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Search Results: 1 - 10 of 58353 matches for " Ying-Chih Lin "
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Computer Tomography and Ultrasonography Image Registration Based on the Cooperation of GPU and CPU  [PDF]
Ying-Chih Lin, Chien-Liang Huang, Chin-Sheng Chen, Wen-Chung Chang, Yu-Jen Chen, Chia-Yuan Liu
Journal of Signal and Information Processing (JSIP) , 2013, DOI: 10.4236/jsip.2013.43B014

Image registration is wildly used in the biomedical image, but there are too many textures and noises in the biomedical image to get a precise image registration. In order to get the excellent registration performance, it needs more complex image processing, and it will spend expensive computation cost. For the real time issue, this paper proposes edge gradient direction image registration applied to Computer Tomography(CT) image and Ultrasonography (US) image based on the cooperation of Graphic Processor Unit (GPU) and Central Processor Unit (CPU). GPU can significantly reduce the computation time. First, the CT image slice is extracted from the CT volume by the region growing and the interpolation algorithm. Secondly, the image pre-processing is employed to reduce the image noises and enhance the image features. There are two kinds of the image pre-processing algorithms invoked in this paper: 1) median filtering and 2) anisotropic diffusion. Last but not least, the image edge gradient information is obtained by Canny operator, and the similarity measurement based on gradient direction is employed to evaluate the similarity between the CT and the US images. The experimental results show that the proposed architecture can distinctively improve the efficiency and are more suitably applied to the real world.

Electrically tunable plasma excitations in AA-stacking multilayer graphene
Ming-Fa Lin,Ying-Chih Chuang,Jhao-Ying Wu
Physics , 2014, DOI: 10.1103/PhysRevB.86.125434
Abstract: We use a tight-binding model and the random-phase approximation to study the Coulomb excitations in simple-hexagonal-stacking multilayer graphene and discuss the field effects. The calculation results include the energy bands, the response functions, and the plasmon dispersions. A perpendicular electric field is predicted to induce significant charge transfer and thus capable of manipulating the energy, intensity, and the number of plasmon modes. This could be further validated by inelastic light scattering or electron-energy-loss spectroscopy.
Analgesic and Anti-Inflammatory Activities of the Ethanolic Extract of Artemisia morrisonensis Hayata in Mice
Shen-Chieh Chou,Yung-Jia Chiu,Chao-Jung Chen,Ying-Chih Lin
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/138954
A P2P Framework for Developing Bioinformatics Applications in Dynamic Cloud Environments
Chun-Hung Richard Lin,Chun-Hao Wen,Ying-Chih Lin,Kuang-Yuan Tung,Rung-Wei Lin,Chun-Yuan Lin
International Journal of Genomics , 2013, DOI: 10.1155/2013/361327
Abstract: Bioinformatics is advanced from in-house computing infrastructure to cloud computing for tackling the vast quantity of biological data. This advance enables large number of collaborative researches to share their works around the world. In view of that, retrieving biological data over the internet becomes more and more difficult because of the explosive growth and frequent changes. Various efforts have been made to address the problems of data discovery and delivery in the cloud framework, but most of them suffer the hindrance by a MapReduce master server to track all available data. In this paper, we propose an alternative approach, called PRKad, which exploits a Peer-to-Peer (P2P) model to achieve efficient data discovery and delivery. PRKad is a Kademlia-based implementation with Round-Trip-Time (RTT) as the associated key, and it locates data according to Distributed Hash Table (DHT) and XOR metric. The simulation results exhibit that our PRKad has the low link latency to retrieve data. As an interdisciplinary application of P2P computing for bioinformatics, PRKad also provides good scalability for servicing a greater number of users in dynamic cloud environments. 1. Introduction Today new technologies in genomics/proteomics generate biological data with an exponential growth. Current Next Generation Sequencing (NGS) technologies can produce gigabase-scales of DNA and RNA sequencing data within a day at a reasonable cost [1–3]. Cloud computing has been regarded as a key approach for processing such a planet-size data, and hence, many bioinformatics applications have been migrated to the cloud environments [4–7]. Bioinformatics clouds are heavily dependent on data, as data are fundamentally crucial for receiving biological insights. The analyses are commonly based on the extensive and repeated use of comparative parallel process via Data-as-a-Service (DaaS) on the web [8–10], most notably in the gene expression analysis. The data are likely to be updated constantly. The sources and users of the data would be connected by various devices over the internet. The effectiveness for locating the deluged data in cloud computing is often overlooked, but it is a key problem. From the aspect of retrieving the up-to-date data with less complexity and delay, we settled the existing problems in data discovery. Along these lines, the high computing ability of P2P framework is adopted as a dynamic cloud infrastructure to resolve the challenge caused by massive datasets [11–13]. Bioinformatics usually requires the collection, organization, and analysis of large
Analgesic and Anti-Inflammatory Activities of the Methanol Extract from Pogostemon cablin
Tsung-Chun Lu,Jung-Chun Liao,Tai-Hung Huang,Ying-Chih Lin,Chia-Yu Liu,Yung-jia Chiu,Wen-Huang Peng
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep183
Abstract: Pogostemon cablin (PC) is a herbal medicine traditionally applied to treat not only common cold, nausea and diarrhea but also headache and fever. The aim of this study was to investigate the analgesic and anti-inflammatory properties of standardized PC methanol extract (PCMeOH) in vivo. Investigations were performed in mice with two analgesic models. One was acetic acid-induced writhing response and the other formalin-induced paw licking. The anti-inflammatory effect was tested by λ-carrageenan (Carr)-induced mice paw edema. These analgesic experimental results indicated that PCMeOH (1.0 g/kg) decreased the acetic acid-induced writhing responses and PCMeOH (0.5 and 1.0 g/kg) decreased the licking time in the second phase of the formalin test. Moreover, Carr-induced paw edema inflammation was significantly reduced in a dose-dependent manner when PCMeOH (0.5 and 1.0 g/kg) was administered 3 and 4 h after the Carr injection. Mechanistic studies showed that PCMeOH decreased the levels of malondialdehyde in the edema paw by increasing the activities of anti-oxidant enzymes, such as superoxide dismutase, glutathione peroxidase and glutathione reductase, in the liver and decreasing the cyclooxygenase 2 and tumor necrosis factor-α activities in the edema paw. This study has demonstrated the analgesic and anti-inflammatory effects of PCMeOH, thus verifying its popular use in traditional medicine.
Antioxidant, Antinociceptive, and Anti-Inflammatory Activities from Actinidia callosa var. callosa In Vitro and In Vivo
Jung-Chun Liao,Jeng-Shyan Deng,Ying-Chih Lin,Chao-Ying Lee,Min-Min Lee,Wen-Chi Hou,Shyh-Shyun Huang,Guan-Jhong Huang
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/129152
Abstract: Actinidia callosa var. callosa has been widely used to treat antipyretic, analgesic, anti-inflammation, abdominal pain, and fever in Taiwan. The aim of this study was to evaluate the antioxidant, antinociceptive, and anti-inflammatory lipopolysaccharide-(LPS-)induced nitric oxide (NO) production in RAW264.7 macrophages and pawedema induced by λ-carrageenan activities of the methanol extract from A. callosa. In HPLC analysis, the fingerprint chromatogram of ethyl-acetate fraction of A. callosa (EAAC) was established. EAAC showed the highest TEAC and DPPH radical scavenging activities, respectively. We evaluated that EAAC and the reference compound of catechin and caffeic acid decreased the LPS-induced NO production in RAW264.7 cells. Treatment of male ICR mice with EAAC significantly inhibited the numbers of acetic acid-induced writhing response and the formalin-induced pain in the late phase. Administration of EAAC showed a concentration-dependent inhibition on paw edema development after Carr treatment in mice. Anti-inflammatory mechanisms of EAAC might be correlated to the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and heme oxygenase-1 (HO-1) in vitro and in vivo. Overall, the results showed that EAAC demonstrated antioxidant, antinociceptive, and anti-inflammatory activity, which supports previous claims of the traditional use for inflammation and pain.
Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice
Shyh-Shyun Huang,Chuan-Sung Chiu,Hsien-Jung Chen,Wen-Chi Hou,Ming-Jyh Sheu,Ying-Chih Lin,Pei-Hsin Shie,Guan-Jhong Huang
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/895857
Abstract: Asiatic acid (AA), a pentacyclic triterpene compound in the medicinal plant Centella asiatica, was evaluated for antinociceptive and anti-inflammatory effects. Treatment of male ICR mice with AA significantly inhibited the numbers of acetic acid-induced writhing responses and the formalin-induced pain in the late phase. In the anti-inflammatory test, AA decreased the paw edema at the 4th and 5th h after λ-carrageenan (Carr) administration and increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the liver tissue. AA decreased the nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) levels on serum level at the 5th h after Carr injection. Western blotting revealed that AA decreased Carr-induced inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), and nuclear factor-κB (NF-κB) expressions at the 5th h in the edema paw. An intraperitoneal (i.p.) injection treatment with AA also diminished neutrophil infiltration into sites of inflammation as did indomethacin (Indo). The anti-inflammatory mechanisms of AA might be related to the decrease in the level of MDA, iNOS, COX-2, and NF-κB in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver.
Transcriptome Profiling and Physiological Studies Reveal a Major Role for Aromatic Amino Acids in Mercury Stress Tolerance in Rice Seedlings
Yun-An Chen, Wen-Chang Chi, Ngoc Nam Trinh, Li-Yao Huang, Ying-Chih Chen, Kai-Teng Cheng, Tsai-Lien Huang, Chung-Yi Lin, Hao-Jen Huang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095163
Abstract: Mercury (Hg) is a serious environmental pollution threat to the planet. The accumulation of Hg in plants disrupts many cellular-level functions and inhibits growth and development, but the mechanism is not fully understood. To gain more insight into the cellular response to Hg, we performed a large-scale analysis of the rice transcriptome during Hg stress. Genes induced with short-term exposure represented functional categories of cell-wall formation, chemical detoxification, secondary metabolism, signal transduction and abiotic stress response. Moreover, Hg stress upregulated several genes involved in aromatic amino acids (Phe and Trp) and increased the level of free Phe and Trp content. Exogenous application of Phe and Trp to rice roots enhanced tolerance to Hg and effectively reduced Hg-induced production of reactive oxygen species. Hg induced calcium accumulation and activated mitogen-activated protein kinase. Further characterization of the Hg-responsive genes we identified may be helpful for better understanding the mechanisms of Hg in plants.
Analgesic and Anti-Inflammatory Activities of the Ethanolic Extract of Artemisia morrisonensis Hayata in Mice
Shen-Chieh Chou,Yung-Jia Chiu,Chao-Jung Chen,Ying-Chih Lin,Chung-Hao Wu,Chien-Ti Chao,Ching-Wen Chang,Wen-Huang Peng
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/138954
Abstract: The aim of this study was to investigate the possible analgesic and anti-inflammatory mechanisms of the ethanolic extract of A. morrisonensis Hayata ( ). Two models were employed for evaluation of the analgesic effects: acetic acid-induced writhing response and formalin-induced paw licking. The results demonstrated that decreased writhing response for both the acetic acid assay and the licking time in the formalin test. The anti-inflammatory effect was evaluated by paw edema of mice induced by λ-carrageenan. significantly decreased induced paw edema three to four hours after λ-carrageenan injection. Additionally, the results indicated that the anti-inflammatory mechanism of may be due to the declined levels of nitric oxide (NO) and malondialdehyde (MDA) in the edematous paw. Furthermore, decreased the tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) levels, leading to the reduction of prostaglandins and subsequently alleviated edema. Isolation and purification of the extract determined p-hydroxyacetophenone to be a major component at 130?mg/g of extract. No mortality was observed in the acute toxicity test given at the dose of 10?g/kg. This study demonstrated the possible mechanisms for the analgesic and anti-inflammatory effects of for mice and provided evidence for the ethnobotanical uses of A. morrisonensis in treating inflammatory diseases. 1. Introduction Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory, and immunological disorder causing joint destruction and disability, typically observed in people between the ages of 30 and 50 [1]. This disease affects 0.5–1% of adults and its incidence and prevalence are higher in industrialized countries [2]. Drug treatment for RA includes nonsteroidal anti-inflammatory drugs (NSAIDs), low-dose oral or intra-articular glucocorticoids, disease-modifying anti-rheumatic drugs, biologic response modifiers, and daily calcium/vitamin D [3]. Inflammation is the result of host defense to tissue injuries and/or against pathogenic stimuli; however, persistent or hyperinflammation can lead to tissue damage and eventually to organ failure if not properly controlled. In response to infectious agents or pro-inflammatory stimuli, activated macrophages/monocytes secrete cytokines, growth factors, and inflammatory mediators including interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), nitric oxide (NO), prostaglandin E2, and reactive oxygen species (ROS) which will cause inflammation injury [4, 5]. Excessive NO will rapidly combine with superoxide anion ( ) to generate
Dynamic Hierarchical Sleep Scheduling for Wireless Ad-Hoc Sensor Networks
Chih-Yu Wen,Ying-Chih Chen
Sensors , 2009, DOI: 10.3390/s90503908
Abstract: This paper presents two scheduling management schemes for wireless sensor networks, which manage the sensors by utilizing the hierarchical network structure and allocate network resources efficiently. A local criterion is used to simultaneously establish the sensing coverage and connectivity such that dynamic cluster-based sleep scheduling can be achieved. The proposed schemes are simulated and analyzed to abstract the network behaviors in a number of settings. The experimental results show that the proposed algorithms provide efficient network power control and can achieve high scalability in wireless sensor networks.
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