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Search Results: 1 - 10 of 154 matches for " Yoshitsugu Mitani "
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Hyperbolic Transformation and Average Elasticity in the Framework of the Fixed Effects Logit Model  [PDF]
Yoshitsugu Kitazawa
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.22034
Abstract: In this paper, a simple transformation is proposed for the fixed effects logit model, which constructs some valid moment conditions including the first-order condition for one of the conditional MLE proposed by Chamberlain (1980) [1]. Some Monte Carlo experiments are carried out for the GMM estimator based on the transformation. In addition, the average elasticity of the logit probability with respect to the exponential function of explanatory variable is proposed in the framework of the fixed effects logit model, which is computable without the fixed effects.
Some Additional Moment Conditions for a Dynamic Count Panel Data Model with Predetermined Explanatory Variables  [PDF]
Yoshitsugu Kitazawa
Open Journal of Statistics (OJS) , 2013, DOI: 10.4236/ojs.2013.35038

This paper proposes some additional moment conditions for the linear feedback model with explanatory variables being predetermined, which is proposed by [1] for the purpose of dealing with count panel data. The newly proposed moment conditions include those associated with the equidispersion, the Negbin I-type model and the stationarity. The GMM estimators are constructed incorporating the additional moment conditions. Some Monte Carlo experiments indicate that the GMM estimators incorporating the additional moment conditions perform well, compared to that using only the conventional moment conditions proposed by [2,3].

MicroRNA Profiling of Salivary Adenoid Cystic Carcinoma: Association of miR-17-92 Upregulation with Poor Outcome
Yoshitsugu Mitani, Dianna B. Roberts, Hanadi Fatani, Randal S. Weber, Merrill S. Kies, Scott M. Lippman, Adel K. El-Naggar
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066778
Abstract: Background Salivary adenoid cystic carcinoma (ACC) is a rare relentlessly progressive malignant tumor. The molecular events associated with ACC tumorigenesis are poorly understood. Variable microRNAs (miRNA) have been correlated with tumorigenesis of several solid tumors but not in ACC. To investigate the association of miRNAs with the development and/or progression of ACC, we performed a comparative analysis of primary ACC specimens and matched normal samples and a pooled salivary gland standard and correlated the results with clinicopathologic factors and validated selected miRNAs in a separate set of 30 tumors. Methods MiRNA array platform was used for the identification of target miRNAs and the data was subjected to informatics and statistical interrelations. The results were also collected with the MYB-NFIB fusion status and the clinicopathologic features. Results Differentially dysregulated miRNAs in ACC were characterized in comparison to normal expression. No significant differences in miRNA expression were found between the MYB-NFIB fusion positive and -negative ACCs. Of the highly dysregulated miRNA in ACC, overexpression of the miR-17 and miR-20a were significantly associated with poor outcome in the screening and validation sets. Conclusion Our study indicates that the upregulation of miR-17-92 may play a role in the biology of ACC and could be potentially targeted in future therapeutic studies.
A Study of Pansharpened Images Based on the HSI Transformation Approach  [PDF]
Yoshihiro Mitani, Yoshihiko Hamamoto
Journal of Software Engineering and Applications (JSEA) , 2012, DOI: 10.4236/jsea.2012.512B031
Abstract: A pan-sharpen technique artificially produces a high-resolution image by image fusion techniques using high-resolution panchromatic and low-resolution multispectral images. Thus, the appearance of the color image can improve. In this paper, the effectiveness of three pan-sharpening methods based on the HSI transform approach is investigated. Three models are the hexcone, double hexcones, and Haydn’s approach. Furthermore, the effect of smoothing the low-resolution multispectral image is also investigated. The smoothing techniques are the Gaussian filter and the bilateral filter. The experimental results show that Haydn’s model is superior to others. The effectiveness of smoothing the low-resolution multispectral image is also shown.
Magnetism and infrared divergence in a Hubbard-phonon interacting system
Yoshitsugu Sekine
Physics , 2010,
Abstract: We show that a finite Hubbard-phonon interacting system has ferromagnetic or unique spin-singlet ground state under the infrared singular condition. The key tool is a unitary transformation introduced by Arai and Hirokawa. We construct a concrete infrared singular representation using the operator algebraic method. The method is essentially same as one for the van Hove model using the Wightman functional method.
Phonon Bose-Einstein condensation in a Hubbard-phonon interacting system with infrared divergence
Yoshitsugu Sekine
Physics , 2013,
Abstract: We show that a finite Hubbard-phonon interacting system exhibits phonon BEC at sufficiently low temperature. We also have the gauge symmetry breaking for phonons. The key tools are a unitary transformation introduced by Arai and Hirokawa \protect{\cite{AH1}} and the Araki-Woods representation. This system is essentially the same as a free system or the van Hove model.
Hideo Mitani
Hideo Mitani
Revista Dental Press de Ortodontia e Ortopedia Facial , 2009, DOI: 10.1590/s1415-54192009000300004
Pinning Down Viral Proteins: A New Prototype for Virus–Host Cell Interaction
Yoshitsugu Kojima,Akihide Ryo
Frontiers in Microbiology , 2010, DOI: 10.3389/fmicb.2010.00107
Abstract: Pin1 is an enzyme that specifically catalyzes the cis–trans isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif in its substrate proteins. Recent studies demonstrate that stability of several viral proteins is regulated by phosphorylation-dependent prolyl-isomerization by a host factor Pin1. Pin1 is now positioned as an important modulator of the molecular crosstalk between virus and host cells and could be a unique target for anti-virus therapy. This new type of post-translational modification by Pin1 might be involved in the regulation of other viral proteins.
Vaccination with Human Induced Pluripotent Stem Cells Creates an Antigen-Specific Immune Response Against HIV-1 gp160
Yoshitsugu Kojima,Akihide Ryo
Frontiers in Microbiology , 2011, DOI: 10.3389/fmicb.2011.00027
Abstract: Induced pluripotent stem cells (iPSCs) are artificially derived from somatic cells that have been transduced with defined reprogramming factors. A previous report has indicated the possibility of using iPSCs as an immune stimulator to generate antigen-specific immunity. In our current study, we have investigated whether human iPSCs (hiPSCs) have the ability to enhance specific immune response against a human immunodeficiency virus type 1 (HIV-1) antigen in a xenogenic mouse model. Our results show that BALB/c mice immunized with hiPSCs transduced with an adenoviral vector encoding HIV-1 gp160 exhibited prominent antigen-specific cellular immune responses. We further found that pre-treatment of hiPSCs with ionizing radiation promotes the secretion of pro-inflammatory cytokines such as interleukin-1 alpha (IL-1α), IL-12, and IL-18. These cytokines might promote the activation of antigen-presenting cells and the effective induction of cellular immunity. Our present findings thus demonstrate that a hiPSCs-based vaccine has the potential to generate cellular immunity against viral antigens such as HIV-1 gp160 in a xenogenic condition.
A B3LYP study on electronic structures of [(X)mMn(μ-oxo)2Mn(Y)n]q+ (X, Y = H2O, OH and O) as a Mn cluster model of OEC  [PDF]
Masashi Katsuda, Masaki Mitani, Yasunori Yoshioka
Journal of Biophysical Chemistry (JBPC) , 2012, DOI: 10.4236/jbpc.2012.32013
Abstract: Electronic and molecular structures of [(X)mMn(μ-oxo)2Mn(Y)n]q+ (X, Y = H2O, OH and O), which are Mn cluster models at catalytic sites of OEC, were studied by broken-symmetry unrestricted B3LYP method. Two paths from the S0 to S3 states of Kok cycle were investigated. One is a path starting from [Mn(II) (μ-oxo)2Mn(III)] at the S0 state, and another is from [Mn(III) (μ-oxo)2Mn(III)] at the S0. Results found in this study are summarized as, 1) In [Mn(II), Mn(III)], it is not possible that H2O molecules coordinate to the Mn atoms with retaining the octahedral configuration. 2) The OHˉ anion selectively coordinates to Mn(IV) rather than Mn(III). 3) When the oxo atom directly bind to the Mn atom, the Mn atom must be a Mn(IV). From these results, the catalytic mechanism for four-electron oxidation of two H2O molecules in OEC is proposed. 1) The Mn4(II, III, IV, IV) at S0 is ruled out. 2) For Mn4(III, III, IV, IV) at S1, the Mn atom coordinated by OHˉ anion is a Mn(IV) not Mn(III). 3) Only Mn(III) ion which is coordinated by a H2O molecule at S0 plays crucial roles for the oxidation.
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