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Search Results: 1 - 10 of 31539 matches for " Young-Suk Lee "
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Characterization of Volatile Components in Makgeolli, a Traditional Korean Rice Wine, with or without Pasteurization, During Storage
Hye-Jung Park,Sang Mi Lee,Sang Hoon Song,Young-Suk Kim
Molecules , 2013, DOI: 10.3390/molecules18055317
Abstract: Changes in the volatile components of unpasteurized and pasteurized makgeolli during 30 days of storage were investigated by gas chromatography-mass spectrometry (GC-MS) and GC-olfactometry (GC-O). A total of 11 odor-active compounds such as 3-methyl-1-butanol (isoamyl alcohol), 2-methyl-1-butanol, 2,3-butanediol, butanoic acid, 3-methylbutanoic acid (isovaleric acid), 2-methylbutanoic acid, 3-(methylthio)-1-propanol (methionol), 2-phenylethanol, ethyl decanoate, ethyl dodecanoate, and ethyl tetradecanoate were determined in both the pasteurized and unpasteurized makgeolli during 30 days of storage. Although there were no significant differences in the concentrations of odor-active compounds at the initial storage time, most of odor-active compounds were more significantly increased in unpasteurized makgeolli compared to the pasteurized one during the storage period.
Monitoring Personalized Trait Using Oscillometric Arterial Blood Pressure Measurements
Young-Suk Shin
Journal of Applied Mathematics , 2012, DOI: 10.1155/2012/591252
Abstract: The blood pressure patterns obtained from a linearly or stepwise deflating cuff exhibit personalized traits, such as fairly uniform peak patterns and regular beat geometry; it can support the diagnosis and monitoring of hypertensive patients with reduced sensitivity to fluctuations in Blood Pressure (BP) over time. Monitoring of personalized trait in Oscillometric Arterial Blood Pressure Measurements (OABPM) uses the Linear Discriminant Analysis (LDA) algorithm. The representation of personalized traits with features from the oscillometric waveforms using LDA algorithm includes four phases. Data collection consists of blood pressure data using auscultatory measurements and pressure oscillations data obtained from the oscillometric method. Preprocessing involves the normalization of various sized oscillometric waveforms to a uniform size. Feature extraction involves the use of features from oscillometric amplitudes, and trait identification involves the use of the LDA algorithm. In this paper, it presents a novel OABPM-based blood pressure monitoring system that can monitor personalized blood pressure pattern. Our approach can reduce sensitivity to fluctuations in blood pressure with the features extracted from the whole area in oscillometric arterial blood pressure measurement. Therefore this technique offers reliable blood pressure patterns. This study provides a cornerstone for the diagnosis and management of hypertension in the foreseeable future.
Determination of Odor Release in Hydrocolloid Model Systems Containing Original or Carboxylated Cellulose at Different pH Values Using Static Headspace Gas Chromatographic (SHS-GC) Analysis
Sang Mi Lee,Gil-Ok Shin,Kyung Min Park,Pahn-Shick Chang,Young-Suk Kim
Sensors , 2013, DOI: 10.3390/s130302818
Abstract: Static headspace gas chromatographic (SHS-GC) analysis was performed to determine the release of 13 odorants in hydrocolloid model systems containing original or regio-selectively carboxylated cellulose at different pH values. The release of most odor compounds was decreased in the hydrocolloid solutions compared to control, with the amounts of 2-propanol, 3-methyl-1-butanol, and 2,3-butanedione released into the headspace being less than those of any other odor compound in the hydrocolloid model systems. However, there was no considerable difference between original cellulose-containing and carboxylated-cellulose containing systems in the release of most compounds, except for relatively long-chain esters such as ethyl caprylate and ethyl nonanoate. The release from the original and carboxylated cellulose solutions controlled to pH 10 was significantly higher than that from solutions adjusted to pH 4 and 7 in the case of some esters (ethyl acetate, methyl propionate, ethyl propionate, ethyl butyrate, butyl propionate, ethyl caproate) and alcohols (2-propanol, 3-methyl-1-butanol), in particular, ethyl butyrate and 3-methyl-1-butanol. In contrast, the release of 2,3-butanedione from both the original and carboxylated cellulose solutions was increased at pH 4 and 7 compared to that at pH 10 by about 70% and 130%, respectively. Our study demonstrated that the release of some odorants could be changed significantly by addition of both original and carboxylated cellulose in hydrocolloid model systems, but only minor effect was observed in pH of the solution.
A Novel Estimation of the Relative Economic Value in Terms of Different Chronic Hepatitis B Treatment Options
Jun Yong Park, Jeong Heo, Tae Jin Lee, Hyung Joon Yim, Jong Eun Yeon, Young-Suk Lim, Min Jeong Seo, Sang Hoon Ahn, Myung Seok Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057900
Abstract: Background Prescribers, payors and healthcare decision-makers are increasingly examining the value of treatments. This study aims at analyzing economic value of chronic hepatitis B (CHB) treatment options, which are available in Korea. Methods CHB infection was simulated using a health-state transition model with disease states defined as mild disease (Ishak F0/F1), fibrosis (F2/F3/F4), advanced fibrosis/cirrhosis (>F4), and complicated disease states (decompensated cirrhosis, hepatocellular carcinoma, liver transplant and death) based on available natural history data. The value of treatment-specific attributes on disease progression/regression was estimated based on published data in terms of events and costs avoided. 5-year treatment duration was assumed except for treatment initiation. Primary model output is the estimated cost savings of entecavir per patient per day of treatment versus the comparator in question for a given CHB patient. Results The simulation of treating with entecavir versus no treatment predicted improved clinical outcomes for entecavir-treatment patients. In the long term, these clinical benefits translate into cost savings of $3.10 per day of treatment. In naive patient treatment, daily cost savings of using entecavir versus lamivudine or telbivudine was estimated at $2.89 and $1.72, respectively. In the case of suboptimal responders who pre-treated with lamivudine, daily cost saving for patients switching to entecavir was $1.38 per day of treatment compared to patients maintaining on lamivudine. Conclusions Entecavir exhibits characteristics of a favourable CHB treatment, which directly translates into economic and therapeutic value as opposed to either no treatment or alternative strategies.
Hedgehog Signaling Regulates the Survival of Gastric Cancer Cells by Regulating the Expression of Bcl-2
Myoung-Eun Han,Young-Suk Lee,Sun-Yong Baek,Bong-Seon Kim,Jae-Bong Kim,Sae-Ock Oh
International Journal of Molecular Sciences , 2009, DOI: 10.3390/ijms10073033
Abstract: Gastric cancer is the second most common cause of cancer deaths worldwide. The underlying molecular mechanisms of its carcinogenesis are relatively poorly characterized. Hedgehog (Hh) signaling, which is critical for development of various organs including the gastrointestinal tract, has been associated with gastric cancer. The present study was undertaken to reveal the underlying mechanism by which Hh signaling controls gastric cancer cell proliferation. Treatment of gastric cancer cells with cyclopamine, a specific inhibitor of Hh signaling pathway, reduced proliferation and induced apoptosis of gastric cancer cells. Cyclopamine treatment induced cytochrome c release from mitochondria and cleavage of caspase 9. Moreover, Bcl-2 expression was significantly reduced by cyclopamine treatment. These results suggest that Hh signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2.
Facial Expression Recognition of Various Internal States via Manifold Learning
Young-Suk Shin,
Young-Suk Shin
,Member,IEEE

计算机科学技术学报 , 2009,
Abstract: Emotions are becoming increasingly important in human-centered interaction architectures.Recognition of facial expressions,which are central to human-computer interactions,seems natural and desirable.However,facial expressions include mixed emotions,continuous rather than discrete,which vary from moment to moment.This paper represents a novel method of recognizing facial expressions of various internal states via manifold learning,to achieve the aim of humancentered interaction studies.A critical review of ...
Stereotactic Body Radiation Therapy as an Alternative Treatment for Small Hepatocellular Carcinoma
Sang Min Yoon, Young-Suk Lim, Mee Jin Park, So Yeon Kim, Byungchul Cho, Ju Hyun Shim, Kang Mo Kim, Han Chu Lee, Young-Hwa Chung, Yung Sang Lee, Sung Gyu Lee, Yu Sun Lee, Jin-hong Park, Jong Hoon Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079854
Abstract: Background Even with early stage hepatocellular carcinoma (HCC), patients are often ineligible for surgical resection, transplantation, or local ablation due to advanced cirrhosis, donor shortage, or difficult location. Stereotactic body radiation therapy (SBRT) has been established as a standard treatment option for patients with stage I lung cancer, who are not eligible for surgery, and may be a promising alternative treatment for patients with small HCC who are not eligible for curative treatment. Materials and Methods A registry database of 93 patients who were treated with SBRT for HCC between 2007 and 2009 was analyzed. A dose of 10-20 Gy per fraction was given over 3-4 consecutive days, resulting in a total dose of 30-60 Gy. The tumor response was determined using dynamic computed tomography or magnetic resonance imaging, which was performed 3 months after completion of SBRT. Results The median follow-up period was 25.6 months. Median size of tumors was 2 cm (range: 1-6 cm). Overall patients’ survival rates at 1 and 3 years were 86.0% and 53.8%, respectively. Complete and partial tumor response were achieved in 15.5% and 45.7% of patients, respectively. Local recurrence-free survival rate was 92.1% at 3 years. Most local failures were found in patients with HCCs > 3 cm, and local control rate at 3 years was 76.3% in patients with HCC > 3 cm, 93.3% in patients with tumors between 2.1-3 cm, and 100% in patients with tumors ≤ 2 cm, respectively. Out-of-field intrahepatic recurrence-free survival rates at 1 and 3 years were 51.9% and 32.4%, respectively. Grade ≥ 3 hepatic toxicity was observed in 6 (6.5%). Conclusions SBRT was effective in local control of small HCC. SBRT may be a promising alternative treatment for patients with small HCC which is unsuitable for other curative therapy.
Regulation of cerebrospinal fluid production by caffeine consumption
Myoung-Eun Han, Hak-Jin Kim, Young-Suk Lee, Dong-Hyun Kim, Joo-Taek Choi, Chul-Sik Pan, Sik Yoon, Sun-Yong Baek, Bong-Seon Kim, Jae-Bong Kim, Sae-Ock Oh
BMC Neuroscience , 2009, DOI: 10.1186/1471-2202-10-110
Abstract: In the present study we found that the long-term consumption of caffeine can induce ventriculomegaly; this was observed in 40% of the study rats. In the caffeine-treated rats with ventriculomegaly, there was increased production of CSF, associated with the increased expression of Na+, K+-ATPase and increased cerebral blood flow (CBF). In contrast to the chronic effects, acute treatment with caffeine decreased the production of CSF, suggesting 'effect inversion' associated with caffeine, which was mediated by increased expression of the A1 adenosine receptor, in the choroid plexus of rats chronically treated with caffeine. The involvement of the A1 adenosine receptor in the effect inversion of caffeine was further supported by the induction of ventriculomegaly and Na+, K+-ATPase, in A1 agonist-treated rats.The results of this study show that long-term consumption of caffeine can induce ventriculomegaly, which is mediated in part by increased production of CSF. Moreover, we also showed that adenosine receptor signaling can regulate the production of CSF by controlling the expression of Na+, K+-ATPase and CBF.Methylxanthine caffeine is present in many common beverages, and is widely consumed worldwide [1,4]. Caffeine consumption has been estimated to be 76 mg per person per day worldwide, as high as 238 mg per person per day in the United States and Canada, and more than 400 mg per person per day in Sweden and Finland [5,6]. Caffeine is absorbed rapidly after oral administration and distributed to various organs and tissues. In the liver, caffeine is metabolized to dimethyl- and monomethylxanthines, dimethyl and monomethyl uric acids, trimethyl- and dimethylallantoin, and uracil derivatives. Some metabolites of caffeine including 1,3-dimethylxanthine (theophylline) and 1,7-dimethylxanthine (paraxanthine) have pharmacological activity similar to caffeine [4]. The half-life of caffeine is ~5 hours in humans and ~1 hour in rats [4,7].The main mechanism of action of caffei
A Case of Secondary Iris Cyst AfterPupilloplasty*  [PDF]
Ja Young Lee, Sun Woong Kim, Eun Suk Koh, Jee Ho Chang
Open Journal of Ophthalmology (OJOph) , 2013, DOI: 10.4236/ojoph.2013.31004
Abstract:

Purpose: To investigate the pathogenesis of a secondary iris cyst with an immunohistochemical method. Methods: Single observational case report. A pathologic specimen was obtained from a 5-year-old girl who was found to have a secondary iris cyst. She had a history of previous penetrating ocular trauma and subsequent cataract surgery and pupilloplasty. Immunohistochemical staining with cytokeratin (CK) 19 and CK3 was used. Results: After immunohistochemical staining, the inner wall showed positive staining for CK19, which is specific for limbal, peripheral cornea and conjunctival epithelium, and negative staining for CK3, which is specific for corneal epithelium. Conclusions: With the aid of immunohistochemical analysis, a conjunctival epithelial origin was indicated, and pupilloplasty was identified as the causal event of the iris cyst while the possibility of primary iris cyst was ruled out.

Nuclear Density-Dependent Effective Coupling Constants in the Mean-Field Theory
Jae Hwang Lee,Young Jae Lee,Suk-Joon Lee
Physics , 1996,
Abstract: It is shown that the equation of state of nuclear matter can be determined within the mean-field theory of $\sigma \omega$ model provided only that the nucleon effective mass curve is given. We use a family of the possible nucleon effective mass curves that reproduce the empirical saturation point in the calculation of the nuclear binding energy curves in order to obtain density-dependent effective coupling constants. The resulting density-dependent coupling constants may be used to study a possible equation of state of nuclear system at high density or neutron matter. Within the constraints used in this paper to $M^*$ of nuclear matter at saturation point and zero density, neutron matter of large incompressibility is strongly bound at high density while soft neutron matter is weakly bound at low density. The study also exhibits the importance of surface vibration modes in the study of nuclear equation of state.
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