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Search Results: 1 - 10 of 186219 matches for " Yi-Yang Li "
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Effects of Qushi Huayu Decoction in prevention and treatment of fatty liver in rats based on adiponection-free fatty acid pathway
Hong-shan LI,Yi-yang HU
Zhong Xi Yi Jie He Xue Bao , 2009,
Abstract: Objective: To explore the effects of Qushi Huayu Decoction (QSHYD), a compound traditional Chinese herbal medicine, in prevention and treatment of non-alcoholic fatty liver disease (NAFLD) in rats.Methods: Forty Wistar male rats were used to establish the NAFLD model by subcutaneous injection of carbon tetrachloride (CCl4) for 4 weeks (twice weekly) along with high-fat and low-protein diet for 2 weeks. After two-week administration, the rats were randomly divided into four groups: untreated group, high-dose QSHYD group, medium-dose QSHYD group and low-dose QSHYD group. Another six rats were used as normal control. After 2-week treatment, the following indexes were detected: (1) liver pathology; (2) contents of serum adiponectin (ADP) and liver triglyceride (TG); (3) concentrations of liver FFA, adiponectin receptor 2 (AdipoR2), malonyl-coenzyme A (malony1-CoA), AMP-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACCase), fatty acid synthase (FAS) and carnitine palmitoyl transferase-1 (CPT-1). Results: Compared with the normal group, there were physiological changes associated with hepatic steatosis and inflammation in liver tissues in the untreated group as observed by oil red O staining and HE staining. The TG, FFA, malony1-CoA, FAS, and ACCase concentrations in liver tissues in the untreated group were elevated significantly. While the contents of ADP in serum and AdipoR2, CPT-1 and AMPK in liver tissues in the untreated group were decreased markedly. The pathological damages in each QSHYD-treated group were significantly less than those in the untreated group. The TG and FFA contents in liver tissues in each QSHYD-treated group were significantly decreased. The FAS, ACCase and malonyl-CoA concentrations in liver tissues of the high QSHYD-treated group were reduced markedly as compared with the untreated group. High- and medium-dose of QSHYD could significantly increase ADP content in serum and AMPK, CPT-1 and AdipoR2 contents in liver tissues. Conclusion: QSHYD can affect the ADP-FFA pathway by increasing the content of serum ADP, which may be one of its important mechanisms in preventing and treating NAFLD in rats.
A criterion for irreducibility of parabolic baby Verma modules of reductive Lie algebras
Yi-Yang Li,Bin Shu,Yu-Feng Yao
Mathematics , 2014,
Abstract: Let $G$ be a connected, reductive algebraic group over an algebraically closed field $k$ of prime characteristic $p$ and $\mathfrak{g}=Lie(G)$. In this paper, we study representations of $\mathfrak{g}$ with a $p$-character $\chi$ of standard Levi form. When $\mathfrak{g}$ is of type $A_n, B_n, C_n$ or $D_n$, a sufficient condition for the irreducibility of standard parabolic baby Verma $\mathfrak{g}$-modules is obtained. This partially answers a question raised by Friedlander and Parshall in [Friedlander E. M. and Parshall B. J., Deformations of Lie algebra representations, Amer. J. Math. 112 (1990), 375-395]. Moreover, as an application, in the special case that $\mathfrak{g}$ is of type $A_n$ or $B_n$, and $\chi$ lies in the sub-regular nilpotent orbit, we recover a result of Jantzen in [Jantzen J. C., Subregular nilpotent representations of $sl_n$ and $so_{2n+1}$, Math. Proc. Cambridge Philos. Soc. 126 (1999), 223-257].
Apolipoprotein A1/C3/A5 haplotypes and serum lipid levels
Rui-Xing Yin, Yi-Yang Li, Chao-Qiang Lai
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-140
Abstract: A total of 1030 unrelated subjects (492 males and 538 females) aged 15-89 were randomly selected from our previous stratified randomized cluster samples. Genotyping of the ApoA1 -75 bp G>A, ApoC3 3238C>G, ApoA5 -1131T>C, ApoA5 c.553G>T and ApoA5 c.457G>A was performed by polymerse chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing. Pair-wise linkage disequilibria and haplotype analysis among the five SNPs were estimated.The levels of high-density lipoprotein cholesterol (HDL-C) and ApoA1 were lower in males than in femailes (P < 0.05 for each). The allelic and genotypic frequencies of the SNPs were no significant difference between males and females except ApoC3 3238C>G. There were 11 haplotypes with a frequency >1% identified in the cluster in our population. At the global level, the haplotypes comprised of all five SNPs were significantly associated with all seven lipid traits. In particular, haplotype G-G-C-C-A (6%; in the order of ApoA5 c.553G>T, ApoA5 c.457G>A, ApoA5 -1131T>C, ApoC3 3238C>G, and ApoA1 -75bp G>A) and G-A-T-C-G (4%) showed consistent association with total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), ApoA1, ApoB, and the ApoA1/ApoB ratio. In addition, carriers of haplotype G-G-T-C-G (26%) had increased serum concentration of HDL-C and ApoA1, whereas carriers of G-G-C-G-G (15%) had high concentrations of TC, triglyceride (TG) and ApoB. We also found that haplotypes with five SNPs explain much more serum lipid variation than any single SNP alone, especially for TG (4.4% for haplotype vs. 2.4% for -1131T>C max based on R-square) and HDL-C (5.1% for haplotype vs. 0.9% for c.553G>T based on R-square). Serum lipid parameters were also correlated with genotypes and several environment factors.Several common SNPs and their haplotypes in the ApoA1/C3/A5 gene cluster are closely associated with modifications of serum lipid parameters in the general Chinese
MicroRNAs and cancer-associated signal transduction pathways
MicroRNA与肿瘤相关的信号转导通路

WU Yi-Yang,LI LING Jesse,
吴易阳
,李岭

遗传 , 2007,
Abstract: 信号转导通路在细胞代谢、生长、增殖、应激、发育和凋亡等生命活动中具有极为重要的作用.干扰这些通路将可能影响细胞的正常发育,甚至导致肿瘤.MicroRNA(miRNA)是近年来在真核生物中发现的、在转录后水平负调节基因表达的一类长度约22个核苷酸的非编码小RNA,其靶基因数目众多,生物学功能广泛.在多种肿瘤中发现了miRNA的异常表达,提示后者与肿瘤发生有关,可能机制为调控癌基因或肿瘤抑制基因的表达.此外亦发现miRNA的靶基因有许多作用于肿瘤相关的信号转导通路.miRNA在肿瘤发生过程中的重要调控功能预示其将成为人类癌症诊断和治疗方面的新星.
Interactions of the Apolipoprotein A5 Gene Polymorphisms and Alcohol Consumption on Serum Lipid Levels
Rui-Xing Yin,Yi-Yang Li,Wan-Ying Liu,Lin Zhang,Jin-Zhen Wu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017954
Abstract: Little is known about the interactions of apolipoprotein (Apo) A5 gene polymorphisms and alcohol consumption on serum lipid profiles. The present study was undertaken to detect the interactions of ApoA5–1131T>C, c.553G>T and c.457G>A polymorphisms and alcohol consumption on serum lipid levels.
Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells
Yi-Yang Hu, Min-Hua Zheng, Gang Cheng, Liang Li, Liang Liang, Fang Gao, Ya-Ning Wei, Luo-An Fu, Hua Han
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-82
Abstract: We isolated and cultivate human GSCs from glioma patient specimens. Then on parallel comparison with NSCs, we inhibited Notch signaling using γ-secretase inhibitors (GSI) and assessed the potential functions of Notch signaling in human GSCs.Similar to the GSI-treated NSCs, the number of the primary and secondary tumor spheres from GSI-treated GSCs decreased significantly, suggesting that the proliferation and self-renewal ability of GSI-treated GSCs were attenuated. GSI-treated GSCs showed increased differentiation into mature neural cell types in differentiation medium, similar to GSI-treated NSCs. Next, we found that GSI-treated tumor spheres were composed of more intermediate progenitors instead of CSCs, compared with the controls. Interestingly, although inhibition of Notch signaling decreased the ratio of proliferating NSCs in long term culture, we found that the ratio of G2+M phase-GSCs were almost undisturbed on GSI treatment within 72 h.These data indicate that like NSCs, Notch signaling maintains the patient-derived GSCs by promoting their self-renewal and inhibiting their differentiation, and support that Notch signal inhibitor GSI might be a prosperous candidate of the treatment targeting CSCs for gliomas, however, with GSI-resistance at the early stage of GSCs cell cycle.Glioma, the most common tumor of the central nervous system (CNS), frequently leads to death. Glioma is derived from brain glial tissue and comprises several diverse tumor forms and grades. Treatment of malignant gliomas is often palliative due to their infiltrating nature and high recurrence. Despite advances in surgery, chemotherapy and radiation gradually result in therapy-resistance. However, genetic events that lead to gliomas are mostly unknown.Recent researches highlight the importance of cancer-initiating cells in the malignancy of gliomas [1-3]. These cells have been referred to as glioma stem cells (GSC), as they share similarities to normal neural stem cells (NSCs) in the brai
Effects of Qushi Huayu Decoction on cathepsin B and tumor necrosis factor-α expression in rats with non-alcoholic steatohepatitis
Hui ZHANG,Yi-yang HU
Zhong Xi Yi Jie He Xue Bao , 2008,
Abstract: Objective: To study the mechanism of Qushi Huayu Decoction (QHD), a compound of traditional Chinese herbal medicine, in prevention and treatment of non-alcoholic steatohepatitis (NASH).Methods: Thirty-five Wistar male rats were randomly divided into normal group, untreated group, QHD group and Ganle (diisopropylamine dichloroacetate) group. The rats except those in normal group were subcutaneously injected with carbon tetrachloride (CCl4) for 4 weeks (twice per week) and simultaneously fed with high-fat and low-protein diet for 2 weeks to induce NASH. Then, the rats were administrated with QHD, Ganle, or distilled water for 2 weeks, respectively. After harvest, alanine aminotransferase (ALT) activity and tumor necrosis factor-α (TNF-α) content in serum as well as triglyceride (TG) and free fatty acid (FFA) in liver tissue were evaluated, and relativity analysis among these parameters was performed. Cathepsin B (Ctsb), phospho-inhibitor kappa B (P-IκB), TNF-α protein expressions in liver tissue were assayed with western-blot. The expression and distribution of ctsb in liver tissue were observed with immunohistochemical method. Results: The contents of TG, FFA and activity of ALT were significantly decreased in QHD group. While in the Ganle group, only the activity of ALT in serum was decreased significantly. Expressions of Ctsb, P-IκB and TNF-α proteins in liver tissues and serum TNF-α level were all enhanced in untreated group which, however, were significantly inhibited in the QHD group. And as expected, there were significant relativities among contents of TG in liver tissues and the content of FFA in liver tissue and activity of ALT in serum, content of TNF-α in serum and content of FFA in liver tissue and activity of ALT in serum. Conclusion: The inhibiting effects of QHD on fat deposition and inflammation in liver are related with its inhibition on the "FFA-Ctsb-TNF-α" pathway of lipo-toxicity.
Effect of JIANPI HUOXUE decoction on inflammatory cytokine secretion pathway in rat liver with lipopolysaccharide challenge
Jing-Hua Peng, Yi-Yang Hu, Yang Cheng, Chong Han, Li-Li Xu, Qin Feng, Shao-Dong Chen, Qing Tao, Hong-Shan Li, Xue-Mei Li
World Journal of Gastroenterology , 2008,
Abstract: AIM: To evaluate the effect of Chinese traditional medicinal prescription, JIANPI HUOXUE decoction (JHD) on cytokine secretion pathway in rat liver induced by lipopolysaccharide (LPS).METHODS: Twenty-four male SD rats were divided into normal group (n = 4), model group (n = 10) and JHD group (n = 10) randomly. Rats in model group and JHD group were administrated with normal saline or JHD via gastrogavage respectively twice a day for 3 d. One hour after the last administration, rats were injected with LPS via tail vein, 50 μg/kg. Simultaneously, rats in normal group were injected with equivalent normal saline. After LPS stimulation for 1.5 h, serum and liver tissue were collected. Pathological change of liver tissues was observed through hematoxylin-eosin (H.E.) staining. Tumor necrosis factor alpha (TNF-α) in serum were assayed by enzyme linked immunosorbent assay (ELISA). The protein expression of TNF-α, phosphorylated inhibit-κB (p-IκB) and CD68 in liver were assayed by Western blot. The distribution of CD68 protein in liver was observed through immunohistochemical staining. The mRNA expression of TNF-α, interleukin-6 (IL-6), CD14, toll-like receptor 2 (TLR2) and TLR4 in liver were assayed by real-time RT-PCR.RESULTS: Predominant microvesicular change, hepatocyte tumefaction and cytoplasm dilution were observed in liver tissues after LPS administration as well as obvious CD68 positive staining in hepatic sinusoidal. After LPS stimulation, serum TNF-α (31.35 ± 6.06 vs 12 225.40 ± 9007.03, P < 0.05), protein expression of CD68 (1.13 ± 0.49 vs 3.36 ± 1.69, P < 0.05), p-IκB (0.01 ± 0.01 vs 2.07 ± 0.83, P < 0.01) and TNF-α (0.27 ± 0.13 vs 1.29 ± 0.37, P < 0.01) in liver and mRNA expression of TNF-α (1.96 ± 2.23 vs 21.45 ± 6.00, P < 0.01), IL-6 (4.80 ± 6.42 vs 193.50 ± 36.36, P < 0.01) and TLR2 (1.44 ± 0.62 vs 4.16 ± 0.08, P < 0.01) in liver were also increased significantly. These pathological changes were all improved in JHD group. On the other hand, TLR4 mRNA (1.22 ± 0.30 vs 0.50 ± 0.15, P < 0.05) was down-regulated and CD14 mRNA increased but not significantly after LPS stimulation.CONCLUSION: JHD can inhibit cytokine secretion pathway induced by LPS in rat liver, which is probably associated with its regulation on CD68, p-IκB and endotoxin receptor TLR2.
Two-dimensional ecological mathematical model of red tide and its application in the Bohai Sea
二维赤潮生态数学模型及其在渤海的应用

LI Da-ming,LIN Yi,SONG Shuang-xia,XIE Yi-yang,HAN Su-qin,LI Pei-yan,
李大鸣
,林毅,宋双霞,解以扬,韩素琴,李培彦

海洋科学 , 2010,
Abstract: 采用ADI 的有限差分方法对不可压缩流体二维浅水环流方程离散和求解, 建立水动力数学模型,用迎风格式离散赤潮生物动力学方程, 通过水动力学和生物动力学相结合的方法, 建立了二维赤潮生态数学模型。将所建立的二维赤潮生态数学模型应用于渤海, 针对渤海海域2004 年6 月11~16 日发生的棕囊藻赤潮进行了数值计算。对EOS/MODIS 卫星拍摄的2004 年6 月份的渤海海区卫星遥感图像进行了处理, 提取出海水中的赤潮信息, 并计算出赤潮面积, 使其与模型计算出的赤潮面积进行对比验证, 结果基本吻合, 表明该模型能够较好地模拟赤潮的生消过程, 为渤海地区的赤潮预报提供了科学依据。
The genetic diversity of Dendrolimus tabulaeformis Tsai et Liu in forests of different stand types
不同林分类型下油松毛虫(Dendrolimus tabulaeformis Tsai et Liu)种群遗传多样性

YUAN Yi-Yang,GAO Bao-Jia,LI Ming,YUAN Sheng-Liang,ZHOU Guo-Na,
袁一杨
,高宝嘉,李明,袁胜亮,周国娜

生态学报 , 2008,
Abstract: Genetic diversity and genetic structure of Dendrolimus tabulaeformis populations in 1 Pinus tabulaeformis- Dahurian larch mixed forest and 2 Pinus tabulaeformis pure forests from Pingquan county were analyzed by using amplified fragment length polymorphism (AFLP),and the environmental conditions of 3 forest communities were also investigated.The results showed that the genetic diversity of populations in pure forests was higher than that in mixed forest.The important factor which influenced the genetic diversity of tabulaeformis in different pure forests was the growth status of forests.Mixed forest has obstructing effect on gene flow.The gene flow between populations was nagetively related with the species abundance of the forest.
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