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Search Results: 1 - 10 of 27906 matches for " Yong Pil Chong "
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Association of Mannose-Binding Lectin 2 Gene Polymorphisms with Persistent Staphylococcus aureus Bacteremia
Yong Pil Chong, Ki-Ho Park, Eun Sil Kim, Mi-Na Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jin-Yong Jeong, Jun Hee Woo, Yang Soo Kim
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089139
Abstract: Objectives Mannose-binding lectin (MBL) is an important component of innate immunity. Structural and promoter polymorphisms in the MBL2 gene that are responsible for low MBL levels are associated with susceptibility to infectious diseases. The objective of this study was to investigate the association of serum MBL levels and MBL2 polymorphisms with persistent Staphylococcus aureus bacteremia (SAB) in adult Korean patients. Methods We conducted a case-control study nested in a prospective cohort of patients with SAB. The study compared 41 patients with persistent bacteremia (≥7 days) and 46 patients with resolving bacteremia (<3 days). In each subject, we genotyped six single-nucleotide polymorphisms in the promoter region (alleles H/L, X/Y, and P/Q) and exon 1 (alleles A/B, A/C, and A/D) of the MBL2 gene and measured serum MBL concentrations. We also compared MBL2 genotypes between SAB patients and healthy people. Results Patients with persistent bacteremia were significantly more likely to have low/deficient MBL-producing genotypes and resultant low serum MBL levels, than were patients with resolving bacteremia (P = 0.019 and P = 0.012, respectively). Independent risk factors for persistent bacteremia were metastatic infection (adjusted odds ratio [aOR], 34.7; 95% confidence interval [CI], 12.83–196.37; P = 0.003), methicillin resistance (aOR, 4.10; 95% CI, 3.19–29.57; P = 0.025), and low/deficient MBL-producing genotypes (aOR, 7.64; 95% CI, 4.12–63.39; P = 0.003). Such genotypes were significantly more common in patients with persistent bacteremia than in healthy people (OR, 2.09; 95% CI, 1.03–4.26; P = 0.040). Conclusions This is the first demonstration of an association of low MBL levels and MBL2 polymorphisms responsible for low or deficient MBL levels with persistent SAB. A combination of factors, including clinical and microbiological characteristics and host defense factors such as MBL levels, may together contribute to the development of persistent SAB.
Persistent Catheter-Related Staphylococcus aureus Bacteremia after Catheter Removal and Initiation of Antimicrobial Therapy
Ki-Ho Park, Yu-Mi Lee, Hyo-Lim Hong, Tark Kim, Hyun Jung Park, So-Youn Park, Song Mi Moon, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jin-Yong Jeong, Mi-Na Kim, Jun Hee Woo, Yang Soo Kim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046389
Abstract: Objectives Catheter-related Staphylococcus aureus bacteremia (CRSAB) occasionally persists despite catheter removal and initiation of appropriate antimicrobial therapy. The aim of this study was to determine the incidence, risk factors, and outcomes of persistent CRSAB after catheter removal and initiation of antimicrobial therapy. Methods Consecutive patients with CRSAB were prospectively included from over a 41-month period. We compared the clinical features, 40 bacterial virulence genes, and outcomes between patients with persistent CRSAB (i.e., bacteremia for >3 days after catheter removal and initiation of appropriate antimicrobial therapy) and non-persistent CRSAB. Results Among the 220 episodes of CRSAB, the catheter was kept in place in 17 (6%) and removed in 203 (94%) cases. In 43 (21%) of the 203 episodes, bacteremia persisted for >3 days after catheter removal and initiation of antimicrobial therapy. Methicillin resistance (Odds ratio [OR], 9.01; 95% confidence interval [CI], 3.05–26.61; P<0.001), non-catheter prosthetic devices (OR, 5.37; 95% CI, 1.62–17.80; P = 0.006), and renal failure (OR, 3.23; 95% CI, 1.48–7.08; P = 0.003) were independently associated with persistent CRSAB. Patients with persistent CRSAB were more like to experience complication than were those with non-persistent CRSAB (72% vs. 15%; P<0.001). Among all episodes due to methicillin-resistant S. aureus, persistent CRSAB isolates were associated with accessory gene regulator (agr) group II (P = .04), but presence of other bacterial virulence genes, distribution of vancomycin minimum inhibitory concentration distribution, and frequency of vancomycin heteroresistance did not differ between the groups. Conclusions In patients with CRSAB, bacteremia persisted in 21% of cases despite catheter removal and initiation of antimicrobial therapy. Methicillin resistance, renal failure, and non-catheter prosthetic devices were independent risk factors for persistent CRSAB, which was associated with a higher rate of complications.
Immunolocalization of Ephexin-1 in the Developing Canine Cerebellum  [PDF]
Hyun Sik Park, In Youb Chang, Han Yong Kim, Sang Pil Yoon
Neuroscience & Medicine (NM) , 2014, DOI: 10.4236/nm.2014.51002
Abstract:

Ephexin-1 functions as guanine nucleotide exchange factors for the Rho-type GTPases which have important roles in neuronal development including axon guidance, migration, morphogenesis, and plasticity of neurons. As little is known about ephexin-1 in the cerebellum, we investigated the immunolocalization of ephexin-1 in the developing canine cerebellum. While the cellular maturation was followed by the temporal pattern, the calbindin D-28k and ephexin-1 immunoreactivities gradually increased in developing canine cerebellum. When compared to the calbindin D-28k immunoreactivities, belated ephexin-1 immunolocalization was observed in the Purkinje cells which aligned a single layer during cerebellar development. These results suggest that ephexin-1 might play an important role in the development of the Purkinje cells during the first two postnatal weeks based on its immunolocalization in the present study.

The Minimal Free Resolution of A Star-Configuration in $\mathbb{P}^n$
Jung Pil Park,Yong-Su Shin
Mathematics , 2014,
Abstract: We find the minimal free resolution of the ideal of a star-configuration in $\mathbb{P}^n$ of type $(r,s)$ defined by general forms in $R=\Bbbk[x_0,x_1,\dots,x_n]$. This generalises the results of \cite{AS:1,GHM} from a specific value of $r=2$ to any value of $1\le r\le n$. Moreover, we show that any star-configuration in $\mathbb{P}^n$ is arithmetically Cohen-Macaulay. As an application, we construct a few of graded Artinian rings, which have the weak Lefschetz property, using the sum of two ideals of star-configurations in $\mathbb{P}^n$.
A Study on Release Property through Self Coating in LSR Injection Process  [PDF]
Sang-Gweon Kim, Hyung-Pil Park, Jeong-Won Lee, Yong-Jun Jeon, Baeg-Soon Cha
Advances in Materials Physics and Chemistry (AMPC) , 2015, DOI: 10.4236/ampc.2015.57024
Abstract: This study explores the molding processes by using the Multi-component-injection molding (MCM) method, in which monolithic products are molded by attaching mixed liquid-silicone-rubbers (LSRs) to polybutylene terephthalate (PBT) that has the characteristic of self-binding while burning due to Pt catalysts. It is seen that this method increases the binding force between LSR and PBT. The surfaces coated with Polytetrafluoroethylene (PTFE), Cr, Ni, etc. have excellent peeling with plastic and such surfaces are compared with those treated with hot forging die and micro blasting without coating. When peeling tests are performed at the specified polymerization temperature and molding time after LSR molding on these surfaces of hot working die molds without coating, these surfaces show excellent peeling of molds and LSR products. In particular, they show better peeling after micro blasting than surfaces with Cr and Ni coating as well as surfaces without coating, and the peeling strength also decreases. The results of contact angle and XPS analysis indicate that the LSR binding force is enhanced as an effect of catalysts, though it is not found by SEM. According to the XPS analysis, the structures of the surfaces are close to methyl and vinyl materials that are produced while LSR molding.
Modeling Representation of Videos for Anomaly Detection using Deep Learning: A Review
Yong Shean Chong,Yong Haur Tay
Computer Science , 2015,
Abstract: This review article surveys the current progresses made toward video-based anomaly detection. We address the most fundamental aspect for video anomaly detection, that is, video feature representation. Much research works have been done in finding the right representation to perform anomaly detection in video streams accurately with an acceptable false alarm rate. However, this is very challenging due to large variations in environment and human movement, and high space-time complexity due to huge dimensionality of video data. The weakly supervised nature of deep learning algorithms can help in learning representations from the video data itself instead of manually designing the right feature for specific scenes. In this paper, we would like to review the existing methods of modeling video representations using deep learning techniques for the task of anomaly detection and action recognition.
An Overview of Multigigabit Wireless through Millimeter Wave Technology: Potentials and Technical Challenges
Yong SuKhiong,Chong Chia-Chin
EURASIP Journal on Wireless Communications and Networking , 2007,
Abstract: This paper presents an overview of 60 GHz technology and its potentials to provide next generation multigigabit wireless communications systems. We begin by reviewing the state-of-art of the 60 GHz radio. Then, the current status of worldwide regulatory efforts and standardization activities for 60 GHz band is summarized. As a result of the worldwide unlicensed 60 GHz band allocation, a number of key applications can be identified using millimeter-wave technology. Despite of its huge potentials to achieve multigigabit wireless communications, 60 GHz radio presents a series of technical challenges that needs to be resolved before its full deployment. Specifically, we will focus on the link budget analysis from the 60 GHz radio propagation standpoint and highlight the roles of antennas in establishing a reliable 60 GHz radio.
An Overview of Multigigabit Wireless through Millimeter Wave Technology: Potentials and Technical Challenges
Su Khiong Yong,Chia-Chin Chong
EURASIP Journal on Wireless Communications and Networking , 2006, DOI: 10.1155/2007/78907
Abstract: This paper presents an overview of 60 GHz technology and its potentials to provide next generation multigigabit wireless communications systems. We begin by reviewing the state-of-art of the 60 GHz radio. Then, the current status of worldwide regulatory efforts and standardization activities for 60 GHz band is summarized. As a result of the worldwide unlicensed 60 GHz band allocation, a number of key applications can be identified using millimeter-wave technology. Despite of its huge potentials to achieve multigigabit wireless communications, 60 GHz radio presents a series of technical challenges that needs to be resolved before its full deployment. Specifically, we will focus on the link budget analysis from the 60 GHz radio propagation standpoint and highlight the roles of antennas in establishing a reliable 60 GHz radio.
Oral Provocation Test in Non-Steroidal Anti-Inflammatory Drug Hypersensitive Patients Referred to Singapore General Hospital  [PDF]
Chaw Su Naing, Yong Yeow Chong
Open Access Library Journal (OALib Journal) , 2017, DOI: 10.4236/oalib.1103435
Abstract:
Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed classes of drugs and are easily accessible as over-the-counter anti-inflammatory drugs in Singapore. NSAIDs hypersensitivity is the second most common referral to allergy clinic in a tertiary referral centre. Methods: Referred patients with history of NSAID intolerance were underwent open challenge with 1) putative NSAID to confirm the diagnosis; 2) Aspirin to determine the cross-reactivity or 3) selective cyclooxygenase-2 (COX-2) inhibitor to identify the suitable alternative. Data were analysed retrospectively. Results: Over a 4-year period (2010-2014), a total of 127 patients (mean age SD 40.7 /- 15.2) underwent a total of 155 open-labelled labelled NSAIDs oral provocation tests (OPT). Overall positive challenge rate is 26.5% (41 out of 155). Despite having a clinical relevant history of causative, only 29.4% (20 out of 68) had positive OPT to putative NSAIDs. Using selective COX-2 inhibitor challenge for assessing the tolerability of suitable alternative, we found only 8.8% (5 out of 57) positive challenge. Conclusions: In our 4-year patients cohort with history of NSAIDs of intolerance, positive OPT rate of 26.5% in confirming diagnosis of NSAIDs hypersensitivity. The intolerance to selective COX-2 inhibitor was found in 8.8% of patients with non-steroidal anti-inflammatory drugs hypersensitivity patients.
Major Achievements and Prospect of the ATLAS Integral Effect Tests
Ki-Yong Choi,Yeon-Sik Kim,Chul-Hwa Song,Won-Pil Baek
Science and Technology of Nuclear Installations , 2012, DOI: 10.1155/2012/375070
Abstract: A large-scale thermal-hydraulic integral effect test facility, ATLAS (Advanced Thermal-hydraulic Test Loop for Accident Simulation), has been operated by KAERI. The reference plant of ATLAS is the APR1400 (Advanced Power Reactor, 1400?MWe). Since 2007, an extensive series of experimental works were successfully carried out, including large break loss of coolant accident tests, small break loss of coolant accident tests at various break locations, steam generator tube rupture tests, feed line break tests, and steam line break tests. These tests contributed toward an understanding of the unique thermal-hydraulic behavior, resolving the safety-related concerns and providing validation data for evaluation of the safety analysis codes and methodology for the advanced pressurized water reactor, APR1400. Major discoveries and lessons found in the past integral effect tests are summarized in this paper. As the demand for integral effect tests is on the rise due to the active national nuclear R&D program in Korea, the future prospects of the application of the ATLAS facility are also discussed. 1. Introduction ATLAS (Advanced Thermal-Hydraulic Test Loop for Accident Simulation) is a large-scale integral effect test facility with a reference plant of APR1400 (Advanced Power Reactor, 1400?MWe), which is under construction in Korea [1]. It was designed to have the capability of simulating various transients and accident conditions at full pressure and temperature conditions, including loss of coolant accident (LOCA) series as well as non-LOCA series. The ATLAS program started in 1997 under a nuclear R&D program funded by the Korean government. The complete installation of ATLAS was finished in 2005. In 2006, extensive commissioning operations were carried out, including startup tests and preliminary tests [2]. In 2007, ATLAS was used for a wide range of integral effect tests on the reflood phase of a large break LOCA to resolve the safety issues of the APR1400 raised by a regulatory body [3]. Afterwards, at the beginning of 2008, ATLAS was modified to have a configuration for simulating the direct vessel injection (DVI) line break accidents of the APR1400. One of the unique design features of ATLAS is its ability to simulate the DVI of the emergency core cooling water. Sensitivity tests for different DVI line break sizes were performed and an integral effect database was established for various break sizes of 5%, 25%, 50%, and 100% [4]. After a series of DVI line break tests were completed, small break LOCA (SBLOCA) tests commenced at the end of 2008. In order to
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