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Predictive Factors of the Presence and Number of Noncalcified Coronary Plaque in Japanese Patients with Zero Coronary Artery Calcium Score Using 64-Slice Multi-Detector Computed Tomography  [PDF]
Yoshiki Noda, Ryo Matsutera, Yoshinori Yasuoka, Kiyoshi Kume, Hidenori Adachi, Susumu Hattori, Ryo Araki, Motohiro Kosugi, Yasuaki Kohama, Tetsufumi Nakashima, Tatsuya Sasaki
Advances in Computed Tomography (ACT) , 2013, DOI: 10.4236/act.2013.23020

Background: Factors that can predict the presence and number of noncalcified coronary plaques (NCP) in Japanese patients with zero coronary artery calcium scores (CACS) essentially remain undefined. Methods and Results: We assessed independent predictors of the presence and number of segments with NCP in 111 Japanese patients with zero CACS who underwent 64-slice multi-detector computed tomography at our hospital. Thirty five patients (32%) had NCP, and 24 patients (22%) had ≥ 2 NCPs. Multiple logistic regression analysis revealed that significant predictors for the presence of NCP were age (odds ratio [OR]: 1.06, 95% confidence interval [CI] 1.01 - 1.11, p = 0.021), male (OR: 3.61, 95% CI 1.40 - 9.35, p = 0.008) and diabetes mellitus (OR: 3.10, 95% CI 1.02 - 9.45, p = 0.046), and those for the presence of ≥ 2 NCPs were age (OR: 1.08, 95% CI 1.02 - 1.15, p = 0.007) and a current smoking habit (OR: 5.09, 95% CI 1.00 - 25.74, p = 0.049). Multiple linear regression analysis identified advanced age, male gender and diabetes mellitus as independent

Multi-locus sequence typing of Salmonella enterica subsp. enterica serovar Enteritidis strains in Japan between 1973 and 2004
Tamie Noda, Koichi Murakami, Tetsuo Asai, Yoshiki Etoh, Tomoe Ishihara, Toshiro Kuroki, Kazumi Horikawa, Shuji Fujimoto
Acta Veterinaria Scandinavica , 2011, DOI: 10.1186/1751-0147-53-38
Abstract: Salmonella enterica subsp. enterica serovar Enteritidis (S. Enteritidis) was responsible for a worldwide pandemic during the 1980s and 1990s; however, changes in the dominant lineage before and after this event remain unknown. It is also difficult to explain why multiple clones of S. Enteritidis (defined by phage types, (PTs)) infecting chicken reproductive tissues emerged simultaneously in geographically separate countries during this pandemic. For example, PT 4 emerged in some European countries during the late 1980s, including England and Wales [1], France [2] and Germany [3], while PT 6 dominated Denmark [4]. PT 8, PT 13a and PT 13 were most common in the USA [5] and in Japan, PT 1 and PT 4 were dominant [6]. To understand the simultaneous emergence of this pathogen, it is necessary to deduce whether these multiple lineages co-instantaneously acquired the ability to colonize chicken reproductive tissues or a single clone that possessed this ability evolved into multiple lineages before the pandemic.Multi-locus sequence typing (MLST) can be used to accurately identify bacterial lineages [7,8]. The genetic distance between two strains can be quantitatively estimated as allelic differences in the nucleotide sequences of housekeeping or virulent genes among bacterial strains [8]. MLST data have been used in evolutionary and population analyses that estimate recombination and mutation rates and also in the investigation of evolutionary relationships among bacteria classified within the same genus [8]. Using MLST, our study aimed to determine the lineages of S. Enteritidis before and after the pandemic during the 1980s and/or 1990s in Fukuoka Prefecture, Japan.Salmonella strains used in this study are listed in Table 1. Human strains from individual food-borne disease outbreaks in 1973-1981 were isolated in the Kanagawa Prefectural Institute of Public Health. Other human strains (isolated from individual outbreaks), the liquid egg strain and the eggshell strain were i
Function of Chemokine (CXC Motif) Ligand 12 in Periodontal Ligament Fibroblasts
Yuichi Yashiro, Yoshiaki Nomura, Mikimoto Kanazashi, Koji Noda, Nobuhiro Hanada, Yoshiki Nakamura
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095676
Abstract: The periodontal ligament (PDL) is one of the connective tissues located between the tooth and bone. It is characterized by rapid turnover. Periodontal ligament fibroblasts (PDLFs) play major roles in the rapid turnover of the PDL. Microarray analysis of human PDLFs (HPDLFs) and human dermal fibroblasts (HDFs) demonstrated markedly high expression of chemokine (CXC motif) ligand 12 (CXCL12) in the HPDLFs. CXCL12 plays an important role in the migration of mesenchymal stem cells (MSCs). The function of CXCL12 in the periodontal ligament was investigated in HPDLFs. Expression of CXCL12 in HPDLFs and HDFs was examined by RT-PCR, qRT-PCR and ELISA. Chemotactic ability of CXCL12 was evaluated in both PDLFs and HDFs by migration assay of MSCs. CXCL12 was also immunohistochemically examined in the PDL in vivo. Expression of CXCL12 in the HPDLFs was much higher than that in HDFs in vitro. Migration assay demonstrated that the number of migrated MSCs by HPDLFs was significantly higher than that by HDFs. In addition, the migrated MSCs also expressed CXCL12 and several genes that are familiar to fibroblasts. CXCL12 was immunohistochemically localized in the fibroblasts in the PDL of rat molars. The results suggest that PDLFs synthesize and secrete CXCL12 protein and that CXCL12 induces migration of MSCs in the PDL in order to maintain rapid turnover of the PDL.
Noninvasive Demonstration of Dual Coronary Artery Fistulas to Main Pulmonary Artery with 64-Slice Multidetector-Computed Tomography: A Case Report
Yoshiki Noda,Ryo Matsutera,Yoshinori Yasuoka,Haruhiko Abe,Hidenori Adachi,Susumu Hattori,Ryo Araki,Takahiro Imanaka,Motohiro Kosugi,Tatsuya Sasaki
Cardiology Research and Practice , 2010, DOI: 10.4061/2010/861068
Abstract: Coronary artery fistulas, including coronary pulmonary fistulas, are usually discovered accidently among the adult population when undergoing invasive coronary angiographies. We report here a 58-year-old woman with dual fistulas originating from the left anterior descending coronary artery and right coronary sinus to the main pulmonary artery, demonstrating noninvasively with multidetector-computed tomography (MDCT) and transthoracic echocardiography (TTE). 1. Introduction Coronary artery fistulas are rare anomalies of coronary arteries detected in around 0.1% to 0.2% of the adult population and usually discovered accidently when undergoing invasive coronary angiographies (ICA) [1, 2]. In addition, dual or multiple coronary fistulas are reported to be quite rare [3, 4]. The definite diagnoses of these patients were made only by ICA in the past. However, it has been reported that coronary artery fistulas can be detected by various kinds of noninvasive cardiac imaging, such as multidetector computed tomography (MDCT) and transthoracic echocardiography (TTE) in recent years [5, 6]. We report here an adult patient with dual fistulas originating from the left anterior descending coronary artery and right coronary sinus to the main pulmonary artery demonstrated noninvasively with MDCT and TTE. 2. Case A 58-year-old woman with no history of cardiac disease was introduced to our hospital with atypical chest pain at rest and before sleeping at night for a month. Her risk factors for coronary artery disease were obesity and dyslipidemia, and she was administered with statin by a local clinic. On clinical examination, she had no murmur, and both chest X-ray and resting electrocardiogram were normal. We performed TTE and 64-slice MDCT (Aquilion 64, Toshiba Medical Systems, Japan) since treadmill exercise test indicated positive finding for myocardial ischemia. TTE revealed continuous flow into the main pulmonary artery which had peak flow in the diastolic phase. MDCT was performed with a retrospective ECG-gated protocol and with a collimation of ?mm, detector pitch of 11.2, gantry rotation time of 350?ms, tube current of 400?mA, and tube voltage of 120?kV. She received 2?mg propranolol hydrochloride and sublingual nitroglycerin before scanning, and 59?mL of contrast medium (370?mg iodine/mL) was used for MDCT angiography. Axial images demonstrated the leakage of contrast medium into the main pulmonary artery from the aberrant artery originating from coronary arteries (Figure 1), and we could not detect any other leakages of contrast medium in the pulmonary artery.
Impact of Robotic Assistance on Precision of Vitreoretinal Surgical Procedures
Yasuo Noda, Yoshiki Ida, Shinichi Tanaka, Taku Toyama, Murilo Felix Roggia, Yasuhiro Tamaki, Naohiko Sugita, Mamoru Mitsuishi, Takashi Ueta
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054116
Abstract: Purpose To elucidate the merits of robotic application for vitreoretinal maneuver in comparison to conventional manual performance using an in-vitro eye model constructed for the present study. Methods Capability to accurately approach the target on the fundus, to stabilize the manipulator tip just above the fundus, and to perceive the contact of the manipulator tip with the fundus were tested. The accuracies were compared between the robotic and manual control, as well as between ophthalmologists and engineering students. Results In case of manual control, ophthalmologists were superior to engineering students in all the 3 test procedures. Robotic assistance significantly improved accuracy of all the test procedures performed by engineering students. For the ophthalmologists including a specialist of vitreoretinal surgery, robotic assistance enhanced the accuracy in the stabilization of manipulator tip (from 90.9 μm to 14.9 μm, P = 0.0006) and the perception of contact with the fundus (from 20.0 mN to 7.84 mN, P = 0.046), while robotic assistance did not improve pointing accuracy. Conclusions It was confirmed that telerobotic assistance has a potential to significantly improve precision in vitreoretinal procedures in both experienced and inexperienced hands.
From bench to bedside, work in cell-based myocardial regeneration therapy  [PDF]
Shigeru Miyagawa, Yoshiki Sawa
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.72012

In clinical cellular cardiomyoplasty, bone marrow cells and myoblasts are introduced mainly to ischemic cardiomyopathy tissue via several cell delivery systems, such as needle injection or catheter. These clinical studies have demonstrated the safety and feasibility of this technique, but its effectiveness for treating heart failure, especially in the long term, is still under discussion. Neither of these cell types can differentiate into cardiomyocytes; rather, they improve the failing heart mainly by the paracrine effects of some cytokines, such as Hepatocyte growth factor (HGF) and Vascular endothelial growth factor (VEGF). Thus, many researchers have a great interest in stem cells, which exist in bone marrow, circulating blood, atrium, and adipose tissue, and can differentiate into cardiomyocytes. Although several stem cells with the potential to differentiate into various cell types have been reported, few can differentiate into cardiomyocytes. Moreover, beating cells that can demonstrate synchronized contraction with native cardiomyocytes are critical for the complete repair of severe heart failure. Therefore, stem cells with a high differentiation capacity should be explored for the goal of completely repairing severely damaged myocardium. In this review, we summarize the clinical protocols and basic experiments for cellular cardiomyoplasty using bone marrow cells, myoblasts, and other stem cells.

Effects of Silvicultural Alternatives on Model-Based Financial Evaluation of Teak (Tectona grandis L.) Farm Forestry Management for Small-Scale Farmers in Northeast Thailand  [PDF]
Iwao Noda, Woraphun Himmapan
Open Journal of Forestry (OJF) , 2014, DOI: 10.4236/ojf.2014.45060
Abstract: Teak (Tectona grandis L.) plantation management is said to be profitable, but small-scale farmers with teak plantations need to find appropriate and effective choices for plantation management because of their small plots. There have been few studies on how combinations of site quality, rotation and plant spacing affect financial evaluations of teak plantation management quantitatively. In this study, we introduced the yield table for teak plantations in Northeast Thailand, and investigated the effects of site quality with rotation (15-year and 20-year) and spacing (2 m × 4 m and 4 m × 4 m) on the financial evaluation of teak plantation management using discounted cash flow analysis. The equivalent annual incomes (EAI) and benefit/cost ratios (BCR) were negative and <1, respectively, at site indexes (SI) of 14 and 18, but increased ~2 - 3 times as SI rose from 22 (site of medium quality) to 26 and 26 to 30. The 20-year rotation was generally preferable to the 15-year one, especially at SI 22. At SI 30, 2 m × 4 m was more profitable than 4 m × 4 m for both rotations, but at SI 22, 20-year rotation with 4 m × 4 m was the most profitable, followed by 20-year with 2 m × 4 m.
Erratum to “Effects of Silvicultural Alternatives on Model-Based Financial Evaluation of Teak (Tectona grandis L.) Farm Forestry Management for Small-Scale Farmers in Northeast Thailand” [Open Journal of Forestry, 4 (2014) 558-569]  [PDF]
Iwao Noda, Woraphun Himmapan
Open Journal of Forestry (OJF) , 2015, DOI: 10.4236/ojf.2015.55048
Abstract: The original online version of this article (Noda, I. et al. (2014). Effects of Silvicultural Alternatives on Model-Based Financial Evaluation of Teak (Tectona grandis L.) Farm Forestry Management for Small-Scale Farmers in Northeast Thailand. Open Journal of Forestry, 4, 558-569. http://dx.doi.org/10.4236/ojf.2014.45060) was published in October. The author wishes to correct Table 5.
Dissemination of Advanced Mouse Resources and Technologies at RIKEN BioResource Center
Atsushi Yoshiki
Interdisciplinary Bio Central , 2010,
Abstract: RIKEN BioResource Center (BRC) has collected, preserved, conducted quality control of, and distributed mouse resources since 2002 as the core facility of the National BioResource Project by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. Our mouse resources include over 5,000 strains such as humanized disease models, fluorescent reporters, and knockout mice. We have developed novel mouse strains such as tissue-specific Cre-drivers and optogenetic strains that are in high demand by the research community. We have removed all our specified pathogens from the deposited mice and used our quality control tests to examine their genetic modifications and backgrounds. RIKEN BRC is a founding member of the Federation of International Mouse Resources and the Asian Mouse Mutagenesis and Resource Association, and provides mouse resources to the one-stop International Mouse Strain Resource database. RIKEN BRC also participates in the International Gene Trap Consortium, having registered 713 gene-trap clones and their sequences in a public library, and is an advisory member of the CREATE (Coordination of resources for conditional expression of mutated mouse alleles) consortium which represents major European and international mouse database holders for the integration and dissemination of Cre-driver strains. RIKEN BRC provides training courses in the use of advanced technologies for the quality control and cryopreservation of mouse strains to promote the effective use of mouse resources worldwide.
Application of Maximum Entropy Method to Semiconductor Engineering
Yoshiki Yonamoto
Entropy , 2013, DOI: 10.3390/e15051663
Abstract: The maximum entropy method (MEM) is widely used in research fields such as linguistics, meteorology, physics, and chemistry. Recently, MEM application has become a subject of interest in the semiconductor engineering field, in which devices utilize very thin films composed of many materials. For thin film fabrication, it is essential to thoroughly understand atomic-scale structures, internal fixed charges, and bulk/interface traps, and many experimental techniques have been developed for evaluating these. However, the difficulty in interpreting the data they provide prevents the improvement of device fabrication processes. As a candidate for a very practical data analyzing technique, MEM is a promising approach to solve this problem. In this paper, we review the application of MEM to thin films used in semiconductor engineering. The method provides interesting and important information that cannot be obtained with conventional methods. This paper explains its theoretical background, important points for practical use, and application results.
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