Abstract:
無 This paper deseribes the idea of Data-oriented Chilifur Authorina System(system name: CAITOOL). CAITOOL, was programmed in PASCAI, language under environment of ET Chinese system, base on independ modulerand data structure. Any courseware desisned by this system only include fileof integer data type (two hytes). so these courseware can he run in differentsoftware or hardware environment. Programmer can design different translator program to-explain these cotirseware data, it will increase the portabilityof CAI courseware.

Abstract:
Background: The Chang Gung University School of Medicine adopted problem-basedlearning (PBL) education 3 years ago. A questionnaire was designed to evaluatethe effectiveness of this teaching method, and the results were analyzedto determine statistical significance.Methods: In June 2001, all the interns in the Medical and Surgical departments of theChang Gung Memorial Hospital were compulsorily assessed using a newlydeveloped questionnaire, which was provided to the residents, chief resident,and attending doctors. The questions involved the interns' ability to perform10 essential skills, namely (1) problem searching, (2) problem solving, (3)initiative learning, (4) thinking process, (5) establishing the patient-doctorrelationship, (6) establishing the doctor-nurse relationship, (7) interactionwith peers, (8) professional knowledge, (9) clinical techniques, and (10)medical notes writing. Forty-three completed questionnaires, evaluating 25interns, were returned. Of these 25 individuals, 14 had participated in PBLeducation and 11 had been taught using the conventional variant.Results: No statistically significant differences were demonstrated for gender or averageschool records between the interns who had been taught using the PBLand conventional methods. Statistically significant superiority was demonstratedfor interns educated using PBL in three of 10 areas including, thinkingprocess, professional knowledge, and clinical techniques.Conclusion: Analysis of the questionnaire results clearly demonstrated that the introductionof the PBL method of teaching at the university was efficacious in termsof the competence demonstrated by the interns when entering clinical practice.

Abstract:
Flemingia macrophylla (Leguminosae) is a popular traditional remedy used in Taiwan as anti-inflammatory, promoting blood circulation and antidiabetes agent. Recent study also suggested its neuroprotective activity against Alzheimer's disease. Therefore, the effects of F. macrophylla on Aβ production and degradation were studied. The effect of F. macrophylla on Aβ metabolism was detected using the cultured mouse neuroblastoma cells N2a transfected with human Swedish mutant APP (swAPP-N2a cells). The effects on Aβ degradation were evaluated on a cell-free system. An ELISA assay was applied to detect the level of Aβ1-40 and Aβ1-42. Western blots assay was employed to measure the levels of soluble amyloid precursor protein and insulin degrading enzyme (IDE). Three fractions of F. macrophylla modified Aβ accumulation by both inhibiting β-secretase and activating IDE. Three flavonoids modified Aβ accumulation by activating IDE. The activated IDE pool by the flavonoids was distinctly regulated by bacitracin (an IDE inhibitor). Furthermore, flavonoid 94-18-13 also modulates Aβ accumulation by enhancing IDE expression. In conclusion, the components of F. macrophylla possess the potential for developing new therapeutic drugs for Alzheimer's disease.

Abstract:
We study the properties of the odd Catalan numbers, C_n, modulo 2^k for k >= 2. We show that there exist only k - 1 different congruences of the odd Catalan numbers modulo 2^k. Moreover, these congruences can be obtained by C_{2^m - 1} (mod 2^k) for m = 1, 2, ..., k - 1.

Abstract:
Under some hypotheses on the singular type of the one-parameter family of elliptic curves in a primitively polarized $K3$ surface $S$ determined by its polarization (which is expected to be true for a very general polarized $K3$ surface), we give a more geometric proof of the fact that the second Chern class of $S$ is equal to $24 \cdot o_S$ in the Chow group of $0$-cycles where $o_S$ is the Beauville-Voisin canonical $0$-cycle.

Abstract:
The purpose of this short note is to study dominant rational maps from punctual Hilbert schemes of length $k>1$ of projective K3 surfaces $S$ containing infinitely many rational curves. Precisely, we prove that their image is necessarily rationally connected if this rational map is not generically finite. As an application, we simplify the proof of C. Voisin's of the fact that symplectic involutions of any projective K3 surface $S$ act trivially on $\mathrm{CH}_0(S)$.

Abstract:
We show that the image of a dominant meromorphic map from an irreducible compact Calabi-Yau manifold in a wider sense $X$ whose general fiber is of dimension strictly between $0$ and $\dim X$ is rationally connected. Using this result, we construct for any hyper-K\"ahler manifold $X$ admitting a Lagrangian fibration a Lagrangian constant cycle subvariety $\Sigma_H$ in $X$ for every divisor class $H$ whose restriction to some smooth Lagrangian fiber is ample. We also show that up to a scalar multiple, the class of a zero-cycle supported on $\Sigma_H$ in $CH_0(X)$ does not depend neither on $H$ nor on the Lagrangian fibration (provided $b_2(X) \ge 7$).

Abstract:
For a generalized Kummer variety X of dimension 2n, we will construct for each 0 < i < n some co-isotropic subvarieties in X foliated by i-dimensional constant cycle subvarieties. These subvarieties serve to prove that the rational orbit filtration introduced by Voisin on the Chow group of zero-cycles of a generalized Kummer variety coincides with the induced Beauville decomposition from the Chow ring of abelian varieties. As a consequence, the rational orbit filtration is opposite to the conjectural Bloch-Beilinson filtration for generalized Kummer varieties.