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Search Results: 1 - 10 of 36998 matches for " YuYing Zhao "
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Therapeutic effects of human umbilical cord-derived mesenchymal stem cells against acute tubular necrosis quantified through measures of iNOS, BMP-7 and Bcl-2  [PDF]
Fang Li, Feng Xiong, Yun Zhang, Yuying Li, Hongmei Zhao, S. Charles Cho, Thomas E. Ichim, Xiaofei Yang, Xiang Hu
Open Journal of Regenerative Medicine (OJRM) , 2013, DOI: 10.4236/ojrm.2013.22006

Introduction: Acute tubular necrosis (ATN) is the most prevalent cause of acute renal failure (ARF). Mesenchymal stem cell transplantation has been studied as a potential treatment for renal dysfunction due to ATN. Inducible nitric oxide synthase (iNOS), bone morphogenetic protein-7 (BMP-7) and B-cell lymphoma 2 (Bcl-2) are surrogate markers of renal tubular epithelial regeneration and subsequent recovery of renal function following ATN. Methods: Serum creatinine (Scr) and blood urea nitrogen (BUN), as well as expression of iNOS, BMP-7 and Bcl-2 in gentamycin-induced ATN rat kidneys was investigated after human umbilical cord-derived mesenchymal stem cell (HUC-MSC) transplantation. Immunohistochemical staining was performed in 3 groups of rats: gentamycin-induced ATN treated with HUC-MSC, gentamycin-induced ATN without HUC-MSC, and untreated rats not receiving any treatments. Results: HUC-MSC transplantation led to a reduction in Scr and BUN in the kidneys of rats with gentamycin-induced ATN. Expression of iNOS in the HUC-MSC treated group occurred later and the expression levels were much lower during gentamycin-induced ATN compared to rats with ATN that were not treated with HUC-MSC. The expression of BMP-7 and Bcl-2 in the MSC-transplanted group was significantly increased compared to both control groups of rats with injured and healthy renal tubules. Conclusions: HUC-MSCs induce renal protection in a rat model of gentamycin-induced ATN, which is associated with reduced iNOS expression and up-regulation of Bcl-2 and BMP-7.

Optimum Location of Tube Blank in Electromagnetic Bulging
Zhiheng ZHAO,Chunfeng LI,Yongzhi WANG,Yuying YANG,

材料科学技术学报 , 2001,
Abstract: Using analytical method, this paper gets 'the mutual inductance between coil and workpiece in tube blank electromagnetic bulging. According to this, we obtain the optimum locations of tube blank with different length of coil and workpiece. There is a good agreement between results calculated and the experimental data.
Water-Soluble N-Acetyl-L-cysteine-Capped CdTe Quantum Dots Application for Hg(II) Detection
Tianming Yang,Qingyi He,Yuying Liu,Chaozhen Zhu,Dan Zhao
Journal of Analytical Methods in Chemistry , 2013, DOI: 10.1155/2013/902951
Abstract: A simple, rapid, and specific method for Hg(II) detection has been proposed based on the fluorescence change of N-acetyl-L-cysteine-capped CdTe quantum dots (QDs). The presence of Hg(II) ions could quench the fluorescence of QDs at 565?nm and meanwhile produce new peak in 700–860?nm wavelength range. The linear response range is 20–430?nM with the detection limit at 8.0?nM Hg(II). It was found that the position of the new peak was irrelevant to the size of QDs. Furthermore, the mechanism of the quenching of QDs fluorescence by Hg(II) and the appearance of new peak in near-infrared area were also discussed and deduced through ultraviolet absorption spectrum, fluorescence spectrum, and X-ray photoelectron spectrum. 1. Introduction As a new class of potential fluorescence probes, quantum dots (QDs) have attracted great interests of the researchers because of their unique and excellent properties over traditional fluorescent dyes and fluorescent proteins [1–3]. Compared to conventional organic fluorescent dyes, QDs possess higher photoluminescence (PL), excellent quantum yield (QY), size-dependent tunable luminescence wavelength, wide continuous absorption, narrow fluorescence band, and better photostability. Over the past two decades, great efforts have been focused on the development of sensors [4–8] based on QDs, and the detection of metal ions is the active field. Some researchers have realized the specific detection of metal ions through modification of QDs with different surface-attached ligands [9–13], such as the detection of Cu2+ ions through thioglycerol-capped CdS QDs [9] and mercaptopropionic acid-coated core/shell CdTe/CdSe QDs [10], the detection of Zn2+ ions through L-cysteine-capped CdS QDs [9], the detection of Ag+ ions through thioglycolic acid-coated CdSe QDs [11], the detection of Cu2+ and Ag+ ions through peptide-coated CdS QDs [12], and the detection of Pb2+ ions through glutathione-capped ZnCdSe and CdTe QDs [13]. As one of the most toxic heavy metals and persistent contaminants which cannot be biodegraded in ecosystem [14, 15], mercuric ion (Hg2+) requires new and efficient detection methods. The major challenges in developing QDs-based Hg probe are the preparation of water-soluble QDs with high luminescence quantum yield and the selectivity of the system [16–19]. Herein, through hydrothermal route, a series of high-quality N-acetyl-L-cysteine- (NAC-) capped QDs with excellent water solubility, stability, and high QY (the average QY is 50%) have been synthesized [20–22]. Based on the prepared NAC-capped CdTe QDs as the fluorescence
Effect of Carotid Artery Stenting and Extracranial-Intracranial By-Pass on Cognitive Function: Preliminary Results  [PDF]
Li Liu, Yuying Zhou
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.66049
Background: To compare the neuropsychological consequences after carotid artery stenting (CAS) and extracranial-intracranial by-pass (EC-IC by-pass). Methods: A total of 43 patients referred to CAS, 32 patients referred to EC-IC by-pass and 43 control subjects were enrolled in the study. Neuropsychologic testing was performed before and three months after procedure. A paired Student t test was used to compare neuropsychologic test scores at baseline and three months after procedure in each group. Cognitive changes in a three-month follow-up were not normally distributed and compared among/between groups with Kruskal-Wallis test. Results: Three months after the treatment both the CAS and EC-IC by-pass groups showed improved cognitive performance compared to baseline, whereas the same improvement wasn’t seen in the control group. The scores from Activities of Daily Living also improved in all three groups in a three-month follow-up, and EC-IC group presented a more distinct increase in daily life abilities comparing to the other two groups. Conclusions: CAS and EC-IC by-pass in patients with a carotid or intracranial stenosis may result in cognitive improvement three months after surgery.
A Graduated Nonconvex Regularization for Sparse High Dimensional Model Estimation  [PDF]
Thomas F. Coleman, Yuying Li
Journal of Computer and Communications (JCC) , 2014, DOI: 10.4236/jcc.2014.211001

Many high dimensional data mining problems can be formulated as minimizing an empirical loss function with a penalty proportional to the number of variables required to describe a model. We propose a graduated non-convexification method to facilitate tracking of a global minimizer of this problem. We prove that under some conditions the proposed regularization problem using the continuous piecewise linear approximation is equivalent to the original lo  regularization problem. In addition, a family of graduated nonconvex approximations are proposed to approximate its l1  continuous approximation. Computational results are presented to illustrate the performance.

An MRI Study of Symptomatic Adhesive Capsulitis
Wen Zhao, Xiaofeng Zheng, Yuying Liu, Wenlu Yang, Vardan Amirbekian, Luis E. Diaz, Xudong Huang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047277
Abstract: Background Appilication of MR imaging to diagnose Adhesive Capsulitis (AC) has previously been described. However, there is insufficient information available for the MRI analysis of AC. This study is to describe and evaluate the pathomorphology of the shoulder in Asian patients with AC compared to healthy volunteers. Methodology/Principal Findings 60 Asian patients with clinically diagnosed AC and 60 healthy volunteers without frozen shoulder underwent MRI of the shoulder joint. All subjects who were age- and sex-matched control ones underwent routine MRI scans of the affected shoulder, including axial, oblique coronal, oblique sagittal T1WI SE and coronal oblique T2WI FSE sequences. Significant abnormal findings were observed on MRI, especially at the rotator cuff interval. The coracohumeral ligament (CHL), articular capsule thickness in the rotator cuff interval as well as the fat space under coracoid process were evaluated. MRI showed that patients with adhesive capsulitis had a significantly thickened coracohumeral ligament and articular capsule in the rotator cuff interval compared to the control subjects (4.2 vs. 2.4 mm, 7.2 vs. 4.4 mm; p<0.05). Partial or complete obliteration of the subcoracoid fat triangle was significantly more frequent in patients with adhesive capsulitis compared with control subjects (73% vs. 13%, 26% vs. 1.6%; p<0.001). Synovitis-like abnormality around the long biceps tendon was significantly more common in patients with adhesive capsulitis than in control subjects. With regards to the inter-observer variability, two MR radiologists had an excellent kappa value of 0.86. Conclusions/Significance MRI can be used to show characteristic findings in diagnosing AC. Thickening of the CHL and the capsule at the rotator cuff interval and complete obliteration of the fat triangle under the coracoid process have been shown to be the most characteristic MR findings seen with AC.
Inhibitory effect of a modified adenovirus type 5E1A gene on the NF-κB activity in porcine aortic endothelial cells induced by TNF-α
Yewei Ma,Xiaoshan Zhou,Qingzheng Zhao,Jun Yang,Xin Gao,Yanchun Li,Yuying Liu,Zheng Wang
Chinese Science Bulletin , 2003, DOI: 10.1007/BF03183340
Abstract: The transcription factor nuclear factor κB (NF-κB) plays a key role in the delayed xenograft rejection (DXR). One of the important objects in the field is how to inhibit the NF-κB activity at optimal level. Thus, a modifiedE1A gene (E1AΔ) containing function domain (1–80 aa) and nuclear localization domain (139–243 aa) was used and cloned into an eucaryotic expression vector pcDNA3 to transfect the porcine aortic endothelial cells (PAEC). The stable transfectants were screened with G418.E1AΔ gene was able to be stably expressed in the PAEC and could not affect the growth of PAEC as analyzed by RT-PCR and cell growth rate. Reporter gene assay demonstrated thatE1AΔ was capable of inhibiting NF-κB activity in the PAEC induced by TNF-α without sensitizing to apoptosis, and the rate of inhibition was 53%. Furthermore,E1AΔ inhibited the expression of a NF-κB-dependent inflammatory geneE-selectin in the cells, and the rate of inhibition was 63%. In summary, the usage ofE1AΔ gene may be a new strategy to overcome DXR in the xenotransplantation.
Specific myeloprotection via multidrug resistance 1 gene controlled by aminopeptidase N myeloid promoter
Libo Liang,Yewei Ma,Xiaoshan Zhou,Jun Yang,Yanchun Li,Yuying Liu,Zheng Wang,Qingzheng Zhao
Chinese Science Bulletin , 2002, DOI: 10.1007/BF03184116
Abstract: In the treatment of tumor patients introduction of multidrug resistance genes into hematopoietic cells has been reported as an approach for reducing myelotoxicity created by antitumor drugs. However, the nonspecific expression of the genes can also increase the chemoresistance of the tumor cells invaded into bone marrow, which influences seriously the effectiveness of chemotherapy. In this study, a new strategy is described for specific myeloprotection. The recombinant retroviral vector containing multidrug resistance 1 (MDR1) gene regulated by aminopeptidase N (APN) myeloid promoter was constructed and then introduced into myeloblastic cells KG1a and tumor cell line BEL7402. The specific transcript ofMDR1 was detected in KG1a cells transduced withMDR1 gene and rhodamine 123 was effectively extruded by Pgp, the protein ofMDR1 gene. The resistance elevated markedly by 10.6, 10.4, 11.2, 4.2 and 14.2 folds inMDR1 gene-transduced KG1a cells to chemotherapeutic drugs such as cochicine, VP-16, vincristine, doxorubicin and paclitaxel, respectively. In contrast, the chemoresistance had no significant changes in BEL7402 cells transduced withMDR1 gene. Expression ofMDR1 directed byAPN myeloid promoter resulted in myelospecific protection during the killing of tumor cells treated with antitumor drugs. The study would provide a new mean for circumventing myelosuppression of tumor patients undergoing chemotherapy.
Cloning of aminopeptidase N promoter and its activity in hematopoietic cell and different tumor cell lines
Libo Liang,Yewei Ma,Qingzheng Zhao,Jun Yang,Yuying Liu,Zheng Wang
Chinese Science Bulletin , 2001, DOI: 10.1007/BF02900628
Abstract: Aminopeptidase N (APN) promoter region was cloned and sequenced from peripheral blood mononuclear cells. The recombinant reporter construct containing the promoter and luciferase gene, designated pXP1-APNLuc, was introduced into myeloblastic cell line, T lymphocyte cell line and various tumor cell lines. Luciferase assay showed that APN upstream promoter is myeloid-specific for high expression in myeloblastic cell line and much lower expression in T lymphocyte cell line. The promoter activity was relatively high in lung adenoma cell line compared with other tumor cell lines including hepatoma cell line, tong cancer cell line and esophageal cancer cell line in which the promoter activity significantly diminished or was almost undetectable. The characteristics of APN promoter may provide a new strategy for specific myeloprotection while tumor patients are being treated with chemotherapy and/or radiotherapy.
Solubilization of benzene and its derivatives in F127 and P123 aqueous micellar solutions

ZHENG Yuying,JIANG Linqin,ZHAO Jianxi,

环境科学学报 , 2001,
Abstract: 用紫外光谱方法考察 35℃时苯、甲苯、二甲苯和氯苯在Pluronic嵌段共聚物F12 7和P12 3胶束中的增溶 .实验发现 ,当Pluronic嵌段共聚物胶束内核成分固定时 ,增溶量随内核体积 (对苯与氯苯系统 ,还包括栅栏层 )增大而线性增加 ,苯、甲苯、二甲苯和氯苯在每个胶束的最大增溶分子数分别为 4.4× 10 3、2 .3× 10 3、1.4× 10 3 和 7.1× 10 3 个 (F12 7)以及 11× 10 3、6 .8×10 3、4.2× 10 3 和 18× 10 3 个 (P12 3) ,这表明F12 7和P12 3是优良的芳香烃化合物增溶载体 .当苯环上增加甲基时 ,头一个甲基(甲苯 )对增溶量的影响比第二个甲基 (二甲苯 )的影响剧烈
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