consequently, we suggest that stroke-induced immunodepression in ischemic experimental models should be interpreted with caution in further experimental and translational studies, at least in rat stroke models that entail cervicotomy and cranial trepanation.
MOCICE-BCubed F$_1$: A New Evaluation Measure for Biclustering Algorithms
Henry Rosales-Méndez,Yunior Ramírez-Cruz
Computer Science , 2015,
Abstract: The validation of biclustering algorithms remains a challenging task, even though a number of measures have been proposed for evaluating the quality of these algorithms. Although no criterion is universally accepted as the overall best, a number of meta-evaluation conditions to be satisfied by biclustering algorithms have been enunciated. In this work, we present MOCICE-BCubed F$_1$, a new external measure for evaluating biclusterings, in the scenario where gold standard annotations are available for both the object clusters and the associated feature subspaces. Our proposal relies on the so-called micro-objects transformation and satisfies the most comprehensive set of meta-evaluation conditions so far enunciated for biclusterings. Additionally, the proposed measure adequately handles the occurrence of overlapping in both the object and feature spaces. Moreover, when used for evaluating traditional clusterings, which are viewed as a particular case of biclustering, the proposed measure also satisfies the most comprehensive set of meta-evaluation conditions so far enunciated for this task.
Factors Secreted by Endothelial Progenitor Cells Enhance Neurorepair Responses after Cerebral Ischemia in Mice
Anna Rosell, Anna Morancho, Miriam Navarro-Sobrino, Elena Martínez-Saez, Mar Hernández-Guillamon, Silvia Lope-Piedrafita, Verónica Barceló, Francesc Borrás, Anna Penalba, Lidia García-Bonilla, Joan Montaner
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073244
Abstract: Cell therapy with endothelial progenitor cells (EPCs) has emerged as a promising strategy to regenerate the brain after stroke. Here, we aimed to investigate if treatment with EPCs or their secreted factors could potentiate angiogenesis and neurogenesis after permanent focal cerebral ischemia in a mouse model of ischemic stroke. BALB/C male mice were subjected to distal occlusion of the middle cerebral artery, and EPCs, cell-free conditioned media (CM) obtained from EPCs, or vehicle media were administered one day after ischemia. Magnetic resonance imaging (MRI) was performed at baseline to confirm that the lesions were similar between groups. Immunohistochemical and histological evaluation of the brain was performed to evaluate angio-neurogenesis and neurological outcome at two weeks. CM contained growth factors, such as VEGF, FGF-b and PDGF-bb. A significant increase in capillary density was noted in the peri-infarct areas of EPC- and CM-treated animals. Bielschowsky’s staining revealed a significant increase in axonal rewiring in EPC-treated animals compared with shams, but not in CM-treated mice, in close proximity with DCX-positive migrating neuroblasts. At the functional level, post-ischemia forelimb strength was significantly improved in animals receiving EPCs or CM, but not in those receiving vehicle media. In conclusion, we demonstrate for the first time that the administration of EPC-secreted factors could become a safe and effective cell-free option to be considered in future therapeutic strategies for stroke.
Translation and Reception of The Wealth of Nations by Spanish and Latin American Authors during Eighteenth and Nineteenth Centuries  [PDF]
Paz Molero Hernández
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.35008
Abstract: The objective of this paper is not the complete work, but namely to analyze the reasons for which in Spain and Latin America The Wealth of Nations, was censored in the eighteenth and nineteenth centuries and to analyze in turn whether the reasons for this censorship correspond to the ideas that Adam Smith effectively defended. It is not intended to judge the intention of any of the parties involved in this process but to understand the context in which they occurred, and to judge whether people in Spanish-speaking countries during those centuries knew what Adam Smith actually wanted to express.
On the Asymptotics of Stochastic Restrictions  [PDF]
José A. Hernández
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.64075
Abstract: This paper investigates inference methods to introduce prior information in econometric modelling through stochastic restrictions. The goal is to show that stochastic restrictions method estimator can be asymptotically more efficient than the estimator ignoring prior information and can achieve efficiency if prior information grows faster than the sample information in the asymptotics. The set up includes the nonlinear least squares and indirect inference estimators. The paper proposes a new indirect inference estimator that incorporates stochastic equality constraints on the parameters of interest. Finally, the proposed approach is applied to a macroeconomics model where high efficiency gains are shown.
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