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Search Results: 1 - 10 of 1091 matches for " Yogesh Dwivedi "
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Brain-derived neurotrophic factor: role in depression and suicide
Yogesh Dwivedi
Neuropsychiatric Disease and Treatment , 2009, DOI: http://dx.doi.org/10.2147/NDT.S5700
Abstract: rain-derived neurotrophic factor: role in depression and suicide Review (10527) Total Article Views Authors: Yogesh Dwivedi Published Date August 2009 Volume 2009:5 Pages 433 - 449 DOI: http://dx.doi.org/10.2147/NDT.S5700 Yogesh Dwivedi Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Abstract: Depression and suicidal behavior have recently been shown to be associated with disturbances in structural and synaptic plasticity. Brain-derived neurotrophic factor (BDNF), one of the major neurotrophic factors, plays an important role in the maintenance and survival of neurons and in synaptic plasticity. Several lines of evidence suggest that BDNF is involved in depression, such that the expression of BDNF is decreased in depressed patients. In addition, antidepressants up-regulate the expression of BDNF. This has led to the proposal of the “neurotrophin hypothesis of depression”. Increasing evidence demonstrates that suicidal behavior is also associated with lower expression of BDNF, which may be independent from depression. Recent genetic studies also support a link of BDNF to depression/suicidal behavior. Not only BDNF, but abnormalities in its cognate receptor tropomycin receptor kinase B (TrkB) and its splice variant (TrkB.T1) have also been reported in depressed/suicidal patients. It has been suggested that epigenetic modulation of the Bdnf and Trkb genes may contribute to their altered expression and functioning. More recently, impairment in the functioning of pan75 neurotrophin receptor has been reported in suicide brain specimens. pan75 neurotrophin receptor is a low-affinity neurotrophin receptor that, when expressed in conjunction with low availability of neurotropins/Trks, induces apoptosis. Overall, these studies suggest the possibility that BDNF and its mediated signaling may participate in the pathophysiology of depression and suicidal behavior. This review focuses on the critical evidence demonstrating the involvement of BDNF in depression and suicide.
Brain-derived neurotrophic factor: role in depression and suicide
Yogesh Dwivedi
Neuropsychiatric Disease and Treatment , 2009,
Abstract: Yogesh DwivediPsychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USAAbstract: Depression and suicidal behavior have recently been shown to be associated with disturbances in structural and synaptic plasticity. Brain-derived neurotrophic factor (BDNF), one of the major neurotrophic factors, plays an important role in the maintenance and survival of neurons and in synaptic plasticity. Several lines of evidence suggest that BDNF is involved in depression, such that the expression of BDNF is decreased in depressed patients. In addition, antidepressants up-regulate the expression of BDNF. This has led to the proposal of the “neurotrophin hypothesis of depression”. Increasing evidence demonstrates that suicidal behavior is also associated with lower expression of BDNF, which may be independent from depression. Recent genetic studies also support a link of BDNF to depression/suicidal behavior. Not only BDNF, but abnormalities in its cognate receptor tropomycin receptor kinase B (TrkB) and its splice variant (TrkB.T1) have also been reported in depressed/suicidal patients. It has been suggested that epigenetic modulation of the Bdnf and Trkb genes may contribute to their altered expression and functioning. More recently, impairment in the functioning of pan75 neurotrophin receptor has been reported in suicide brain specimens. pan75 neurotrophin receptor is a low-affinity neurotrophin receptor that, when expressed in conjunction with low availability of neurotropins/Trks, induces apoptosis. Overall, these studies suggest the possibility that BDNF and its mediated signaling may participate in the pathophysiology of depression and suicidal behavior. This review focuses on the critical evidence demonstrating the involvement of BDNF in depression and suicide.Keywords: BDNF, neurotrophins, p75NTR, Trk receptor, depression, antidepressants, suicide, genetics, epigenetics
Pharmacological Characterization of Inositol 1,4,5-tris Phosphate Receptors in Human Platelet Membranes
Yogesh Dwivedi,Ghanshyam N. Pandey
Cardiovascular Psychiatry and Neurology , 2009, DOI: 10.1155/2009/618586
Abstract: The phosphatidylinositol (PI) hydrolysis signaling system has been shown to be altered in platelets of depressed and schizophrenic subjects. Inositol (1,4,5) trisphosphate (Ins(1,4,5)P3), an integral component of the PI signaling system, mobilizes Ca2
Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A
Yogesh Dwivedi,Ghanshyam N Pandey
Neuropsychiatric Disease and Treatment , 2008,
Abstract: Yogesh Dwivedi, Ghanshyam N PandeyPsychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USAAbstract: Mood disorders are among the most prevalent and recurrent forms of psychiatric illnesses. In the last decade, there has been increased understanding of the biological basis of mood disorders. In fact, novel mechanistic concepts of the neurobiology of unipolar and bipolar disorders are evolving based on recent pre-clinical and clinical studies, most of which now focus on the role of signal transduction mechanisms in these psychiatric illnesses. Particular investigative emphasis has been given to the role of phosphorylating enzymes, which are crucial in regulating gene expression and neuronal and synaptic plasticity. Among the most important phosphorylating enzyme is protein kinase A (PKA), a component of adenylyl cyclase cyclic adenosine monophosphate (AC cAMP) signaling system. In this review, we critically and comprehensively discuss the role of various components of AC cAMP signaling in mood disorders, with a special focus on PKA, because of the interesting observation that have been made about its involvement in unipolar and bipolar disorders. We also discuss the functional significance of the findings regarding PKA by discussing the role of important PKA substrates, namely, Rap-1, cyclicAMP-response element binding protein, and brain-derived neurotrophic factor. These studies suggest the interesting possibility that PKA and related signaling molecules may serve as important neurobiological factors in mood disorders and may be relevant in target-specific therapeutic interventions for these disorders.Keywords: protein kinase A, bipolar disorder, unipolar depression, CREB, BDNF, Rap-1
Investigating the Research Approaches for Examining Technology Adoption Issues
Jyoti Choudrie,Yogesh Kumar Dwivedi
Journal of Research Practice , 2005,
Abstract: Adoption of technology, a research topic within the Information Systems area, is usually studied at two levels: organizational level and user level. This paper examines the range of methods used for studying technology adoption issues at both these levels. The approaches were selected after conducting a review of 48 articles on technology adoption and usage, published in peer reviewed journals between 1985 and 2003. The journals reviewed include the MIS Quarterly, Information Systems Research, European Journal of Information Systems, Information Systems Journal, and other relevant journals in the IS area. The findings suggest that the survey method was used predominantly when investigating the topics of user adoption and the usage of technology. In contrast, the case study method is the most widely used when examining adoption issues at the organizational level.
A test for second order stationarity of a time series based on the Discrete Fourier Transform (Technical Report)
Yogesh Dwivedi,Suhasini Subba Rao
Statistics , 2009,
Abstract: We consider a zero mean discrete time series, and define its discrete Fourier transform at the canonical frequencies. It is well known that the discrete Fourier transform is asymptotically uncorrelated at the canonical frequencies if and if only the time series is second order stationary. Exploiting this important property, we construct a Portmanteau type test statistic for testing stationarity of the time series. It is shown that under the null of stationarity, the test statistic is approximately a chi square distribution. To examine the power of the test statistic, the asymptotic distribution under the locally stationary alternative is established. It is shown to be a type of noncentral chi-square, where the noncentrality parameter measures the deviation from stationarity. The test is illustrated with simulations, where is it shown to have good power. Some real examples are also included to illustrate the test.
Enoxacin Elevates MicroRNA Levels in Rat Frontal Cortex and Prevents Learned Helplessness
Neil R. Smalheiser,Hui Zhang,Yogesh Dwivedi
Frontiers in Psychiatry , 2014, DOI: 10.3389/fpsyt.2014.00006
Abstract: Major depressive disorder (MDD) is a major public health concern. Despite tremendous advancement, the pathogenic mechanisms associated with MDD are still unclear. Moreover, a significant number of MDD subjects do not respond to the currently available medication. MicroRNAs (miRNAs) are a class of small non-coding RNAs that control gene expression by modulating translation, mRNA degradation or stability of mRNA targets. The role of miRNAs in disease pathophysiology is emerging rapidly. Recently, we reported that miRNA expression is down-regulated in frontal cortex of depressed suicide subjects, and that rats exposed to repeated inescapable shock show differential miRNA changes depending on whether they exhibited normal adaptive responses or learned helpless (LH) behavior. Enoxacin, a fluoroquinolone used clinically as an anti-bacterial compound, enhances the production of miRNAs in vitro and in peripheral tissues in vivo, but has not yet been tested as an experimental tool to study the relation of miRNA expression to neural functions or behavior. Treatment of rats with 10 or 25 mg/kg enoxacin for 1 week increased the expression of miRNAs in frontal cortex and decreased the proportion of rats exhibiting LH behavior following inescapable shock. Further studies are warranted to learn whether enoxacin may ameliorate depressive behavior in other rodent paradigms and in human clinical situations, and if so whether its mechanism is due to upregulation of miRNAs.
A Critical Review on Traditional Herbal Drugs: An Emerging Alternative Drug for Diabetes  [PDF]
Krishna Bihari Pandeya, Indra Prasad Tripathi, Mahendra Kumar Mishra, Neelesh Dwivedi, Yogesh Pardhi, Arti Kamal, Priyanka Gupta, Nupa Dwivedi, Chinmayi Mishra
International Journal of Organic Chemistry (IJOC) , 2013, DOI: 10.4236/ijoc.2013.31001
Abstract:

Diabetes is a chronic metabolic disease reaching an epidemic proportion in many parts of the world. By the year 2025 it is expected that 333 million people of the world will have diabetes as their main ailment. As today, India assumes the position of the diabetic capital of the world with the highest percentage of its population suffering from diabetes. It is pathetic to mention that in proportion to its people suffering from diabetes, this country has very weak spending power for treatment because of wide spread poverty. Therefore, this review is aimed at opening up new vistas in realizing the therapeutic potential of Ayurveda in treatment of diabetes and other chronic diseases. All drugs which we have discussed in this review have a significant role in therapy of diabetes mellitus.

Design and Comparative analysis of a Metamaterial included Slotted Patch Antenna with a Metamaterial Cover over Patch
Surabhi Dwivedi,Dr. Vivekanand Mishra,,Dr. Yogesh P. Kosta
International Journal of Recent Technology and Engineering , 2013,
Abstract: A metamaterial is introduced into the cover of apatch antenna and its band structure is analyzed. Themetamaterial cover with correct selection of the workingfrequency increases the patch antenna’s directivity. Based on themethodology, optimization of structure is proposed for theapplication of metamaterials as antenna substrate to primarilyenhance directivity by minimizing its refractive index. Theexperimental results are presented thoroughly and compared withthe analytic calculations. This paper aims to review and criticallydiscuss the comparision of a metamaterial included patch andmetamaterial cover over the patch. An analytical method is usedto predict the features of the simulation results, implying thatwithin a certain frequency range, comparision can be madebetween these two models. The S-parameters as a performancematrix are obtained from antenna simulations carried onCADFEKO Silverlite version 5.5. Simulations have been carriedout for different shapes of microstrip patch antenna in themicrowave regime. 2010 ISRO – Indian Space ResearchOrganisation
Clean-Slate Design of Next-Generation Optical Access
Kyeong Soo Kim,Karin Ennser,Yogesh K. Dwivedi
Computer Science , 2013, DOI: 10.1109/ICTON.2011.5970910
Abstract: We report the current status of our research on the clean-slate design of next-generation optical access (NGOA). We have been studying candidate architectures with a major focus on their elasticity to user demands, energy efficiency, and support of better Quality of Experience (QoE). One of the major challenges in this study is to establish a comparative analysis framework where we can assess the performances of candidate architectures in an objective and quantifiable way. In this paper we describe our efforts to meet this challenge: (1) the development of a new comparison framework based on integrated QoE and statistical hypothesis testing and (2) the implementation of a virtual test bed capturing important aspects from physical layer to application layer to end-user behaviour governing traffic generation. The comparison framework and the virtual test bed will provide researchers a sound basis and useful tools for comparative analysis in the clean-slate design of NGOA.
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