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Search Results: 1 - 10 of 36731 matches for " Yuhai Zhao "
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TREM2 signaling, miRNA-34a and the extinction of phagocytosis
Yuhai Zhao,Walter J. Lukiw
Frontiers in Cellular Neuroscience , 2013, DOI: 10.3389/fncel.2013.00131
Abstract:
miRNAs and viroids utilize common strategies in genetic signal transfer
Yuhai Zhao,Surjyadipta Bhattacharjee,Walter J. Lukiw
Frontiers in Molecular Neuroscience , 2014, DOI: 10.3389/fnmol.2014.00010
Abstract:
Regulating amyloidogenesis through the natural triggering receptor expressed in myeloid/microglial cells 2 (TREM2)
Surjyadipta Bhattacharjee,Yuhai Zhao,Walter J. Lukiw
Frontiers in Cellular Neuroscience , 2014, DOI: 10.3389/fncel.2014.00094
Abstract:
Aluminum-Induced Amyloidogenesis and Impairment in the Clearance of Amyloid Peptides from the Central Nervous System in Alzheimer’s Disease
Yuhai Zhao,Surjyadipta Bhattacharjee,Walter J. Lukiw
Frontiers in Neurology , 2014, DOI: 10.3389/fneur.2014.00167
Abstract:
Attitudes toward statistics in medical postgraduates: measuring, evaluating and monitoring
Zhang Yuhai,Shang Lei,Wang Rui,Zhao Qinbo
BMC Medical Education , 2012, DOI: 10.1186/1472-6920-12-117
Abstract: Background In medical training, statistics is considered a very difficult course to learn and teach. Current studies have found that students’ attitudes toward statistics can influence their learning process. Measuring, evaluating and monitoring the changes of students’ attitudes toward statistics are important. Few studies have focused on the attitudes of postgraduates, especially medical postgraduates. Our purpose was to understand current attitudes regarding statistics held by medical postgraduates and explore their effects on students’ achievement. We also wanted to explore the influencing factors and the sources of these attitudes and monitor their changes after a systematic statistics course. Methods A total of 539 medical postgraduates enrolled in a systematic statistics course completed the pre-form of the Survey of Attitudes Toward Statistics 28 scale, and 83 postgraduates were selected randomly from among them to complete the post-form scale after the course. Results Most medical postgraduates held positive attitudes toward statistics, but they thought statistics was a very difficult subject. The attitudes mainly came from experiences in a former statistical or mathematical class. Age, level of statistical education, research experience, specialty and mathematics basis may influence postgraduate attitudes toward statistics. There were significant positive correlations between course achievement and attitudes toward statistics. In general, student attitudes showed negative changes after completing a statistics course. Conclusions The importance of student attitudes toward statistics must be recognized in medical postgraduate training. To make sure all students have a positive learning environment, statistics teachers should measure their students’ attitudes and monitor their change of status during a course. Some necessary assistance should be offered for those students who develop negative attitudes.
Determination of Melamine in Quail Egg and Milk with Capillary Zone Electrophoresis  [PDF]
Yu Kong, Chong Wei, Zilong Wang, Zhanwu Hou, Hua Li, Jiang Yu, Jiaqiang Yuan, Yongxi Zhao, Jiangang Long, Yuhai Tang, Meili Gao
American Journal of Analytical Chemistry (AJAC) , 2014, DOI: 10.4236/ajac.2014.54032
Abstract: A capillary zone electrophoresis method was developed for determination of melamine in food samples, such as quail egg and milk products. The CE procedure was performed on fused silica capillary (41 cm × 75 μm I.D.) at 17 kV using pH3.1 60mmol/L phosphate buffer as run buffer and detecting at 200 nm. The proposed method showed good linearity (0.5 - 10.0 μmol/L) and low LOD (0.5 μmol/L) with good reproducibility (RSD% was 2.4 and 3.2 for migration time and peak area respectively), which made it suitable for quantity control of the related food product.
Worm Structure in Modified Swift-Hohenberg Equation for Electroconvection
Yuhai Tu
Physics , 1997, DOI: 10.1103/PhysRevE.56.R3765
Abstract: A theoretical model for studying pattern formation in electroconvection is proposed in the form of a modified Swift-Hohenberg equation. A localized state is found in two dimension, in agreement with the experimentally observed ``worm" state. The corresponding one dimensional model is also studied, and a novel stationary localized state due to nonadiabatic effect is found. The existence of the 1D localized state is shown to be responsible for the formation of the two dimensional ``worm" state in our model.
Smaller Genetic Risk in Catabolic Process Explains Lower Energy Expenditure, More Athletic Capability and Higher Prevalence of Obesity in Africans
Cheng Xue, Yun-Xin Fu, Yuhai Zhao, Yun Gong, Xiaoming Liu
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026027
Abstract: Lower energy expenditure (EE) for physical activity was observed in Africans than in Europeans, which might contribute to the higher prevalence of obesity and more athletic capability in Africans. But it is still unclear why EE is lower among African populations. In this study we tried to explore the genetic mechanism underlying lower EE in Africans. We screened 231 common variants with possibly harmful impact on 182 genes in the catabolic process. The genetic risk, including the total number of mutations and the sum of harmful probabilities, was calculated and analyzed for the screened variants at a population level. Results of the genetic risk among human groups showed that most Africans (3 out of 4 groups) had a significantly smaller genetic risk in the catabolic process than Europeans and Asians, which might result in higher efficiency of generating energy among Africans. In sport competitions, athletes need massive amounts of energy expenditure in a short period of time, so higher efficiency of energy generation might help make African-descendent athletes more powerful. On the other hand, higher efficiency of generating energy might also result in consuming smaller volumes of body mass. As a result, Africans might be more vulnerable to obesity compared to the other races when under the same or similar conditions. Therefore, the smaller genetic risk in the catabolic process might be at the core of understanding lower EE, more athletic capability and higher prevalence of obesity in Africans.
Metal-Sulfate Induced Generation of ROS in Human Brain Cells: Detection Using an Isomeric Mixture of 5- and 6-Carboxy-2′,7′-Dichlorofluorescein Diacetate (Carboxy-DCFDA) as a Cell Permeant Tracer
Aileen I. Pogue,Brandon M. Jones,Surjyadipta Bhattacharjee,Maire E. Percy,Yuhai Zhao,Walter J. Lukiw
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13089615
Abstract: Evolution of reactive oxygen species (ROS), generated during the patho-physiological stress of nervous tissue, has been implicated in the etiology of several progressive human neurological disorders including Alzheimer’s disease (AD) and amylotrophic lateral sclerosis (ALS). In this brief communication we used mixed isomers of 5-(and-6)-carboxy-2′,7′-dichlorofluorescein diacetate (carboxy-DCFDA; C 25H 14C l2O 9; MW 529.3), a novel fluorescent indicator, to assess ROS generation within human neuronal-glial (HNG) cells in primary co-culture. We introduced pathological stress using the sulfates of 12 environmentally-, industrially- and agriculturally-relevant divalent and trivalent metals including Al, Cd, Cu, Fe, Hg, Ga, Mg, Mn, Ni, Pb, Sn and Zn. In this experimental test system, of all the metal sulfates analyzed, aluminum sulfate showed by far the greatest ability to induce intracellular ROS. These studies indicate the utility of using isomeric mixtures of carboxy-H 2DCFDA diacetates as novel and highly sensitive, long-lasting, cell-permeant, fluorescein-based tracers for quantifying ROS generation in intact, metabolizing human brain cells, and in analyzing the potential epigenetic contribution of different metal sulfates to ROS-generation and ROS-mediated neurological dysfunction.
Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models
Yuhai Zhao,Frederic Calon,Carl Julien,Jeremy W. Winkler,Nicos A. Petasis,Walter J. Lukiw,Nicolas G. Bazan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0015816
Abstract: Neuroprotectin D1 (NPD1) is a stereoselective mediator derived from the omega-3 essential fatty acid docosahexaenoic acid (DHA) with potent inflammatory resolving and neuroprotective bioactivity. NPD1 reduces Aβ42 peptide release from aging human brain cells and is severely depleted in Alzheimer's disease (AD) brain. Here we further characterize the mechanism of NPD1's neurogenic actions using 3xTg-AD mouse models and human neuronal-glial (HNG) cells in primary culture, either challenged with Aβ42 oligomeric peptide, or transfected with beta amyloid precursor protein (βAPP)sw (Swedish double mutation APP695sw, K595N-M596L). We also show that NPD1 downregulates Aβ42-triggered expression of the pro-inflammatory enzyme cyclooxygenase-2 (COX-2) and of B-94 (a TNF-α-inducible pro-inflammatory element) and apoptosis in HNG cells. Moreover, NPD1 suppresses Aβ42 peptide shedding by down-regulating β-secretase-1 (BACE1) while activating the α-secretase ADAM10 and up-regulating sAPPα, thus shifting the cleavage of βAPP holoenzyme from an amyloidogenic into the non-amyloidogenic pathway. Use of the thiazolidinedione peroxisome proliferator-activated receptor gamma (PPARγ) agonist rosiglitazone, the irreversible PPARγ antagonist GW9662, and overexpressing PPARγ suggests that the NPD1-mediated down-regulation of BACE1 and Aβ42 peptide release is PPARγ-dependent. In conclusion, NPD1 bioactivity potently down regulates inflammatory signaling, amyloidogenic APP cleavage and apoptosis, underscoring the potential of this lipid mediator to rescue human brain cells in early stages of neurodegenerations.
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