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Search Results: 1 - 10 of 20457 matches for " Yoonjung Kim "
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Spectrum of EGFR Gene Copy Number Changes and KRAS Gene Mutation Status in Korean Triple Negative Breast Cancer Patients
Yoonjung Kim, Juwon Kim, Hy-De Lee, Joon Jeong, Woochang Lee, Kyung-A Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079014
Abstract: Anti-epidermal growth factor receptor (EGFR) therapy has been tried in triple negative breast cancer (TNBC) patients without evaluation of molecular and clinical predictors in several randomized clinical studies. Only fewer than 20% of metastatic TNBCs showed response to anti-EGFR therapy. In order to increase the overall response rate, first step would be to classify TNBC into good or poor responders according to oncogenic mutation profiles. This study provides the molecular characteristics of TNBCs including EGFR gene copy number changes and mutation status of EGFR and KRAS gene in Korean TNBC patients. Mutation analysis for EGFR, KRAS, BRAF and TP53 from a total of 105 TNBC tissue samples was performed by direct sequencing, peptide nucleic acid-mediated PCR clamping method and real-time PCR. Copy number changes of EGFR gene were evaluated using multiplex ligation-dependent probe amplification. Out of all 105 TNBCs, 15.2% (16/105) showed EGFR copy number changes. Among them, increased or decreased EGFR copy number was detected in 13 (5 single copy gain, 2 amplification and 4 high-copy number amplification) and 3 cases (3 hemizygous deletion), respectively. The mutation frequencies of KRAS, EGFR and TP53 gene were 1.9% (G12V and G12D), 1.0% (exon 19 del) and 31.4%, respectively. There was no BRAF V600E mutation found. Future studies are needed to evaluate the clinical outcomes of TNBC patients who undergo anti-EGFR therapy according to the genetic status of EGFR.
Expression of MMP-9 and -13 on the Pressure Side under Orthodontic Loading  [PDF]
Su-Jung Mah, Yoonjung Lee, Youn-Sic Chun, Won Hee Lim
Open Journal of Stomatology (OJST) , 2014, DOI: 10.4236/ojst.2014.48055
Abstract: Purpose: The purpose of this study was to investigate the expression of MMP-9 and MMP-13 on compression side of tooth movement. Material and Methods: Twenty male Wistar rats were used for this experiment. Maxillary right first molar was moved orthodontically with a constant force of 20 g and on the side of the maxillary left first molar was used as control group. On the 4th, 10th and 17th days after experiment, 5 rats were euthanized, respectively. Histologic process was processed for immunohistochemical staining of MMP-9 and -13. Results: MMP-9 and -13 expressions were upregulated at day 4 after tooth movement. The expression of MMP-9 was not observed at days 7, 10 and 14, while the expression of MMP-13 was greatly increased at days 7 and 10. Conclusion: This study suggests that different characteristics of MMPs expression may contribute to the remodeling process of collagen fibers in the PDL during tooth movement.
Effects of interventions on oxidative stress and inflammation of cardiovascular diseases
Sewon Lee,Yoonjung Park,Mozow Yusof Zuidema,Mark Hannink
World Journal of Cardiology , 2011,
Abstract: Excessive oxidative stress and low-grade chronic inflammation are major pathophysiological factors contributing to the development of cardiovascular diseases (CVD) such as hypertension, diabetes and atherosclerosis. Accumulating evidence suggests that a compromised anti-oxidant system can lead to excessive oxidative stress in cardiovascular related organs, resulting in cell damage and death. In addition, increased circulating levels of pro-inflammatory cytokines, such as tumor necrosis factor α, interleukin-6 and C-reactive protein, are closely related to morbidity and mortality of cardiovascular complications. Emerging evidence suggests that interventions including nutrition, pharmacology and exercise may activate expression of cellular anti-oxidant systems via the nuclear factor erythroid 2-related factor 2-Kelch-like ECH-associated protein 1 signaling pathway and play a role in preventing inflammatory processes in CVD. The focus of the present review is to summarize recent evidence showing the role of these anti-oxidant and anti-inflammatory interventions in cardiovascular disease. We believe that these findings may prompt new effective pathogenesis-oriented interventions, based on the exercise-induced protection from disease in the cardiovascular system, aimed at targeting oxidant stress and inflammation.
Design of Quantification Model for Ransom Ware Prevent  [PDF]
Donghyun Kim, Seoksoo Kim
World Journal of Engineering and Technology (WJET) , 2015, DOI: 10.4236/wjet.2015.33C030
Abstract:

The growth of ICT within the society has become increasingly digitized, thus, the overall activity has amounted to various researches for protecting any data from malicious threats. Recently, ransomware has been a rapidly propagated subject for social engineering techniques especially the ransomware. Users can delete a ransomeware code using an antivirus software code. However, the encrypted data would be impossible to recover. Therefore, ransomware must be prevented and must have early detection before it infects any data. In this paper, we are proposing a quantification model to prevent and detect any cryptographic operations in the local drive.

Trends of Noninvasive Radiofrequency and Minimally Invasive Treatment for the Management of Facial Aging  [PDF]
Sunghee Kim, Moonjong Kim
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2019, DOI: 10.4236/jcdsa.2019.91003
Abstract: Various treatments for the management of facial aging have been performed among which noninvasive radio-frequency (RF; i.e., thermage) treatment and minimally invasive treatments are on the rise. The purpose of this study was to analyze trends of the treatment of facial aging in Korea and to investigate relationships between the use of noninvasive RF and minimally invasive treatments. A retrospective analysis conducted on data from 4021 patients showed that thermage treatment increased by 134.9% over 5 years. As a person ages, the rate of facial treatment with both the botulinum toxin (for the masseter and lines of the glabella, lateral canthus, and forehead) and the PDO thread lift increases. The use of the treatments, nasolabial fold filler and Silhouette Soft Thread, however, was not associated with aging. The patients receiving thermage treatment were less likely to undergo any of the other treatments including PDO thread lift, Silhouette Soft Thread, nasolabial fold filler, or any of the botulinum toxin treatments. Overall, the results showed that patients who had received noninvasive RF tended to receive less minimally invasive treatment.
The Effect of Prunella on Anti-Inflammatory Activity in RAW264.7 Mouse Macrophage Cells  [PDF]
Meehye Kim
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.39170
Abstract: The extracts of Prunella vulgaris L. (Labiatae), a popular Western and Chinese herbal medicine, was shown to have anti-inflammatory properties, which might be due to partially, their rosmarinic acid content. Inhition of prostaglandine E2 (PGE2) production in lipopolysaccharide (LPS) stimulated RAW264.7 mouse macrophage cells was assessed with an enzyme immunoassay (EIA) following 8-hour treatments with Prunella vulgaris extracts or fractions. Results showed that 95% ethanol extracts from P. vulgaris significantly inhibited PGE2 production. In further studies, fraction 2 from the 95% ethanol extract of P. vulgaris significantly reduced PGE2 production at 66 µg/ml (72% reduction). Cytotoxic-ity did not play a role in the noted reduction of PGE2 seen in either the extracts or fractions from P. vulgaris. High performance liquid chromatography analysis showed that there was 1.4 mM rosmarinic acid in 95% ethanol Prunella extract (201 mg/ml crude extract). Our results suggest that rosmarinic acid may contribute toward the anti-inflammatory activity of Prunella in a dose-response manner. Prunella might have a potential to be used as a functional food for anti-inflammatory activity.
An Effect of the Elastic Energy Stored in the Muscle-Tendon Complex at Two Different Coupling-Time Conditions during Vertical Jump  [PDF]
Sukwon Kim
Advances in Physical Education (APE) , 2013, DOI: 10.4236/ape.2013.31002
Abstract:

A study was performed to evaluate effects of elastic energy stored pre-stretch on the mechanical work output while performing vertical jump. Eight male volunteers of age between 21-29 years old participated in the present study. The present study hypothesized that the vertical jump height during countermovement jumps (CMJ) would be higher than that during squat jump (SJ). During squat jump, a volunteer paused 0.5 sec before making upward movement. The results showed that ground reaction forces and vertical jump displacements were higher in CMJ in comparison to SJ. The study concluded that part of the positive work measured did derive from the recoil of the elastic component of the muscle-tendon complex.

Material Resource Planning (MRP): Will You Need MRP without the Customer?  [PDF]
Kwahng Kim
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.24027
Abstract: The objective of this paper is to introduce a new philosophy that when integrated with existing methodologies, will improve customer service within the manufacturing sector. This paper intends to provide the reader with an understanding that the entire operation has to be involved and collectively focused in order to continuously exceed customer expectations. Short falls of existing systems will be examined with a key focus on the importance of not tying all expectations on MRP, a historical algorithmic electronic scheduling system.
A Study for Building Smart Home Environment Based on Modular Equipment Design Concept  [PDF]
Seokjin Kim
Art and Design Review (ADR) , 2015, DOI: 10.4236/adr.2015.32007
Abstract: In this paper, we propose a modular equipment design concept for building smart-home environment, which can deal with the problems such as life expectancy and complicated cable networks. Recently, the advancement of digital technology in residential networking and connections (i.e., internet cables, power cables, and network cables) has made a positive alteration to the interspatial relationship between appliances. Moreover, the interaction and communication between user and application has understood progressive changes. In future home environment, the living room is a place that has become a haven for the family and a place for entertainment as well. The downside of the new technologies is the life expectancy of the product, which is affected by a simple change to the development of digital technology.
The Impacts of Nonnative Japanese Eelgrass (Zostera japonica) on Commercial Shellfish Production in Willapa Bay, WA  [PDF]
Kim Patten
Agricultural Sciences (AS) , 2014, DOI: 10.4236/as.2014.57066
Abstract:

Eelgrass species worldwide are valued for the ecosystem service they provide to estuarine and marine habitats. One species, Zostera japonica, however, has some negative impacts outside its native range and is considered invasive. In Willapa Bay WA, USA, the nonnative eelgrass has expanded to the level where the shellfish industry is concerned about its potential impacts on its livelihood. Studies were conducted using paired plots, Z. japonica controlled with the herbicide imazamox vs. untreated controls, to assess the effects of Z. japonica on Manila clams (Ruditapes philippinarum) and Pacific oysters (Crassostrea gigas). Recruitment of new Manila clams was not affected by Z. japonica. The growth of young clams, total commercial clam harvests, clam quality and clam harvest efficiency, however, were greater on plots where Z. japonica was chemically controlled than where it was not treated. The response of oysters to Z. japonica control varied by site; there was no effect at one site, while the other sites had a 15% increase in shucked meat with Z. japonica control. The potential economic impact of a

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