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Search Results: 1 - 10 of 26182 matches for " Yong Chul Bae "
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First Contact to Odors: Our Current Knowledge about Odorant Receptor
Hyoung-Gon Song,Jae Young Kwon,Hyung Soo Han,Yong-Chul Bae,Cheil Moon
Sensors , 2008, DOI: 10.3390/s8106303
Abstract: Chemical senses – especially smell – are known to be important for the fundamental life events such as sensing predators, selecting mates, as well as finding food. The chemical senses are decoded in the olfactory system which is able to detect and differentiate thousands of odorous substances comprised of chemically divergent structures (i.e. odorants). The high selectivity of the olfactory system is heavily dependent on the receptors for each odorants (i.e. odorant receptors). Thus, studying odorant receptors may not only facilitate our understanding the initial events of olfaction but provide crucial knowledge for developing a novel, odorant receptor-based biosensor for chemical screening. Here we provide a review of recent advances in our understanding of odorant receptors.
Central Connectivity of Transient Receptor Potential Melastatin 8-Expressing Axons in the Brain Stem and Spinal Dorsal Horn
Yun Sook Kim, Jun Hong Park, Su Jung Choi, Jin Young Bae, Dong Kuk Ahn, David D. McKemy, Yong Chul Bae
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094080
Abstract: Transient receptor potential melastatin 8 (TRPM8) ion channels mediate the detection of noxious and innocuous cold and are expressed by primary sensory neurons, but little is known about the processing of the TRPM8-mediated cold information within the trigeminal sensory nuclei (TSN) and the spinal dorsal horn (DH). To address this issue, we characterized TRPM8-positive (+) neurons in the trigeminal ganglion and investigated the distribution of TRPM8+ axons and terminals, and their synaptic organization in the TSN and in the DH using light and electron microscopic immunohistochemistry in transgenic mice expressing a genetically encoded axonal tracer in TRPM8+ neurons. TRPM8 was expressed in a fraction of small myelinated primary afferent fibers (23.7%) and unmyelinated fibers (76.3%), suggesting that TRPM8-mediated cold is conveyed via C and Aδ afferents. TRPM8+ axons were observed in all TSN, but at different densities in the dorsal and ventral areas of the rostral TSN, which dominantly receive sensory afferents from intra- and peri-oral structures and from the face, respectively. While synaptic boutons arising from Aδ and non-peptidergic C afferents usually receive many axoaxonic contacts and form complex synaptic arrangements, TRPM8+ boutons arising from afferents of the same classes of fibers showed a unique synaptic connectivity; simple synapses with one or two dendrites and sparse axoaxonic contacts. These findings suggest that TRPM8-mediated cold is conveyed via a specific subset of C and Aδ afferent neurons and is processed in a unique manner and differently in the TSN and DH.
dTULP, the Drosophila melanogaster Homolog of Tubby, Regulates Transient Receptor Potential Channel Localization in Cilia
Jina Park equal contributor,Jeongmi Lee equal contributor,Jaewon Shim,Woongsu Han,Jinu Lee,Yong Chul Bae,Yun Doo Chung,Chul Hoon Kim ,Seok Jun Moon
PLOS Genetics , 2013, DOI: 10.1371/journal.pgen.1003814
Abstract: Mechanically gated ion channels convert sound into an electrical signal for the sense of hearing. In Drosophila melanogaster, several transient receptor potential (TRP) channels have been implicated to be involved in this process. TRPN (NompC) and TRPV (Inactive) channels are localized in the distal and proximal ciliary zones of auditory receptor neurons, respectively. This segregated ciliary localization suggests distinct roles in auditory transduction. However, the regulation of this localization is not fully understood. Here we show that the Drosophila Tubby homolog, King tubby (hereafter called dTULP) regulates ciliary localization of TRPs. dTULP-deficient flies show uncoordinated movement and complete loss of sound-evoked action potentials. Inactive and NompC are mislocalized in the cilia of auditory receptor neurons in the dTulp mutants, indicating that dTULP is required for proper cilia membrane protein localization. This is the first demonstration that dTULP regulates TRP channel localization in cilia, and suggests that dTULP is a protein that regulates ciliary neurosensory functions.
Staphylococcus aureus Produces Membrane-Derived Vesicles That Induce Host Cell Death
Mamata Gurung, Dong Chan Moon, Chi Won Choi, Jung Hwa Lee, Yong Chul Bae, Jungmin Kim, Yoo Chul Lee, Sung Yong Seol, Dong Taek Cho, Seung Il Kim, Je Chul Lee
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027958
Abstract: Gram-negative bacteria produce outer membrane vesicles that play a role in the delivery of virulence factors to host cells. However, little is known about the membrane-derived vesicles (MVs) produced by Gram-positive bacteria. The present study examined the production of MVs from Staphylococcus aureus and investigated the delivery of MVs to host cells and subsequent cytotoxicity. Four S. aureus strains tested, two type strains and two clinical isolates, produced spherical nanovesicles during in vitro culture. MVs were also produced during in vivo infection of a clinical S. aureus isolate in a mouse pneumonia model. Proteomic analysis showed that 143 different proteins were identified in the S. aureus-derived MVs. S. aureus MVs were interacted with the plasma membrane of host cells via a cholesterol-rich membrane microdomain and then delivered their component protein A to host cells within 30 min. Intact S. aureus MVs induced apoptosis of HEp-2 cells in a dose-dependent manner, whereas lysed MVs neither delivered their component into the cytosol of host cells nor induced cytotoxicity. In conclusion, this study is the first report that S. aureus MVs are an important vehicle for delivery of bacterial effector molecules to host cells.
Avian WNT4 in the Female Reproductive Tracts: Potential Role of Oviduct Development and Ovarian Carcinogenesis
Chul-Hong Lim, Whasun Lim, Wooyoung Jeong, Jin-Young Lee, Seung-Min Bae, Jinyoung Kim, Jae Yong Han, Fuller W. Bazer, Gwonhwa Song
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065935
Abstract: The wingless-type MMTV integration site family of proteins (WNTs) is highly conserved secreted lipid-modified signaling molecules that play a variety of pivotal roles in developmental events such as embryogenesis, tissue homeostasis and cell polarity. Although, of these proteins, WNT4 is known to be involved in genital development in fetuses of mammalian species, its role is unknown in avian species. Therefore, in this study, we investigated expression profiles, as well as hormonal and post-transcriptional regulation of WNT4 expression in the reproductive tract of female chickens. Results of this study demonstrated that WNT4 is most abundant in the stromal and luminal epithelial cells of the isthmus and shell gland of the oviduct, respectively. WNT4 is also most abundant in the glandular epithelium of the shell gland of the oviduct of laying hens at 3 h post-ovulation during the laying cycle. In addition, treatment of young chicks with diethylstilbestrol (DES, a synthetic estrogen agonist) stimulated WNT4 only in the glandular epithelial cells of the isthmus and shell gland of the oviduct. Moreover, results of our study demonstrated that miR-1786 influences WNT4 expression via specific binding sites in its 3′-UTR. On the other hand, our results also indicate that WNT4 is expressed predominantly in the glandular epithelium of cancerous ovaries, but not in normal ovaries of hens. Collectively, these results indicate cell-specific expression of WNT4 in the reproductive tract of chickens and that it likely has crucial roles in development and function of oviduct as well as initiation of ovarian carcinogenesis in laying hens.
-Subalgebras in BCK/BCI-Algebras Based on Point -Structures
Young Bae Jun,Min Su Kang,Chul Hwan Park
International Journal of Mathematics and Mathematical Sciences , 2010, DOI: 10.1155/2010/303412
Abstract: The notion of -subalgebras of several types is introduced, and related properties are investigated. Conditions for an -structure to be an -subalgebra of type are provided, and a characterization of an -subalgebra of type is considered. 1. Introduction A (crisp) set in a universe can be defined in the form of its characteristic function yielding the value for elements belonging to the set and the value for elements excluded from the set So far, most of the generalization of the crisp set have been conducted on the unit interval and they are consistent with the asymmetry observation. In other words, the generalization of the crisp set to fuzzy sets relied on spreading positive information that fit the crisp point into the interval Because no negative meaning of information is suggested, we now feel a need to deal with negative information. To do so, we also feel a need to supply mathematical tool. To attain such object, Jun et al. [1] introduced a new function which is called negative-valued function, and constructed -structures. They applied -structures to BCK/BCI-algebras, and discussed -subalgebras and -ideals in BCK/BCI-algebras. Jun et al. [2] considered closed ideals in BCH-algebras based on -structures. To obtain more general form of an -subalgebra in BCK/BCI-algebras, we define the notions of -subalgebras of types , and and investigate related properties. We provide a characterization of an -subalgebra of type We give conditions for an -structure to be an -subalgebra of type 2. Preliminaries Let be the class of all algebras with type . By a BCI-algebra we mean a system in which the following axioms hold: (i) (ii) (iii) (iv) for all If a BCI-algebra satisfies for all then we say that is a BCK-algebra. We can define a partial ordering by In a BCK/BCI-algebra , the following hold: for all A nonempty subset of a BCK/BCI-algebra is called a subalgebra of if for all For our convenience, the empty set is regarded as a subalgebra of We refer the reader to the books [3, 4] for further information regarding BCK/BCI-algebras. For any family of real numbers, we define Denote by the collection of functions from a set to We say that an element of is a negative-valued function from to (briefly, -function on ). By an -structure we mean an ordered pair of and an -function on In what follows, let denote a BCK/BCI-algebra and an -function on unless otherwise specified. Definition 2.1 (see [1]). By a subalgebra of based on -function (briefly, -subalgebra of ), we mean an -structure in which satisfies the following assertion: For any -structure and the set is called a
Implicative Ideals of BCK-Algebras Based on the Fuzzy Sets and the Theory of Falling Shadows
Young Bae Jun,Min Su Kang,Chul Hwan Park
International Journal of Mathematics and Mathematical Sciences , 2010, DOI: 10.1155/2010/819463
Abstract: Based on the theory of falling shadows and fuzzy sets, the notion of a falling fuzzy implicative ideal of a BCK-algebra is introduced. Relations among falling fuzzy ideals, falling fuzzy implicative ideals, falling fuzzy positive implicative ideals, and falling fuzzy commutative ideals are given. Relations between fuzzy implicative ideals and falling fuzzy implicative ideals are provided. 1. Introduction and Preliminaries 1.1. Introduction In the study of a unified treatment of uncertainty modelled by means of combining probability and fuzzy set theory, Goodman [1] pointed out the equivalence of a fuzzy set and a class of random sets. Wang and Sanchez [2] introduced the theory of falling shadows which directly relates probability concepts with the membership function of fuzzy sets. Falling shadow representation theory shows us the way of selection relaid on the joint degrees distributions. It is reasonable and convenient approach for the theoretical development and the practical applications of fuzzy sets and fuzzy logics. The mathematical structure of the theory of falling shadows is formulated in [3]. Tan et al. [4, 5] established a theoretical approach to define a fuzzy inference relation and fuzzy set operations based on the theory of falling shadows. Jun and Park [6] discussed the notion of a falling fuzzy subalgebra/ideal of a BCK/BCI-algebra. Jun and Kang [7, 8] also considered falling fuzzy positive implicative ideals and falling fuzzy commutative ideals. In this paper, we establish a theoretical approach to define a fuzzy implicative ideal in a BCK-algebra based on the theory of falling shadows. We consider relations between fuzzy implicative ideals and falling fuzzy implicative ideals. We provide relations among falling fuzzy ideals, falling fuzzy implicative ideals, falling fuzzy positive implicative ideals, and falling fuzzy commutative ideals. 1.2. Basic Results on BCK-Algebras and Fuzzy Aspects A BCK/BCI-algebra is an important class of logical algebras introduced by Iséki and was extensively investigated by several researchers. An algebra of type is called a BCI-algebra if it satisfies the following conditions: (i) , (ii) , (iii) , (iv) . If a BCI-algebra satisfies the following identity: (v) , then is called a -algebra. Any BCK-algebra satisfies the following axioms: (a1) , (a2) , (a3) , where if and only if .A subset of a BCK-algebra is called an ideal of if it satisfies the following: (b1) , (b2) . Every ideal of a BCK-algebra has the following assertion: A subset of a BCK-algebra is called a positive implicative ideal of if it
Coderivations of Ranked Bigroupoids
Young Bae Jun,Kyoung Ja Lee,Chul Hwan Park
Journal of Applied Mathematics , 2012, DOI: 10.1155/2012/626781
Abstract: The notion of (co)derivations of ranked bigroupoids is discussed by Alshehri et al. (in press), and their generalized version is studied by Jun et al. (under review press). In particular, Jun et al. (under review press) studied coderivations of ranked bigroupoids. In this paper, the generalization of coderivations of ranked bigroupoids is discussed. The notion of generalized coderivations in ranked bigroupoids is introduced, and new generalized coderivations of ranked bigroupoids are obtained by combining a generalized self-coderivation with a rankomorphism. From the notion of (,?,&)-derivation, the existence of a rankomorphism of ranked bigroupoids is established.
Meniscoplasty for stable osteochondritis dissecans of the lateral femoral condyle combined with a discoid lateral meniscus: a case report
Hong-Chul Lim, Ji-Hoon Bae
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-434
Abstract: We present the case of a seven-year-old Korean girl who had osteochondritis dissecans of the lateral femoral condyle combined with a discoid lateral meniscus, which healed after meniscoplasty for the symptomatic lateral discoid meniscus without surgical intervention for the osteochondritis dissecans. In addition, healing of the osteochondritis dissecans lesion was confirmed by an MRI scan five months after the operation.Meniscoplasty can be recommended for symptomatic stable juvenile osteochondritis dissecans of the lateral femoral condyle combined with a discoid lateral meniscus when conservative treatment fails.Osteochondritis dissecans (OCD) is a condition of the joints that appears to primarily affect subchondral bone, with secondary effects on articular cartilage. Initially, softening of the overlying articular cartilage is noted with an intact articular surface; this can progress to early articular cartilage separation, partial detachment of an articular lesion, and eventually osteochondral separation with a loose body. Etiologic theories of traumatic, ischemic, accessory ossification center persistence and various genetic factors have been proposed [1-5].Several investigators have shown subsequently that there is an increased occurrence of OCD lesions of the lateral femoral condyle associated with a discoid lateral meniscus [6-9]. A discoid lateral meniscus might play an important role in causing OCD of the lateral femoral condyle among patients who are still growing. Repetitive abnormal stress on weaker osteochondral structures produced by a discoid meniscus during growth may cause OCD of the lateral femoral condyle. Given the potential for healing, conservative management is indicated for stable OCD in patients who are skeletally immature. However, patients with OCD of the lateral femoral condyle combined with a discoid lateral meniscus often have persistent symptoms despite conservative management [8,10].We present a case of OCD of lateral femoral condyle
Estimation of micro-biota in the Upo wetland using eukaryotic barcode molecular markers
Hyun Chul Park,Chang Hwan Bae,Jumin Jun,Myounghai Kwak
Journal of Ecology and Field Biology , 2011,
Abstract: Biodiversity and the community composition of micro-eukaryotic organisms were investigated in the Upo wetland inKorea using molecular analysis. Molecular identification was performed using cytochrome oxidase I (COI) and smallsubunit ribosomal DNA (SSU rDNA). The genomic DNA was isolated directly from soil samples. The COI and SSU rDNAregions were amplified using universal primers and then sequenced after cloning. In a similarity search of the obtainedsequences with BLAST in the Genbank database, the closely related sequences from NCBI were used to identify theamplified sequences. A total of six eukaryotic groups (Annelida, Arthropoda, Rotifera, Chlorophyta, Bacillariophyta, andStramenopiles) with COI and six groups (Annelida, Arthropoda, Rotifera, Alveolata, Fungi, and Apicomplexa) with SSUrDNA genes were determined in the Upo wetland. Among 38 taxa in 20 genera, which are closely related to the amplifiedsequences, 10 genera (50%) were newly reported in Korea and five genera (25%) were shown to be distributed in theUpo wetland. This approach is applicable to the development of an efficient method for monitoring biodiversity withouttraditional taxonomic processes and is expected to produce more accurate results in depositing molecular barcode datain the near future.
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