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Search Results: 1 - 10 of 56164 matches for " Ying-Yi Qin "
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P16 gene hypermethylation and hepatocellular carcinoma: A systematic review and meta-analysis
Jia-Jie Zang,Feng Xie,Jin-Fang Xu,Ying-Yi Qin
World Journal of Gastroenterology , 2011, DOI: 10.3748/wjg.v17.i25.3043
Abstract: AIM: To quantitatively investigate the effect of p16 hypermethylation on hepatocellular carcinoma (HCC) and hepatocirrhosis using a meta-analysis of available case-control studies. METHODS: Previous studies have primarily evaluated the incidence of p16 hypermethylation in HCC and corresponding control groups, and compared the incidence of p16 hypermethylation in tumor tissues, pericancer liver tissues, normal liver tissues and non-tumor liver tissues with that in other diseases. Data regarding publication information, study characteristics, and incidence of p16 hypermethylation in both groups were collected from these studies and summarized. RESULTS: Fifteen studies, including 744 cases of HCC and 645 non-tumor cases, were identified for meta-analysis. Statistically significant odds ratios (ORs) of p16 hypermethylation were obtained from tumor tissues and non-tumorous liver tissues of HCC patients (OR 7.04, 95% CI: 3.87%-12.78%, P < 0.0001), tumor tissues of HCC patients and healthy liver tissues of patients with other diseases (OR 12.17, 95% CI: 6.64%-22.31%, P < 0.0001), tumor tissues of HCC patients and liver tissues of patients with non-tumorous liver diseases (OR 6.82, 95% CI: 4.31%-10.79%, P < 0.0001), and cirrhotic liver tissues and non-cirrhotic liver tissues (OR 4.96, 95% CI: 1.45%-16.96%, P = 0.01). The pooled analysis showed significantly increased ORs of p16 hypermethylation (OR 6.98, 95% CI: 4.64%-10.49%, P < 0.001) from HCC tissues and cirrhotic tissues. CONCLUSION: P16 hypermethylation induces the inactivation of p16 gene, plays an important role in hepatocarcinogenesis, and is associated with an increased risk of HCC and liver cirrhosis.
Effects of Combined Aspirin and Clopidogrel Therapy on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Yu-Hao Zhou, Xin Wei, Jian Lu, Xiao-Fei Ye, Mei-Jing Wu, Jin-Fang Xu, Ying-Yi Qin, Jia He
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031642
Abstract: Background Aspirin and clopidogrel monotherapies are effective treatments for preventing vascular disease. However, new evidence has emerged regarding the use of combined aspirin and clopidogrel therapy to prevent cardiovascular events. We therefore performed a comprehensive systematic review and meta-analysis to evaluate the benefits and harms of combined aspirin and clopidogrel therapy on major cardiovascular outcomes. Methodology/Principal Findings We systematically searched Medline, Embase, the Cochrane Central Register of Controlled Trials, reference lists of articles, and proceedings of major meetings to identify studies to fit our analysis. Eligible studies were randomized controlled trials assessing the effect of combined aspirin and clopidogrel therapy compared with aspirin or clopidogrel monotherapy. We identified 7 trials providing data with a total of 48248 patients. These studies reported 5134 major cardiovascular events, 1626 myocardial infarctions, 1927 strokes, and 1147 major bleeding events. Overall, the addition of aspirin to clopidogrel therapy as compared to single drug therapy resulted in a 9% RR reduction (95%CI, 2 to 17) in major cardiovascular events, 14% RR reduction (95%CI, 3 to 24) in myocardial infarction, 16% RR reduction (95%CI, 1 to 28) in stroke, and 62% RR increase (95%CI, 26 to 108) in major bleeding events. We also present the data as ARR to explore net value as the reduction in cardiovascular events. Overall, we observed that combined therapy yielded 1.06% decrease (95%CI, 0.23% to 1.99%) in major cardiovascular events and 1.23% increase (95%CI, 0.52% to 2.14%) in major bleeding events. Conclusion/Significance Although the addition of aspirin to clopidogrel resulted in small relative reductions in major cardiovascular events, myocardial infarction, and stroke, it also resulted in a relative increase in major bleeding events. In absolute terms the benefits of combined therapy, a 1.06% reduction in major cardiovascular events, does not outweigh the harms, a 1.23% increase in major bleeding events.
Effect of Folic Acid Supplementation on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Yu-Hao Zhou,Jian-Yuan Tang,Mei-Jing Wu,Jian Lu,Xin Wei,Ying-Yi Qin,Chao Wang,Jin-Fang Xu,Jia He
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0025142
Abstract: Folic acid is widely used to lower homocysteine concentrations and prevent adverse cardiovascular outcomes. However, the effect of folic acid on cardiovascular events is not clear at the present time. We carried out a comprehensive systematic review and meta-analysis to assess the effects of folic acid supplementation on cardiovascular outcomes.
Adjuvant Chemotherapy, with or without Taxanes, in Early or Operable Breast Cancer: A Meta-Analysis of 19 Randomized Trials with 30698 Patients
Ying-Yi Qin, Hui Li, Xiao-Jing Guo, Xiao-Fei Ye, Xin Wei, Yu-Hao Zhou, Xin-Ji Zhang, Chao Wang, Wei Qian, Jian Lu, Jia He
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026946
Abstract: Background Taxanes have been extensively used as adjuvant chemotherapy for the treatment of early or operable breast cancer, particularly in high risk, node-negative breast cancer. Previous studies, however, have reported inconsistent findings regarding their clinical efficacy and safety. We investigated disease-free survival (DFS), overall survival (OS), and drug-related toxicities of taxanes by a systematic review and meta-analysis. Methodology and Principal Findings We systematically searched PubMed, EMBASE, the Cochrane Center Register of Controlled Trials, proceedings of major meetings, and reference lists of articles for studies conducted between January 1980 and April 2011. Randomized controlled trials (RCTs) comparing chemotherapy with and without taxanes in the treatment of patients with early-stage or operable breast cancer were eligible for inclusion in our analysis. The primary endpoint was DFS. Nineteen RCTs including 30698 patients were identified, including 8426 recurrence events and 3803 deaths. Taxanes administration yielded a 17% reduction of hazard ratio (HR) for DFS (HR = 0.83, 95% CI 0.79–0.88, p<0.001) and a 17% reduction of HR for OS (HR = 0.83, 95% CI 0.77–0.90, p<0.001). For high risk, node-negative breast cancer, the pooled HR also favoured the taxane-based treatment arm over the taxane-free treatment arm (HR = 0.82, 95% CI 0.77–0.87, p = 0.022). A significantly increased rate of neutropenia, febrile neutropenia, fatigue, diarrhea, stomatitis, and oedema was observed in the taxane-based treatment arm. Conclusions/Significance Adjuvant chemotherapy with taxanes could reduce the risk of cancer recurrence and death in patients with early or operable breast cancer, although the drug-related toxicities should be balanced. Furthermore, we also demonstrated that patients with high risk, node-negative breast cancer also benefited from taxanes therapy, a result that was not observed in previous studies.
FollowMeLite: A Lightweight Middleware for Pervasive Computing
FollowMeLite:用于普适计算的轻量级中间件平台

LI Jun,TAO Xian-Ping,BU Ying-Yi,CHEN Sha-Xun,YIN Qin,LU Jian,
李俊
,陶先平,卜颖毅,陈沙寻,殷琴,吕建

计算机科学 , 2007,
Abstract: The goal of pervasive computing is to serve human being well by integrating environments and computational resources. To achieve the goal, mobile and embedded devices play an important role in pervasive computing. However, due to the limited resources, the diversity and unsteadiness of the network and the heterogeneousness of the hardware and software, developing context-aware applications on mobile and embedded devices is still complexand time-consuming. The ultimate reason is lacking a uniform middleware support. To address this problem, we proposed a lightweight middleware for pervasive computing, called FollowMeLite. FollowMeLite is part of FollowMe which is a perva sive infrastructure. Based on OSGi, it integrated Ontology based context model, workflow based programming model and network service for dynamic communication. By deploying different components, FollowMeLite can be applied to various application environments.
Trends in In-Hospital Mortality among Patients with Stroke in China
Qian He, Cheng Wu, Hong Luo, Zhi-Yong Wang, Xiu-Qiang Ma, Yan-Fang Zhao, Jian Lu, Chun Xiang, Ying-Yi Qin, Shun-Quan Wu, Fei-Fei Yu, Jia He
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0092763
Abstract: Background The incidence and burden of stroke in China is increasing rapidly. However, little is known about trends in mortality during stroke hospitalization. The objectives of this study were to assess trends of in-hospital mortality among patients with stroke and explore influence factors of in-hospital death after stroke in China. Methods 109 grade III class A hospitals were sampled by multistage stratified cluster sampling. All patients admitted to hospitals between 2007 and 2010 with a discharge diagnosis of stroke were included. Trends in in-hospital mortality among patients with stroke were assessed. Influence factors of in-hospital death after stroke were explored using multivariable logistic regression. Results Overall stroke hospitalizations increased from 79,894 in 2007 to 85,475 in 2010, and in-hospital mortality of stroke decreased from 3.16% to 2.30% (P<0.0001). The percentage of severe patients increased while odds of mortality (2010 versus 2007) decreased regardless of stroke type: subarachnoid hemorrhage (OR 0.792, 95% CI = 0.636 to 0.987), intracerebral hemorrhage (OR 0.647, 95% CI = 0.591 to 0.708), and ischemic stroke (OR 0.588, 95% CI = 0.532 to 0.649). In multivariable analyses, older age, male, basic health insurance, multiple comorbidities and severity of disease were linked to higher odds of in-hospital mortality. Conclusions The mortality of stroke hospitalizations decreased likely reflecting advancements in stroke care and prevention. Decreasing of mortality with increasing of severe stroke patients indicated that we should pay more attention to rehabilitation and life quality of stroke patients. Specific individual and hospital-level characteristics may be targets for facilitating further declines.
Nonintrusive Energy Monitoring for Microgrids Using Hybrid Self-Organizing Feature-Mapping Networks
Ying-Yi Hong,Jing-Han Chou
Energies , 2012, DOI: 10.3390/en5072578
Abstract: Microgrids can increase power penetration from distributed generation (DG) in the power system. The interface ( i.e., the point of common coupling, PCC) between the microgrid and the power utility must satisfy certain standards, such as IEEE Sd. 1547. Energy monitoring of the microgrid at the PCC by the power utility is crucial if the utility cannot install advanced meters at different locations in the microgrid (e.g., a factory). This paper presents a new nonintrusive energy monitoring method using a hybrid self-organizing feature-mapping neural network (SOFMNN). The components of the FFT spectra for voltage, current, kW and kVAR, measured at the PCC, serve as the signatures for the hybrid SOFMNN inputs. The nonintrusive energy monitoring at the PCC identifies different load levels for individual linear/nonlinear loads and output levels for wind power generators in the microgrid. Using this energy monitoring result, the power utility can establish an energy management policy. The simulation results from a microgrid, consisting of a diesel generator, a wind-turbine-generator, a rectifier and a cyclo-converter, show the practicability of the proposed method.
Day-Ahead Electricity Price Forecasting Using a Hybrid Principal Component Analysis Network
Ying-Yi Hong,Ching-Ping Wu
Energies , 2012, DOI: 10.3390/en5114711
Abstract: Bidding competition is one of the main transaction approaches in a deregulated electricity market. Locational marginal prices (LMPs) resulting from bidding competition and system operation conditions indicate electricity values at a node or in an area. The LMP reveals important information for market participants in developing their bidding strategies. Moreover, LMP is also a vital indicator for the Security Coordinator to perform market redispatch for congestion management. This paper presents a method using a principal component analysis (PCA) network cascaded with a multi-layer feedforward (MLF) network for forecasting LMPs in a day-ahead market. The PCA network extracts essential features from periodic information in the market. These features serve as inputs to the MLF network for forecasting LMPs. The historical LMPs in the PJM market are employed to test the proposed method. It is found that the proposed method is capable of forecasting day-ahead LMP values efficiently.
Autoreactive marginal zone B cells enter the follicles and interact with CD4+ T cells in lupus-prone mice
Zhenhai Zhou, Haitao Niu, Ying-Yi Zheng, Laurence Morel
BMC Immunology , 2011, DOI: 10.1186/1471-2172-12-7
Abstract: The intrafollicular location of B6.TC MZB cells starts before disease manifestations and puts MZB cells in direct contact with CD4+ T cells. Two different autoreactive B cell receptor (BCR) transgenic models showed that the expression of the Sle susceptibility loci enhances the presence of MZB cells inside the follicles. In vitro, B6.TC MZB cells were better effectors than B6 MZB cells with enhanced proliferation and antibody (Ab) production, including anti-DNA Ab, in response to stimulation with TLR ligands, immune complexes or anti-CD40. Furthermore, B6.TC MZB and CD4+ T cells showed a reciprocally enhanced activation, which indicated that their contacts inside B6.TC follicles have functional consequences that suggest an amplification loop between these two cell types.These results showed that the NZM2410 susceptibility loci induce MZB cells to locate into the follicles, and that this breach of follicular exclusion occurs early in the development of the autoimmune pathogenesis. The enhanced responses to stimulation and increased effector functions of MZB cells from lupus-prone mice as compare to non-autoimmune MZB cells provide a mechanism by which the failure of MZB cell follicular exclusion contributes to the autoimmune process.Systemic lupus erythematosus (SLE) is an autoimmune disease in which defects in multiple B cell subsets have long been recognized [1]. Marginal zone (MZ) B cells are enriched for autoreactive specificities through the expression of self-reactive germline-encoded BCRs [2]. MZB cells transport antigen inside the follicles [3] and are potent T-cell activators that respond more rapidly than follicular (FO) B cells to T-dependent antigen [4]. MZB cells also differentiate rapidly into plasma cells [5-9]. Finally, MZB cells respond better to T cells than FOB cells in vitro but not in vivo [10], showing that physiological barriers prevent in vivo activation of MZB cells [11]. These observations have led to hypothesize the existence of a tolerance
Smoothness of the curvature of an HCMU on S2 or T2
在S2或T2上HCMU的曲率的光滑性

WU Ying-Yi,
吴英毅

中国科学院研究生院学报 , 2008,
Abstract: An HCMU is a kind of extremal metric with singularities on a Riemann surface. If the area and Calabi energy are both bounded, the Gauss curvature of an HCMU is a continuous function on the Riemann surface. In this paper we get an explicit construction of an HCMU on S2 which has no saddle point of the Gauss curvature of the metric. Further more we prove that on S2 or T2 the Gauss curvature of an HCMU is smooth if and only all of the singular angles are integers.
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