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Search Results: 1 - 10 of 6548 matches for " YuFang Pei "
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The Impact of Imputation on Meta-Analysis of Genome-Wide Association Studies
Jian Li, Yan-fang Guo, Yufang Pei, Hong-Wen Deng
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0034486
Abstract: Genotype imputation is often used in the meta-analysis of genome-wide association studies (GWAS), for combining data from different studies and/or genotyping platforms, in order to improve the ability for detecting disease variants with small to moderate effects. However, how genotype imputation affects the performance of the meta-analysis of GWAS is largely unknown. In this study, we investigated the effects of genotype imputation on the performance of meta-analysis through simulations based on empirical data from the Framingham Heart Study. We found that when fix-effects models were used, considerable between-study heterogeneity was detected when causal variants were typed in only some but not all individual studies, resulting in up to ~25% reduction of detection power. For certain situations, the power of the meta-analysis can be even less than that of individual studies. Additional analyses showed that the detection power was slightly improved when between-study heterogeneity was partially controlled through the random-effects model, relative to that of the fixed-effects model. Our study may aid in the planning, data analysis, and interpretation of GWAS meta-analysis results when genotype imputation is necessary.
Bivariate genome-wide association study suggests that the DARC gene influences lean body mass and age at menarche
Rong Hai,Lei Zhang,YuFang Pei,LanJuan Zhao,Shu Ran,YingYing Han,XueZhen Zhu,Hui Shen,Qing Tian,HongWen Deng
Science China Life Sciences , 2012, DOI: 10.1007/s11427-012-4327-6
Abstract: Lean body mass (LBM) and age at menarche (AAM) are two important complex traits for human health. The aim of this study was to identify pleiotropic genes for both traits using a powerful bivariate genome-wide association study (GWAS). Two studies, a discovery study and a replication study, were performed. In the discovery study, 909622 single nucleotide polymorphisms (SNPs) were genotyped in 801 unrelated female Han Chinese subjects using the Affymetrix human genome-wide SNP array 6.0 platform. Then, a bivariate GWAS was performed to identify the SNPs that may be important for LBM and AAM. In the replication study, significant findings from the discovery study were validated in 1692 unrelated Caucasian female subjects. One SNP rs3027009 that was bivariately associated with left arm lean mass and AAM in the discovery samples (P=7.26×10 6) and in the replication samples (P=0.005) was identified. The SNP is located at the upstream of DARC (Duffy antigen receptor for chemokines) gene, suggesting that DARC may play an important role in regulating the metabolisms of both LBM and AAM.
The UNIX Localization and Chinese Information Processing System
计算机科学技术学报 , 1991,
Abstract: To facilitate the wider use of computers all over the world,it is necessary to provide National Language Support in the computer systems.This paper introduces some aspects of design and implementation of the UNIX-based Chinese Information Processing Systems (CIPS). Due to the special nature of the Oriental languages,and in order to be able to share resources and exchange in formation between different countries,it is necessary to create a standard of multilingual information exchange code.The unified Chinese/Japanese/Korean character code,Han Character Collection(HCC),was proposed to ISO/IEC JTC1/SC2/WG2 by China Computer and Information Processing Standardization Technical Committee.Based on this character set and the corresponding coding system,it is possible to create a true Internationalized UNIX System.
Requirements and issues for handling Chinese in internationalized applications
Requirements and Issues for Handling Chinese in Internationalized Applications

Yufang Sun,

计算机科学技术学报 , 1992,
Hanzix and Chinese open system platform
Hanzix and Chinese Open System Platform

Sun Yufang,

计算机科学技术学报 , 1997,
Abstract: International use of the UNIX system in recent years provokes a need to expand its functionality. Extensions are needed to process data in various languages as the market requirement dictate1,2]. With the advent of open systems and interfaces, the method of internationalization (I18N) has become standardized. Hanzix Association was founded by the fortitute of Software, The Chinese Academy of Sciences (ISAS, Beijing), Institute of Information Industry (III, Taipei) and Chinese University of Hong Kong (CUHK, Hong Kong), and its aim is to promote an open system standard for Chinese character (Hanzi) processing. This paper presents Hanzix, an open system environment to support Hanzi processing, including enhancemed recommended for Hanzi API,input method mechedsm, codeset conversion and armuncement, and reviews the current work.
A genome-wide association analysis implicates SOX6 as a candidate gene for wrist bone mass
LiJun Tan,Rong Liu,ShuFeng Lei,Rong Pan,TieLin Yang,Han Yan,YuFang Pei,Fang Yang,Feng Zhang,Feng Pan,YinPin Zhang,HongGang Hu,Shawn Levy,HongWen Deng
Science China Life Sciences , 2010, DOI: 10.1007/s11427-010-4056-7
Abstract: Osteoporosis is a highly heritable common bone disease leading to fractures that severely impair the life quality of patients. Wrist fractures caused by osteoporosis are largely due to the scarcity of wrist bone mass. Here we report the results of a genome-wide association study (GWAS) of wrist bone mineral density (BMD). We examined ~500000 SNP markers in 1000 unrelated homogeneous Caucasian subjects and found a novel allelic association with wrist BMD at rs11023787 in the SOX6 (SRY (sex determining region Y)-box 6) gene (P=9.00×10 5). Subjects carrying the C allele of rs11023787 in SOX6 had significantly higher mean wrist BMD values than those with the T allele (0.485:0.462 g cm 2 for C allele vs. T allele carriers). For validation, we performed SOX6 association for BMD in an independent Chinese sample and found that SNP rs11023787 was significantly associated with wrist BMD in the Chinese sample (P=6.41×10 3). Meta-analyses of the GWAS scan and the replication studies yielded P-values of 5.20×10 6 for rs11023787. Results of this study, together with the functional relevance of SOX6 in cartilage formation, support the SOX6 gene as an important gene for BMD variation.
Genome-Wide Association Study Identified Copy Number Variants Important for Appendicular Lean Mass
Shu Ran, Yong-Jun Liu, Lei Zhang, Yufang Pei, Tie-Lin Yang, Rong Hai, Ying-Ying Han, Yong Lin, Qing Tian, Hong-Wen Deng
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089776
Abstract: Skeletal muscle is a major component of the human body. Age-related loss of muscle mass and function contributes to some public health problems such as sarcopenia and osteoporosis. Skeletal muscle, mainly composed of appendicular lean mass (ALM), is a heritable trait. Copy number variation (CNV) is a common type of human genome variant which may play an important role in the etiology of many human diseases. In this study, we performed genome-wide association analyses of CNV for ALM in 2,286 Caucasian subjects. We then replicated the major findings in 1,627 Chinese subjects. Two CNVs, CNV1191 and CNV2580, were detected to be associated with ALM (p = 2.26×10?2 and 3.34×10?3, respectively). In the Chinese replication sample, the two CNVs achieved p-values of 3.26×10?2 and 0.107, respectively. CNV1191 covers a gene, GTPase of the immunity-associated protein family (GIMAP1), which is important for skeletal muscle cell survival/death in humans. CNV2580 is located in the Serine hydrolase-like protein (SERHL) gene, which plays an important role in normal peroxisome function and skeletal muscle growth in response to mechanical stimuli. In summary, our study suggested two novel CNVs and the related genes that may contribute to variation in ALM.
Electrophysiological research of synapse formation from beginning to maturity
Zuoping Xie,Yufang Zheng
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02885513
Abstract: The development of synapses is an important question in neurobiology. We employ patchclamp technique to record MEPCs and EPCs of myoballs inXenopus cell culture. The rate of EPC/MEPC is related with synapses maturation. Accordingly, we define the mature synapses as those whose rate of presynaptic membrane ’ s EPC to MEPC is more than 8. The process of maturation needs about 2–5 h after neuntes contact with myoballs. We divide the development of synapses into three stages: young, developing and mature. The neurotransmitters stack gradually and increase by hundreds of times along with young synapses growing into maturity. So the process of synapses maturation should include presynaptic membrane specialization, postsynaptic membrane specialization and neurotransmitters stack.
Help Less or Help More —Perceived Intergroup Threat and Out-Group Helping
Tingyan Li,Yufang Zhao
International Journal of Psychological Studies , 2012, DOI: 10.5539/ijps.v4n4p90
Abstract: The present research investigated the relationship between intergroup threat and prosocial actions toward out-group members. We proposed that intergroup threat not only results in direct negative intergroup attitudes and behavior, but also promotes an indirect reduction in out-group helping. Study 1 (N = 54) was conducted in a realistic setting, whereas Study 2 (N = 92) employed an experimental context. Willingness to help (help intent) and monetary donation (help behavior) was compared between the threatening out-group and the non-threatening out-group. The results showed that when intergroup threat was experienced, more help was offered to the non-threatening out-group than the threatening out-group. The findings suggest that perceived intergroup threat attenuates prosocial behavior toward out-group members.
Simple Cocasting Method to Prepare Magnetic Mesoporous FePt/C Composites and Their Protein Adsorption Property
Yufang Zhu,Xing He
Journal of Chemistry , 2013, DOI: 10.1155/2013/530143
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