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Search Results: 1 - 10 of 80878 matches for " Yinan Liu "
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Expression Profile of Epithelial Protein Lost in Neoplasm-Alpha (EPLIN-α) in Human Pulmonary Cancer and Its Impact on SKMES-1 Cells in vitro  [PDF]
Yinan Liu, Andrew J. Sanders, Lijian Zhang, Wen G. Jiang
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.324058
Abstract: Epithelial Protein Lost in Neoplasm (EPLIN) is a cytoskeletal associated protein implicated in regulating actin dynamoics and cellular motility and whose expression is frequently downregulated in a number of human cancers. The current study examined the expression levels of EPLIN-α in a pulmonary cancer cohort and its association with clinical pathological factors using quantitative polymerase chain reaction. Additionally, EPLIN-α was over-expressed in the SKMES-1 pulmonary cancer cell line through transfection with a plasmid containing the expression sequence for EPLIN-α. The role of EPLIN-α was subsequently examined using a variety of in vitro functional assays. Decreased levels of EPLIN-α were seen in cancerous tissues compared to normal background tissue. Lower levels of EPLIN-α were also associated with higher TNM stage and nodal involvement. In vitro over-expression of EPLIN-α inhibited SKMES-1 growth rates (p = 0.05 vs. plasmid control) and motility (p = 0.002 vs. plasmid control), though did not have any significant effects on cell-matrix adhesion or cell invasion. Taken together, the current study indicates that lower levels of EPLIN-α may be associated with poorer prognosis and more advanced pulmonary cancer, where this molecule appears to play a suppressive role on cell growth and migration.
Chinese Tibetan Guozhuang Dance from the Perspective of Sports
Qian Liu,Jianqiang Wang,Yinan Qin
Asian Social Science , 2012, DOI: 10.5539/ass.v8n7p240
Abstract: The authors study Chinese Tibetan Guozhuang dance from the perspective of sports. And they discover that Guozhuang dance has such features as national tradition, holistic arts and public entertainment, etc., and is a kind of national traditional sports activity that has low requirements for sports field, has robust and straight movement, no much exercise intensity and in which the movement amount can be randomly adjusted to satisfy the movement aesthetic requirement. In the process of development, it has manifested such important historical and cultural value as strengthening Chinese Tibetan national cohesion, extending and inheriting Chinese Tibetan culture and promoting different national cultural communication, etc. In the realistic life of the areas where Chinese Tibetans inhabit, Guozhuang dance also has such important sports value as promoting Chinese Tibetan people's physical and psychological health, facilitating social sports, school sports and sports tourism development, etc.
Determination of Triclocarban, Triclosan and Methyl-Triclosan in Environmental Water by Silicon Dioxide/Polystyrene Composite Microspheres Solid-Phase Extraction Combined with HPLC-ESI-MS  [PDF]
Yinan Wang, Pengfei Li, Yan Liu, Bing Chen, Jinyu Li, Xikui Wang
Journal of Geoscience and Environment Protection (GEP) , 2013, DOI: 10.4236/gep.2013.12003
Abstract: This paper developed a sensitive and efficient analytical method for triclocarban (TCC), triclosan (TCS) and Methyl-triclosan (MTCS) determination in environmental water, which involves enrichment by using silicon dioxide/polystyrene composite microspheres solid-phase extraction and detection with HPLC-ESI-MS. The influence of several operational parameters, including the eluant and its volume, the flow rate and acidity of water sample were investigated and optimized. Under the optimum conditions, the limits of detection were 1.0 ng/L, 2.5 and 4.5 ng/L for TCC, TCS, and MTCS, respectively. The linearity of the method was observed in the range of 5-2000 ng/L, with correlation coefficients (r2) >.99. The spiked recoveries of TCC, TCS and MTCS in water sampleswereachieved in the range of 89.5% -96.8% with RSD below 5.7%. The proposed method has been successfully applied to analyze real water samples and satisfactory results were achieved.
Computing finite abstractions with robustness margins via local reachable set over-approximation
Yinan Li,Jun Liu,Necmiye Ozay
Mathematics , 2015,
Abstract: This paper proposes a method to compute finite abstractions that can be used for synthesizing robust hybrid control strategies for nonlinear systems. Most existing methods for computing finite abstractions utilize some global, analytical function to provide bounds on the reachable sets of nonlinear systems, which can be conservative and lead to spurious transitions in the abstract systems. This problem is even more pronounced in the presence of imperfect measurements and modelling uncertainties, where control synthesis can easily become infeasible due to added spurious transitions. To mitigate this problem, we propose to compute finite abstractions with robustness margins by over-approximating the local reachable sets of nonlinear systems. We do so by linearizing the nonlinear dynamics into linear affine systems and keeping track of the linearization error. It is shown that this approach provides tighter approximations and several numerical examples are used to illustrate of effectiveness of the proposed methods.
Isolation of Immune-Relating 185/333-1 Gene from Sea Urchin(Strongylocentrotus intermedius) and Its Expression Analysis Isolation of Immune-Relating 185/333-1 Gene from Sea Urchin(Strongylocentrotus intermedius) and Its Expression Analysis
WANG Yinan,DING Jun,LIU Yang,LIU Xuewei,CHANG Yaqing
- , 2016,
Abstract: The 185/333 gene family involved in the immune response of sea urchin.One 185/333 c DNA was isolated from Strongylocentrotus intermedius,and named as Si185/333-1.Its full-length c DNA was 1246 bp in length with a 906 bp open reading frame encoding a protein of 301 aa.The molecular weight of the deduced protein was approximately 33.1 k D with an estimated PI of p H 6.26.Si185/333-1 had high identities(70%–86%) to most of Sp185/333.An extraordinary identity of 92% was found between Si185/333-1 and Sp185/333 C5 alpha(ABR22474).Moderate identities(63%–64%) were displayed between Si185/333-1 and He185/333.Si185/333-1 had similar structure to Sp185/333.A signal-peptide,a gly-rich region and a his-rich region were found in its secondary structure.RGD motif was found in gly-rich region at position 116–118aa.There was no transmembrane region in Si185/333-1.The element pattern of Si185/333-1 is different from any available pattern that identified in Sp185/333.Si185/333-1 clustered together with pattern C Sp185/333 in phylogenetic tree.The Si185/333-1 m RNA could be detected in tissues including peristomial membrane,coelomocytes,muscle of Aristotles lantern,gut and tube feet,with the highest expression level detected in peristomial membrane and a relatively low expression in ovary and testis.The temporal expression of Si185/333-1 in peristomial membrane and coelomocytes were up-regulated after bacterial,β-D-glucan and ds RNA challenges,reaching the maximum at 12 h post-stimulation.The up-regulation was more obvious in coelomocytes,and bacterial challenge triggered the highest response.These results proved that 185/333-1 gene was involved in the immune defense of S.intermedius,while more studies were necessary for its function in S.intermedius immunity
Nonlinear Adaptive Block Backstepping Control Using Command Filter and Neural Networks Approximation
Cao Lijia,Zhang Shengxiu,Li Xiaofeng,Liu Yinan
Information Technology Journal , 2011,
Abstract: A nonlinear adaptive block backstepping control approach is designed for a class of n-th order Multiple-input Multiple-output (MIMO) nonlinear systems with uncertainties and disturbances. The problem of explosion of complexity in traditional backstepping is avoided by using command filter to replace the differentiations of virtual control law. Radial Basis Function Neural Networks (RBF NNs) are employed to adaptively approximate the unknown nonlinear functions. The closed-loop system is guaranteed to be bounded and tracking errors are also proved to converge exponentially to a small residual set around the origin by Lyapunov approach. The nonlinear six Degrees-of-freedom (DOF) flight simulation on an Unmanned Aerial Vehicle (UAV) model is provided to demonstrate the effectiveness of the designed control scheme.
Random Forest in Clinical Metabolomics for Phenotypic Discrimination and Biomarker Selection
Tianlu Chen,Yu Cao,Yinan Zhang,Jiajian Liu
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/298183
Abstract:
Compression behavior and equation of state of Ni77P23 amorphous alloy
LI Gong,GAO YunPeng,SUN YiNan,MA MingZhen,LIU Jing,LIU RiPing,
LI
,Gong,GAO,YunPeng,SUN,YiNan,MA,MingZhen,LIU,Jing,LIU,RiPing

科学通报(英文版) , 2007,
Abstract: The compression behavior of Ni77P23 amorphous alloy is investigated at room temperature in a diamond-anvil cell instrument using in-situ high pressure energy dispersive X-ray diffraction with a synchrotron radiation source. The equation of state is determined by fitting the experimental data according to Birch-Murnaghan equation: ΔV/V 0=0.08606P 3.2×10 4 P 2+5.7×10 6 P 3. It is found that the structure of Ni77P23 amorphous alloy is stable under pressures up to 30.5 GPa. Supported by the National Natural Science Foundation of China (Grant No. 50325103), Hebei Natural Science Foundation (Grant No. 503278), and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry and SKPBRC (Grant No. 2006CB605201)
Compression behavior and equation of state of Ni77P23 amorphous alloy
Gong Li,YunPeng Gao,YiNan Sun,MingZhen Ma,Jing Liu,RiPing Liu
Chinese Science Bulletin , 2007, DOI: 10.1007/s11434-007-0067-6
Abstract: The compression behavior of Ni77P23 amorphous alloy is investigated at room temperature in a diamond-anvil cell instrument using in-situ high pressure energy dispersive X-ray diffraction with a synchrotron radiation source. The equation of state is determined by fitting the experimental data according to Birch-Murnaghan equation: ΔV/V 0=0.08606P 3.2×10 4 P 2+5.7×10 6 P 3. It is found that the structure of Ni77P23 amorphous alloy is stable under pressures up to 30.5 GPa.
ISL1 Promotes Pancreatic Islet Cell Proliferation
Ting Guo, Weiping Wang, Hui Zhang, Yinan Liu, Ping Chen, Kangtao Ma, Chunyan Zhou
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0022387
Abstract: Background Islet 1 (ISL1), a LIM-homeodomain transcription factor is essential for promoting pancreatic islets proliferation and maintaining endocrine cells survival in embryonic and postnatal pancreatic islets. However, how ISL1 exerts the role in adult islets is, to date, not clear. Methodology/Principal Findings Our results show that ISL1 expression was up-regulated at the mRNA level both in cultured pancreatic cells undergoing glucose oxidase stimulation as well in type 1 and type 2 diabetes mouse models. The knockdown of ISL1 expression increased the apoptosis level of HIT-T15 pancreatic islet cells. Using HIT-T15 and primary adult islet cells as cell models, we show that ISL1 promoted adult pancreatic islet cell proliferation with increased c-Myc and CyclinD1 transcription, while knockdown of ISL1 increased the proportion of cells in G1 phase and decreased the proportion of cells in G2/M and S phases. Further investigation shows that ISL1 activated both c-Myc and CyclinD1 transcription through direct binding on their promoters. Conclusions/Significance ISL1 promoted adult pancreatic islet cell proliferation and probably by activating c-Myc and CyclinD1 transcription through direct binding on their promoters. Our findings extend the knowledge about the crucial role of ISL1 in maintaining mature islet cells homeostasis. Our results also provide insights into the new regulation relationships between ISL1 and other growth factors.
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