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Search Results: 1 - 10 of 3120 matches for " Yuko Yoshida "
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Effects of Green Tea Powder Feed Supplement on Performance of Hens in the Late Stage of Laying
Sadao Kojima,Yuko Yoshida
International Journal of Poultry Science , 2008,
Abstract: The effects of green tea powder on the levels of alpha-tocopherol in egg yolk, egg production and egg quality of laying hens were examined. Twenty 84-week-old laying hens were divided into 4 dietary groups of 5 hens each in the late stages of laying. Four levels of green tea powder (0% = control diet, 1%, 5% and 10%) were fed to the hens for 3 weeks. At the end of 3 weeks, all experimental diets were switched to the control diet (0% green tea powder) for 3 weeks. The first group was fed the controlled diet throughout the experimental period. The egg weight, egg mass and feed intake were the highest for the 0% and 1% green tea powder diets and the lowest for the 5% and 10% diets (P < 0.05). The rate of egg production and the intake of feed decreased significantly with an increase in the intake of green tea powder (P < 0.05). The weights of the hens who received up to 5% green tea powder in their diets decreased. However, the gain in the hens` weight was not influenced by the intake of 1% green tea powder diet. There were no significant differences in the yolk color fan score for the 4 treatment diets. The egg shell strength decreased with increasing green tea powder intake, while the alpha-tocopherol content of egg yolk of the hens fed the experimental diet increased with increasing green tea powder intake. The fatty acid composition of yolk was not affected by the diet. The results suggested that the transfer of alpha-tocopherol from dietary green tea powder to egg yolk was sensitive to the alpha-tocopherol intake and that green tea supplementation would support adequate egg production and egg weight when used up to a level of 1% in the diets of laying hens.
Identification of a Morphogenic Intermediate of the Bacteriophage Mu Baseplate  [PDF]
Nao Tsukamoto, Yuko Kanazawa, Yuzuki Shimamori, Keiko Yoshida, Shigeki Takeda
Advances in Microbiology (AiM) , 2014, DOI: 10.4236/aim.2014.416125
Abstract: Bacteriophage morphogenesis is a model system for investigating sequential molecular assembly. The Mu phage is one of the most classical Myoviridae. Although it is well known as a mobile genetic element, the details of its morphogenesis remain unclear. Analysis of conditional lethal mutants and genome analysis of the Mu phage have suggested that genes 42, 43, 44, 45, 46, 47, and 48 are essential for its baseplate assembly. Since we have already reported X-ray structures of the products of genes 44 (gp44) and 45 (gp45), we here tried to purify the remaining Mu phage baseplate subunits, gp42, gp43, gp46, gp47, and gp48, to investigate the baseplate assembly process. In the case of gp42 expression, the transformed E. coli cells showed growth inhibition after induction and no gp42 fractions were observed. However, gp43, gp46, gp47, and gp48 were successfully expressed and purified, although gp48 could not be applied to further analysis, because the amount of soluble fraction was very low. Based on analytical ultracentrifugation, we concluded that gp43 formed a monomer, gp46 was a monomer, and gp47 occurred as both a monomer and dimer in solution. Moreover, we found that gp43 and gp45 formed an intermediate complex in the baseplate assembly process.
The State of Fatigue and Sleep among Clinical Nurses in Japan  [PDF]
Naomi Sumi, Naotaka Sugimura, Yuko Yoshida, Rika Yano
Open Journal of Nursing (OJN) , 2017, DOI: 10.4236/ojn.2017.712104
The objective of this study was to investigate the state of fatigue and sleep among clinical nurses in Japan. This descriptive cross-sectional study was conducted from December 2015 to January 2016. The participants were nurses who worked in public hospitals with 500 beds in the major cities and regional cities of Hokkaido. Fatigue was quantitatively assessed using the Cumulative Fatigue Symptoms Index (CFSI). Among nurses in their twenties, the rate of complaints about anxiety and decrease in vitality were high, which was replaced with complaints about irritability among nurses in their thirties. The most popular complaint among nurses in their forties was general fatigue. There was no difference in complaint ratios concerning the workplace location among nurses in their twenties and thirties, nurses in their forties working in suburban areas complained about fatigue more than their urban area. Nurses with sleep problems related to anxiety have a significantly higher complaint rate for all the eight items of CFSI compared with the nurses who do not have such problems (p < 0.001). This is an intermediate report and is part of a study that aims to develop a health management program for hospital nurses regarding fatigue and sleep.
Investigation of the Burnout Stages Experienced by Nurses Working in Hospitals and Related Factors  [PDF]
Naomi Sumi, Yuko Yoshida, Naotaka Sugimura, Rika Yano
Open Journal of Nursing (OJN) , 2018, DOI: 10.4236/ojn.2018.84022
Background: The purpose of this study was to elucidate the stages of nurse burnout in hospitals (their states of emotional exhaustion and depersonalization) as well as factors related to the nurses personal characteristics and coping behaviors in order to obtain suggestions for stress and health management strategies that nurses themselves can employ. Methods: We conducted a cross-sectional study using anonymous self-administered questionnaires. The subjects were nurses employed at public hospitals with 500 beds in 3 cities in Hokkaido, Japan. The questionnaire items for burnout were those included on the Japanese Maslach Burnout Inventory (MBI), which are designed to ascertain the subjects’ emotional exhaustion, depersonalization, and sense of personal accomplishment. In addition, we used 11 items related to physical and mental stress responses on the Stress Coping Inventory and the Brief Job Stress Questionnaire to determine factors such as the nurses’ basic attributes, whether or not they worked night shifts, and their overtime hours, etc. Results: We received responses from 1461 hospital nurses. Those whose scores for both emotional exhaustion and depersonalization were the mean or above were 40.2% of those in their twenties, 35.8% of those in their thirties, and 26.8% of those in their forties or older. The results of logistic regression analysis indicated that among those in the group that scored high for both emotional exhaustion and depersonalization, the influential factors were stress score (odds ratio 1.889), twenties age group (odds ratio 1.982), thirties age group (odds ratio 1.720), coping behavior: avoidance-focused behaviors (odds ratio 1.140), and engaged in childcare (odds ratio 0.487). Similarly, when looked at by age group, being in the twenties age group and having a spouse were influential factors (odds ratio 3.114 - 4.171).
Relationship between Sleep and Subjective Fatigue in Rotating Shift Nurses: Validation Using a Wearable Device  [PDF]
Yuko Yoshida, Naomi Sumi, Naotaka Sugimura, Fumie Nemoto, Rika Yano
Open Journal of Nursing (OJN) , 2018, DOI: 10.4236/ojn.2018.84023
The objective of this study was to determine if sleep indicators are associated with subjective fatigue in nurses working in a rotating, two-shift system with a 16-hour night shift, using the wearable device Fitbit One. Subjective fatigue was evaluated using the Subjective Fatigue Symptom Questionnaire (SFSQ), a rating scale developed by the Working Group for Occupational Fatigue of the Japan Society for Occupational Health. Subjects were asked to continuously wear a Fitbit One to obtain the following data: time in bed (TIB), deep sleep time, length and frequency of nighttime awakening, sleep efficiency, waking time, and bed time. Nurses had a mean age and standard deviation of 33.2 ± 7.5 years and had worked as nurses for 9.8 ± 6.2 years on average. Eight nurses were in their 20s (42.1%), 5 in their 30s (26.3%), and 6 in their 40s (31.6%). All participants were female. Participants SFSQ scores calculated from the 9 evenings in the study period were averaged to establish a threshold for categorizing high-fatigue (HF) and low-fatigue (LF) groups. No significant differences were found between HF and LF nurses in terms of TIB, deep sleep time, nighttime awakening time or frequency, or sleep efficiency on any type of day (as classified by shift, day off, etc.). Nurses in both groups woke up significantly later on days off and on pre-night-shift days than on day-shift days. These results demonstrate the variation in sleep patterns of nurses on a rotating, two-shift system between day-shift and night-shift days.
Mechanism of Growth Inhibition of Human Cancer Cells by Conjugated Eicosapentaenoic Acid, an Inhibitor of DNA Polymerase and Topoisomerase
Yuko Yonezawa,Hiromi Yoshida,Yoshiyuki Mizushina
International Journal of Molecular Sciences , 2007, DOI: 10.3390/i8121206
Abstract: DNA topoisomerases (topos) and DNA polymerases (pols) are involved in manyaspects of DNA metabolism such as replication reactions. We found that long chainunsaturated fatty acids such as polyunsaturated fatty acids (PUFA) (i.e., eicosapentaenoicacid (EPA) and docosahexaenoic acid (DHA)) inhibited the activities of eukaryotic pols andtopos in vitro, and the inhibitory effect of conjugated fatty acids converted from EPA andDHA (cEPA and cDHA) on pols and topos was stronger than that of normal EPA and DHA.cEPA and cDHA did not affect the activities of plant and prokaryotic pols or other DNAmetabolic enzymes tested. cEPA was a stronger inhibitor than cDHA with IC50 values formammalian pols and human topos of 11.0 - 31.8 and 0.5 - 2.5 μM, respectively. cEPAinhibited the proliferation of two human leukemia cell lines, NALM-6, which is a p53-wildtype, and HL-60, which is a p53-null mutant, and the inhibitory effect was stronger than thatof normal EPA. In both cell lines, cEPA arrested in the G1 phase, and increased cyclin Eprotein levels, indicating that it blocks the primary step of in vivo DNA replication byinhibiting the activity of replicative pols rather than topos. DNA replication-relatedproteins, such as RPA70, ATR and phosphorylated-Chk1/2, were increased by cEPAtreatment in the cell lines, suggesting that cEPA led to DNA replication fork stressinhibiting the activities of pols and topos, and the ATR-dependent DNA damage response pathway could respond to the inhibitor of DNA replication. The compound induced cellapoptosis through both p53-dependent and p53-independent pathways in cell lines NALM-6and HL-60, respectively. These results suggested the therapeutic potential of conjugatedPUFA, such as cEPA, as a leading anti-cancer compound that inhibited pols and toposactivities.
Reinforcement Learning for a New Piano Mover
Yuko Ishiwaka,Tomohiro Yoshida,Yukinori Kakazu
Journal of Systemics, Cybernetics and Informatics , 2005,
Abstract: We attempt to achieve corporative behavior of autonomous decentralized agents constructed via Q-Learning, which is a type of reinforcement learning. As such, in the present paper, we examine the piano mover's problem. We propose a multi-agent architecture that has a training agent, learning agents and intermediate agent. Learning agents are heterogeneous and can communicate with each other. The movement of an object with three kinds of agent depends on the composition of the actions of the learning agents. By learning its own shape through the learning agents, avoidance of obstacles by the object is expected. We simulate the proposed method in a two-dimensional continuous world. Results obtained in the present investigation reveal the effectiveness of the proposed method.
Different Magnetic Resonance Imaging Manifestations of Diabetic Chorea in a Case with Hyperglycemia and Another One with Hypoglycemia  [PDF]
Hodaka Yamada, Rika Saikawa, Suzuki Daisuke, Yuko Matsumoto, Masashi Yoshida, Kazuo Hara
Case Reports in Clinical Medicine (CRCM) , 2018, DOI: 10.4236/crcm.2018.73019
Abstract: Diabetic chorea (DC) is a rare complication of diabetes. Here we describe two cases of DC; patient 1 was an 87-year-old woman with chronic kidney disease and was administered with sulphonylurea and dipeptidylpeptodase-4 inhibitor. She showed right side hemiballismus and head magnetic resonance imaging T1-weighted images revealed a high intensity area in the putamen and caudate nucleus. Patient 2 was a 51-year-old woman who was diagnosed with diabetic ketoacidosis. She showed right side hemiballism and multiple, small hyperintense regions in both the periventricular sides in diffusion weighted images. Based on the hemiballism, we concluded a diagnosis of DC in the diabetic patient, although the case presentation is rare or has atypical MRI findings.
Limited Functional Health Literacy, Health Information Sources, and Health Behavior among Community-Dwelling Older Adults in Japan
Yuko Yoshida,Hajime Iwasa,Shu Kumagai,Takao Suzuki,Hideyo Yoshida
ISRN Geriatrics , 2014, DOI: 10.1155/2014/952908
Abstract: The objectives of this study were to explore how health information sources vary by functional health literacy levels and the relationship between health literacy and health behaviors among the old-old, community-dwelling adults. A cross-sectional study was used. The sample included 620 participants from a rural community in northern Japan. We used structured questionnaires to gather demographic information and assess health-related behaviors, information sources utilized, and functional health literacy. Functional health literacy scores were categorized into three groups, namely, low, middle, and high literacy. Individuals with limited health literacy were more likely to drink less alcohol, were less physically active, had less dietary variety, and had a low rate of medical check-ups. They were also less likely to use printed media, organization or medical procedure, electronic media, and accessed fewer health-related information sources. This study highlights the necessity of information tools that facilitate better access to information among older adults with limited health literacy. 1. Introduction Limited health literacy is a barrier to adequate health care. Health literacy is defined as “the degree to which individuals have the capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions” [1]. People with limited health literacy typically have a poor understanding of their medical condition and medical prescriptions, as well as poorer disease management, making it difficult for them to make good decisions regarding various aspects of their health [2]. Limited health literacy among older adults is a major concern because it has implications for their overall health. Previous research has shown a limited health literacy rate of around 24% [3–5] among community-dwelling older adults. Therefore, in the interests of community service, it is important to consider ways of providing health information to older adults who have limited health literacy. Previous studies have shown that limited health literacy is independently associated with a poorer health status, inclusive of physical and mental health [4], as well as mortality [6–9]. Older adults with limited health literacy have a poor understanding of health-related information [10] and tend to have limited access to health care services [3, 11]. Thus, health care access may act as a mediator between limited health literacy and poor health status among older adults. Furthermore, varying health literacy levels may contribute to disparities
Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells
Sachiko Tsukamoto,Yuko Yamashita,Takushi Yoshida,Tomihisa Ohta
Marine Drugs , 2004, DOI: 10.3390/md204170
Abstract: The extract of the sea hare, Aplysia kurodai, showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded two active compounds, which were subsequently identified to be parguerol and isoparguerol by spectroscopic analysis. It was found that both parguerol and isoparguerol induced neurite outgrowth in PC-12 cells at concentrations of 25 and 50 μM, respectively.
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