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Search Results: 1 - 10 of 142073 matches for " Yue-hua Wang "
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Effects of the active components of Chinese herbal medicine Xiaoxuming Decoction on memory behavior and brain injury in rats with chronic cerebral ischemia
Yue-hua Wang
Zhong Xi Yi Jie He Xue Bao , 2012,
Abstract: OBJECTIVE: To study the effects of the active components of Xiaoxuming Decoction (XXM), a compound traditional Chinese herbal medicine, on chronic cerebral ischemia in rats.METHODS: Chronic cerebral ischemia was induced in rats by occlusion of bilateral common carotid arteries. Then, the rats with chronic cerebral ischemia were randomly divided into five groups: model group, extract of Ginkgo biloba group and low-, medium- and high-dose active components of XXM groups. Another 11 rats without occlusion of common carotid arteries were used as the sham-operation group. Memory behavior was investigated by Morris water maze test. The structure of hippocampus and cortex neurons was observed with Nissel staining. The white matter lesion was stained with Klüver-Barrera stain method to observe the pathological changes. The astrocyte activation was observed using immunohistochemical method with glial fibrillary acidic protein (GFAP) antibody. RESULTS: The active components of XXM could significantly improve the impairment of learning and memory induced by chronic cerebral ischemia in rats. Compared with the model group, the time to reach the platform for rats was shortened by treating with the active components of XXM in Morris water maze test, particularly in the medium-dose group (P<0.05). In addition, the low- and medium-dose active components of XXM improved the decrease of cerebrovascular reactivity induced by chronic cerebral ischemia. The results of the pathological analysis also suggested that the active components of XXM could ameliorate the pathological damage induced by chronic cerebral ischemia in rats with the number of neurons increased, and the morphology and distribution of neurons recovered to normal levels. The low-dose active components of XXM significantly reduced the white matter lesions (P<0.05, P<0.01). Active components of XXM treatment could also reduce the activation of astrocytes.CONCLUSION: The active components of XXM may attenuate the chronic cerebral ischemic injury in rats.
High-throughput screening assay for groups of effective components extracted from Xiaoxuming Recipe
Yue-Hua WANG,Guan-Hua DU
Zhong Xi Yi Jie He Xue Bao , 2006,
Abstract: Objective: To present a new approach for the research of effective components extracted from compounds of traditional Chinese medicine and their action mechanisms by high-throughput screening assay. Methods: We observed the anti-oxidation activities of 240 sequential components (L1-L120 and A1-A120) extracted from Xiaoxuming Recipe, the effects of these components on SH-SY5Y cells with H2O2-induced and L-glutamic acid-induced damages and the levels of resting calcium ion in neurocytes of rats. Results: Some components (L1-L40, A100-A120) extracted from Xiaoxuming Recipe had the corresponding effects listed above. The combination of these components was regarded as the groups of effective components of Xiaoxuming Recipe in treating sequelae resulting from brain ischemia. Conclusion: Xiaoxuming Recipe has protective effect on brain-ischemia-induced damages through the actions of multiple components with multiple targets.
Effects of the effective component group of Chinese herbal medicine Xiaoxuming Decoction on brain mitochondria in rats with chronic cerebral ischemia
Yue-hua Wang,Guan-hua Du
Zhong Xi Yi Jie He Xue Bao , 2012,
Abstract: OBJECTIVE: To investigate the effects of the effective component group of Xiaoxuming Decoction (XXM), a compound traditional Chinese herbal medicine, on cerebral mitochondria in rats with chronic cerebral ischemia.METHODS: Rats were subjected to permanent bilateral common carotid artery occlusion to induce chronic cerebral ischemia. Then, the rats with chronic cerebral ischemia were randomly divided into five groups: model group, extract of Ginkgo biloba group and low-, medium- and high-dose effective component group of XXM groups. Another 11 rats without common carotid artery occlusion were used as a sham control. Gradient centrifugation was used to obtain the mitochondria from the rat brain. Clark oxygen electrode method was used to determine mitochondrial respiratory function. Photometric determination was used to measure mitochondrial swelling. Rodamine 123 was used to measure mitochondrial membrane potential. Western blotting was used to detect mitochondrial apoptosis.RESULTS: Compared with the sham group, the mitochondria dysfunction was caused by chronic cerebral ischemia associated with the decrease of oxidative phosphorylation parameters and the mitochondrial membrane potential, the increase of the mitochondrial degree, the elevation of reactive oxygen species level, the decrease in Bcl-2/Bax ratio, and the release of cytochrome c. The effective component group of XXM could reduce mitochondrial damage induced by chronic cerebral ischemia by improving the indexes mentioned above.CONCLUSION: The effective component group of Xiaoxuming Decoction can protect brain mitochondrial homeostasis and improve the function of mitochondria in rats with chronic cerebral ischemia, which may be the mechanism of its protection against chronic cerebral ischemia.
Prospective study on the effect of omega-3 fish oil emulsion on inflammatory responses, immune function, and prognosis in patients with liver transplantation
Yue-hua WANG,Tao JIANG,Xuan WANG,Lei LU
Medical Journal of Chinese People's Liberation Army , 2012,
Abstract: Objective To investigate the effect of omega-3 fish oil emulsion on the inflammatory responses, immune function, and prognosis of patients after liver transplantation. Methods Thirty-six patients undergoing orthotopic liver transplantation at the Liver Transplantion Center of No. 81 Hospital of PLA from January 2009 to December 2010 were enrolled in this study. The patients were randomly divided into two study groups: the fish-oil group, in which patients were given omega-3 fish oil emulsion (n=18), and the control group (n=18). All the patients received isocaloric and isonitrogenous nutrition for six days, starting on the day after the operation. Blood samples were obtained pre-operatively and on the 2nd, 5th, and 8th days post-operation to measure cytokines (IL-1β, IL-2, IL-6, IL-10, TNF-α), C-reactive protein (CRP), and lymphocyte subpopulation (CD4, CD8, HLA-DR). The incidence of infection, and acute rejection, mortality, length of ICU stay, and postoperative length of hospital stay were also recorded. Results The cytokine levels after liver transplantation in all the patients were higher than those before operation. The IL-1β, IL-2, IL-6, and TNF-αlevels in the fish-oil group were significantly lower than those in the control group (P<0.05 or P<0.01). CRP level in the fish-oil group was significantly lower than that in the control group on the 5th postoperative day (POD5) (P<0.01). The CD4/CD8 ratio in the fish-oil group was significantly higher than that in the control group on POD5 (P<0.01). In addition, the IL-10 and TNF-αlevels in the fish-oil group were significantly higher than those in the control group (P<0.01). HLA-DR+ lymphocyte count in the fish-oil group was significantly lower than that in the control group on POD8 (P<0.05). The incidence rate of infection in the fish-oil group (16.7%) was significantly lower than that in the control group (55.6%, P=0.035). Moreover, the incidence rate of acute rejection and mortality showed no statistical difference between the two groups. However, patients in the fish-oil group had significantly shorter postoperative ICU and hospital stays (3.9±1.9d, 28.6±7.2d, respectively) than the control group (5.8±3.1d and 35.7±10.6d; P=0.034, P=0.024, respectively). Conclusion The administration of omega-3 fish oil emulsion to liver transplant patients can reduce excessive inflammatory responses, maintain the balance of pro-/antiinflammatory cytokines, modulate the immune function, lower the incidence of infection, and improve prognosis.
Is Sexual Ornamentation an Honest Signal of Male Quality in the Chinese Grouse (Tetrastes sewerzowi)?
Chen Yang, Jie Wang, Yun Fang, Yue-Hua Sun
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0082972
Abstract: We examined the variation in sexual ornamentation of male Chinese grouse (Tetrastes sewerzowi) in the Gansu Province, China, seeking to identify factors involved in whether ornament size and brightness are honest signals of male quality. Compared to unmated males, mated males had significantly larger and redder combs and, although they did not have significantly larger territories, they defended them more vigorously. Mated males had significantly higher blood carotenoid and testosterone levels, significantly better body condition, and significantly lower parasite loads than unmated males. Our findings are thus consistent with the hypothesis that comb size and color are honest signals of better male quality in the grouse, mediated through lower parasite loads and/or higher testosterone levels.
Investigation on Impedencemetric―type NO2 Sensor Based on La0.75Sr0.25Mn0.5Co0.5O3―δ Sensing Electrode
HAO Zeng-Chuan, WANG Ling, DAI Lei, CUI Guang-Hua, LI Yue-Hua
无机材料学报 , 2011, DOI: 10.3724/sp.j.1077.2011.00523
Abstract: The perovskite nanoparticle materials La0.75Sr0.25Mn0.5Co0.5O3―δ were prepared in YSZ porous layer by infiltration technology. An impedancemetric―type NO2 sensor was prepared with the nanoparticle materials as sensing electrode and YSZ as solid state electrolyte.The crystalline phase and microstructure of sensing electrode in the NO2 sensor were investigated by XRD and SEM. The result of XRD indicated that perovskite LSCM was obtained in porous YSZ after infiltrating precursor solution and heat―treatment. SEM analysis demonstrated that the grain size of LSCM was 50―100 nm, and the LSCM nanoparticles were closely incorporated with YSZ frames in porous layer. The sensing characteristics of the present device were also investigated at 450―600 . The results suggested that the sensor showed preferential sensitivity to NO2 with NO2 concentration from 0 to 1000uL/L. When frequency was fixed at 0.1 Hz, the total impedance of the sensor changed almost linearly with NO2 concentration. The real response time of the sensor to NO2 gas was around 40s at gas flow rate of 400mL/min. It is also found that the response of sensor is stable at given time and the sensor has good anti―interference to O2 and CO2.
Baicalein Prevents 6-Hydroxydopamine-Induced Mitochondrial Dysfunction in SH-SY5Y Cells via Inhibition of Mitochondrial Oxidation and Up-Regulation of DJ-1 Protein Expression
Yue-Hua Wang,Hai-Tao Yu,Xiao-Ping Pu,Guan-Hua Du
Molecules , 2013, DOI: 10.3390/molecules181214726
Abstract: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DA) neurons at the substantia nigra. Mitochondrial dysfunction is involved in the mechanism of cell damage in Parkinson’s disease (PD). 6-Hydroxydopamine (6-OHDA) is a dopamine analog which specifically damages dopaminergic neurons. Baicalein has been previously reported to have potential in the treatment of PD. The purpose of the present study was to investigate the mechanism of action of baicalein against 6-OHDA injury in SH-SY5Y cells. The results showed that baicalein significantly alleviated alterations of mitochondrial redox activity and mitochondrial membrane potential induced by 6-OHDA in a dose-dependent manner in SH-SY5Y cells compared with vehicle group. Futhermore, baicalein decreased the production of ROS and upregulated the DJ-1 protein expression in SH-SY5Y cells. In addition, baicalein also inhibited ROS production and lipid peroxidation (IC 50 = 6.32 ± 0.03 μM) in rat brain mitochondia. In summary, the underlying mechanisms of baicalein against 6-OHDA-induced mitochondrial dysfunction may involve inhibition of mitochondrial oxidation and upregulation of DJ-1 protein expression.
Overview of Quality Evaluation Methods of Fused Infrared and Visible Images
红外与可见光图像融合质量评价方法综述

WANG Yue-hua,TAO Zhong-xiang,
王跃华
,陶忠祥

红外 , 2012,
Abstract: Quality evaluation of fused images is one of the problems to be solved badly in image fusion at present. In different scenes, both choosing proper fusion algorithms to improve the existing fusion algorithm and studying new fusion algorithms are very important. The objective quality evaluation methods with no reference are overviewed. The image fusion quality evaluation method based on structural similarity is described. Finally, the development trend of image fusion quality evaluation methods is discussed.
2-(Hydrazonomethyl)phenol
Yan-Fang Shang,Qing-Ming Wang,Miao-Li Zhu,Yue-Hua Zhang
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809045504
Abstract: The conformation of the title compound, C7H8N2O, is stabilized by an intramolecular O—H...N hydrogen bond. The crystal structure shows intermolecular N—H...O hydrogen bonds.
N,N′-Disalicyloylhydrazine
Yu-Ting Chen,Da-Cheng Li,Da-Qi Wang,Yue-Hua Zhu
Acta Crystallographica Section E , 2008, DOI: 10.1107/s160053680706312x
Abstract: The approximately planar molecule of the title compound, C14H12N2O4, is centrosymmetric and has an E configuration with respect to the N—N bond. This compound adopts the ketoamine form with C=O and C—N distances of 1.233 (3) and 1.331 (4) , respectively. Adjacent molecules are assembled into a two-dimensional supramolecular structure parallel to the (101) plane via intermolecular O—H...O hydrogen bonds.
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