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Search Results: 1 - 10 of 79125 matches for " Yung-Husan Chen "
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New Benzoyl Glucosides and Cytotoxic Pterosin Sesquiterpenes from Pteris ensiformis Burm.
Yung-Husan Chen,Fang-Rong Chang,Mei-Chin Lu,Pei-Wen Hsieh,Ming-Jiuan Wu,Ying-Chi Du,Yang-Chang Wu
Molecules , 2008, DOI: 10.3390/molecules13020255
Abstract: Three new compounds: 2R,3R-pterosin L 3-O-β-D-glucopyranoside (1), β-Dxylopyranosyl(1→2)-7-O-benzoyl-β-D-glucopyranoside (2) and 4-O-benzoyl-β-D-xylopyranosyl(1→2)-7-O-benzoyl-β-D-glucopyranoside (3), together with nine knowncompounds, were isolated from the ethyl acetate extract of Pteris ensiformis. 5-[2-Hydroxyethylidene]-2(5H)-furanone (4), which had been synthesized, was isolated fromnatural sources for the first time. The structures of all isolated compounds were determinedon the basis of mass and spectroscopic evidence. Compound 1 and pterosin B (5) showcytotoxicity against HL 60 cells (human leukemia) with the IC50 values of 3.7 and 8.7μg/mL, respectively.
Pseudoalteromone B: A Novel 15C Compound from a Marine Bacterium Pseudoalteromonas sp. CGH2XX
Yu-Hsin Chen,Jimmy Kuo,Jui-Hsin Su,Tsong-Long Hwang,Yung-Husan Chen,Chia-Hung Lee,Ching-Feng Weng,Ping-Jyun Sung
Marine Drugs , 2012, DOI: 10.3390/md10071566
Abstract: A novel 15C compound, pseudoalteromone B ( 1), possessing a novel carbon skeleton, was obtained from a marine bacterium Pseudoalteromonas sp. CGH2XX. This bacterium was originally isolated from a cultured-type octocoral Lobophytum crassum, that was growing in cultivating tanks equipped with a flow-through sea water system. The structure of 1 was established by spectroscopic methods. Pseudoalteromone B ( 1) displayed a modestly inhibitory effect on the release of elastase by human neutrophils.
Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp.
Yung-Husan Chen,Chia-Ying Tai,Tsong-Long Hwang,Ching-Feng Weng,Jan-Jung Li,Lee-Shing Fang,Wei-Hsien Wang,Yang-Chang Wu,Ping-Jyun Sung
Marine Drugs , 2010, DOI: 10.3390/md8122936
Abstract: Two new eunicellin-type diterpenoids, cladielloides A ( 1) and B ( 2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B ( 2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human?neutrophils.
Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)
Chih-Yang Liu,Tsong-Long Hwang,Mei-Ru Lin,Yung-Husan Chen,Yu-Chia Chang,Lee-Shing Fang,Wei-Hsien Wang,Yang-Chang Wu,Ping-Jyun Sung
Marine Drugs , 2010, DOI: 10.3390/md8072014
Abstract: A new bioactive sterol glycoside, 3 β- O-(3 ',4 '-di- O-acetyl- β-D-arabinopyranosyl)-25 ξ-cholestane-3 β,5 α,6 β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A ( 1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.
Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.
Yung-Husan Chen,Chia-Ying Tai,Yin-Di Su,Yu-Chia Chang,Mei-Chin Lu,Ching-Feng Weng,Jui-Hsin Su,Tsong-Long Hwang,Yang-Chang Wu,Ping-Jyun Sung
Marine Drugs , 2011, DOI: 10.3390/md9060934
Abstract: Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F ( 1) and (–)-solenopodin C ( 2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin? 2 was found to be an enantiomer of the known eunicellin solenopodin C ( 3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.
Antioxidant Activities of Extracts and Main Components of Pigeonpea [Cajanus cajan (L.) Millsp.] Leaves
Nan Wu,Kuang Fu,Yu-Jie Fu,Yuan-Gang Zu,Fang-Rong Chang,Yung-Husan Chen,Xiao-Lei Liu,Yu Kong,Wei Liu,Cheng-Bo Gu
Molecules , 2009, DOI: 10.3390/molecules14031032
Abstract: Antioxidant activities of the aqueous and ethanol extracts of pigeonpea [Cajanus cajan (L.) Millsp.] leaves, as well as petroleum ether, ethyl acetate, n-butanol and water fractions and the four main compounds separated from the ethanol extract, i.e. cajaninstilbene acid (3-hydroxy-4-prenylmethoxystilbene-2-carboxylic acid), pinostrobin, vitexin and orientin, were examined by a DPPH radical-scavenging assay and a β-carotene-linoleic acid test. In the DPPH system, the antioxidant activity of the ethanol extracts was superior to that of the aqueous extracts, with IC50 values were 242.01 and 404.91 μg/mL, respectively. Among the four fractions, the ethyl acetate one showed the highest scavenging activity, with an IC50 value of 194.98 μg/mL. Cajaninstilbene acid (302.12 μg/mL) and orientin (316.21 μg/mL) showed more efficient radical-scavenging abilities than pinostrobin and vitexin. In the β-carotene-linoleic acid test, the inhibition ratio (%) of the ethyl acetate fraction (94.13%±3.41%) was found to be the highest, being almost equal to the inhibition capacity of the positive control BHT (93.89%±1.45%) at 4 mg/mL. Pinostrobin (>500 μg/mL) and vitexin (>500 μg/mL) showed insignificant antioxidant activities compared with cajaninstilbene (321.53 μg/mL) and orientin (444.61 μg/mL). In general, the ethyl acetate fraction of the ethanol extract showed greater activity than the main compounds in both systems, such results might be attributed to the synergistic effects of the components. The antioxidant activities of all the tested samples were concentration-dependent. Based on the results obtained, we can conclude that the pigeonpea leaf extracts may be valuable natural antioxidant sources and are potentially applicable in both medicine and the healthy food industry.
A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli
Wei-Hsuan Yen,Wu-Fu Chen,Ching-Hsiao Cheng,Chang-Feng Dai,Mei-Chin Lu,Jui-Hsin Su,Yin-Di Su,Yu-Hsin Chen,Yu-Chia Chang,Yung-Husan Chen,Jyh-Horng Sheu,Chan-Shing Lin,Zhi-Hong Wen,Ping-Jyun Sung
Molecules , 2013, DOI: 10.3390/molecules18032895
Abstract: A new sterol, (22 R,23 R,24 R)-5α,8α-epidioxy-22,23-methylene-24-methyl-cholest-6,9(11)-dien-3β-ol ( 1), and two known sterols, (22 R,23 R,24 R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest-6-en-3β-ol ( 2) and 24-methylenecholestane-1α,3β,5α, 6β,11α-pentol ( 3), were isolated from the soft coral Sinularia gaweli. The structure of sterol 1 was established by spectroscopic methods and by comparison of the spectral data with those of known analogues. The cytotoxicity of sterols 1– 3 towards various tumor cells is reported.
Natural Product Chemistry of Gorgonian Corals of the Family Plexauridae Distributed in the Indo-Pacific Ocean
Li-Hsueh Wang,Jyh-Horng Sheu,Shih-Yao Kao,Jui-Hsin Su,Yung-Husan Chen,Yu-Hsin Chen,Yin-Di Su,Yu-Chia Chang,Lee-Shing Fang,Wei-Hsien Wang,Yang-Chang Wu,Ping-Jyun Sung
Marine Drugs , 2012, DOI: 10.3390/md10112415
Abstract: The structures, names, bioactivities and references of 105 natural products obtained from gorgonian corals belonging to the family Plexauridae with an Indo-Pacific distribution are described in this review. All compounds mentioned in this review were obtained from gorgonian corals belonging to the genera Astrogorgia, Bebryce, Echinomuricea, Euplexaura and Menella.
Cembrane Derivatives from the Soft Corals, Sinularia gaweli and Sinularia flexibilis
Li-Chung Hu,Wei-Hsuan Yen,Jui-Hsin Su,Michael Yen-Nan Chiang,Zhi-Hong Wen,Wu-Fu Chen,Ting-Jang Lu,Yu-Wei Chang,Yung-Husan Chen,Wei-Hsien Wang,Yang-Chang Wu,Ping-Jyun Sung
Marine Drugs , 2013, DOI: 10.3390/md11062154
Abstract: A new norcembranoidal diterpene, 1- epi-sinulanorcembranolide A ( 1), and a new cembranoidal diterpene, flexibilin D ( 2), were isolated from the soft corals, Sinularia gaweli and Sinularia flexibilis, respectively. The structures of new metabolites 1 and 2 were elucidated by spectroscopic methods, and compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. In addition, S. flexibilis yielded a known cembrane, 5-dehydrosinulariolide ( 3); the structure, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis.
Excavatoids O and P, New 12-Hydroxybriaranes from the Octocoral Briareum excavatum
Ping-Jyun Sung,Gung-Ying Li,Yin-Di Su,Mei-Ru Lin,Yu-Chia Chang,Ting-Hsuan Kung,Chan-Shing Lin,Yung-Husan Chen,Jui-Hsin Su,Mei-Chin Lu,Jimmy Kuo,Ching-Feng Weng,Tsong-Long Hwang
Marine Drugs , 2010, DOI: 10.3390/md8102639
Abstract: Two new 12-hydroxybriarane diterpenoids, designated as excavatoids O ( 1) and P ( 2), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1 and 2 were established on the basis of extensive spectral data analysis. Excavatoid P ( 2) is the first metabolite which possesses a 6 b-chlorine atom in briarane analogues.
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