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Search Results: 1 - 10 of 228 matches for " Yoshiro Ishimaru "
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Expression Analysis of Taste Signal Transduction Molecules in the Fungiform and Circumvallate Papillae of the Rhesus Macaque, Macaca mulatta
Yoshiro Ishimaru, Miki Abe, Tomiko Asakura, Hiroo Imai, Keiko Abe
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045426
Abstract: The molecular mechanisms of the mammalian gustatory system have been examined in many studies using rodents as model organisms. In this study, we examined the mRNA expression of molecules involved in taste signal transduction in the fungiform papillae (FuP) and circumvallate papillae (CvP) of the rhesus macaque, Macaca mulatta, using in situ hybridization. TAS1R1, TAS1R2, TAS2Rs, and PKD1L3 were exclusively expressed in different subsets of taste receptor cells (TRCs) in the FuP and CvP. This finding suggests that TRCs sensing different basic taste modalities are mutually segregated in macaque taste buds. Individual TAS2Rs exhibited a variety of expression patterns in terms of the apparent level of expression and the number of TRCs expressing these genes, as in the case of human TAS2Rs. GNAT3, but not GNA14, was expressed in TRCs of FuP, whereas GNA14 was expressed in a small population of TRCs of CvP, which were distinct from GNAT3- or TAS1R2-positive TRCs. These results demonstrate similarities and differences between primates and rodents in the expression profiles of genes involved in taste signal transduction.
Sour Taste Responses in Mice Lacking PKD Channels
Nao Horio,Ryusuke Yoshida,Keiko Yasumatsu,Yuchio Yanagawa,Yoshiro Ishimaru,Hiroaki Matsunami,Yuzo Ninomiya
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020007
Abstract: The polycystic kidney disease-like ion channel PKD2L1 and its associated partner PKD1L3 are potential candidates for sour taste receptors. PKD2L1 is expressed in type III taste cells that respond to sour stimuli and genetic elimination of cells expressing PKD2L1 substantially reduces chorda tympani nerve responses to sour taste stimuli. However, the contribution of PKD2L1 and PKD1L3 to sour taste responses remains unclear.
Additional Nitrogen Fertilization at Heading Time of Rice Down-Regulates Cellulose Synthesis in Seed Endosperm
Keiko Midorikawa, Masaharu Kuroda, Kaede Terauchi, Masako Hoshi, Sachiko Ikenaga, Yoshiro Ishimaru, Keiko Abe, Tomiko Asakura
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0098738
Abstract: The balance between carbon and nitrogen is a key determinant of seed storage components, and thus, is of great importance to rice and other seed-based food crops. To clarify the influence of the rhizosphere carbon/nitrogen balance during the maturation stage of several seed components, transcriptome analysis was performed on the seeds from rice plants that were provided additional nitrogen fertilization at heading time. As a result, it was assessed that genes associated with molecular processes such as photosynthesis, trehalose metabolism, carbon fixation, amino acid metabolism, and cell wall metabolism were differentially expressed. Moreover, cellulose and sucrose synthases, which are involved in cellulose synthesis, were down-regulated. Therefore, we compared cellulose content of mature seeds that were treated with additional nitrogen fertilization with those from control plants using calcofluor staining. In these experiments, cellulose content in endosperm from plants receiving additional nitrogen fertilization was less than that in control endosperm. Other starch synthesis-related genes such as starch synthase 1, starch phosphorylase 2, and branching enzyme 3 were also down-regulated, whereas some α-amylase and β-amylase genes were up-regulated. On the other hand, mRNA expression of amino acid biosynthesis-related molecules was up-regulated. Moreover, additional nitrogen fertilization caused accumulation of storage proteins and up-regulated Cys-poor prolamin mRNA expression. These data suggest that additional nitrogen fertilization at heading time changes the expression of some storage substance-related genes and reduces cellulose levels in endosperm.
Sensation of Balance Dysregulation Caused/Aggravated by a Collection of Electromagnetic Waves in a Dental Implant  [PDF]
Yoshiro Fujii
Open Journal of Antennas and Propagation (OJAPr) , 2014, DOI: 10.4236/ojapr.2014.23004
Abstract: Cell phone and personal computer users have increased considerably in recent years, particularly in more developed countries. These devices have facilitated communication on a global scale. However, there have been a number of reports of abnormalities occurring in the body due to the electromagnetic waves emitted by such electronic devices. The long lists of both general and severe symptoms, including headaches, fatigue, tinnitus, dizziness, memory loss, irregular heartbeat, and whole-body skin symptoms, have been reported that are apparently associated with the condition of electromagnetic hypersensitivity. In dentistry, titanium dental implants may be commonly associated with antenna-like activity, but the underlying mechanism remains unknown. In the current case studies, balance difficulties were found to occur when the patients had titanium dental implants. These implants seemed to be acting as antennae and collecting harmful electromagnetic waves. Further studies are required to confirm this hypothesis.
Gold Alloy Dental Inlay for Preventing Involuntary Body Movements Caused by Electromagnetic Waves Emitted by a Cell Phone  [PDF]
Yoshiro Fujii
Open Journal of Antennas and Propagation (OJAPr) , 2014, DOI: 10.4236/ojapr.2014.24005
Abstract: Cell phone and personal computer use has increased considerably in recent years, particularly in developed countries. These devices have facilitated communication on a global scale. However, there have been a number of reports of health problems related to the electromagnetic waves emitted by such electronic devices. A long list of both general and severe symptoms, including headaches, fatigue, tinnitus, dizziness, memory loss, irregular heartbeat and whole-body skin le-sions, have been reported. These are reportedly associated with the condition known as electro-magnetic hypersensitivity (EHS). This report shows how a subject’s abnormal involuntary body movements, caused by electromagnetic waves emitted by a cell phone, are prevented by placing a gold alloy inlay in the subject’s mouth. It appears that the subject’s involuntary movements are the result of balance dysregulation resulting from EHS. The subject’s various symptoms improve after the specific dental treatment. However, the underlying mechanism of the symptoms and the rea-sons why this treatment is so successful remain unknown. Further research is required to clarify these issues.
Dental Treatment for Dizziness and Joint Mobility Disorder Caused by Harmful Electromagnetic Waves  [PDF]
Yoshiro Fujii
Open Journal of Antennas and Propagation (OJAPr) , 2015, DOI: 10.4236/ojapr.2015.31001
Abstract: With the development of an IT (Information Technology) society, the opportunity to use electronic devices, such as cell phones and personal computers, has increased. These electronic devices pro-vide many benefits to society. However, there have been a number of reports of electromagnetic hypersensitivity (EHS) related to the use of electronic devices. The symptoms of EHS may include headaches, fatigue, tinnitus, dizziness, memory loss, irregular heartbeat, and skin trouble. Since the pathogenic mechanism of such conditions is not yet clear, further research is required. This report shows how a subject’s dizziness and joint mobility disorder, caused by electromagnetic waves emitted by electronic devices, were cured by removing an onlay from the patient’s mouth and replacing it with a gold alloy onlay. The result indicates that the subject’s symptoms were caused by EHS. Although the symptoms were improved after the dental treatment, the underlying mechanism of the symptoms and the reason why this treatment is successful remain unclear. Further research is required to clarify these issues.
Calling into Question the Efficacy of Evidence-Based Medicine: Is It Always the Best Approach? Is That Really the Placebo Effect?  [PDF]
Yoshiro Fujii
Natural Science (NS) , 2015, DOI: 10.4236/ns.2015.74019
Abstract: The techniques of evidence-based medicine (EBM) are being frequently used recently. The generally accepted theory is that if a medicine is not absorbed by the body, it will have no effect. However, the author has noticed that even when substances, including medicines, are not absorbed by the body, they can have a marked effect. In some cases, just bringing the substance close to the body can have an effect; in such cases, the efficacy of EBM for estimating the therapeutic value of medicines may be debatable. Therefore, a more accurate evaluation method should be devised. The author proposes that another group be introduced into trials. This group would include subjects who were exposed to but did not have an opportunity to absorb the medicine being tested.
Dental Stimulation to the Buccal Mucous Membrane Causes Lumbago: A Report of Two Cases  [PDF]
Yoshiro Fujii
Case Reports in Clinical Medicine (CRCM) , 2015, DOI: 10.4236/crcm.2015.48058
Abstract: This study aims to demonstrate that harmful stimulation of the buccal mucosa because of a rough tooth surface may cause lumbago. This report illustrates two cases of women in their 30s and 40s who are suffering from lumbago due to unknown causes. The patients are cured by a simple dental procedure in which the buccal surface of a molar is smoothened, thereby inhibiting the negative stimulation of the buccal mucosa. Soon after this treatment, the symptoms of lumbago have subsided. The reason for the effectiveness of this treatment remains unclear. However, the balance dysregulation observed in the patient may have been due to stimulation of the oral mucous membrane by the rough surface of the tooth. It is important for dentists to pay attention to the effects of tooth formation, dental restorations, and dental prosthetics on the entire body. A dental condition may have an effect on diseases affecting other parts of the body; thus a dental treatment may be considered as an option for the management of other systemic disorders. It appears that cooperation between the fields of dentistry and medicine is of utmost importance.
Electromagnetic Waves Collected by a Dental Amalgam Filling Induced Balance Dysregulation and Dizziness over a Period Exceeding 10 Years  [PDF]
Yoshiro Fujii
Open Journal of Stomatology (OJST) , 2015, DOI: 10.4236/ojst.2015.510029
Abstract: This case report describes a woman aged approximately 50 years who has suffered from balance dysregulation and dizziness for more than 10 years. Although the subject underwent several examinations to confirm the etiology of her symptoms, the root cause remained unknown. The symptoms were thought to be caused by electromagnetic wave hypersensitivity because the subject experienced uneasiness and dizziness when a cell phone was held close to her body. A cell phone was used to diagnose the collection of harmful electromagnetic waves, and an amalgam filling was determined to be the cause. The amalgam filling was removed under strict protection, and the subject’s symptoms completely disappeared soon after the filling was removed.
Use of Dental Inlay for Treatment of Hip Joint Dysregulation: A Case Report  [PDF]
Yoshiro Fujii
Case Reports in Clinical Medicine (CRCM) , 2015, DOI: 10.4236/crcm.2015.411072
Abstract: The purpose of this study was to demonstrate the improvement of hip joint dysregulation, including pain (coxalgia), tension, and restriction of joint mobility, using a dental gold alloy inlay. The subject was a 63-year-old man who was suffering from the abovementioned symptoms for several months. On placement of the gold alloy inlay on his chest, the joint flexibility was observed to increase, and the severity of the abovementioned symptoms decreased. When the inlay was placed in his tooth, the flexibility of the joint further increased, and all other symptoms disappeared. No side effects were observed, and the prognosis was good. We believe that these effects may be explained using the electromagnetic waves emitted by the inlay and by the restoration of biting conditions. Future multidisciplinary research focusing on possible underlying mechanisms regarding the relation between electromagnetic waves and dentistry is necessary.
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