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Search Results: 1 - 10 of 51040 matches for " Yun-Feng Lan "
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Effects of nerve growth factor on the action potential duration and repolariz-ing currents in a rabbit model of myocardial infarction
Yun-Feng Lan,Jian-Cheng Zhang,Jin-Lao Gao,Xue-Ping Wang
老年心脏病学杂志(英文版) , 2013,
Abstract: Objectives To investigate the effect of nerve growth factor (NGF) on the action potential and potassium currents of non-infarcted myocardium in the myocardial infarcted rabbit model. Methods Rabbits with occlusion of the left anterior descending coronary artery were prepared and allowed to recover for eight weeks (healed myocardial infarction, HMI). During ligation surgery of the left coronary artery, a polyethylene tube was placed near the left stellate ganglion in the subcutis of the neck for the purpose of administering NGF 400 U/d for eight weeks (HMI + NGF group). Cardiomyocytes were isolated from regions of the non-infarcted left ventricular wall and the action potentials and ion currents in these cells were recorded using whole-cell patch clamps. Results Compared with HMI and control cardiomyocytes, significant prolongation of APD50 or APD90 (Action potential duration (APD) measured at 50% and 90% of repolarization) in HMI + NGF cardiomyocytes was found. The results showed that the 4-aminopyridine sensitive transient outward potas sium current (Ito), the rapidly activated omponent of delayed rectifier potassium current (IKr), the slowly activated component of delayed rectifier potassium current (IKs), and the L-type calcium current (ICaL) were significantly altered in NGF + HMI cardiomyocytes compared with HMI and control cells. Conclusions Our results suggest that NGF treatment significantly prolongs APD in HMI cardiomyocytes and that a decrease in outward potassium currents and an increase of inward Ca2+ current are likely the underlying mechanism of action.
Ion mechanism of isoproterenol on delayed afterdepolarization and triggered activity in the infarcted ventricle
Jin-Liao Gao,Hong-Juan Wang,Yun-Feng Lan,Zhou Fang
老年心脏病学杂志(英文版) , 2010,
Abstract: Objectives This study aimed at investigating the cellular mechanism of isoproterenol (ISO) on delayed after depolarizations (DADs) and triggered activity (TA) of the noninfarcted myocardium in the myocardial infarcted rabbit model. Methods Rabbits with the left anterior descending coronary artery occlusion were prepared and recovered for 8 wk (healed myocardial infarction, HMI). Myocytes were isolated from regions of the noninfarcted left ventricular free wall. ISO was added to cellular surface by perfusion way. Action potentials and ion currents were recorded with whole-cell patch clamp. Results The results showed that treatment with ISO induced more DADs and TA events in HMI myocytes. Inward transient current (Iti) and ICa-L of myocytes treated with ISO were increased significantly compared with HMI cells, which contributed to DADs-related triggered arrhythmia. Conclusions The results suggested that more arrhythmia events of DADs and TA developed in myocytes with ISO treatment. The underlying mechanism was associated with the augment of Iti and calcium influxing.
Age-related increase of early afterdepolarization in calsequestrin-2 knock-in mouse cardiomycyte
Yun-Feng Lan,Yi Wen,Zhou Fang,Jin-Lao Gao
老年心脏病学杂志(英文版) , 2010,
Abstract: Objective To characterize early afterdepolarizations (EADs) caused triggered activity (TA) among calsequestrin-2 (CASQ2) knock-in (CASQ2 KI) mice and its relationship with aging. Methods Electrophysiological properties of ventricular myocytes from 3-month (mo, young), 9-mo (adult-1) and 12-mo (adult-2) in wild-type (WT) and CASQ2 KI mice were investigated with patch-clamp technique. Results The incidences of EADs and TA in CASQ2 KI cardiomyocytes increased with increasing age. In contrast, WT mice cardiomyocytes showed no significant change in matched-age groups. Compared with that in 3-mo CASQ2 KI mice, the 50% repolarization of action potential (APD50) showed prolongation in both 9-mo and 12-mo ones (9.2 ± 0.9 ms of 9-mo and 10.3 ± 1.2 ms of 12-mo vs. 5.6 ± 0.3 ms of 3-mo), while the 90% repolarization of action potential (APD90) was similar among 3 age groups. Compared with 3-mo mice, the 9-mo and 12-mo CASQ2 KI mice showed markedly reduced transient outward potassium current (Ito) densities but increased L-type calcium current (ICa-L) densities. Conlcusion This study suggested that events of EADs and TA in CASQ2 KI mice increased with increasing age. It might be associated partly with the augment of cellular calcium concentration and the prolongation of APD50 induced by decrease of Ito and increase of ICa-L in adult CASQ2 KI mice.
Natural Gas Exploration Using Carbon Isotopic Fractionation Effect: A Case Study of Shanxi Formation, Upper Palaeozoic Group in the Center of Ordos Basin, China
Yun-Feng Zhang
International Journal of Chemical Engineering and Applications , 2013, DOI: 10.7763/ijcea.2013.v4.252
Abstract: Carbon isotopic fractionation would occur during the process of natural gas generation and migration. As for ‘self-generating and self-preserving’ tight sandstone gas reservoir, carbon isotope better keeps the current maturity and migration results. In this paper, three local hydrocarbon generation centers and two relatively lower permeability zones were determined from the study area and it is suggested that natural gas migrated roughly from south to north direction through the analysis of carbon isotope isoline. Thus, we predict three favorable exploration areas using natural gas storage index combined with above isotopic results.
On Semantic and Syntactical Selective Constraints among Multiple Words in Context
Yun-feng LIU
Cross-Cultural Communication , 2006, DOI: 10.3968/585
Abstract: The semantic and syntactical selective constraints among multiple words in context are surveyed. Main types of selective constraints in context are: selective constraint between immediate constitutes, the one among multiple words in the same sentence, the one among multiple words in different sentences and that between words and situational factors. And they are further grouped into different categories. The knowledge of these selective constraints must be used in syntactical analysis of natural language processing for disambiguation. Keywords: context, multiple words, selective constraints, disambiguation Résumé Cet essai travaille sur les relations sélectives et contraignantes des expressions dans le texte sous l’angle sémantique et syntaxique. Les principales sélections et contraintes des expressions viennent des mots voisins, du troisième mot de la même phrase, du troisième mot d’une autre phrase, du contexte, etc. L’auteur fait une classification de ces sélections et contraintes. On doit recourir aux sélections et contraintes de différents niveux pour éliminer les interprétations différentes dans l’analyse syntaxique. Mots-clés: texte, expressions, sélections et contraintes, élimination des interprétaions différentes 摘要 本文在語篇中考察多詞項間的語義句法選擇限制關係。語篇中的詞項所受到的選擇限制主要有:句 內直接成分間的選擇限制、句內第三個詞項的選擇限制、跨句中第三個詞項的選擇限制、以及語境因素的選 擇限制等,並對這些選擇限制作了歸類。句法分析中必須利用各種層面的選擇限制信息來進行歧義消解。 關鍵詞:中文摘要語篇;多詞項;選擇限制;歧義消除
On-chip Single Nanoparticle Detection and Sizing by Mode Splitting in an Ultra-high-Q Microresonator
Jiangang Zhu,Sahin Kaya Ozdemir,Yun-Feng Xiao,Lin Li,Lina He,Da-ren Chen,Lan Yang
Physics , 2009, DOI: 10.1038/nphoton.2009.237
Abstract: The ability to detect and size individual nanoparticles with high resolution is crucial to understanding behaviours of single particles and effectively using their strong size-dependent properties to develop innovative products. We report real-time, in-situ detection and sizing of single nanoparticles, down to 30 nm in radius, using mode-splitting in a monolithic ultra-high-Q whispering-gallery-mode (WGM) microtoroid resonator. Particle binding splits a WGM into two spectrally shifted resonance modes, forming a self-referenced detection scheme. This technique provides superior noise suppression and enables extracting accurate size information in a single-shot measurement. Our method requires neither labelling of the particles nor apriori information on their presence in the medium, providing an effective platform to study nanoparticles at single particle resolution.
Ion mechanism of isoproterenol on delayed afterdepolarization and triggered activity in the infarcted ventricle

Jin-Liao Gao,Hong-Juan Wang,Yun-Feng Lan,Zhou Fang,Yan Liu,Min Lin,Yi-Cheng Fu,Yang Li,

老年心脏病学杂志(英文版) , 2010,
Abstract: Objectives This study aimed at investigating the cellular mechanism of isoproterenol (ISO) on delayed afterdepolarizations (DADs) and triggered activity (TA) of the noninfarcted myocardium in the myocardial infarcted rabbit model.Methods Rabbits with the left anterior descending coronary artery occlusion were prepared and recovered for 8 wk (healed myocardial infarction, HMI). Myocytes were isolated from regions of the noninfarcted left ventricular free wall. ISO was added to cellular surface by perfusion way. Action potentials and ion currents were recorded with whole-cell patch clamp. Results The results showed that treatment with ISO induced more DADs and TA events in HMI myocytes. Iti and ICa-L of myocytes treated with ISO were increased significantly compared with HMI cells, which contributed to DADs-related triggered arrhythmia. Conclusions The results suggested that more arrhythmia events of DADs and TA developed in myocytes with ISO treatment. The underlying mechanism was associated with the augment of Iti and calcium influxing (J Geriatr Cardiol 2010; 7:180-183).
A Light-Deprivation Mouse Model Potentially for Studying the Complete Congenital Stationary Night Blindness  [PDF]
Chanyi Lu, Qiqin Li, Yaoyao Li, Yun Wang, Yun-Feng Zhang
World Journal of Neuroscience (WJNS) , 2016, DOI: 10.4236/wjns.2016.63022
Abstract: Current rodent models of the complete congenital stationary night blindness (CSNB1) were time- consuming in breeding and validation, which makes it imperative to find a more “easily handle” animal model to broaden our understanding of this disorder. In the present study, a light-deprivation (LD) mouse model was made to validate whether it was a more “suitable” animal mode for investigating the pathogenesis of the CSNB1. Compared with controls, the LD mice exhibited a remarkable reduction in the amplitude of the dark-adapted electroretinogram (ERG) b-wave, the Max-ERG b-wave and also the oscillatory potentials (Ops), indicating an abnormal activity of rod bipolar cells in the retina. However, the ERG a-wave was relatively normal in the LD mice, which was quite consistent with what was confirmed in previously reported animal models of the CSNB1 and CSNB patients. Taken together, the LD mouse model showed CSNB1-like negative ERG responses as evidenced by the abnormal b-wave. Our study will provide a potentially useful animal model to decipher the pathogenesis of the CSNB1.
A Short Glance at the Neural Circuitry Mechanism Underlying Depression  [PDF]
Chanyi Lu, Qiqin Li, Yaoyao Li, Yun Wang, Yun-Feng Zhang
World Journal of Neuroscience (WJNS) , 2016, DOI: 10.4236/wjns.2016.63023
Abstract: Depression leads to a large social burden because of its substantial impairment and disability in everyday activities. The prevalence and considerable impact of this disorder call for a better understanding of its pathophysiology to improve the diagnosis, treatment and prevention. Though productive animal models and pathophysiological theories have been documented, it is still very far to uncover the complex array of symptoms caused by depression. Moreover, the neural circuitry mechanism underlying behavioral changes in some depression-like behavior animals is still limited. Changes in the neural circuitry of amygdala, dorsal raphe nucleus, ventral tegmental area, hippocampus, locus coeruleus and nucleus accumbens are related to depression. However, the interactions between individual neural circuitry of different brain areas, have not yet been fully elucidated. The purpose of the present review is to examine and summarize the current evidence for the pathophysiological mechanism of depression, with a focus on the neural circuitry, and emphasize the necessity and importance of integrating individual neural circuitry in different brain regions to understand depression.
Implementation of Outline Font in VxWorks5.5
VxWorks5.5 平台下矢量字体显示的实现

LING Yun-Feng,
凌云锋

计算机系统应用 , 2011,
Abstract: Bitmap fonts are used to display in VxWorks5.5,which is simple and widely used.But it will not meet the demand when we don't make sure which font size is ok as each bitmap font file has only one font and one size.We can achieve a variety of fonts and sizes by using the TrueType fonts and FreeType font engine.This paper describes the basic principle of TrueType and FreeType technology,and how to realize outline font display by using WindML,FreeType and TrueType fonts.
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