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Search Results: 1 - 10 of 728 matches for " Yuko Furuhashi "
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Risperidone Versus Yokukansan in the Treatment of Severe Alzheimer’s Disease  [PDF]
Yuko Furuhashi, Kouichi Shin
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.22028
Abstract: PURPOSE: Patients with AD commonly exhibit behavioral and psychological symptoms of dementia (BPSD). This study is aimed to compare the efficacy of yokukansan (YKS) and risperidone (RIS) on BPSD in patients with severe Alzheimer’s disease (AD). METHODS: Thirty eight inpatients with AD were investigated. Patients were randomly as-signed to the YKS group (N = 18) or the RIS group (N = 20) and treated for 4 weeks. The primary outcomes were changes in the scores on the Neuropsychiatric Inventory (NPI), the Mini-Mental State Examination (MMSE), the Bar-thel Index, and the Cohen-Mansfield Agitation Inventory (CMAI). The frequency of extrapyramidal symptoms (EPS) and other adverse events were recorded at every visit. RESULTS: All participants in both groups completed the trial. The Barthel Index did not significantly change either in the RIS group or the YKS group. The MMSE scores did not change either in the RIS group or the YKS group. Significant improvements in mean total NPI and CMAI scores showed in both groups. Between the YKS and the RIS groups, there were no significant differences in the NPI or the CMAI scores. EPS and other serious adverse effects were not observed in either group. CONCLUSIONS: In this 4-week trial, YKS treatment significantly improved BPSD in the patients with severe AD. The present study suggests that YKS is as effective as RIS on BPSD with severe AD.
Acute Normalization of Thyroxine Induced Hallucinations and Delusions  [PDF]
Yuko Furuhashi, Masaya Ishikawa
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.35066
Abstract: The association between disorders of thyroid function and psychiatric symptoms is well established. Generally, hypo-thyroidism is recognized as being able to induce psychotic symptoms. However, psychotic symptoms without affective and cognitive disturbances are rare in hyperthyroidism. We presented a patient with Graves’ disease who suffered from delusions and hallucinations without affective and cognitive disturbances following abrupt normalization of thyroid function. Furthermore, the patient was clinically and biochemically euthyroid when the psychotic symptoms developed. There was resolution of psychotic symptoms in this case. It is suggested that the abrupt change of thyroxine may cause susceptible individuals to become transient psychotic state.
Adult Onset Cerebral X-Linked Adrenoleuokodystrophy in 18 Cases  [PDF]
Yuko Furuhashi, Masaya Ishikawa
Health (Health) , 2015, DOI: 10.4236/health.2015.76086
Abstract: Adrenoleukodystrophy (ALD) is an X-linked inherited metabolic disease associated with the accumulation of very long chain fatty acids (VLCFA) in the nervous system, adrenal cortex, and testes. At least seven phenotypes can be distinguished, which are Addison only, childhood, adolescent and adult cerebral ALD, adrenomyeloneuropathy (AMN), and symptomatic or asymptomatic carriers. Children most often develop rapidly a progressive cerebral disease, whereas adults rarely develop a cerebral disease. The majority of adult-onset ALD patients are AMN. The prognosis of ALD remains unpredictable in individual patients. Family history can be very informative. The plasma VLCFA assay permits precise diagnosis. Specific changes on brain Magnetic Resonance Imaging (MRI) can have diagnostic utility. However, there is considerable overlap among adult-onset leukodystrophies. Adult onset form of cerebral X-linked ALD (AOCALD) is a rare disease. The disease progresses rapidly with widespread demyelination of the cerebral hemispheres. AOCALD is an important differential diagnosis for adults with psychiatric symptoms and progressive cognitive changes. In this article, we review on case reports of AOCALD.
Sleep Related Eating Disorder as an Unexpected Effect of Zolpidem  [PDF]
Yuko Furuhashi, Sumiko Satomura
Neuroscience & Medicine (NM) , 2019, DOI: 10.4236/nm.2019.102005
Abstract: Zolpidem is a sedative-hypnotic drug used to treat in sleep disorders, and it is the most commonly prescribed drug for insomnia. It reduces sleep latency and increases total sleep time. However, some studies have reported that zolpidem might induce sleep related eating disorder (SRED). SRED is characterized by recurrent episodes of compulsive and involuntary eating during night sleep, accompanied by partial consciousness and limited subsequent recall. The pathophysiology of SRED is unknown. Patients with SRED usually suffer from other sleep disorders such as sleepwalking, restless legs syndrome, and obstructive sleep apnea. In this article, we present an overview of case reports on SRED induced by zolpidem.
Lifestyle Adjustment Process to Maintain Family Life for Mothers with Children Who Need Home Medical Care  [PDF]
Yuko Nakakita, Yuko Tomari
Health (Health) , 2018, DOI: 10.4236/health.2018.1012127
Abstract: This aim is to clarify lifestyle adjustment process to maintain family life for mothers with children who need home medical care. We conducted semi-structured interviews with the mothers of children who required home medical care comprising procedures such as suction of sputum and respiratory management over a period of several years since the initiation of home medical care, and analyzed the results using the modified grounded theory approach (M-GTA). We found the process to be composed of nine categories. Immediately after their child who required home medical care began living at home, mothers were concerned about the protection of their unstable child and, therefore, made care of the child a priority. However, they gradually started experiencing the need to engage services for the child in the course of their daily lives and live their lives with assistance. In the course of this new lifestyle, mothers began to regulate their fluctuating feelings and discover a new lifestyle for the family by making the father’s role clear and having him take on some responsibilities, such as dealing with people outside the household. As a result, once making home medical care consistent with the family’s lifestyle, even if this care was not at the same level as that provided while the child was hospitalized, mothers felt they found a way that allowed them to spend time with their other children. In addition, they began to perceive the necessity of maintaining their health, which is crucial to the child’s care. Overall, this facilitated incorporation of prospects for the family’s future life because they tended to pay more attention to their health and the health of their other children. Further, this contributed in coordination of the selection of services that would benefit the entire family, thereby maintaining the family’s lifestyle.
Relationship between Family Care and Public Care Services for the Elderly  [PDF]
Yuko Mihara
Modern Economy (ME) , 2015, DOI: 10.4236/me.2015.69089
Abstract: Japan has been experiencing significant changes in its demographics. This study examines the effects of public care services and in doing so, aims to show that it is possible to improve overall welfare level by substituting family care with public care services, particularly when family care and public care services are interchangeable. In addition, we show that instead of reducing family care to zero, further expanding public care services can help achieve welfare optimization.
Instability of Massive Scalar Fields in Kerr-Newman Spacetime
Hironobu Furuhashi,Yasusada Nambu
Physics , 2004, DOI: 10.1143/PTP.112.983
Abstract: We investigate the instability of charged massive scalar fields in Kerr-Newman spacetime. Due to the super-radiant effect of the background geometry, the bound state of the scalar field is unstable, and its amplitude grows in time. By solving the Klein-Gordon equation of the scalar field as an eigenvalue problem, we numerically obtain the growth rate of the amplitude of the scalar field. Although the dependence of the scalar field mass and the scalar field charge on this growth rate agrees with the result of the analytic approximation, the maximum value of the growth rate is three times larger than that of the analytic approximation. We also discuss the effect of the electric charge on the instability of the scalar field.
Photobiont Flexibility in Paramecium bursaria: Double and Triple Photobiont Co-Habitation  [PDF]
Ryo Hoshina, Yuko Fujiwara
Advances in Microbiology (AiM) , 2012, DOI: 10.4236/aim.2012.23027
Abstract: The green ciliate, Paramecium bursaria, has evolved a mutualistic relationship with endosymbiotic green algae (photobionts). Under culture conditions, photobionts are usually unified (to be single species) within each P. bursaria strain. In most cases, the algal partners are restricted to either Chlorella variabilis or Micractinium reisseri (Chlorellaceae, Trebouxiophyceae). Both species are characterized by particular physiology and atypical group I intron insertions, although they are morphologically indistinguishable from each other or from other Chlorella-related species. Both algae are exclusive species that are viable only within P. bursaria cells, and therefore their symbiotic relationship can be considered persistent. In a few cases, the other algal species have been reported as P. bursaria photobionts. Namely, P. bursaria have occasionally replaced their photobiont partner. This paper introduces some P. bursaria strains that maintain more than one species of algae for a long period. This situation prompts speculations about flexibility of host-photo-biont relationships, how P. bursaria replaced these photobionts, and the infection theory of the group I introns.
Expression and Localization of NANOS1 in Spermatogenic Cells during Spermatogenesis in Rat  [PDF]
Sadaki Yokota, Yuko Onohara
CellBio (CellBio) , 2013, DOI: 10.4236/cellbio.2013.21001

Expression and localization of NANOS1 in the spermatogenic cells of rat testis were studied by immunofluorescence and immunoelectron microscopy. Using immunofluorescence techniques, NANOS1 was localized in the cytoplasm and discrete granules of spermatocytes and spermatids. The staining intensity of NANOS1 signal varied depending upon the stage of the cycle of seminiferous epithelium. Double immunofluorescence staining with antibodies against NANOS1 and DDX4 showed that several DDX4-positive compartments of nuage were also stained for NONOS1. Immunoelectron microscopy revealed that the major subcellular localization sites for NANOS1 were the chromatoid body (CB) and satellite body (SB), and the minor sites were the rest of the nuage compartments, including the irregularly-shaped perinuclear granules (ISPG), and intermitochondrial cement (IMC). Non-nuage structures such as mitochondria-associated granules (MAG), granulated body (GB), and reticulated body (RB) were also labeled by theNANOS1 antibody. In addition, NANOS1 was found in the outer dense fibers of flagella of spermatids at steps 12-19, and in the head cap of late spermatids after step 15. These results suggest that NANOS1 is one of the nuage proteins and functions mainly in the CBs as well as in the cytoplasm. NANOS1 may also have additional functions in non-nuage structures such as MAGs, GBs and RBs.

Thinking Process of Nursing Students’ Clinical Judgment in Pediatric Nursing Practicum  [PDF]
Mari Okada, Yuko Tomari
Open Journal of Nursing (OJN) , 2017, DOI: 10.4236/ojn.2017.711091

This aim is to clarify thinking process of nursing students clinical judgment, i.e., how nursing students act and think and what influences this thinking process of identifying approaches necessary for the children under their care in pediatric nursing practicum. By the analysis of M-GTA, students concurrently performed “A: Analytically contemplating the state of this child’s body” and B: Contextually contemplating this child’s?individuality”. As a result, they acquired “C: Understandingof this child as a familiar existence.” This allows students to enable them to “D: Identify the necessary approach using judgment criteria for this child.” Furthermore, as situations that promote thinking by relating to all processes of thinking, students experienced “E: Attempts to solve problems through various measures” and “F: Encouragement of thinking through reflection.” Meanwhile, G: Stagnation of thinking because of concerning matters” inhibited the progress of thinking. We found a need for education after grasping the process of student thought.

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