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Beating drug tests and defending positive results: a toxicologist's perspective
Mauricio Yonamine
Brazilian Journal of Pharmaceutical Sciences , 2010, DOI: 10.1590/s1984-82502010000400033
Abstract:
Drug abuse among workers in Brazilian regions
Silva,Ovandir Alves; Yonamine,Mauricio;
Revista de Saúde Pública , 2004, DOI: 10.1590/S0034-89102004000400011
Abstract: objective: many business organizations in brazil have adopted drug testing programs in the workplace since 1992. rehabilitation, rather than layoff and disciplinary measures, has been offered as part of the brazilian employee assistance programs. the purpose study is to profile drug abuse among company workers of different brazilian geographical regions. methods: urine samples of 12,700 workers from five geographical regions were tested for the most common illicit drugs of abuse in the country: marijuana, cocaine, and amphetamine. enzyme multiplied immunoassay technique (emit) and gas chromatography coupled with mass spectrometry (gc/ms) were the techniques utilized for urine testing. the distribution of collected urine samples according to geographical regions was: 72.0% southeast, 13.8% northeast, 7.9% south, 5.7% central west and 0.6% north. results: of all samples analyzed, 1.8% was found to be positive for drugs: 0.5% from the south region, 1.1% from northeast, 1.2% from central west, 1.3% from north, and 2.2% from southeast. of these, 59.9% was marijuana, 17.7% cocaine, 14.6% amphetamine, and 7.7% associated drugs. conclusions: the distribution of drugs found in the samples shows a regional variation. marijuana, however, was found in all regions. cocaine was seen only in central west and southeast regions. amphetamine was found in northeast, central west, and southeast regions.
Características da comunica??o em indivíduos com a síndrome do X frágil
Yonamine, Sueli Mami;Silva, Ariovaldo Armando da;
Arquivos de Neuro-Psiquiatria , 2002, DOI: 10.1590/S0004-282X2002000600018
Abstract: the aim of this study was to make a characterization of the communication in a group with fragile x syndrome (fxs), based on normal development scale. the sample has 10 boys, between 6 and 13 years and with fxs. all of them were submitted to language evaluation. the most part of them had the communication in linguistic form (80%), until 3 years old. it was considered that the data confirmed the significant delay in the acquisition and development of the communication, being necessary an early and specialized intervention.
Características da comunica o em indivíduos com a síndrome do X frágil
Yonamine Sueli Mami,Silva Ariovaldo Armando da
Arquivos de Neuro-Psiquiatria , 2002,
Abstract: O objetivo deste estudo foi, a partir da avalia o de linguagem de um grupo de 10 meninos com idades variando entre 6 e 13 anos e com a síndrome do cromossomo X frágil (SXF), caracterizar o nível de comunica o desses indivíduos a partir de escalas de desenvolvimento normal. Constatou-se que dentro desta amostra, os indivíduos apresentaram predominantemente forma de comunica o linguística (80%), atingindo o nível máximo de até 3 anos de idade. Concluiu-se que os dados obtidos confirmam o significativo atraso na aquisi o e desenvolvimento da comunica o, necessitando, portanto, de interven o precoce e especializada.
Valida??o de método para determina??o de 3,4-metilenodioximetanfetamina (MDMA) em comprimidos de ecstasy por cromatografia em fase gasosa
Lapachinske, Silvio Fernandes;Yonamine, Mauricio;Moreau, Regina Lucia de Moraes;
Revista Brasileira de Ciências Farmacêuticas , 2004, DOI: 10.1590/S1516-93322004000100012
Abstract: ecstasy is illegally commercialized in the form of tablets with different aspects, colors, sizes, and logotypes. chemically, ecstasy is 3,4-methylenedioxymethamphetamine (mdma), a synthetic compound with stimulant and hallucinogenic proprieties. due to the great expansion of ecstasy abuse, the number of cases of intoxications by mdma, analogs and eventual adulterant compounds has also increased. some mdma analog substances, such as 3,4-methylenedioxyethylamphetamine (mdea), 3,4-methylenedioxyamphetamine (mda), methamphetamine and amphetamine have already been identified in ecstasy tablets. caffeine and ephedrines are the most common adulterants also found. the aim of this paper is to describe the validation of an analytical method to quantify mdma in ecstasy tablets and capsules. gas-chromatography with nitrogen/phosphorous detector was used in the method, which consisted in the direct dissolution of the sample in methanol, centrifugation and convenient dilution of the supernatant. analog substances to mdma and adulterants were also identified. the limits of detection and quantification (loq and lod) for mdma were 1.5 and 3.0 mg/100 mg of tablet. samples from 25 lots of tablets seized in the city of s?o paulo were analyzed showing a considerable variability in composition and quantity of mdma.
An Approach to Creating and Maintaining House-Watching Network in MANET
Jiahong Wang,Yuhiro Yonamine,Takashi Iokawa,Eiichiro Kodama
Lecture Notes in Engineering and Computer Science , 2012,
Abstract:
Ayahuasca: uma revis o dos aspectos farmacológicos e toxicológicos
Ana Paula Salum Pires,Carolina Dizioli Rodrigues Oliveira,Mauricio Yonamine
Revista de Ciências Farmacêuticas Básica e Aplicada , 2010,
Abstract: A ayahuasca é uma bebida psicoativa originariamente utilizada em rituais de tribos indígenas da regi o amaz nica. Esta bebida é preparada pela infus o de caules da Banisteriopsis caapi Morton, que contém β-carbolinas que s o inibidoras da monoaminoxidase (MAO), e de folhas da Psychotria viridis Ruiz & Pavón, que contém o alucinógeno N,N-dimetiltriptamina (DMT). A enzima MAO degrada a DMT no fígado e intestino. No Brasil, a ayahuasca tem sido incorporada em rituais de grupos sincréticos religiosos e seu uso dentro do contexto religioso é amparado por lei federal. Atualmente, esses grupos têm se espalhado na Europa e Estados Unidos, chamando a aten o de pesquisadores internacionais quanto aos efeitos da ayahuasca. Estudos têm indicado que a ayahuasca poderia ter aplica es terapêuticas como no tratamento da farmacodependência e até sugerem seu uso seguro por adultos sadios. Entretanto, poucos estudos têm sido conduzidos para melhor avalia o de suas propriedades. O objetivo do artigo é mostrar uma revis o geral da história até as recentes descobertas envolvendo a farmacologia e a toxicologia da ayahuasca. Palavras-chave: Ayahuasca. Alucinógenos. Dimetiltriptamina. Carbolinas. ABSTRACT Ayahuasca: a review of pharmacological and toxicological aspects Ayahuasca (or caapi in Brazil) is a psychoactive plant beverage initially used by shamans in religious rituals practiced by indigenous peoples in the Amazon region. It is prepared by infusing the pounded stems of Banisteriopsis caapi Morton, a liana which contains betacarbolines, alkaloids that are potent monoamine oxidase (MAO) inhibitors, together with the leaves of Psychotria viridis Ruiz & Pavón, which contains the psychedelic agent N,N-dimethyltryptamine (DMT). The enzyme MAO normally degrades DMT in the liver and gut. In Brazil, the use of ayahuasca within religious ceremonies is protected by law and it has been incorporated into rituals of syncretic religious groups. Some of these groups have established themselves in the United States and European countries, attracting international research interest in the effects of ayahuasca. Studies suggest that it may have therapeutic applications, such as in the treatment of drug addiction, and that it can be used safely by healthy adults. However, too few studies have been performed for a good assessment of its properties to be made. The aim of this article is to present a review of the history of ayahuasca, up to the recent discoveries concerning its pharmacology and toxicology. Keywords: Ayahuasca. Hallucinogens. Dimethyltryptamine. Carbolines.
Uso de esteróides andrógenos anabólicos por praticantes de atividade física das principais academias de Erechim e Passo Fundo/RS
F. Frizon,S. M.D. Macedo,M. Yonamine
Revista de Ciências Farmacêuticas Básica e Aplicada , 2009,
Abstract: Os esteróides andrógenos anabólicos (EAA) s o substancias quimicamente semelhantes à testosterona e que teriam a propriedade de aumentar a for a e a massa muscular. Apesar de estarem associados a uma série de efeitos nocivos, principalmente sobre os sistemas cardiovascular, hepático e neuro-endócrino, verifica-se que o abuso de EAA tem aumentado consideravelmente nos últimos anos. No presente trabalho, o perfil dos praticantes de atividade física das academias de Erechim e Passo Fundo/RS e a incidência de uso de EAA foram verificados. Responderam aos questionários 418 praticantes de atividade física, de um total de 700 questionários distribuídos. A percentagem de uso foi de 6,5%; todos usuários do sexo masculino, de uma popula o de 83% de homens. O EAA mais utilizado foi o decanoato de nandrolona (35,29%). Os EAA foram adquiridos em farmácias com receita médica (37,04%). O perfil dos praticantes pode ser assim delineado: idade entre 21 e 25 anos, homens, estudantes universitários (62,67%) e motivados por estética e ganho de for a. Este estudo ressalta a necessidade de a es preventivas e educativas junto à popula o jovem. Palavras-chave: Esteróides andrógenos anabólicos, atividade física, estética.
Development and validation of lean body mass prediction equations for male children aged. 12 - 14 years
Renato Shoei Yonamine,Candido Sim?es Pires-Neto
Revista Brasileira de Cineantropometria e Desempenho Humano , 2000,
Abstract: The objectives of this study were: a) to develop and validate equations to estimate lean body mass of males aged 12 to 14 years old; b) to validate lean body mass equations developed by other researchers. Data were collected from 93 male children aged 12-14 years. A stepwise regression technique was used to develop all prediction equations for lean body mass. Validation analysis of the proposed equations was performed using Pearson’s correlation, paired Student t test, constant error (CE) and standard error estimates (SEE). Four models were developed with bioresistance variables and one model using anthropometric variables. The multiple correlation coeffi cients (Rm) of the equations developed ranged from 0.905 to 0.965 and SEE from 2.413 kg to 1.847 kg. Validation analysis was undertaken using an independent sample of 22 children who were not part of the regression sample. In conclusion, the equations that were developed are valid for male children aged 12 to 14 years old. RESUMO Os objetivos deste estudo foram: a) desenvolver e validar equa es para estimar a massa corporal magra, específica para meninos de 12 a 14 anos de idade; b) validar equa es estimativas desenvolvidas por outros investigadores. Participaram do estudo 93 meninos de 12 a 14 anos. Para o desenvolvimento das equa es, foi usada a técnica de regress o múltipla “passo a passo”. A análise de valida o das equa es propostas foi realizada através de correla o simples de Pearson, teste t pareado, erro constante (EC) e erro padr o de estimativa (EPE). Foram desenvolvidos quatro modelos com variáveis de biorresistência e um com variáveis antropométricas. As correla es múltiplas (Rm) variaram de 0,905 a 0,965 e EPE de 2,413 kg a 1,847 kg. A valida o foi realizada em 22 meninos que n o participaram da amostra de regress o. Concluindo, as equa es desenvolvidas validadas para serem usadas em meninos de 12 a 14 anos, estudantes da rede pública de Campo Grande-MS.
Rea o granulomatosa pós-estapedotomia Post-stapedotomy granulomatous reaction
Fernando Kaoru Yonamine,Danilo Kanashiro Segalla,Marcos Luiz Antunes
Brazilian Journal of Otorhinolaryngology , 2010, DOI: 10.1590/s1808-86942010000100024
Abstract:
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