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Search Results: 1 - 10 of 578 matches for " Yoshinobu Hirose "
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Surgical Treatment by Partial Petrosectomy for a Middle-Ear Carcinoid with Progressive Extension: A Case Report and Review of the Literature
Mitsuhiro Aoki,Keisuke Mizuta,Natsuko Ueda,Nansei Yamada,Yatsuji Ito,Hiroki Kato,Yoshinobu Hirose
International Journal of Otolaryngology , 2010, DOI: 10.1155/2010/818673
Abstract: We herein report a 59-year-old male patient with a recurrent carcinoid tumor of the middle ear 7 years after a tympanomastoidectomy. The CT and dynamic MRI demonstrated an extensive tumor close to the carotid artery canal and the jugular bulb, and the tumor was removed by a partial petrosectomy with a transmastoid approach. The histopathological findings revealed a solid and trabecular tumor with cells positive for cytokeratin, chromogranin A, synaptophysin, and CD56. The MIB-1 antibody for the Ki-67 antigen was positive in 6.6% of the tumor cells. The relevant literature is reviewed in regard to the present case.
C57BL/KsJ-db/db-ApcMin/+ Mice Exhibit an Increased Incidence of Intestinal Neoplasms
Kazuya Hata,Masaya Kubota,Masahito Shimizu,Hisataka Moriwaki,Toshiya Kuno,Takuji Tanaka,Akira Hara,Yoshinobu Hirose
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12118133
Abstract: The numbers of obese people and diabetic patients are ever increasing. Obesity and diabetes are high-risk conditions for chronic diseases, including certain types of cancer, such as colorectal cancer (CRC). The aim of this study was to develop a novel animal model in order to clarify the pathobiology of CRC development in obese and diabetic patients. We developed an animal model of obesity and colorectal cancer by breeding the C57BL/KsJ- db /db (db/db) mouse, an animal model of obesity and type II diabetes, and the C57BL/6J- ApcMin/+ (Min/+) mouse, a model of familial adenomatous polyposis. At 15 weeks of age, the N9 backcross generation of C57BL/KsJ- db /db- ApcMin/+ (db/db-Min/+) mice developed an increased incidence and multiplicity of adenomas in the intestinal tract when compared to the db/m-Min/+ and m/m-Min/+ mice. Blood biochemical profile showed significant increases in insulin (8.3-fold to 11.7-fold), cholesterol (1.2-fold to 1.7-fold), and triglyceride (1.2-fold to 1.3-fold) in the db/db-Min/+ mice, when compared to those of the db/m-Min/+ and m/m-Min/+ mice. Increases (1.4-fold to 2.6-fold) in RNA levels of insulin-like growth factor (IGF)-1, IRF-1R, and IGF-2 were also observed in the db/db-Min/+ mice. These results suggested that the IGFs, as well as hyperlipidemia and hyperinsulinemia, promoted adenoma formation in the db/db-Min/+ mice. Our results thus suggested that the db/db-Min/+ mice should be invaluable for studies on the pathogenesis of CRC in obese and diabetes patients and the therapy and prevention of CRC in these patients.
Intraventricular glioneuronal tumor with disseminated lesions at diagnosis - a case report -
Hirohito Yano, Noriyuki Nakayama, Yoshinobu Hirose, Naoyuki Ohe, Jun Shinoda, Shin-ichi Yoshimura, Toru Iwama
Diagnostic Pathology , 2011, DOI: 10.1186/1746-1596-6-119
Abstract: Many types of brain tumors originate in the ventricles. For tumors with neuronal differentiation that occupy the anterior central part of the lateral ventricles in adults, central neurocytoma is typically the diagnosis [1]. However, new entities of tumors with neuronal differentiation, which are rare, have been found in this region. Herein, we report an unusual case of a patient who had an atypical tumor with glioneuronal differentiation that arose from the lateral ventricles and that was already accompanied with intraventricular disseminations at the time of diagnosis. We discuss the rationale for the pathological diagnosis on the basis of the immunohistochemistry, the pathophysiology of the dissemination in the early clinical stages, and possible therapies for this tumor with a review of the literature.A 55-year-old man had a 6-month history of memory loss and stagger. He was admitted to our hospital with the diagnosis of an intraventricular tumor. Upon admission, his consciousness level was clear without focal neurological deficits. His Hasegawa's dementia scale (HDR) score had deteriorated to 12/30 points due to his recent memory disturbance. He did not show any symptoms of increased intracranial pressure. His hematological tests and physiological function tests were in the normal range. A computed tomography (CT) scan showed a large mass lesion of about 6 cm in diameter in the central part of the lateral ventricles. No calcification was shown in the lesion. Magnetic resonance imaging (MRI) revealed that the lesions had spread to the third and fourth ventricles (Figure 1a-d). MRI did not show any spinal lesions. The tumor occupying the lateral ventricle showed a low-signal intensity on T1-weighted images (WI), a high-signal intensity on T2-WI and fluid-attenuated inversion recovery (FLAIR) images, and the tumor was enhanced homogeneously with gadolinium (Gd). Positron emission tomography showed a homogeneously high uptake of 11C-methionine and a moderate uptake
Surgical Treatment by Partial Petrosectomy for a Middle-Ear Carcinoid with Progressive Extension: A Case Report and Review of the Literature
Mitsuhiro Aoki,Keisuke Mizuta,Natsuko Ueda,Nansei Yamada,Yatsuji Ito,Hiroki Kato,Yoshinobu Hirose
International Journal of Otolaryngology , 2010, DOI: 10.1155/2010/818673
Abstract: We herein report a 59-year-old male patient with a recurrent carcinoid tumor of the middle ear 7 years after a tympanomastoidectomy. The CT and dynamic MRI demonstrated an extensive tumor close to the carotid artery canal and the jugular bulb, and the tumor was removed by a partial petrosectomy with a transmastoid approach. The histopathological findings revealed a solid and trabecular tumor with cells positive for cytokeratin, chromogranin A, synaptophysin, and CD56. The MIB-1 antibody for the Ki-67 antigen was positive in 6.6% of the tumor cells. The relevant literature is reviewed in regard to the present case. 1. Introduction Carcinoid tumors primarily originate from gastrointestinal organs and the trachea. Carcinoid tumors of the middle ear are very rare; however, there have been more than 50 reports of such tumors since 1980 [1]. A middle-ear carcinoid tumor is usually confined to the tympanum, and osteolytic extension of the tumor is rare [2]. Several patients show osteolytic invasion and cervical lymph node metastasis, suggesting that the middle-ear carcinoid should be classified as a low-grade malignancy [3–5]. The current report presents a patient with extensive osteolytic enlargement of a middle-ear carcinoid close to the jugular bulb and carotid artery canal, and also reviews the previous studies of carcinoid tumors of the middle ear. 2. Case Report A 59-year-old male patient presented with ear pain and bleeding of the left ear, and upon closer investigation a reddish bulging mass extending through the left tympanic membrane from the middle ear was observed. The pure tone audiogram showed an 80-dB mixed hearing loss with an increased threshold of bone conduction in the high tone frequency range. The patient experienced no dizziness or facial palsy. The tympanum and mastoid were filled with an isodensity shadow indicating bone erosion, and the wall of the carotid artery canal and the jugular bulb appeared to be thick and erosive on CT (Figure 1). The mass was close to the carotid artery and jugular bulb through the tympanum, and the mastoid space was enhanced in the early and late phases of the dynamic MRI. The enhanced mass also appeared on the underside of the promontory of the middle ear (Figure 2). The patient had experienced a tympanomastoidectomy for tumors in the tympanum 7 years previously and the pathological diagnosis was adenoma of the middle ear. Figure 1: CT. The tympanum and mastoid were filled with an isodensity shadow with bone erosion. The wall of the carotid artery and jugular bulb appeared to be thick and erosive. CA:
On Quaternionic 3 CR-Structure and Pseudo-Riemannian Metric  [PDF]
Yoshinobu Kamishima
Applied Mathematics (AM) , 2018, DOI: 10.4236/am.2018.92008
Abstract:
A CR-structure on a 2n +1-manifold gives a conformal class of Lorentz metrics on the Fefferman S1-bundle. This analogy is carried out to the quarternionic conformal 3-CR structure (a generalization of quaternionic CR- structure) on a 4n + 3 -manifold M. This structure produces a conformal class [g] of a pseudo-Riemannian metric g of type (4n + 3,3) on M × S3. Let (PSp(n +1,1), S4n+3) be the geometric model obtained from the projective boundary of the complete simply connected quaternionic hyperbolic manifold. We shall prove that M is locally modeled on (PSp(n +1,1), S4n+3) if and only if (M × S3 ,[g]) is conformally flat (i.e. the Weyl conformal curvature tensor vanishes).
Unrecognized States in the Former USSR and Kosovo: A Focus on Standing Armies  [PDF]
Yoko Hirose
Open Journal of Political Science (OJPS) , 2016, DOI: 10.4236/ojps.2016.61007
Abstract: The end of the Cold War and the collapse of the USSR and Yugoslavia result in a proliferation of unrecognized and weak states, which continue to exist today. This article considers the relationship between unrecognized states and the major powers, Russia and the United States, by focusing on the foreign military bases or standing armies of the latter. In addition, unrecognized states, their parent countries, and similar states have received significant merits and profits from being unrecognized states, and this situation has also helped the survival of unrecognized states. It is possible that unrecognized states can be understood as part of the global strategies of the two great powers and that these states have been maintained through a complex negotiation process that is designed to maintain the superpowers’ global influence.
Rheological Behavior of Nanosilica Suspensions in Poly(Ethylene Oxide) Solutions with Sodium Chloride  [PDF]
Yuji Hirose
Materials Sciences and Applications (MSA) , 2017, DOI: 10.4236/msa.2017.85022
Abstract: Suspensions of silica nanoparticles showed shear-thickening profiles under steady shear conditions up on addition of a small amount of poly(ethylene oxide) (PEO). The suspensions turned into gels upon shaking and their fluidity was recovered several minutes after resting. We studied the rheological properties of these shake gels with small amounts of sodium chloride (NaCl). Gelation occurred at lower shear rates upon addition of small amounts of NaCl. In addition, the time taken by the gelated samples to recover their original viscosity increased with the increasing NaCl content. The weakened repulsive interactions between the silica particles upon NaCl addition lead to particles in closer proximity, and three-dimensional networks of PEO chains are easily formed as the electric double layer of the particles becomes thinner.
GEP100-Arf6-AMAP1-Cortactin Pathway Frequently Used in Cancer Invasion Is Activated by VEGFR2 to Promote Angiogenesis
Ari Hashimoto, Shigeru Hashimoto, Ryo Ando, Kosuke Noda, Eiji Ogawa, Hirokazu Kotani, Mayumi Hirose, Toshi Menju, Masaki Morishige, Toshiaki Manabe, Yoshinobu Toda, Susumu Ishida, Hisataka Sabe
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0023359
Abstract: Angiogenesis and cancer invasiveness greatly contribute to cancer malignancy. Arf6 and its effector, AMAP1, are frequently overexpressed in breast cancer, and constitute a central pathway to induce the invasion and metastasis. In this pathway, Arf6 is activated by EGFR via GEP100. Arf6 is highly expressed also in human umbilical vein endothelial cells (HUVECs) and is implicated in angiogenesis. Here, we found that HUVECs also highly express AMAP1, and that vascular endothelial growth factor receptor-2 (VEGFR2) recruits GEP100 to activate Arf6. AMAP1 functions by binding to cortactin in cancer invasion and metastasis. We demonstrate that the same GEP100-Arf6-AMAP1-cortactin pathway is essential for angiogenesis activities, including cell migration and tubular formation, as well as for the enhancement of cell permeability and VE-cadherin endocytosis of VEGF-stimulated HUVECs. Components of this pathway are highly expressed in pathologic angiogenesis, and blocking of this pathway effectively inhibits VEGF- or tumor-induced angiogenesis and choroidal neovascularization. The GEP100-Arf6-AMAP1-cortactin pathway, activated by receptor tyrosine kinases, appears to be common in angiogenesis and cancer invasion and metastasis, and provides their new therapeutic targets.
Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells
Masanori Nakashima, Seiji Adachi, Ichiro Yasuda, Takahiro Yamauchi, Junji Kawaguchi, Toshimasa Hanamatsu, Takashi Yoshioka, Yukio Okano, Yoshinobu Hirose, Osamu Kozawa, Hisataka Moriwaki
Molecular Cancer , 2011, DOI: 10.1186/1476-4598-10-79
Abstract: In these cells, Y27632, a specific ROCK inhibitor, enhanced EGF-induced BrdU incorporation. The blockade of EGF stimulation utilizing anti-EGFR-neutralizing antibodies suppressed Panc1 cell proliferation. EGF induced RhoA activity, as well as the phosphorylation of cofilin and myosin light chain (MLC), both targets of ROCK signaling, and Y27632 suppressed both of these processes, indicating that the phosphorylation of cofilin and MLC by EGF occurs through ROCK in Panc1 cells. EGF-induced phosphorylation of EGFR at tyrosine residues was augmented when the cells were pretreated with Y27632 or were subjected to gene silencing using ROCK-siRNA. We also obtained similar results using transforming growth factor-α. In addition, EGF-induced phosphorylation of p44/p42 mitogen-activated protein kinase and Akt were also enhanced by Y27632 or ROCK-siRNA. Moreover, an immunofluorescence microscope study revealed that pretreatment with Y27632 delayed EGF-induced internalization of EGFR. Taken together, these data indicate that ROCK functions to switch off EGFR signaling by promoting the internalization of the EGFR.While EGF first stimulates the activation of the EGFR and subsequently increases cancer cell proliferation, EGF concurrently induces the activation of ROCK, which then turns off the activated EGFR pathway via a negative feedback system.Pancreatic cancer is a common malignancy, ranking thirteenth in incidence, and eighth as the cause of cancer-related death worldwide [1]. Surgical resection is the only curable treatment at present, but only 10-15% of patients are able to undergo surgery at the time of diagnosis. Most pancreatic cancer has already reached an advanced stage when the first symptoms appear. Furthermore, it is difficult to diagnose pancreatic cancer at an early stage, even with advanced medical imaging techniques such as computed tomography and magnetic resonance imaging.The standard treatment for patients with advanced pancreatic cancer is chemotherapy. Gemc
Measurement of Membrane Characteristics Using the Phenomenological Equation and the Overall Mass Transport Equation in Ion-Exchange Membrane Electrodialysis of Saline Water
Yoshinobu Tanaka
International Journal of Chemical Engineering , 2012, DOI: 10.1155/2012/148147
Abstract: The overall membrane pair characteristics included in the overall mass transport equation are understandable using the phenomenological equations expressed in the irreversible thermodynamics. In this investigation, the overall membrane pair characteristics (overall transport number , overall solute permeability , overall electro-osmotic permeability and overall hydraulic permeability ) were measured by seawater electrodialysis changing current density, temperature and salt concentration, and it was found that occasionally takes minus value. For understanding the above phenomenon, new concept of the overall concentration reflection coefficient is introduced from the phenomenological equation. This is the aim of this investigation. is defined for describing the permselectivity between solutes and water molecules in the electrodialysis system just after an electric current interruption. is expressed by the function of and . is generally larger than 1 and is positive, but occasionally becomes less than 1 and becomes negative. Negative means that ions are transferred with water molecules (solvent) from desalting cells toward concentrating cells just after an electric current interruption, indicating up-hill transport or coupled transport between water molecules and solutes. 1. Introduction Mass transport across the membrane must be discussed fundamentally on the basis of the thermodynamics because the thermodynamics describes the rule of energy changes inevitably generating in the mass transport. However, the classical thermodynamics discusses only reversible phenomena and it does not treat transport rate. The irreversible thermodynamics came to succeed in discussing the transport rate by introducing the concept of “time” in its system [1–4]. Basic theory of the irreversible thermodynamics is established on the assumption of “microscopic irreversibility” [5–7]. This assumption holds more strictly in the circumstance being more close to equilibrium states. The actual electrodialysis process is not formed in the equilibrium states, so that the irreversible thermodynamics is assumed to exhibit only approximated meaning in the electrodialysis system. However, the irreversible thermodynamics is considered to be applicable in the circumstances being apart to some extent from equilibrium states [8, 9]. The irreversible thermodynamics is the fundamental rule of mass transport and it is expressed by the functions including phenomenological coefficients. On the other hand, the performance of an electrodialyzer is expressed by the functions including parameters such as
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