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Search Results: 1 - 10 of 34388 matches for " Yuanrong Lu "
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Beam optimization of RFQ and SFRFQ combined accelerator at Peking University
Minglei Kang,Yuanrong Lu,Zhi Wang,Kun Zhu,Xueqing Yan,Shuli Gao,Shixiang Peng,Zhiyu Guo,Jiaxun Fang,Jiaer Chen
Physics , 2010,
Abstract: The Peking University Integral Split Ring Radio Frequency Quadrupole(ISR RFQ) accelerator was constructed in 1999 with a high duty factor 16.7% and repetition frequency 166Hz, and it was able to accelerate N+, O+,O-, C+ and He+ from 1.6kev/u to 65keV/u. It was later upgraded as an injector of the Separated Function RFQ (SFRFQ). The experiments indicated that the maximum accelerated O+ beam current could exceed 3.2mA with energy 1.03MeV and an energy spread (FWHM) 3.1%. Then the beam transports through a 1m-long magnetic triplet to the entrance of SFRFQ and is finally accelerated to 1.64MeV. The beam conditioning of RFQ were carefully optimized to satisfy the requirements of the SFRFQ. The combined accelerator eventually can deliver 0.53mA O+ beam with energy 1.65MeV, which has sufficiently demonstrated the feasibility of the SFRFQ structure.
Efficacy of Neonatal HBV Vaccination on Liver Cancer and Other Liver Diseases over 30-Year Follow-up of the Qidong Hepatitis B Intervention Study: A Cluster Randomized Controlled Trial
Chunfeng Qu equal contributor ,Taoyang Chen equal contributor,Chunsun Fan,Qimin Zhan,Yuting Wang,Jianhua Lu,Ling-ling Lu,Zhengping Ni,Fei Huang,Hongyu Yao,Jian Zhu,Jian Fan,Yuanrong Zhu,Zhiyuan Wu,Guoting Liu,Wenhong Gao,Mengya Zang,Dongmei Wang,Min Dai,Chu Chieh Hsia,Yawei Zhang ,Zongtang Sun
PLOS Medicine , 2014, DOI: 10.1371/journal.pmed.1001774
Abstract: Background Neonatal hepatitis B vaccination has been implemented worldwide to prevent hepatitis B virus (HBV) infections. Its long-term protective efficacy on primary liver cancer (PLC) and other liver diseases has not been fully examined. Methods and Findings The Qidong Hepatitis B Intervention Study, a population-based, cluster randomized, controlled trial between 1985 and 1990 in Qidong, China, included 39,292 newborns who were randomly assigned to the vaccination group in which 38,366 participants completed the HBV vaccination series and 34,441 newborns who were randomly assigned to the control group in which the participants received neither a vaccine nor a placebo. However, 23,368 (67.8%) participants in the control group received catch-up vaccination at age 10–14 years. By December 2013, a total of 3,895 (10.2%) in the vaccination group and 3,898 (11.3%) in the control group were lost to follow-up. Information on PLC incidence and liver disease mortality were collected through linkage of all remaining cohort members to a well-established population-based tumor registry until December 31, 2013. Two cross-sectional surveys on HBV surface antigen (HBsAg) seroprevalence were conducted in 1996–2000 and 2008–2012. The participation rates of the two surveys were 57.5% (21,770) and 50.7% (17,204) in the vaccination group and 36.3% (12,184) and 58.6% (17,395) in the control group, respectively. Using intention-to-treat analysis, we found that the incidence rate of PLC and the mortality rates of severe end-stage liver diseases and infant fulminant hepatitis were significantly lower in the vaccination group than the control group with efficacies of 84% (95% CI 23%–97%), 70% (95% CI 15%–89%), and 69% (95% CI 34%–85%), respectively. The estimated efficacy of catch-up vaccination on HBsAg seroprevalence in early adulthood was 21% (95% CI 10%–30%), substantially weaker than that of the neonatal vaccination (72%, 95% CI 68%–75%). Receiving a booster at age 10–14 years decreased HBsAg seroprevalence if participants were born to HBsAg-positive mothers (hazard ratio [HR] = 0.68, 95% CI 0.47–0.97). Limitations to consider in interpreting the study results include the small number of individuals with PLC, participants lost to follow-up, and the large proportion of participants who did not provide serum samples at follow-up. Conclusions Neonatal HBV vaccination was found to significantly decrease HBsAg seroprevalence in childhood through young adulthood and subsequently reduce the risk of PLC and other liver diseases in young adults in rural China. The findings
Influence of MSA on Cell Growth and Spontaneousn Metastasis of L9981-Luc Lung Cancer Transplanted Model in Nude Mice by Bioluminescence Imaging
Yuanrong REN,Yuli WANG,Hongyu LIU,Huiqin YAN
Chinese Journal of Lung Cancer , 2013, DOI: 10.3779/j.issn.1009-3419.2013.02.02
Abstract: Background and objective Methylseleninic acid (MSA) is an artificially developed selenium compound. It has been proven that MSA could inhibit growth and metastasis on many tumor cells. This study investigated whether MSA has an impact on the growth and metastasis of L9981-Luc lung cancer transplanted model in nude mice or not. Methods A transplantated tumor model was established in nude mice. Fifteen nude mice were randomly divided into three groups: the control group treated with normal saline (0.2 mL/d), the MSA group treated with MSA solution (0.2 mL), and the cisplatin (DDP) group injected intraperitoneally with DDP (4 mg/kg/w). Inhibition of MSA on tumor growth and tumor metastasis was observed using the IVIS Imaging System 200 Series. Results A significant difference was obserced in the primary tumor bioluminescence among the three groups (P=0.002) on 21 days post-inoculation. Primary tumor bioluminescence in the DDP group (P=0.001) and in the MSA group (P=0.031) was significantly lower than that in the control group (P=0.001). No significant difference in the metastasis bioluminescence of the thoracic area was indicated among the three groups (P>0.05). Conclusion MSA can inhibit the growth of planted tumor of transgenic lung cancer cell lines L9981-Luc in nude mice. MSA may also suppress the distant metastasis of the transplanted tumor of transgenic lung cancer cell lines L9981-Luc in nude mice.
The study of the tumorigenicity and metastasis ability in human lung cancer cell line L9981 using in vivo imaging
Yuanrong REN,Jun CHEN,Hongyu LIU,Huiqin YAN
Chinese Journal of Lung Cancer , 2008,
Abstract: Background and objective The aim of this work is to study the tumorigenicity and metastasis ability in human large cell lung caner cell line L9981 by in vivo imaging. Methods We firstly transfected the plasmids with firefly luciferase (luc) gene into L9981 cells and then established the stable transfected L9981-luc cell line with G418. Then the positive L9981-Lue cells were implanted subcutaneously into mice and were monitored for tumor growth and micrometastases with in vivo imaging technique. Results The results showed that the bioluminescence density of the stable transfected L9981-Lue cells correlated to the numbers of the tumor cells in vitro. The L9981-Luc cells still keep the high metastasis characterization. After the L9981-Luc cells were implanted into mice subcutaneously for several weeks, we found the metastasis lesions in the different organs of the mice using in vivo imaging machine and the bioluminescence of the tumor correlated with its size. Furthermore, we confirmed the metastasis lesions by scarifying the mice and analyzing with pathological staining. Conclusion We established a stable L9981-Luc cell line with high metastasis character that can be used to analyze the tumor invasion ad metastasis in animal model by in vivo imaging.
Baculovirus Superinfection: A Probable Restriction Factor on the Surface Display of Proteins for Library Screening
Xiaodong Xu, Yuanrong Chen, Yu Zhao, Xiaofen Liu, Beitao Dong, Ian M. Jones, Hongying Chen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054631
Abstract: In addition to the expression of recombinant proteins, baculoviruses have been developed as a platform for the display of complex eukaryotic proteins on the surface of virus particles or infected insect cells. Surface display has been used extensively for antigen presentation and targeted gene delivery but is also a candidate for the display of protein libraries for molecular screening. However, although baculovirus gene libraries can be efficiently expressed and displayed on the surface of insect cells, target gene selection is inefficient probably due to super-infection which gives rise to cells expressing more than one protein. In this report baculovirus superinfection of Sf9 cells has been investigated by the use of two recombinant multiple nucleopolyhedrovirus carrying green or red fluorescent proteins under the control of both early and late promoters (vAcBacGFP and vAcBacDsRed). The reporter gene expression was detected 8 hours after the infection of vAcBacGFP and cells in early and late phases of infection could be distinguished by the fluorescence intensity of the expressed protein. Simultaneous infection with vAcBacGFP and vAcBacDsRed viruses each at 0.5 MOI resulted in 80% of infected cells co-expressing the two fluorescent proteins at 48 hours post infection (hpi), and subsequent infection with the two viruses resulted in similar co-infection rate. Most Sf9 cells were re-infectable within the first several hours post infection, but the re-infection rate then decreased to a very low level by 16 hpi. Our data demonstrate that Sf9 cells were easily super-infectable during baculovirus infection, and super-infection could occur simultaneously at the time of the primary infection or subsequently during secondary infection by progeny viruses. The efficiency of super-infection may explain the difficulties of baculovirus display library screening but would benefit the production of complex proteins requiring co-expression of multiple polypeptides.
Mobile Payments—Why They Are So Successful?  [PDF]
Lu Lu
Open Journal of Business and Management (OJBM) , 2019, DOI: 10.4236/ojbm.2019.73078
Abstract: Mobile payment service is exploding at an impressive rate as the global mobile payment revenue almost tripled over the last five years. But the reasons behind this phenomenon are still not clear. This paper thus focuses on identifying the key factors that contribute to the success of mobile payments. We firstly take a look at the current status of mobile payments. With this brief background in mind, we then address several questions associated with three key actors of mobile payment ecosystem: m-payment service provider, consumer, merchants. Specifically, the business model of mobile payments firms (including value proposition, market contribution, revenue source), consumer preferences and merchant. Conclusions: Mobile payment is gradually developing towards diversification and cross-border integration with highly sophisticated technology behind; the success of mobile payments application is based on aprofitable and valuable business model; in order to gain a competitive advantage when facing with fierce competition in the market, firms should respond best to consumer change and merchant feedback.
Transactivation of elements in the human endogenous retrovirus W family by viral infection
Christoffer Nell?ker, Yuanrong Yao, Lorraine Jones-Brando, Fran?ois Mallet, Robert H Yolken, H?kan Karlsson
Retrovirology , 2006, DOI: 10.1186/1742-4690-3-44
Abstract: Relative levels of transcripts encoding HERV-W elements and cellular genes were analyzed by qPCR methods. An analysis of amplicon melting temperatures was used to detect variations in the frequencies of amplicons in discrete ranges of such melting temperatures. These frequency-distributions were taken as proxy markers for the repertoires of transcribed HERV-W elements in the cells.We report cell-specific expression patterns of HERV-W elements during base-line conditions. Expressed elements include those with intact regulatory long terminal repeat regions (LTRs) as well as elements flanked by truncated LTRs. Subsets of HERV-W elements were transactivated by viral infection in the different cell-lines. Transcriptional activation of these elements, including that encoding syncytin, was dependent on viral replication and was not induced by antiviral responses. Serum deprivation of cells induced similar changes in the expression of HERV-W elements suggesting that the observed phenomena are, in part, an effect of cellular stress.We found that HERV-W elements, including elements lacking regulatory LTRs, are expressed in cell-specific patterns which can be modulated by environmental influences. This brings into light that mechanisms behind the regulation of expression of HERV-W elements are more complex than previously assumed and suggests biological functions of these transcripts.Human endogenous retroviruses (HERV) are assumed to be remnants of ancient retroviral infections of our ancestors' germ-line cells. HERV sequences constitute approximately 3–8% of the human genome and can be classified into at least 31 families [1,2]. Tissue-specific hybridization patterns toarrays of sequences representative of different HERV families was recently reported, indicating a discrete and diversified regulation of their transcriptional activities [3,4].The differential detection of pol transcripts related to one of these families, HERV-W [5], was previously observed in cerebrospinal fl
A Novel Efficient Mode Selection Approach for H.264  [PDF]
Lu Lu, Wei Zhou
Journal of Software Engineering and Applications (JSEA) , 2010, DOI: 10.4236/jsea.2010.35053
Abstract: H.264 video coding standard introduces motion estimation with multiple block sizes to achieve a considerably higher coding efficiency than other video coding algorithms. However, this comes at the greatly increased computing complexity at the encoder. In this paper, a method is proposed to eliminate some redundant coding modes that contribute very little coding gain. The simulation results show that the algorithm can remarkably decrease the complexity at the encoder while keeping satisfying coding efficiency.
Research on Risk Factors Identification of P2P Lending Platforms  [PDF]
Caimei Lu, Lu Zhang
American Journal of Industrial and Business Management (AJIBM) , 2018, DOI: 10.4236/ajibm.2018.85091
Abstract: We take 2259 P2P Lending platforms as the sample, and integrate 14 variables from five dimensions to analyze the risk factors of P2P Lending problematic platforms by binary logistic model. The empirical results show that the 11 variables which are the type of company, platform background, operation time, the type of project, interest rate, fund custody, term of loan, day-bid, transfer of creditor’s rights, automatic bidding and information disclosure, have significant influences on the operating status of the platform, while the other variables such as registered capital, the number of employees and security mechanism have no obvious impact on the operating status of the platform. The results provide a reference for investors and regulators.
Recent advance in the study of persistent organic pollutants bioremediation

HUANG Xu,LUO Yuanrong,HU Zhong,TIAN Yun,ZHENG Tianling,

环境科学学报 , 2006,
Abstract: Due to the potential toxicity and poor degradation of POPs, advanced bioremediation, a novel effectively removing technique to POPs in various contaminated environmental media including water, sediments and soils, was more and more concerned by public. . With recent advances in the field of biomolecular engineering, the capability of microorganisms to bioremediate POPs could be greatly improved. Low bioavailability, the bottleneck of in situ bioremediation, would be broken through by the study of biosurfactant and chemtaxis; Metagenome could provide us with a large amount of useful genes involved in POPs degradation which traditional culture technique couldn't do. Recently, elevation of POPs bioavailabiliity, exploration of degradation gene from non-cultured microorganism, and construction of Genomic Engineering microorganism(GEM), are three hotspots in research of POPs bioremediation.
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