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Search Results: 1 - 10 of 92071 matches for " Yu Jerry Zhou "
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CD91-Dependent Modulation of Immune Responses by Heat Shock Proteins: A Role in Autoimmunity
Robert J. Binder,Yu Jerry Zhou,Michelle N. Messmer,Sudesh Pawaria
Autoimmune Diseases , 2012, DOI: 10.1155/2012/863041
Abstract: Heat shock proteins (HSPs) have been known for decades for their ability to protect cells under stressful conditions. In the 1980s a new role was ascribed for several HSPs given their ability to elicit specific immune responses in the setting of cancer and infectious disease. These immune responses have primarily been harnessed for the immunotherapy of cancer in the clinical setting. However, because of the ability of HSPs to prime diverse immune responses, they have also been used for modulation of immune responses during autoimmunity. The apparent dichotomy of immune responses elicited by HSPs is discussed here on a molecular and cellular level. The potential clinical application of HSP-mediated immune responses for therapy of autoimmune diseases is reviewed. 1. Introduction: HSPs in Immunity Expression of HSPs is generally upregulated in cells in response to a variety of stressful conditions including nonphysiological temperature, nutrient deprivation, and hypoxia [1]. It is the inherent chaperoning function of HSPs that allows them to provide their cytoprotective function in assisting correct protein/polypeptide folding and preventing further protein denaturation. It has become evident over the past two decades that the chaperoning function of HSPs also plays a key role in several processes during the development of immune responses [2]. Within the cell, several HSPs act as chaperones of peptides that are ultimately presented by MHC I and MHC II molecules. Thus, the HSPs in the cytosol and in the endoplasmic reticulum form a relay line for the transport of peptides from their formation by the proteasome to the MHC I heavy chain (HC). This is discussed in the next subheading. As the HSPs are some of the most abundant proteins in cells, their liberation into the extracellular environment has been shown to be a key indicator of loss of cellular integrity and they are rapidly recognized by the cellular sentinels of the immune system. Such recognition allows for cross-priming of the potential antigens that the HSPs chaperone. The efficiency of this pathway predicted a cell surface receptor on the cross-presenting cells and that receptor has now been shown to be CD91. These events are discussed in the next two subheadings. The isolation of HSPs (and the associated peptides) from tumor cells or cells infected with pathogens therefore provides a single entity that primes immune responses specific for the chaperoned peptides and thus for the cell that harbored these antigens. This application has been tested in a vast number of rodent models of cancer and
An oversampling system for ECG acquisition  [PDF]
Yu Zhou
Journal of Biomedical Science and Engineering (JBiSE) , 2009, DOI: 10.4236/jbise.2009.27075
Abstract: Traditional ECG acquisition system lacks for flexibility. To improve the flexibility of ECG acquisition system and the signal-to-noise ratio of ECG, a new ECG acquisition system was designed based on DAQ card and Labview and oversampling was implemented in Labview. And analog signal conditioning circuit was improved on. The result indicated that the system could detect ECG signal accurately with high signal-to-noise ratio and the signal processing methods could be adjusted easily. So the new system can satisfy many kinds of ECG acquisition. It is a flexible experiment platform for exploring new ECG acquisition methods.
An Efficient and Robust Fall Detection System Using Wireless Gait Analysis Sensor with Artificial Neural Network (ANN) and Support Vector Machine (SVM) Algorithms  [PDF]
Bhargava Teja Nukala, Naohiro Shibuya, Amanda Rodriguez, Jerry Tsay, Jerry Lopez, Tam Nguyen, Steven Zupancic, Donald Yu-Chun Lie
Open Journal of Applied Biosensor (OJAB) , 2014, DOI: 10.4236/ojab.2014.34004
Abstract: In this work, a total of 322 tests were taken on young volunteers by performing 10 different falls, 6 different Activities of Daily Living (ADL) and 7 Dynamic Gait Index (DGI) tests using a custom-designed Wireless Gait Analysis Sensor (WGAS). In order to perform automatic fall detection, we used Back Propagation Artificial Neural Network (BP-ANN) and Support Vector Machine (SVM) based on the 6 features extracted from the raw data. The WGAS, which includes a tri-axial accelerometer, 2 gyroscopes, and a MSP430 microcontroller, is worn by the subjects at either T4 (at back) or as a belt-clip in front of the waist during the various tests. The raw data is wirelessly transmitted from the WGAS to a near-by PC for real-time fall classification. The BP ANN is optimized by varying the training, testing and validation data sets and training the network with different learning schemes. SVM is optimized by using three different kernels and selecting the kernel for best classification rate. The overall accuracy of BP ANN is obtained as 98.20% with LM and RPROP training from the T4 data, while from the data taken at the belt, we achieved 98.70% with LM and SCG learning. The overall accuracy using SVM was 98.80% and 98.71% with RBF kernel from the T4 and belt position data, respectively.
Cell Surface Markers in Colorectal Cancer Prognosis
Larissa Belov,Jerry Zhou,Richard I. Christopherson
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12010078
Abstract: The classification of colorectal cancers (CRC) is currently based largely on histologically determined tumour characteristics, such as differentiation status and tumour stage, i.e., depth of tumour invasion, involvement of regional lymph nodes and the occurrence of metastatic spread to other organs. These are the conventional prognostic factors for patient survival and often determine the requirement for adjuvant therapy after surgical resection of the primary tumour. However, patients with the same CRC stage can have very different disease-related outcomes. For some, surgical removal of early-stage tumours leads to full recovery, while for others, disease recurrence and metastasis may occur regardless of adjuvant therapy. It is therefore important to understand the molecular processes that lead to disease progression and metastasis and to find more reliable prognostic markers and novel targets for therapy. This review focuses on cell surface proteins that correlate with tumour progression, metastasis and patient outcome, and discusses some of the challenges in finding prognostic protein markers in CRC.
Semi-Solid and Solid Bolus Swallows in High-Resolution Oesophageal Manometry for the Detection of Motility Disorders  [PDF]
Jerry Zhou, Catherine Sykes, Vincent Ho
Open Journal of Gastroenterology (OJGas) , 2018, DOI: 10.4236/ojgas.2018.81001
Background/Aims: High-resolution oesophageal manometry utilises water swallows to evaluate oesophageal function. However, small volumes of water are not representative of normal eating and as a result often produce normal manometry studies in patients with dysphagia. This study sets out to establish optimal diagnostic thresholds for semi-solid solid swallows and evaluate their ability to uncover motility abnormalities in patients with motility disorders. Method: Manometry was performed using ten 5-mL single water swallows followed by two semi-solid and two solid swallows in the upright position. Normative values for the adjunctive tests were obtained from patient controls while patients with major motility disorders were used to establish the optimal diagnostic thresholds. Diagnostic thresholds identified were prospectively tested in patients with normal water swallows but oesophagus related symptoms and in those with minor and major motility disorders. Results: Normal values for semi-solid and solid were determined in patient controls (n = 100). Development of diagnostic thresholds included 120 patients with major motility disorders. Optimal diagnostic thresholds identified for oesophagogastric junction dysfunction in semi-solid and solid swallows (IRP > 15.5 mmHg). Hypercontractilty and spasm used existing thresholds (>8000 mmHg-s-cm and < 4.5 s, respectively) but modified frequency of ≥50% of adjunctive swallows. Diagnostic thresholds were applied to symptomatic patients with normal water swallows (n = 70) identifying 12/70 (17%) to have abnormal adjunctive swallows. One of 30 patients (3%) with ineffective motility had abnormal adjunctive swallow and 12 patients with oesophageal spasm, oesophagogastric junction obstruction, and hypercontractility had abnormal adjunctive swallows that moved them up the motility disorder hierarchy. Conclusions: Semi-solid and solid challenge increase diagnostic yield of motility disorders.
A New Transmission Control Protocol for Satellite Networks  [PDF]
Liang Yu, Gang Zhou
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2011, DOI: 10.4236/ijcns.2011.44031
Abstract: According to technical statistics, current TCP protocols with approximately 80% Internet applications run on perform very well on wired networks. However, due to the effects of long propagation delay, great bandwidth asymmetry, high sporadic Bit Error Rate (BER) and etc., TCP performance degrades obviously on the satellite communication networks. To avoid the problems, TP-S, a novel transport control protocol, is introduced for satellite IP networks. Firstly, in order to increase the increment speed of Congestion Window (cwnd) at the beginning of data transmission, the traditional Slow Start strategy is replaced by a new strategy, known as Super Start. Secondly, a new packet lost discriminated scheme based on IP packets alternately sending with different priority is used in the protocol to decouple congestion decision from errors. Thirdly, bandwidth asymmetry problem is avoided by adopting Modified NACK (M-NACK) in receiving ends, which is sent periodically. In addition, the sending strategy in routers is also modified along with other’s changes to support the protocol. Finally, the simulation experiments show that the new protocol can not only significantly enhance throughput performance, but also reduce sharply bandwidth used in the reverse path as compared with traditional TCP protocols and those protocols, which are recently proposed for satellite IP networks.
Study on Revenue Management Considering Strategic Customer Behavior  [PDF]
Chuiri Zhou, Yu Wu
Journal of Service Science and Management (JSSM) , 2011, DOI: 10.4236/jssm.2011.44058
Abstract: This article reviews the literatures of revenue management and introduces the status of traditional research about perishable products in this field. We analyse revenue management considering strategic customer behavior and the related researches about dynamic pricing, finally we discuss the existing problems and suggest several future research directions.
Red or Blue? The Influence of Background Color on Promotion Value Perception  [PDF]
Yanxin Yu, Hong Zhou
American Journal of Industrial and Business Management (AJIBM) , 2018, DOI: 10.4236/ajibm.2018.83041
Abstract: Promotions are commonly used marketing tools for enterprises; the effectiveness of promotional posters is related to the success or failure of promotional activities. This paper embarks from two major elements of poster-promotional information and background color, and studies the effects of different promotional frames and background colors on the perceived value of consumer activity. This study divides the promotional framework into positive promotional framework and negative promotion framework. Through two experiments, the paper discusses how the matching of promotional frame and background color affects consumers value perception of promotional activities, and studies the mediating effect of perceptual diagnosis on the relationship, and the moderating effect of individual control sense on the relationship. The conclusion of the experiment is that the match between the promotional frame and the background color has an interactive effect on the value perception of the promotional activities. The experiment second verifies the existence of this interaction effect and verifies the mediating effect of perceptual diagnostics.
Cloud Computing framework for Computer Vision Research:An Introduction
Yu Zhou
Computer Science , 2013,
Abstract: Cloud computing offers the potential to help scientists to process massive number of computing resources often required in machine learning application such as computer vision problems. This proposal would like to show that which benefits can be obtained from cloud in order to help medical image analysis users (including scientists, clinicians, and research institutes). As security and privacy of algorithms are important for most of algorithms inventors, these algorithms can be hidden in a cloud to allow the users to use the algorithms as a package without any access to see/change their inside. In another word, in the user part, users send their images to the cloud and configure the algorithm via an interface. In the cloud part, the algorithms are applied to this image and the results are returned back to the user. My proposal has two parts: (1) investigate the potential of cloud computing for computer vision problems and (2) study the components of a proposed cloud-based framework for medical image analysis application and develop them (depending on the length of the internship). The investigation part will involve a study on several aspects of the problem including security, usability (for medical end users of the service), appropriate programming abstractions for vision problems, scalability and resource requirements. In the second part of this proposal I am going to thoroughly study of the proposed framework components and their relations and develop them. The proposed cloud-based framework includes an integrated environment to enable scientists and clinicians to access to the previous and current medical image analysis algorithms using a handful user interface without any access to the algorithm codes and procedures.
Evaluating Pharmacokinetic and Pharmacodynamic Interactions with Computational Models in Supporting Cumulative Risk Assessment
Yu-Mei Tan,Harvey Clewell,Jerry Campbell,Melvin Andersen
International Journal of Environmental Research and Public Health , 2011, DOI: 10.3390/ijerph8051613
Abstract: Simultaneous or sequential exposure to multiple chemicals may cause interactions in the pharmacokinetics (PK) and/or pharmacodynamics (PD) of the individual chemicals. Such interactions can cause modification of the internal or target dose/response of one chemical in the mixture by other chemical(s), resulting in a change in the toxicity from that predicted from the summation of the effects of the single chemicals using dose additivity. In such cases, conducting quantitative cumulative risk assessment for chemicals present as a mixture is difficult. The uncertainties that arise from PK interactions can be addressed by developing physiologically based pharmacokinetic (PBPK) models to describe the disposition of chemical mixtures. Further, PK models can be developed to describe mechanisms of action and tissue responses. In this article, PBPK/PD modeling efforts conducted to investigate chemical interactions at the PK and PD levels are reviewed to demonstrate the use of this predictive modeling framework in assessing health risks associated with exposures to complex chemical mixtures.
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