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Search Results: 1 - 10 of 62372 matches for " Ying-Ting Lin "
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Modeling for the Dynamics of Human Innovative Behaviors
Ying-Ting Lin,Xiao-Pu Han,Bing-Hong Wang
Computer Science , 2013,
Abstract: How to promote the innovative activities is an important problem for modern society. In this paper, combining with the evolutionary games and information spreading, we propose a lattice model to investigate dynamics of human innovative behaviors based on benefit-driven assumption. Simulations show several properties in agreement with peoples' daily cognition on innovative behaviors, such as slow diffusion of innovative behaviors, gathering of innovative strategy on "innovative centers", and quasi-localized dynamics. Furthermore, our model also emerges rich non-Poisson properties in the temporal-spacial patterns of the innovative status, including the scaling law in the interval time of innovation releases and the bimodal distributions on the spreading range of innovations, which would be universal in human innovative behaviors. Our model provide a basic framework on the study of the issue relevant to the evolution of human innovative behaviors and the promotion measurement of innovative activities.
MCRS2 represses the transactivation activities of Nrf1
Jia-Long Wu, Young-Sun Lin, Chi-Chiang Yang, Yu-Jen Lin, Shan-Fu Wu, Ying-Ting Lin, Chien-Fu Huang
BMC Cell Biology , 2009, DOI: 10.1186/1471-2121-10-9
Abstract: To find other proteins interacting with the CNC bZIP domain of Nrf1, the CNC-bZIP region of Nrf1 was used as a bait in a yeast two-hybrid screening assay. MCRS2, a splicing variant of p78/MCRS1, was isolated as the Nrf1-interacting partner from the screenings. The interaction between Nrf1 and MCRS2 was confirmed in vitro by GST pull-down assays and in vivo by co-immunoprecipitation. Further, the Nrf1-MCRS2 interaction domains were mapped to the residues 354–447 of Nrf1 as well as the residues 314–475 of MCRS2 respectively, by yeast two-hybrid and GST pull-down assays. By immunofluorescence, MCRS2-FLAG was shown to colocalize with HA-Nrf1 in the nucleus and didn't result in the redistribution of Nrf1. This suggested the existence of Nrf1-MCRS2 complex in vivo. To further confirm the biological function, a reporter driven by CNC-bZIP protein binding sites was also shown to be repressed by MCRS2 in a transient transfection assay. An artificial reporter gene activated by LexA-Nrf1 was also specifically repressed by MCRS2.From the results, we showed MCRS2, a new Nrf1-interacting protein, has a repression effect on Nrf1-mediated transcriptional activation. This was the first ever identified repressor protein related to Nrf1 transactivation.Nrf1 (NF-E2 related factor1) belongs to the Cap'n'Collar-basic leucine zipper proteins (CNC-bZIP). The CNC-bZIP family is identified by its homology region, named the CNC domain, immediately N-terminal to the bZIP domain [1]. This family contains a basic domain interacting with sequence-specific DNA and a leucine zipper domain (bZIP) involved in protein-protein dimerization [2-4]. The members of Cap'n'Collar (CNC) family contain Nrf1, Nrf2, Nrf3, p45 NF-E2, Drosophila CNC protein, as well as C. elegans Skn-1 [5-9]. There are two known transcriptional roles of the CNC-bZIP family. First, they are involved in globin gene expression. Transcriptional control of the human beta-globin gene cluster is mediated by four DNase I hypersensitive si
Suppression of Heregulin-β1/HER2-Modulated Invasive and Aggressive Phenotype of Breast Carcinoma by Pterostilbene via Inhibition of Matrix Metalloproteinase-9, p38 Kinase Cascade and Akt Activation
Min-Hsiung Pan,Ying-Ting Lin,Chih-Li Lin,Chi-Shiang Wei,Chi-Tang Ho,Wei-Jen Chen
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep093
Abstract: Invasive breast cancer is the major cause of death among females and its incidence is closely linked to HER2 (human epidermal growth factor receptor 2) overexpression. Pterostilbene, a natural analog of resveratrol, exerts its cancer chemopreventive activity similar to resveratrol by inhibiting cancer cell proliferation and inducing apoptosis. However, the anti-invasive effect of pterostilbene on HER2-bearing breast cancer has not been evaluated. Here, we used heregulin-β1 (HRG-β1), a ligand for HER3, to transactivate HER2 signaling. We found that pterostilbene was able to suppress HRG-β1-mediated cell invasion, motility and cell transformation of MCF-7 human breast carcinoma through down-regulation of matrix metalloproteinase-9 (MMP-9) activity and growth inhibition. In parallel, pterostilbene also inhibited protein and mRNA expression of MMP-9 driven by HRG-β1, suggesting that pterostilbene decreased HRG-β1-mediated MMP-9 induction via transcriptional regulation. Examining the signaling pathways responsible for HRG-β1-associated MMP-9 induction and growth inhibition, we observed that pterostilbene, as well as SB203580 (p38 kinase inhibitor), can abolish the phosphorylation of p38 mitogen-activated protein kinase (p38 kinase), a downstream HRG-β1-responsive kinase responsible for MMP-9 induction. In addition, HRG-β1-driven Akt phosphorylation required for cell proliferation was also suppressed by pterostilbene. Taken together, our present results suggest that pterostilbene may serve as a chemopreventive agent to inhibit HRG-β1/HER2-mediated aggressive and invasive phenotype of breast carcinoma through down-regulation of MMP-9, p38 kinase and Akt activation.
Green Tea Phenolic Epicatechins Inhibit Hepatitis C Virus Replication via Cycloxygenase-2 and Attenuate Virus-Induced Inflammation
Ying-Ting Lin, Yu-Hsuan Wu, Chin-Kai Tseng, Chun-Kuang Lin, Wei-Chun Chen, Yao-Chin Hsu, Jin-Ching Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054466
Abstract: Chronic hepatitis C virus (HCV) infection is the leading risk factor for hepatocellular carcinoma (HCC) and chronic liver disease worldwide. Green tea, in addition to being consumed as a healthy beverage, contains phenolic catechins that have been used as medicinal substances. In the present study, we illustrated that the epicatechin isomers (+)-epicatechin and (?)-epicatechin concentration-dependently inhibited HCV replication at nontoxic concentrations by using in vitro cell-based HCV replicon and JFH-1 infectious systems. In addition to significantly suppressing virus-induced cyclooxygenase-2 (COX-2) expression, our results revealed that the anti-HCV activity of the epicatechin isomers occurred through the down-regulation of COX-2. Furthermore, both the epicatechin isomers additively inhibited HCV replication in combination with either interferon-α or viral enzyme inhibitors [2′-C-methylcytidine (NM-107) or telaprevir]. They also had prominent anti-inflammatory effects by inhibiting the gene expression of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and inducible nitrite oxide synthase as well as the COX-2 in viral protein-expressing hepatoma Huh-7 cells. Collectively, (+)-epicatechin and (?)-epicatechin may serve as therapeutic supplements for treating HCV-related diseases.
10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer
Chung-Yi Chen,Kuo-Chen Cheng,Andy Y Chang,Ying-Ting Lin,You-Cheng Hseu,Hui-Min Wang
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13021762
Abstract: In this work, one of Zingiber officinale components, 10-shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in transforming growth factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, 10-shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.
Synthesis and Biological Evaluation of Phenanthrenes as Cytotoxic Agents with Pharmacophore Modeling and ChemGPS-NP Prediction as Topo II Inhibitors
Chia-Lin Lee, Ying-Ting Lin, Fang-Rong Chang, Guan-Yu Chen, Anders Backlund, Juan-Chang Yang, Shu-Li Chen, Yang-Chang Wu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037897
Abstract: In a structure-activity relationship (SAR) study, 3-methoxy-1,4-phenanthrenequinones, calanquinone A (6a), denbinobin (6b), 5-OAc-calanquinone A (7a) and 5-OAc-denbinobin (7b), have significantly promising cytotoxicity against various human cancer cell lines (IC50 0.08–1.66 μg/mL). Moreover, we also established a superior pharmacophore model for cytotoxicity (r = 0.931) containing three hydrogen bond acceptors (HBA1, HBA2 and HBA3) and one hydrophobic feature (HYD) against MCF-7 breast cancer cell line. The pharmacophore model indicates that HBA3 is an essential feature for the oxygen atom of 5-OH in 6a–b and for the carbonyl group of 5-OCOCH3 in 7a–b, important for their cytotoxic properties. The SAR for moderately active 5a–b (5-OCH3), and highly active 6a–b and 7a–b, are also elaborated in a spatial aspect model. Further rational design and synthesis of new cytotoxic phenanthrene analogs can be implemented via this model. Additionally, employing a ChemGPS-NP based model for cytotoxicity mode of action (MOA) provides support for a preliminary classification of compounds 6a–b as topoisomerase II inhibitors.
Selective Activation of p120ctn-Kaiso Signaling to Unlock Contact Inhibition of ARPE-19 Cells without Epithelial-Mesenchymal Transition
Hung-Chi Chen, Ying-Ting Zhu, Szu-Yu Chen, Scheffer C. G. Tseng
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0036864
Abstract: Contact-inhibition ubiquitously exists in non-transformed cells and explains the poor regenerative capacity of in vivo human retinal pigment epithelial cells (RPE) during aging, injury and diseases. RPE injury or degeneration may unlock mitotic block mediated by contact inhibition but may also promote epithelial-mesenchymal transition (EMT) contributing to retinal blindness. Herein, we confirmed that EMT ensued in post-confluent ARPE-19 cells when contact inhibition was disrupted with EGTA followed by addition of EGF and FGF-2 because of activation of canonical Wnt and Smad/ZEB signaling. In contrast, knockdown of p120-catenin (p120) unlocked such mitotic block by activating p120/Kaiso, but not activating canonical Wnt and Smad/ZEB signaling, thus avoiding EMT. Nuclear BrdU labeling was correlated with nuclear release of Kaiso through p120 nuclear translocation, which was associated with activation of RhoA-ROCK signaling, destabilization of microtubules. Prolonged p120 siRNA knockdown followed by withdrawal further expanded RPE into more compact monolayers with a normal phenotype and a higher density. This new strategy based on selective activation of p120/Kaiso but not Wnt/β-catenin signaling obviates the need of using single cells and the risk of EMT, and may be deployed to engineer surgical grafts containing RPE and other tissues.
Eating behaviour patterns in Chinese children aged 12-18 months and association with relative weight - factorial validation of the Children's Eating Behaviour Questionnaire
Ying-Ting Cao, Viktoria Svensson, Claude Marcus, Jing Zhang, Jian-Duan Zhang, Tanja Sobko
International Journal of Behavioral Nutrition and Physical Activity , 2012, DOI: 10.1186/1479-5868-9-5
Abstract: 219 questionnaires were filled out by the caregivers, approached in community health care centers in two cities in China. BMI of each child was calculated and converted to BMI SDS. Factor validation (Principal Component Analysis, exploratory factor analysis) on all CEBQ items was performed and gender difference in eating behaviours was examined. Correlations between eating behaviours and the child's BMI SDS were analyzed by linear regression analysis controlling for gender, parental combined weight, and education.The factor analysis revealed a seven-factor solution, with factor 'food responsiveness' (FR) split into two. 'Satiety responsiveness' (SR) and 'Enjoyment of food' (EF) factors were not detected. Interestingly, boys scored higher than girls in the FR scales, whereas girls had a higher score in 'food fussiness' (FF) scale.We conclude that although a valuable psychometric instrument, CEBQ might be affected by age and cultural differences. Therefore, adjusting it in order to fit the Chinese population was suggested. We did not find an association between eating behaviours and children's BMI SDS, when it was controlled for gender and parental weight.Childhood obesity has become one of the most serious public health challenges worldwide in the last century, with 42 million overweight children under the age of five. The vast majority (80%) of these live in low and middle-income countries [1]. This trend has affected China and the prevalence of childhood obesity in some urban Chinese populations is already reached similar levels of the developed countries [2]. In 2005, total 7.73% of Chinese youth were overweight and 3.71% of them were obese. Partly explained by the explosive economic development and improvement of living conditions in China [3], general raise in income in China today enables a decreasing consumption of cereals and starchy roots, and an increasing consumption of high-caloric foods [4]. In addition, fast food and snack consumption together with incr


物理学报 , 1976,
Abstract: 穆斯堡尔效应是指固体中无反冲的核γ射线的共振吸收。利用这一效应可以研究固态物质的微观结构,例如磁超精细相互作用、电四极相互作用和同质异能移位等,以及微观结构与宏观性能的关系。通过这项研究,可以获得有关固体的晶体结构、电子构型、磁性和晶场等的认识。因此,在固体物理、磁学、材料科学以及化学、地球科学、生物学和工农业生产中,这一效应都越来越获得较为广泛的应用。
Application of Digital Surgical Guide in Immediate Implantation

, LIU Juan, GUO Hui, LIU Ying-ting

- , 2017, DOI: 10.13701/j.cnki.kqyxyj.2017.09.024
Abstract: 摘要 目的:研究和评估数字化种植导板在口腔即刻种植中的应用效果。方法:选择2015年1月~2016年12月于云南省一院口腔中心就诊的患者22例,这些患者口腔内有1个或者数个牙根无法保留需行种植修复,在种植数字化导板引导下不翻瓣于拔除牙根同期植入植体,收集患者影像学资料并对比分析种植体实际植入位置和预设位置之间的偏差,进行系统性研究。分别测量术后即刻和术后半年永久性修复时的边缘骨水平,永久修复完成后第2天以及1年以后随访时软组织指数并进行统计学分析。结果:共39颗种植体纳入本研究,28例患者均无种植体脱落现象,植入种植体的角度偏差为(3.25±1.6)°,位置偏差(0.54±0.38) mm,深度偏差(0.51±0.38) mm;术后半年种植体颊侧垂直向骨吸收(1.3±0.6) mm,舌侧垂直向骨吸收为(0.3±0.2) mm,改良出血指数(mBI)为(0.91±0.45),探诊深度(PD)为(2.05±0.3) mm;随访时39颗种植体的mBI为(1.18 ± 0.72),PD为(2.10±0.2) mm。随访时mBI较术后半年时有所降低,且差异有统计学意义(P<0.05)。结论:在即刻种植中应用数字化导板,可以固定种植钻针,引导种植体按照预设位置精确植入,保证种植修复的效果。在组织稳定性和美学效果的稳定性方面还需要长期的临床观察
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