Abstract:
Aminoacyl-tRNA synthetases (ARSs) and ARS-interacting multifunctional proteins (AIMPs) exhibit remarkable functional versatility beyond their catalytic activities in protein synthesis. Their non-canonical functions have been pathologically linked to cancers. Here we described our integrative genome-wide analysis of ARSs to show cancer-associated activities in glioblastoma multiforme (GBM), the most aggressive malignant primary brain tumor. We first selected 23 ARS/AIMPs (together referred to as ARSN), 124 cancer-associated druggable target genes (DTGs) and 404 protein-protein interactors (PPIs) of ARSs using NCI’s cancer gene index. 254 GBM affymetrix microarray data in The Cancer Genome Atlas (TCGA) were used to identify the probe sets whose expression were most strongly correlated with survival (Kaplan-Meier plots versus survival times, log-rank t-test <0.05). The analysis identified 122 probe sets as survival signatures, including 5 of ARSN (VARS, QARS, CARS, NARS, FARS), and 115 of DTGs and PPIs (PARD3, RXRB, ATP5C1, HSP90AA1, CD44, THRA, TRAF2, KRT10, MED12, etc). Of note, 61 survival-related probes were differentially expressed in three different prognosis subgroups in GBM patients and showed correlation with established prognosis markers such as age and phenotypic molecular signatures. CARS and FARS also showed significantly higher association with different molecular networks in GBM patients. Taken together, our findings demonstrate evidence for an ARSN biology-dominant contribution in the biology of GBM.

Abstract:
Hardening and overaging mechanisms were examined in a semi-precious Au Ag Cu Pd dental alloy with small amounts of In, Zn and Ir. The alloy showed maximum age-hardenability at the aging temperature of 400°C. The hardness value increased to reach the maximum value, and then decreased continuously with aging time. In the early stage of aging process, the matrix of the single α0 phase separated into the α1 and AuCu I phases, and the fine InPd-based precipitates containing Zn and Cu formed at the grain boundaries. During further aging, the grain boundary precipitates grew toward the grain interior. In overaged specimens, the original matrix was replaced by the coarse lamellar structure composed of the AuCu I phase containing Pd and Zn and the Ag Au-based α1 phase of Cu-, Pdand Zn-depleted. The hardness increase in the early stage of aging process was caused by the nucleation of the InPd-based phase and the AuCu I phase in the ga0 matrix; this introduced significant lattice strains into the interface with the matrix. The hardness decrease in the latter stage of aging process was caused by the formation and coarsening of the lamellar structure composed of the α1 phase and the AuCu I phase. The minor constituent, In formed InPd-based grain boundary precipitates prior to the lamellar structure formation of α1 and AuCu I.

Abstract:
The matrix metalloproteinase (MMP) family is involved in the breakdown of extracellular matrix in normal physiological processes, as well as in the disease processes such as arthritis and cancer metastasis. In the present study, dieckol was obtained with high yield from marine brown alga Ecklonia cava (EC), and its effect was assessed on the expression of MMP-2 and -9 and morphological changes in human fibrosarcoma cell line (HT1080). Dieckol inhibited the expression of MMP-2 and -9 in a dose-dependent manner and also suppressed the cell invasion and the cytomorphology in 3D culture system on HT1080 cells. Moreover, dieckol may influence nuclear factor kappa B (NF-κB) pathway without obvious influence on activator protein-1 (AP-1) pathway and tissue inhibitor of metalloproteinases (TIMPs). In conclusion, dieckol could significantly suppress MMP-2 and -9 expression and alter cytomorphology of HT1080 cell line via NF-κB pathway. 1. Introduction The past few decades of cancer research has revealed that matrix metalloproteinases (MMPs) play a significant role in a variety of pathologic conditions. Especially in malignant tumors, the activities of MMPs are deregulated and their expressions are often associated with poor prognosis. Among all the MMPs, MMP-2 and -9 have demonstrated to play a major role in the establishment of metastasis, which substantially increases in majority of malignant tumors. Therefore, inhibition of MMP-2 and -9 is thought to have a therapeutic benefit for cancer [1–8]. Recently, significant achievements have been made in synthetic bioactive applications. However, natural compounds and their derivatives are still known as the richest source of bioactive compounds with huge pharmaceutical application potential [9]. Dieckol (Figure 1) is a phloroglucinal derivative isolated from marine brown alga Ecklonia cava (EC) with a variety of biological functions in vitro and in vivo, for example, antioxidant, antitumor, antihuman immunodeficiency virus (-HIV), and anti-inflammatory activities. For instance, dieckol is a novel safe phloroglucinal derivative which inhibited the cytopathic effects of HIV-1 including HIV-1-induced syncytia formation, lytic effects, and viral p24 antigen production, as well as exhibited reverse transcriptase enzymes inhibitory and HIV-1 entry activity in addition to its other biological properties [10, 11]. Figure 1: Chemical structure of dieckol. In the present study, effect of dieckol on the expression of MMP-2 and -9, cytotoxicity, and cellular invasiveness was evaluated in HT1080 cells. The selectivity of this

Abstract:
The integrated Mission Planning System？(MPS) of Unmanned Surface Vehicle？(USV) refers to the process which can recognize, decide, plan situations and carry out missions, such as human beings, for all incidental or complex events occurring at sea. In the actual operating environment, it is necessary to develop a simulation software environment and analyze, verify it in advance so as to make an appropriate mission plan considering equipment, sensor, fuel, and other available resources. The existing USV mission planning process methodology has several limitations in the analysis of USV missions because the scenario to be tested is limited and autonomy of USV is not considered sufficiently. To overcome these problems, we constructed a process that considers various missions and is more autonomous, and an integrated environment in which to experiment. In this study, we designed a multi-agent based USV Integrated Mission Planning System and modeled each component. In addition, we constructed the USV remote operation S/W based on M&S that user can experiment with the modeled process and verified the usefulness of the developed system through simulations.

Abstract:
A new combinatorial interpretation of the Howe dual pair $(\hat{\frak{gl}}_{\infty|\infty},\frak{gl}_n)$ acting on an infinite dimensional Fock space $\frak{F}^n$ of level $n$ is presented. The character of a quasi-finite irreducible highest weight representation of $\hat{\frak{gl}}_{\infty|\infty}$ occurring in $\frak{F}^n$ is realized in terms of certain bitableaux of skew shapes. We study a general combinatorics of these bitableaux, including Robinson-Schensted-Knuth correspondence and Littlewood-Richardson rule, and then its dual relation with the rational semistandard tableaux for $\frak{gl}_n$. This result also explains other Howe dual pairs including $\frak{gl}_n$.

Abstract:
We give a new representation theoretic interpretation of the ring of quasi-symmetric functions. This is obtained by showing that the super analogue of the Gessel's fundamental quasi-symmetric function can be realized as the character of an irreducible crystal for the Lie superalgebra $\frak{gl}_{n|n}$ associated to its non-standard Borel subalgebra with a maximal number of odd isotropic simple roots. We also present an algebraic characterization of these super quasi-symmetric functions.

Abstract:
We give a new bijective interpretation of the Cauchy identity for Schur operators which is a commutation relation between two formal power series with operator coefficients. We introduce a plactic algebra associated with the Kashiwara's extremal weight crystals over the Kac-Moody algebra of type $A_{+\infty}$, and construct a Knuth type correspondence preserving the plactic relations. This bijection yields the Cauchy identity for Schur operators as a homomorphic image of its associated identity for plactic characters of extremal weight crystals, and also recovers the Sagan and Stanley's correspondence for skew tableaux as its restriction.

Abstract:
We give a new combinatorial model of the Kirillov-Reshetikhin crystals of type $A_n^{(1)}$ in terms of non-negative integral matrices based on the classical RSK algorithm, which has a simple description of the affine crystal structure without using a promotion operator. We also have a similar description of the Kirillov-Reshetikhin crystals associated to exceptional nodes in the Dynkin diagrams of classical affine or non-exceptional type.

Abstract:
We introduce a semisimple tensor category $\mc{O}^{int}_q(m|n)$ of modules over an quantum ortho-symplectic superalgebra. It is a natural counterpart of the category of finitely dominated integrable modules over the quantum classical (super) algebra of type $B_{m+n}$, $C_{m+n}$, $D_{m+n}$ or $B(0,m+n)$ from a viewpoint of super duality. We classify the irreducible modules in $\mc{O}^{int}_q(m|n)$ and show that an irreducible module in $\mc{O}^{int}_q(m|n)$ has a unique crystal base in case of type $B$ and $C$. An explicit description of the crystal graph is given in terms of a new combinatorial object called ortho-symplectic tableaux.

Abstract:
We give a realization of the level zero fundamental weight representation $W(\varpi_k)$ of the quantum affine algebra $U_q'(\mf{g})$, when $\mf{g}$ has a maximal parabolic subalgebra of type $C_n$. We define a semisimple $U'_q({\mf g})$-module structure on $\E^{\otimes 2}$ in terms of q-deformed Clifford generators, where $\E$ is the exterior algebra generated by a dual natural representation $V$ of $U_q(\mf{sl}_{n})$. We show that each $W(\varpi_k)$ appears as an irreducible summand (not necessarily multiplicity free) in $\E^{\otimes 2}$. As a byproduct, we obtain a simple description of the affine crystal structure of $W(\varpi_k)$ in terms of $n\times 2$ binary matrices and their $(\mf{sl}_n,\mf{sl}_2)$-bicrystal structure.