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Search Results: 1 - 10 of 6516 matches for " Yoon Pin Lim "
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Proteome-Wide Profiling of the MCF10AT Breast Cancer Progression Model
Lee Yee Choong,Simin Lim,Poh Kuan Chong,Chow Yin Wong,Nilesh Shah,Yoon Pin Lim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011030
Abstract: Mapping the expression changes during breast cancer development should facilitate basic and translational research that will eventually improve our understanding and clinical management of cancer. However, most studies in this area are challenged by genetic and environmental heterogeneities associated with cancer.
Evaluation of Global Differential Gene and Protein Expression in Primary Pterygium: S100A8 and S100A9 as Possible Drivers of a Signaling Network
Aihua Hou, Wanwen Lan, Kai Pong Law, Ser Chin Jasmine Khoo, Min Qi Tin, Yoon Pin Lim, Louis Tong
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097402
Abstract: Purpose Pterygium is a wing shaped fibrovascular growth on the ocular surface, characterized by fibrosis, angiogenesis, extracellular matrix remodeling, and inflammatory infiltrates. Epidemiologic studies have linked pterygium formation to various chronic inflammatory conditions, such as ultraviolet radiation, sawdust exposure, and dry eye disease. The purpose of this study is to identify proteins that are differentially expressed in primary pterygium by using a combination of gene microarray and proteomic platforms. Methods Paired pterygium and uninvolved conjunctiva tissues of four patients were evaluated for differences in global gene transcript levels using a genechip microarray. Proteins extracted from another four pairs of tissues were quantified by iTRAQ approach. Western blot and immunofluorescent staining on additional patients were used to validate dysregulated protein expression obtained from microarray and proteomics data. In addition, primary conjunctival fibroblasts were treated with recombinant S100A8, S100A9 or both. Transcript level changes of a panel of potential target genes were evaluated by real time-PCR. Results The following were up-regulated at both protein and transcript levels S100 A8 and A9, aldehyde dehydrogenase 3 family, member1 (ALDH3A1) and vimentin (VIM). Conversely, serpin peptidase inhibitor clade A member 1 (SERPINA1) and transferrin (TF) were down-regulated. Upon adding S100A8, S100A9 or both, the inflammatory chemokine CXCL1, matrix proteins vimentin, biglycan, and gelsolin, as well as annexin-A2, thymosin-β4, chymase (CMA1), member of Ras oncogene family RAB10 and SERPINA1 were found to be up-regulated. Conclusions We identified 3 up-regulated and 2 down-regulated proteins by using a stringent approach comparing microarray and proteomic data. On stimulating cells with S100A8/9, a repertoire of key genes found to be up-regulated in pterygium tissue, were induced in these cells. S100A8/9 may be an upstream trigger for inflammation and other disease pathways in pterygium.
Antimicrobial Effect of Skin for Allograft and Management in Burn Wound  [PDF]
Kihwan Lim, Cheonjae Yoon, Jungsuk Lee
Open Journal of Organ Transplant Surgery (OJOTS) , 2017, DOI: 10.4236/ojots.2017.71001
Abstract: One of the most important functions of skins is to protect our bodies from microbes or pollutant sources. Skins containing physical substances serve as a physical barrier which protects our bodies from pathogens. A healthy skin contains a variety of antibacterial substances such as defensin, cathelicidin and psoriasin. However deep and wide burns cause the skin to lose its original functions, so our skins are exposed to various danger factors. For the burn patients, human alloskin graft serves as a very important temporary biological wound dressing. It protects the wound before autograft procedure, forms revascularization and granulation tissues and protects the wound from an invasion of microbes. This study was conducted with the aim to analyze the antimicrobial effect of cryopreserved allograft (CPA) and glycerol-preserved allograft (GPA) which was a type of allograft widely used for burn patients, and measure the difference in comparison with the fresh skin before processing it. The most common contaminants found in burn patients such as S. aureus, P. aeruginosa, C. albicans and E. coli, were used for experiment. The antimicrobial effect against S. aureus and E. coli was observed in fresh skin and some CPA. In some clinical cases, infection is frequently observed in the wounds treated with allograft, indicating the allograft completely block every kind of microbes. To prevent the infection, it is required to use antibiotics and manage wounds thoroughly.
Rings with involution whose symmetric elements are central
Taw Pin Lim
International Journal of Mathematics and Mathematical Sciences , 1980, DOI: 10.1155/s0161171280000178
Abstract: In a ring R with involution whose symmetric elements S are central, the skew-symmetric elements K form a Lie algebra over the commutative ring S. The classification of such rings which are 2-torsion free is equivalent to the classification of Lie algebras K over S equipped with a bilinear form f that is symmetric, invariant and satisfies [[x,y],z]=f(y,z)x ¢ ’f(z,x)y. If S is a field of char ¢ ‰ 2, f ¢ ‰ 0 and dimK>1 then K is a semisimple Lie algebra if and only if f is nondegenerate. Moreover, the derived algebra K ¢ € 2 is either the pure quaternions over S or a direct sum of mutually orthogonal abelian Lie ideals of dim ¢ ‰ ¤2.
Division Technique Training Tool for Problem Solving Methods of IPR  [PDF]
Gil Su Yoon, You Heon Kim, Sung Ju Lim
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.38205
Abstract: We have developed a training tool of division technique among 5 techniques in ASIT for problem solving method for Intellectual Property Right. Even though with its good capability, there were not yet an applicable training tool to use for division training because of its easy disassembled shape with small disturbance. To develop a division technique training tool, we have applied ASIT to game T. We have chosen game shape parts with magnetic rubber and board as the plate coated with zinc. The adhesive strength of the game shape parts to board is enough to keep fixed position even in turn down. Developed division training tool is expected to be used for the e-learning of problem solving training for student education and lifelong education. It is under Korean utility model application. E-learning with open resources including beneficial training for solving problem will be developed together with the foundation of life-long education. This division training device is proposed to younger generation as the educational auxiliary training tool for problem solving method. We are looking for the international cooperation with this division training tool. With the encouragement of this division training tool we have patented Korean patent of the lifting method of methane hydrate which can be extended to various fields of IPR.
Division Technique Training Tool for Problem Solving Methods of IPR  [PDF]
Gil Su Yoon, You Heon Kim, Sung Ju Lim
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.38B027
Abstract: We have developed a training tool of division technique among 5 techniques in ASIT for problem solving method for Intellectual Property Right.  Even though with its good capability, there were no applicable training tool to use for division training because of its easy disassembled shape with small disturbance. To develop a division technique training tool, we have applied ASIT to game T. We have chosen game shape parts with magnetic rubber and board as the plate coated with zinc. The adhesive strength of the game shape parts to board is enough to keep fixed position even in turn down. Developed tool is expected to use for the e-learning of problem solving training for student education and lifelong education. It is under Korean utility model application. E-learning with open resources including beneficial training for solving problem will develop together in foundation of life-long education. This division training device is proposed to younger generation as the educational auxiliary training tool for problem solving method. We have applied for Korean patent of the lifting method of methan hydrate which can be extended to various fields of IPR.
Parasitic-Element-Loaded UWB Antenna with Band-Stop Function for Mobile Handset Wireless USB
Yohan Lim,Young Joong Yoon,Byungwoon Jung
International Journal of Antennas and Propagation , 2012, DOI: 10.1155/2012/427841
Abstract: A UWB antenna loaded by parasitic elements for wireless USB of mobile handsets is proposed for UWB service in which a band-stop function of 5.725–5.825?GHz WLAN band is required. Two kinds of parasitic elements are incorporated into a rectangular radiator to obtain enhanced impedance bandwidth and band-stop function. The proposed antenna is very compact in size. Wide bandwidths of 3.15–4.75?GHz and 7.2–10.2?GHz are achieved while 5.725–5.825?GHz is notched. Three different shapes of conventional mobile terminals are also considered for measurement. 1. Introduction Ultra-wideband (UWB) antenna technology has been one of the most fascinating design areas in indoor communications, and it has been used with a variety of antennas [1–10]. It has the merits of high-speed transmission rate, low power consumption, and simple hardware configuration over conventional wireless communication systems. The main challenge for UWB antennas is to maintain high performance over a large bandwidth while having small dimensions. Another design concern is that a UWB antenna can allow a potential interference with a wireless local area network (WLAN) [11–13]. Recently, there have been attempts to include UWB systems in USB dongles [14–17]. However, previous UWB antennas for wireless USB devices are too large to be inserted into the terminals of mobile handsets, and interference with the WLAN was not considered in these designs. In this paper, a UWB antenna for wireless USB for mobile handsets is proposed that has both small size and a band-stop function at the upper WLAN band of 5.725–5.825?GHz. Two parasitic elements are used to achieve wideband characteristics and the band-stop function. A tapered and folded feed line is also used to obtain an enhanced impedance matching characteristic [18]. All simulations in this work were carried out using CST Microwave Studio. A design example of the proposed antenna is demonstrated. 2. Antenna Structure The three dimensional configuration of the proposed antenna with its planar figure is shown in Figure 1. A rectangular radiator and parasitic elements are fabricated on the FR4 substrate with a dielectric constant of 4.5 and a height of 1?mm and mounted in the top left-hand corner of a mobile handset board. The optimum design parameters are: AW = 6.4?mm, AL = 6?mm, SL = 4.95?mm, GW = 8?mm, GL = 2.5?mm, BW = 2.6?mm, FL = 7?mm, and FW = 1.5?mm. The size of the radiator is 6.4?mm × 6?mm × 3?mm, and the antenna clearance is 14.4?mm × 16?mm. It has not only very compact size, but also low profile. The PCB size is 35?mm × 80?mm × 1?mm, which
Malicious Node Detection Using a Dual Threshold in Wireless Sensor Networks
Sung Yul Lim,Yoon-Hwa Choi
Journal of Sensor and Actuator Networks , 2013, DOI: 10.3390/jsan2010070
Abstract: Sensor networks for various event detection applications cannot function effectively if they are vulnerable to attacks. Malicious nodes can generate incorrect readings and misleading reports in such a way that event detection accuracy and false alarm rates are unacceptably low and high, respectively. In this paper, we present a malicious node detection scheme for wireless sensor networks. Unlike others using a single threshold, the proposed scheme employs two thresholds to cope with the strong trade-off between event detection accuracy and false alarm rate, resulting in improved malicious node detection performance. In addition, each sensor node maintains the trust values of its neighboring nodes to reflect their behavior in decision-making. Computer simulation shows that the proposed scheme achieves high malicious node detection accuracy without sacrificing normal sensor nodes and outperforms the scheme using a single threshold.
Cross-Layer Dynamic Spectrum Map Management Framework for White Space Applications
Yoon Seungil,Lim Kyutae,Kim Jongman
EURASIP Journal on Wireless Communications and Networking , 2010,
Abstract: White space, unused TV spectrum, will be allowed for unlicensed use by wireless communication devices "the so called white space applications (WSAs)." WSAs retrieve a location-based spectrum map, a list of open white space channels, from a spectrum map server and can select one on the list as their operating channel for the broadband Internet access. However, since not only primary users such as TV broadcasting services use white space shortly or longly but also neighboring WSAs do, WSAs need to perform spectrum sensing that determines the occupancy status, either occupied or unoccupied, of white space channels and select one among the unoccupied channels according to the spectrum sensing results. In a conventional spectrum sensing, they can execute unnecessary spectrum sensing on the already occupied channels. This paper proposes a dynamic management framework of white space that extends a spectrum map to contain occupancy information with the assistance of WSAs. Our framework enables WSAs to avoid unnecessary spectrum sensing on the channels that are marked as occupied according to the extended spectrum map. In return for the provision of the spectrum map, a spectrum map server obtains the spectrum sensing results of associated WSAs to update the extended spectrum map about the channel occupancy status. Theoretical analysis indicates that the proposed framework can contribute to shortening the total spectrum sensing time of WSAs by up to 50%.
Cross-Layer Dynamic Spectrum Map Management Framework for White Space Applications
Seungil Yoon,Kyutae Lim,Jongman Kim
EURASIP Journal on Wireless Communications and Networking , 2010, DOI: 10.1155/2010/870976
Abstract:
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