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Search Results: 1 - 10 of 42552 matches for " YiYao Xu "
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The Developing Trend of Independent Designer Brands and Brand Managing Company in China  [PDF]
Yiyao Zhu
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.311013
Abstract: Recent years, more and more independent designer brands have stepped into public’s awareness, becoming a newly emerging force of online apparel sales. In this context, brand managing company and corresponding electronic business platform only for independent designer brands emerge gradually as the time requires. Brand managing company means a company who possesses or cooperates with many independent designer brands. Some of these brand managing companies are originated from traditional fashion apparel company. The objective of this research is to describe and explain the developing trend of the apparel industry, brand managing company and independent designers in China. And the outline is also according to these three parts.
Adult congenital diaphragmatic hernia of the liver: a rare case report
LiGuo Liu,YiYao Xu,YiLei Mao,XinTing Sang,ZhiYing Yang,Xin Lu,ShouXian Zhong,JieFu Huang
Science China Life Sciences , 2010, DOI: 10.1007/s11427-010-0022-7
The role and clinical implications of microRNAs in hepatocellular carcinoma
Xue Zhao,Zhen Yang,GuangBing Li,DongKai Li,Yi Zhao,Yan Wu,Simon C. Robson,Lian He,YiYao Xu,RuoYu Miao,HaiTao Zhao
Science China Life Sciences , 2012, DOI: 10.1007/s11427-012-4384-x
Abstract: Hepatocellular carcinoma (HCC) is common and one of the most aggressive of all human cancers. Recent studies have indicated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early diagnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumorigenesis.
Preparation, characterization and release of methyl viologen from a novel nanoparticle delivery system with double shells of silica and PLGA
Hong Yang,Hirokazu Miyoshi,ChangChun Lou,ZhengLong Ren,YiYao Liu
Chinese Science Bulletin , 2010, DOI: 10.1007/s11434-009-0561-0
Abstract: The use of nanotechnology in drug delivery is a rapidly expanding field. Biodegradable or nontoxic nanomaterials have the most promising application potentials in nanomedicine. Herein, we report a novel core-shell nanoparticle with double shell coatings (silica and poly(D,L-lactide-co-glycolide) (PLGA)) with the total shell thickness of (8.7 ± 1.3) nm. The outer shell of PLGA is biodegradable and used for controlled and sustained release, and the inner shell of silica is mesoporous for the preservation of the chemical radiation therapeutic of methyl viologen (MV), an oxidant that produces reactive oxygen species during cancer radiation therapy. The dissolution time course data and transmission electron microscopy images showed that the novel nanoparticles (Au@SiO2&PLGA) have been successfully prepared, and silica and PLGA coated well the gold (Au) template surfaces. Nanocapsules (MV@SiO2&PLGA) were obtained after the gold templates were dissolved using sodium cyanide. The sustained release property was characterized through detecting fluorescence quenching time course of fluorescent isothiocyanate after mixing with MV@SiO2&PLGA nanocapsules that encapsulate MV molecules. The sustained release of MV molecules could be extended to approximately four weeks. This novel delivery system has high potential in future application for the delivery of therapeutic drugs, particularly for the treatment of cancer by radiation therapy.
The Roles of Platelet GPIIb/IIIa and αvβ3 Integrins during HeLa Cells Adhesion, Migration, and Invasion to Monolayer Endothelium under Static and Dynamic Shear Flow
Yiyao Liu,Fenglong Zhao,Wentian Gu,Haishiu Yang,Quoquan Meng,Yunxiang Zhang,Hong Yang,Qi Duan
Journal of Biomedicine and Biotechnology , 2009, DOI: 10.1155/2009/829243
Abstract: During their passage through the circulatory system, tumor cells undergo extensive interactions with various host cells including endothelial cells and platelets. Mechanisms mediating tumor cell adhesion, migration, and metastasis to vessel wall under flow condition are largely unknown. The aim of this study was to investigate the potential roles of GPIIb/IIIa and 3 integrins underlying the HeLa-endothelium interaction in static and dynamic flow conditions. HeLa cell migration and invasion were studied by using Millicell cell culture insert system. The numbers of transmigrated or invaded HeLa cells significantly increased by thrombin-activated platelets and reduced by eptifibatide, a platelet inhibitor. Meanwhile, RGDWE peptides, a specific inhibitor of 3 integrin, also inhibited HeLa cell transmigration. Interestingly, the presence of endothelial cells had significant effect on HeLa cell migration regardless of static or cocultured flow condition. The adhesion capability of HeLa cells to endothelial monolayer was also significantly affected by GPIIb/IIIa and 3 integrins. The arrested HeLa cells increased nearly 5-fold in the presence of thrombin-activated platelets at shear stress condition (1.84 dyn/cm2 exposure for 1 hour) than the control (static). Our findings showed that GPIIb/IIIa and 3 integrins are important mediators in the pathology of cervical cancer and provide a molecular basis for the future therapy, and the efficient antitumor benefit should target multiple receptors on tumor cells and platelets.
Adaptive evolution and structure modeling of rbcL gene in Ephedra
Nian Liu,QingBiao Wang,Jie Chen,Yong Zhu,Tsering Tashi,YiYao Hu,Fan Chen,Yang Zhong
Chinese Science Bulletin , 2010, DOI: 10.1007/s11434-010-3023-9
Abstract: The adaptive evolution of the rbcL gene in 14 species of Ephedra and 9 other gymnosperms was tested by the PAML program. Three large-scale selections were found in the catalytic region of the RbcL protein by branch model. Species in Ephedra with positive selection at the 365th codon site in rbcL gene were detected by branch-site model. 3D structure modeling showed that the 365th codon could change the spatial structure of the β-sheet (βG, βH, or βE) of the RbcL protein. These changes may be associated with the adaptation of the protein in Ephedra to the environment.
Notch-1 Signaling Promotes the Malignant Features of Human Breast Cancer through NF-κB Activation
Li Li, Fenglong Zhao, Juan Lu, Tingting Li, Hong Yang, Chunhui Wu, Yiyao Liu
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095912
Abstract: The aberrant activation of Notch-1 signaling pathway has been proven to be associated with the development and progression of cancers. However, the specific roles and the underlying mechanisms of Notch-1 signaling pathway on the malignant behaviors of breast cancer are poorly understood. In this study, using multiple cellular and molecular approaches, we demonstrated that activation of Notch-1 signaling pathway promoted the malignant behaviors of MDA-MB-231 cells such as increased cell proliferation, colony formation, adhesion, migration, and invasion, and inhibited apoptosis; whereas deactivation of this signaling pathway led to the reversal of the aforementioned malignant cellular behaviors. Furthermore, we found that activation of Notch-1 signaling pathway triggered the activation of NF-κB signaling pathway and up-regulated the expression of NF-κB target genes including MMP-2/-9, VEGF, Survivin, Bcl-xL, and Cyclin D1. These results suggest that Notch-1 signaling pathway play important roles in promoting the malignant phenotype of breast cancer, which may be mediated partly through the activation of NF-κB signaling pathway. Our results further suggest that targeting Notch-1 signaling pathway may become a newer approach to halt the progression of breast cancer.
An empirical study on the effect of non-interest income business on the comprehensive business performance of listed commercial banks in China

YUE Yiding
, LI Yiyao

- , 2016, DOI: 1672-3104(2016)02-0092-07
Abstract: 摘 要: 以往学术界通常采用总资产收益率和股权收益率两个指标衡量银行的经营绩效,而这两个指标仅仅只能反映银行的盈利能力,不能全面反映银行的经营绩效。考虑到这两个指标的局限性,通过考察上市商业银行盈利性、流动性、风险性、清偿能力及安全性,应用银行综合经营绩效来衡量银行经营绩效,选取沪深两市16家上市商业银行2007―2014年的相关数据,构建面板回归模型分析了非利息收入业务对上市商业银行综合经营绩效的影响。研究结果表明,非利息收入业务与上市国有控股商业银行综合经营绩效显著负相关,与上市股份制商业银行综合经营绩效显著正相关。
Abstract: In the past, the academic circles in our country generally used the total assets return rate and the stock return rate of two indicators to measure the bank’s business performance, but these two indicators could only reflect the profitability of the banks rather than the business performance of the banks. The present study, by considering the limitations of these two indicators, adopts the bank’s comprehensive business performance to measure business performance, selects data from 16 listed commercial banks from 2007 to 2014 as a sample, lists profitability, liquidity, risk, solvency and security, and constructs the panel data regression model to analyze the effect of non-interest income on the performance of listed commercial banks in China. Research results show that the non-interest income has a significant negative correlation with the performance of listed state-owned commercial banks. And non-interest income has a significant positive correlation with the performance of listed joint-stock commercial banks
Serious diarrhea with weight loss caused by Capillaria philippinensis acquired in China: a case report
Zhigang Fan, Yongdong Huang, Shiyun Qian, Gang Lv, Yiyao Chen, Bo Yang, Saifeng Zhong, Guifen Lin, Guogang Yan
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-554
Abstract: A 33-year-old woman from the outskirts of Danzhou city, Hainan province, China, had an 11-month history of chronic diarrhea with abdominal pain, edema, hypoalbuminemia, and severe weight loss. The patient was misdiagnosed at an outpatient clinic and one hospital. She was finally correctly diagnosed with C. philippinensis by stool examination. The patient was given a 30-days course of albendazole (400 mg/day) and had an uneventful and stable recovery.Doctors cannot lose sight of patients’ dietary histories, must query stool examination results, and need to expand their knowledge of certain nonlocal and global diseases, especially those described in new case reports. Some diagnostic examinations must be performed repeatedly. Hainan province may be the epidemic focus of C. philippinensis.Parasites are rarely suspected as causes for diarrheal episodes because of their decreasing infestation rates and endemic zones. Capillaria philippinensis (C. philippinensis) is a rare food-borne nematodiasis that has appeared in more than 12 regions or countries worldwide, including the Philippines [1], Indonesia [2], Thailand [3], Lao People’s Democratic Republic [4], India [5], Iran [6], Korea [7], and Japan [8]. More than 2000 cases involving almost 200 deaths have been documented worldwide. However, no cases have been reported in China with the exception of Taiwan province [9-11]. C. philippinensis may cause diarrhea, hypoalbuminemia, and death in humans [8,12]. We herein report a case of serious diarrhea with weight loss caused by C. philippinensis from Hainan province in China.A 33-year-old woman came from the outskirts of Danzhou city, Hainan province, China. In April 2010, she reported an 11-month history of recurrent diarrhea associated with colicky pain. The watery diarrhea had persisted since May 2009, occurring about three to four times daily. She also experienced weight loss of 12.5 kg. She was admitted to an outpatient clinic and one hospital in Danzhou. Since May 2009 t
Automatic Identification of Motion Artifacts in EHG Recording for Robust Analysis of Uterine Contractions
Yiyao Ye-Lin,Javier Garcia-Casado,Gema Prats-Boluda,José Alberola-Rubio,Alfredo Perales
Computational and Mathematical Methods in Medicine , 2014, DOI: 10.1155/2014/470786
Abstract: Electrohysterography (EHG) is a noninvasive technique for monitoring uterine electrical activity. However, the presence of artifacts in the EHG signal may give rise to erroneous interpretations and make it difficult to extract useful information from these recordings. The aim of this work was to develop an automatic system of segmenting EHG recordings that distinguishes between uterine contractions and artifacts. Firstly, the segmentation is performed using an algorithm that generates the TOCO-like signal derived from the EHG and detects windows with significant changes in amplitude. After that, these segments are classified in two groups: artifacted and nonartifacted signals. To develop a classifier, a total of eleven spectral, temporal, and nonlinear features were calculated from EHG signal windows from 12 women in the first stage of labor that had previously been classified by experts. The combination of characteristics that led to the highest degree of accuracy in detecting artifacts was then determined. The results showed that it is possible to obtain automatic detection of motion artifacts in segmented EHG recordings with a precision of 92.2% using only seven features. The proposed algorithm and classifier together compose a useful tool for analyzing EHG signals and would help to promote clinical applications of this technique. 1. Introduction Monitoring uterine contractions is commonly used to estimate the time of an approaching labour. In spite of the fact that intrauterine pressure (IUP) is regarded as the gold standard in monitoring these contractions, its use in clinical practice is limited since it requires rupturing the membranes to place a catheter inside the uterus. This not only leads to delivery but may also increase the risk of intrapartum infection [1]. Hospitals often use a pressure transducer (TOCOdynamometer or TOCO) placed on the mother’s abdomen for basic noninvasive monitoring of uterine activity, thus obtaining the frequency and duration of contractions. However, the TOCO is not a reliable technique, as the measurements obtained are by no means precise and depend to a large extent on the subjective criteria of the operator [2–4]. Neither do they provide much additional information on the efficiency of contractions in order to decide whether parturition is near. However, in spite of these disadvantages, the technique is widely used in maternity clinics due to its non-invasive nature. The electrohysterogram (EHG) is the recording of uterine electrical activity from the abdominal surface. Earlier studies have shown that the EHG
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