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Search Results: 1 - 10 of 130720 matches for " Yu-Jen Chen "
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Modulation of Fatty Acid Oxidation and Glucose Uptake by Oxytocin in Adipocytes  [PDF]
Han-Jen Lin, Yu-Shan Chen, Yu-Jen Chen, Yuan-Yu Lin, Harry J. Mersmann, Shih-Torng Ding
Journal of Biomedical Science and Engineering (JBiSE) , 2017, DOI: 10.4236/jbise.2017.102005
Abstract: Oxytocin (OT) is a hypothalamic neuropeptide synthesized and secreted by OT neurons. In addition to its conventional role in reproductive physiology, central OT also regulates various social behaviors, such as care, trust, and emotions. Central and subcutaneous OT infusions stimulate lipid metabolism in mice and rats when fed standard or high fat diets. Mice lacking the OT receptor (OTR) or OT peptide develop late-onset obesity with greater fat pad weights, larger adipocyte size and elevated plasma levels of leptin. To study the effects of OT on lipid metabolism, we examined the effects of serial OT doses (0, 10, 30, 100, 150, 300 nM) on 3T3L1 adipocytes, together with long (144 hours, 6 days) and short (24 hours, 1 day) term treatments. The short-term treatment with 150 nM OT increased triacylglycerol (TAG) accumulation and decreased mRNA expressions of carnitine palmitoyltransferase 1α (CPT-1α) and fatty acid binding protein 4 (FABP4). After long-term incubation with 150 nM OT, only the CPT-1α mRNA was decreased. In differentiated adipocytes derived from pig adipose tissue stem cells, only hormone sensitive lipase mRNA was decreased after short- or long-term treatment with OT. To obtain further insight into the underlying mechanism of OT induction, we tested the involvement of the AKT/PKB pathway; however, AKT phosphorylation was decreased after treatment with 150 nM OT, suggesting that OT effects may be independent from the AKT/PKB pathway. Taken together, OT effects on adipocyte glucose and lipid metabolism are probably through mechanisms other than the AKT/PKB pathway.
Computer Tomography and Ultrasonography Image Registration Based on the Cooperation of GPU and CPU  [PDF]
Ying-Chih Lin, Chien-Liang Huang, Chin-Sheng Chen, Wen-Chung Chang, Yu-Jen Chen, Chia-Yuan Liu
Journal of Signal and Information Processing (JSIP) , 2013, DOI: 10.4236/jsip.2013.43B014

Image registration is wildly used in the biomedical image, but there are too many textures and noises in the biomedical image to get a precise image registration. In order to get the excellent registration performance, it needs more complex image processing, and it will spend expensive computation cost. For the real time issue, this paper proposes edge gradient direction image registration applied to Computer Tomography(CT) image and Ultrasonography (US) image based on the cooperation of Graphic Processor Unit (GPU) and Central Processor Unit (CPU). GPU can significantly reduce the computation time. First, the CT image slice is extracted from the CT volume by the region growing and the interpolation algorithm. Secondly, the image pre-processing is employed to reduce the image noises and enhance the image features. There are two kinds of the image pre-processing algorithms invoked in this paper: 1) median filtering and 2) anisotropic diffusion. Last but not least, the image edge gradient information is obtained by Canny operator, and the similarity measurement based on gradient direction is employed to evaluate the similarity between the CT and the US images. The experimental results show that the proposed architecture can distinctively improve the efficiency and are more suitably applied to the real world.

Establishing an E-Business CMM with the Concepts of Capability, Maturity and Institutionalization
Chung-Yang Chen,Yu-Jen Chen,Pei-Jung Yu
International Journal of Electronic Business Management , 2006,
Abstract: E-Business has now become a buzzword. Businesses and organizations are paying more attention on resolving and implementing e-Business (EB) issues and solutions. Ad-hoc EB implementations conducted by organizations have in fact different levels or scopes, but they are all called e-Business achievement. Based on the concepts of capability and maturity from CMM, this paper proposes process orientated EB-CMM. EB-CMM not only as a reference model for an organization who wants to implement e-Business environments; but also as a communication protocol as partners in supply chains try to establish an EB collaborative environment. Furthermore, this paper studies cosmetic & drug industry and use it as the example in order to demonstrate the use of the proposed model.
The Study of e-Marketplace - A Case Study of Formosa Technologies e-Marketplace
Yu-Jen Chen,Chung-Yang Chen,Ronlon Tsai,Wei Chen
International Journal of Electronic Business Management , 2005,
Abstract: Enterprises often need to communicate and exchange data among each other. Previously, such communication was mainly achieved by human contact, letter exchange, by telephone and by fax. In the early stage of the Internet and electronic procurement (e-Procurement), enterprises built the channel for exchanging data by using EDI (Electronic Data Interchange). However, in the later stage of the development of the Internet, which is known as the globalized electronic marketplace (e-Marketplace) stage, the standard of data interchange has become the major factor for suppliers to succeed in e-Marketplace. Furthermore, when developing information systems on the Internet, the data integration problem should be considered seriously. It was especially challenging on the Business-to-Business (B2B) data interchange issue. In many standards of data interchange, ebXML, which is designed for interchanging data amongst electronic enterprises, is the most widely approved and accepted. ebXML defines many specifications for B2B electronic data interchange. This paper uses Formosa Technologies e-Marketplace as an example of e-Marketplace, starting from globalized e-Marketplace to discuss the role of ebXML in the e-Marketplace. Finally, the suggestion for improvement to the architecture of Formosa Technologies e-Marketplace is provided.
Functional Representation and Realization of E-Procurement: A Case Study in the Cosmetic and Drug Industry
Chung-Yang Chen,Pei-Chi Chen,Hui-Ju Lee,Yu-Jen Chen
International Journal of Electronic Business Management , 2006,
Abstract: E-Procurement (EP) is a critical issue in electronic business. If the functional ecology of EP can be regarded as an information system (IS) in a broad sense, then its functional use ought to be modeled for institutionalizing the systematic implementation. This article focuses on functional representation of such an IS using object concepts and UML. Moreover, “form” is an ordinary document that connects functional processes and transfers necessary information inside an IS. This article argues that such an entity class and the contextual relationships of its instances could be one effective way that embodies and realizes the management on process automation and information sharing of EP. A case study regarding the Cosmetic & Drug industry is supplied to help demonstrate the proposed functional analysis and realization inside EP.
Effect of Wasabi Component 6-(Methylsulfinyl)hexyl Isothiocyanate and Derivatives on Human Pancreatic Cancer Cells
Yu-Jen Chen,Yu-Chuen Huang,Tung-Hu Tsai,Hui-Fen Liao
Evidence-Based Complementary and Alternative Medicine , 2014, DOI: 10.1155/2014/494739
Abstract: The naturally occurring compound 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) was isolated from Wasabia japonica (Wasabi), a pungent spice used in Japanese food worldwide. The synthetic derivatives 6-(methylsulfenyl)hexyl isothiocyanate (I7447) and 6-(methylsulfonyl)hexyl isothiocyanate (I7557) are small molecule compounds derived from 6-MITC. This study aimed to evaluate the effect of these compounds on human pancreatic cancer cells. Human pancreatic cancer cell lines PANC-1 and BxPC-3 were used to perform an MTT assay for cell viability and Liu’s stain for morphological observation. The cell cycle was analyzed by DNA histogram. Aldehyde dehydrogenase (ALDH) activity was used as a marker for cancer stem cells (CSC). Western blotting was performed for the expression of proteins related to CSC signaling. The results showed that compounds 6-MITC and I7557, but not I7447, inhibited viability of both PANC-1 and BxPC-3 cells. Morphological observation showed mitotic arrest and apoptosis in 6-MITC- and I7557-treated cells. These two compounds induced G2/M phase arrest and hypoploid population. Percentages of ALDH-positive PANC-1 cells were markedly reduced by 6-MITC and I7557 treatment. The expression of CSC signaling molecule SOX2, but not NOTCH1, ABCG2, Sonic hedgehog, or OCT4, was inhibited by 6-MITC and I7557. In conclusion, wasabi compounds 6-MITC and I7557 may possess activity against the growth and CSC phenotypes of human pancreatic cancer cells. 1. Introduction The naturally occurring compound 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) was isolated from Wasabia japonica (wasabi), a pungent spice used in Japanese food worldwide. This compound has been reported as having anti-inflammatory [1], chemopreventive [2], and antimelanoma [3] activities. The synthetic compounds derived from 6-MITC include 6-(methylsulfenyl)hexyl isothiocyanate (I7447) and 6-(methylsulfonyl)hexyl isothiocyanate (I7557). Pancreatic cancer is a malignancy with increasing incidence and has been the fourth leading cause of cancer related death [4]. Due to the difficulty in making an early diagnosis, an unresectable stage at diagnosis in the majority, and resistance to chemotherapy or radiotherapy, the prognosis is poor with a 5-year survival rate of only 5–25% even after aggressive treatment [5]. It has been demonstrated that cancer stem cells (CSC) are crucial factors for treatment resistance and metastasis in many types of malignancies, including pancreatic cancer [6, 7]. Several signal transduction pathways involve the development and survival of CSC, such as Sonic
McDonaldisation and the Labour Process: Impacts and Resistance
Yu-Jen Wu
Asian Social Science , 2009, DOI: 10.5539/ass.v5n5p103
Abstract: McDonaldisation is the process by which the principles of the fast-food restaurant are coming to dominate more and more sectors of society. The aims of this article are to explore the possible impacts of McDonaldisation on the labour process and expose the hidden agenda behind McDonaldisation. My main argument is that McDonaldisation is the realization of an extremely instrumental rationality which deliberately develops a variety of strategies to achieve the interests of capital. The article indicates that, despite the prevailing of McDonaldisation, there might be two forces that seems likely to drive the labour process away from the McDonaldised working rules: subjectivity and flexibility. The article is concluded that McDonaldisation is gradually blurring and even eroding the boundary between the customers and the workers. The customers used to be the source of profit-making but are now asked to a part of the labour force, that is an exploitation of the customers to supplement McDonaldisation in the exploitation of labours.
Reduction and Immobilization of Potassium Permanganate on Iron Oxide Catalyst by Fluidized-Bed Crystallization Technology
Guang-Xia Li,Yao-Hui Huaug,Teng-Chien Chen,Yu-Jen Shih,Hui Zhang
Applied Sciences , 2012, DOI: 10.3390/app2010166
Abstract: A manganese immobilization technology in a fluidized-bed reactor (FBR) was developed by using a waste iron oxide ( i.e., BT-3) as catalyst which is a by-product from the fluidized-bed Fenton reaction (FBR-Fenton). It was found that BT-3 could easily reduce potassium permanganate (KMnO 4) to MnO 2. Furthermore, MnO 2 could accumulate on the surface of BT-3 catalyst to form a new Fe-Mn oxide. Laboratory experiments were carried out to investigate the KMnO 4-reduction mechanism, including the effect of KMnO 4 concentration, BT-3 dosage, and operational solution pH. The results showed that the pH solution was a significant factor in the reduction of KMnO 4. At the optimum level, pH f 6, KMnO 4 was virtually reduced in 10 min. A pseudo-first order reaction was employed to describe the reduction rate of KMnO 4.
Multiple bowel intussusceptions from metastatic localized malignant pleural mesothelioma: A case report
Hsien Liu, Yu-Jen Cheng, Hsin-Pao Chen, Jau-Chung Hwang, Po-Chih Chang
World Journal of Gastroenterology , 2010,
Abstract: Localized malignant pleural mesothelioma (LMPM) is a rare occurrence, and gastrointestinal intra-luminal metastases have not previously been reported. Herein, we report a patient with LMPM who presented with a local recurrence 10 mo after initial en bloc surgical resection. Abdominal computed tomography was performed for intractable, vague abdominal pain with episodic vomiting, which showed a “target sign” over the left lower quadrant. Laparotomy revealed several intra-luminal metastatic tumors in the small intestine and colon and a segmental resection of metastatic lesions was performed. Unfortunately, the patient died of sepsis despite successful surgical intervention. Though local recurrence is more frequent in LMPM, the possibility of distant metastasis should not be ignored in patients with non-specific abdominal pain.
Small-Molecule Synthetic Compound Norcantharidin Reverses Multi-Drug Resistance by Regulating Sonic Hedgehog Signaling in Human Breast Cancer Cells
Yu-Jen Chen, Cheng-Deng Kuo, Szu-Han Chen, Wei-Jen Chen, Wen-Chien Huang, K. S. Clifford Chao, Hui-Fen Liao
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037006
Abstract: Multi-drug resistance (MDR), an unfavorable factor compromising treatment efficacy of anticancer drugs, involves upregulated ATP binding cassette (ABC) transporters and activated Sonic hedgehog (Shh) signaling. By preparing human breast cancer MCF-7 cells resistant to doxorubicin (DOX), we examined the effect and mechanism of norcantharidin (NCTD), a small-molecule synthetic compound, on reversing multidrug resistance. The DOX-prepared MCF-7R cells also possessed resistance to vinorelbine, characteristic of MDR. At suboptimal concentration, NCTD significantly inhibited the viability of DOX-sensitive (MCF-7S) and DOX-resistant (MCF-7R) cells and reversed the resistance to DOX and vinorelbine. NCTD increased the intracellular accumulation of DOX in MCF-7R cells and suppressed the upregulated the mdr-1 mRNA, P-gp and BCRP protein expression, but not the MRP-1. The role of P-gp was strengthened by partial reversal of the DOX and vinorelbine resistance by cyclosporine A. NCTD treatment suppressed the upregulation of Shh expression and nuclear translocation of Gli-1, a hallmark of Shh signaling activation in the resistant clone. Furthermore, the Shh ligand upregulated the expression of P-gp and attenuated the growth inhibitory effect of NCTD. The knockdown of mdr-1 mRNA had not altered the expression of Shh and Smoothened in both MCF-7S and MCF-7R cells. This indicates that the role of Shh signaling in MDR might be upstream to mdr-1/P-gp, and similar effect was shown in breast cancer MDA-MB-231 and BT-474 cells. This study demonstrated that NCTD may overcome multidrug resistance through inhibiting Shh signaling and expression of its downstream mdr-1/P-gp expression in human breast cancer cells.
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