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Search Results: 1 - 10 of 120051 matches for " Yuemin Wang "
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Application of Novel Subspace Pursuit on Guided Wave NDT Signal Decomposition and Recognition Based on Improved Evolutionary Algorithm
Chuanjun Shen,Yuemin Wang,Yan Liu,Fangjun Zhou
Research Journal of Applied Sciences, Engineering and Technology , 2012,
Abstract: In this study, we propose and apply a kind of novel subspace pursuit method to guided wave Non-Destructive Testing (NDT) signal decomposition and recognition to reduce the complexity of subspace pursuit. Modified Differential Evolution Algorithm (MDEA) is applied to the Modified Subspace Pursuit (MSP) by choosing chirplet function as match atoms. A steel pipe with hole and notch is detected by guided wave and the measured signal is decomposed and reconstructed by MSP. The matching result is compared to the matching result from MP with DEA. The defect echo can be identified easily from the processed signal. The matched parameters get by MSP and MP are compared and analyzed. The defect locations are more exactly get from MSP than from MP.
Role and molecular mechanism of HO-1-mediated NF-κB modulation in fibrosis progression of nonalcoholic steatohepatitis
NAN Yuemin
Journal of Clinical Hepatology , 2013,
Abstract: ObjectiveTo investigate the potential effects and molecular mechanisms of heme oxygenase-1 (HO-1)-mediated modulation of nuclear factor-kappa B (NF-κB), and its downstream activation of intercellular adhesion molecule 1 (ICAM-1) and platelet derived growth factor (PDGF), in fibrosis progression of non-alcoholic steatohepatitis (NASH) using the methionine and choline deficient (MCD) mouse model of NASH. Methods Forty C57BL/6J male mice (18-20 g) were randomly divided into four groups (n=10 each): NASH model group, administered the MCD diet; HO-1 agonist group, administered the MCD diet with intraperitoneal (ip) injections of hemin (30 μmol/kg every other day); HO-1 inhibitor group, administered the MCD diet with ip injections of zinc protoporphyrin (ZnPP-IX; 20 μmol/kg every other day); and control group, administered a methionine and choline sufficient (MCS) diet, without agonist nor inhibitor injections. After eight weeks, the mice were sacrificed and resected liver tissues used to assess successful model establishment by histological analysis (hematoxylin-eosin and Masson staining) and the differential mRNA expression of HO-1, NF-κB, ICAM-1, and PDGF by real-time quantitative PCR (GAPDH normalized) and protein expression of HO-1 and PDGF by western blotting ( β-actin normalized). Significance of an intergroup difference was assessed by single-factor analysis of variance test, and the Student-Newman-Keuls test was used for pairwise comparisons. ResultsThe NASH model group showed the appropriate histologic features of hepatic steatosis, necroinflammation and fibrogenesis, while the control group showed normal lobular architecture. In addition, the NASH model group showed significantly higher expression of HO-1, NF-κB, ICAM-1 and PDGF mRNA (all P<0.05), and concomitant increases in HO-1 and PDGF protein. The group treated with HO-1 agonist showed significant down-regulation of the NASH-induced NF-κB, ICAM-1 and PDGF expressions, while the opposite effect (accompanied by severe liver injury) was observed in the group treated with HO-1 inhibitor. Conclusion Inhibiting HO-1 activation in NASH could attenuate NF-κB signaling and expression of its downstream effectors ICAM-1 and PDGF to protect against fibrosis- and inflammation-related liver injury.
The Internet and the Rise of Information Network Cities in China

WANG Mingfeng,NING Yuemin,

地理学报 , 2004,
Abstract: Advanced information and telecommunication technology has brought human being into a new information age, resulting in the emerging of an informational, global, and networked society. In the 1990s, the rapid growth of the Internet not only had strong impacts on the social and economic fields, but also restructured the organizations of global physical and virtual spaces. In recent years, the scholarly research on Internet has rapidly increased in many fields such as urban geography in the western developed countries. However, little research on the cities of developing countries exists in the Internet studies literature, and almost none addresses the topic of China, despite of their obvious implications for urban development in China. This paper seeks to fill this gap and understand the impact of Internet on the urban system in China. Based on the measurement of Internet backbone networks, it analyses the spatial structure of the Internet city network and ranks these cities in China. Beijing, Shanghai and Guangzhou and their linkages constitute the core level of long-distance telecommunication network. The investments in infrastructure are rewriting the map of competitive advantage of cities. An urban network of the information network cities is emerging in which the geographical factor plays an important role.
Global Production Networks of Computer Industry and Its Development in Mainland China
计算机产业全球生产网络分析 —— 兼论其在中国大陆的发展

LI Jian,NING Yuemin,WANG Mingfeng,

地理学报 , 2008,
Abstract: The development of globalization and advancement of production technology further lead to the transformation of social production organization.New international division of labor has penetrated into the inner layer of products,and the global value chain and the global production networks have been brought into multidisciplinary research.The new theories can better explain the new changes of production organization in modern world.Based on introducing the concepts and remarks of global production networks,this paper firstly discusses the general organization of global production networks of computer industry.Secondly,according to two indexes of value increment and profitability,the paper proposes two kinds of smiling curve and takes the GPN framework to explain it,including value analysis and its spatial competition,corporation organization and power distribution.Thirdly,the paper studies the smiling curve of Chinese computer industry,and holds discussions on value and its spatial competition,and then discusses embeddness of Chinese computer industry to global production networks.
Slip energy barriers in aluminum and implications for ductile versus brittle behavior
Yuemin Sun,Efthimios Kaxiras
Physics , 1996, DOI: 10.1080/01418619708214014
Abstract: We conisder the brittle versus ductile behavior of aluminum in the framework of the Peierls-model analysis of dislocation emission from a crack tip. To this end, we perform first-principles quantum mechanical calculations for the unstable stacking energy $\gamma_{us}$ of aluminum along the Shockley partial slip route. Our calculations are based on density functional theory and the local density approximation and include full atomic and volume relaxation. We find that in aluminum $\gamma_{us} = 0.224$ J/m$^2$. Within the Peierls-model analysis, this value would predict a brittle solid which poses an interesting problem since aluminum is typically considered ductile. The resolution may be given by one of three possibilites: (a) Aluminum is indeed brittle at zero temperature, and becomes ductile at a finite temperature due to motion of pre-existing dislocations which relax the stress concentration at the crack tip. (b) Dislocation emission at the crack tip is itself a thermally activated process. (c) Aluminum is actually ductile at all temperatures and the theoretical model employed needs to be significantly improved in order to resolve the apparent contradiction.
Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice
Lingbo Kong, Weiguang Ren, Wencong Li, Suxian Zhao, Hongmei Mi, Rongqi Wang, Yuguo Zhang, Wenjuan Wu, Yuemin Nan, Jun Yu
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-246
Abstract: C57BL/6J mice fed with 4% ethanol-containing Lieber-DeCarli liquid diet for 12 weeks exhibited hepatocyte steatosis, necrosis and inflammatory infiltration, accompanied with elevated serum alanine aminotransferase (ALT) and aspartic transaminase (AST) levels, decreased hepatic expression of PPARα, lipids oxidation promoting genes and anti-inflammatory factors, as well as enhanced hepatic expression of fatty acids synthesis promoting genes and pro-inflammatory cytokines. Induction of PPARα by PPARα agonist WY14643 treatment for 2 weeks ameliorated the severity of liver injury and restored expression of genes altered by ethanol treatment. However, administration of PPARα antagonist GW6471 for 2 weeks promoted the inflammatory response.The present study provided the evidence for the protective role of PPARα in ameliorating ethanol induced liver injury through modulation of the genes related to lipid metabolism and inflammatory response.Alcoholic liver injury is a progressive process encompassing hepatic steatosis and steatohepatitis. The latter may progress to liver fibrosis, cirrhosis and even hepatocellular carcinoma [1]. Chronic ethanol exposure impairs fatty acid oxidation and enhances lipogenesis by targeting key transcriptional regulators of genes controlling these metabolic processes, including peroxisome proliferators activated receptor gamma coactivator 1 alpha (PGC-1α) [2], sterol regulatory element binding protein 1 (SREBP-1) and its downstream genes, such as fatty acid synthase (FAS) [2], resulting in the accumulation of triglyceride in the liver (steatosis). Fat accumulation renders the liver more susceptible to other injuries. Ethanol also contributes to the up-regulation of pro-inflammatory factors, osteopontin (OPN) [3-5] and cyclooxygenase-2 (COX-2) [6] in the liver, which promotes inflammatory injury and causes alcoholic steatohepatitis. Pharmacological treatment for patient with alcoholic steatohepatitis is still not available. There is compelling ne
Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice
YueMin Nan, RongQi Wang, SuXian Zhao, Fang Han, Wen Wu, LingBo Kong, Na Fu, Li Kong, Jun Yu
Lipids in Health and Disease , 2010, DOI: 10.1186/1476-511x-9-124
Abstract: C57BL/6J mice were fed with methionine-choline deficient (MCD) diet for four weeks to induce hepatic steatohepatitis. HO-1 chemical inducer (hemin), HO-1 chemical inhibitor zinc protoporphyrin IX (ZnPP-IX) and/or adenovirus carrying HO-1 gene (Ad-HO-1) were administered to mice, respectively. Hepatocyte apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay, the mRNA and protein expression of apoptosis related genes were assayed by quantitative real-time PCR and Western blot.Hepatocyte signs of oxidative related apoptotic injury were presented in mice fed with MCD diet for 4 weeks. Induction of HO-1 by hemin or Ad-HO-1 significantly attenuated the severity of liver histology, which was associated with decreased hepatic lipid peroxidation content, reduced number of apoptotic cells by TUNEL staining, down-regulated expression of pro-apoptosis related genes including Fas/FasL, Bax, caspase-3 and caspase-9, reduced expression of cytochrome p4502E1 (CYP2E1), inhibited cytochrome c (Cyt-c) release, and up-regulated expression of anti-apoptosis gene Bcl-2. Whereas, inhibition of HO-1 by ZnPP-IX caused oxidative stress related hepatic injury, which concomitant with increased number of TUNEL positive cells and up-regulated expression of pro-apoptosis related genes.The present study provided evidences for the protective role of HO-1 in preventing nutritional steatohepatitis through suppressing hepatocyte apoptosis in mice.Non-alcoholic steatohepatitis (NASH) is a chronic progressive liver disease which comprises steatosis, balloon degeneration, inflammation, and fibrosis in varying degrees [1]. The estimated prevalence of NASH is 3%-5% in general population [2]. Once NASH occurs, about 30% ~ 50% of individuals demonstrate advanced fibrosis or cirrhosis within a decade [3]. Up to now, the pathogenesis of NASH leading to disease progression remains poorly understood. The most widely accepted explanation is the two hit hypotheses [4
Akt-Signal Integration Is Involved in the Differentiation of Embryonal Carcinoma Cells
Bo Chen, Zheng Xue, Guanghui Yang, Bingyang Shi, Ben Yang, Yuemin Yan, Xue Wang, Daishu Han, Yue Huang, Wenji Dong
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0064877
Abstract: The mechanism by which Akt modulates stem cell homeostasis is still incompletely defined. Here we demonstrate that Akt phosphorylates special AT-rich sequences binding protein 1 (SATB1) at serine 47 and protects SATB1 from apoptotic cleavage. Meanwhile, Akt phosphorylates Oct4 at threonine 228 and Klf4 at threonine 399, and accelerates their degradation. Moreover, PI3K/Akt signaling enhances the binding of SATB1 to Sox2, thereby probably impairing the formation of Oct4/Sox2 regulatory complexes. During retinoic acid (RA)-induced differentiation of mouse F9 embryonal carcinoma cells (ECCs), the Akt activation profile as well as its substrate spectrum is strikingly correlated with the down-regulation of Oct4, Klf4 and Nanog, which suggests Akt activation is coupled to the onset of differentiation. Accordingly, Akt-mediated phosphorylation is crucial for the capability of SATB1 to repress Nanog expression and to activate transcription of Bcl2 and Nestin genes. Taken together, we conclude that Akt is involved in the differentiation of ECCs through coordinated phosphorylations of pluripotency/differentiation factors.
Nischarin Is Differentially Expressed in Rat Brain and Regulates Neuronal Migration
Yuemin Ding, Ruyi Zhang, Kena Zhang, Xinyou Lv, Yanan Chen, Aiqing Li, Linlin Wang, Xiong Zhang, Qiang Xia
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054563
Abstract: Nischarin is a protein known to inhibit breast cancer cell motility by regulating the signaling of the Rho GTPase family. However, little is known about its location and function in the nervous system. The aim of the present study was to investigate the regional and cellular expression and functions of Nischarin in the adult rodent brain. As assessed by real-time PCR, Western blot analysis and immunostaining, we found that Nischarin was widely distributed throughout the brain, with a higher expression in the cerebral cortex and hippocampus. Double-labeling showed that Nischarin was expressed in neurons and was mainly located in the perinuclear region and F-actin-rich protrusions. The expression pattern of Nischarin in the brain was thought to be closely associated with its function. This was verified by our findings from cell migration assays that Nischarin regulated neuronal migration. These results provide a preliminary survey of the distribution of Nischarin in different regions and cell types in the rat brain. This might help to elucidate its physiological roles, and to evaluate its potential clinical implications.
Catalytic Behaviour of Mesoporous Cobalt-Aluminum Oxides for CO Oxidation
Ankur Bordoloi,Miguel Sanchez,Heshmat Noei,Stefan Kaluza,Dennis Gro?mann,Yuemin Wang,Wolfgang Grünert,Martin Muhler
Journal of Catalysts , 2014, DOI: 10.1155/2014/807545
Abstract: Ordered mesoporous materials are promising catalyst supports due to their uniform pore size distribution, high specific surface area and pore volume, tunable pore sizes, and long-range ordering of the pore packing. The evaporation-induced self-assembly (EISA) process was applied to synthesize mesoporous mixed oxides, which consist of cobalt ions highly dispersed in an alumina matrix. The characterization of the mesoporous mixed cobalt-aluminum oxides with cobalt loadings in the range from 5 to 15?wt% and calcination temperatures of 673, 973, and 1073?K indicates that Co2+ is homogeneously distributed in the mesoporous alumina matrix. As a function of the Co loading, different phases are present comprising poorly crystalline alumina and mixed cobalt aluminum oxides of the spinel type. The mixed cobalt-aluminum oxides were applied as catalysts in CO oxidation and turned out to be highly active. 1. Introduction Supported metal oxide catalysts have attracted much attention in recent years due to their widespread applicability in industrially and academically important reactions. The extent and nature of the interaction, dispersion, and reducibility of the metal oxides depend on the synthesis method, loading, calcination temperature, and time. Cobalt supported on alumina is a typical catalyst, which is specially important for Fischer-Tropsch synthesis. Conventionally, the preparation of cobalt catalysts is performed by incipient wetness impregnation using suitable cobalt precursors on commercial alumina at low pH. Weak interaction is normally observed between the positively charged alumina carrier and the cobalt cations resulting in relatively large crystallite sizes [1–4]. Continuous efforts have been made in the last few decades by several groups [5–7] to synthesize porous alumina with high surface area by high-temperature dehydration of bulk powders [8], modified sol-gel synthesis in the presence of organic moieties [9, 10], different surfactants [3], block copolymers [11–14], or evaporation-induced self-assembly (EISA) with colloidal precursors and amine structural agents [15, 16]. These materials represent an active support, which may participate positively or negatively in the formation of the final catalysts. Moreover, the methods of hard templating [17] (carbon template) and microwave irradiation [18] in the presence of surfactants have been applied to synthesize alumina materials with crystalline, ordered, and uniform mesopores. However, this process is very time consuming and hardly scalable for industrial applications. Ordered mesoporous materials
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