Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2019 ( 67 )

2018 ( 594 )

2017 ( 528 )

2016 ( 546 )

Custom range...

Search Results: 1 - 10 of 40246 matches for " Yi-Ling Tung "
All listed articles are free for downloading (OA Articles)
Page 1 /40246
Display every page Item
Quantitative Protein Localization Signatures Reveal an Association between Spatial and Functional Divergences of Proteins
Lit-Hsin Loo ,Danai Laksameethanasan,Yi-Ling Tung
PLOS Computational Biology , 2014, DOI: doi/10.1371/journal.pcbi.1003504
Abstract: Protein subcellular localization is a major determinant of protein function. However, this important protein feature is often described in terms of discrete and qualitative categories of subcellular compartments, and therefore it has limited applications in quantitative protein function analyses. Here, we present Protein Localization Analysis and Search Tools (PLAST), an automated analysis framework for constructing and comparing quantitative signatures of protein subcellular localization patterns based on microscopy images. PLAST produces human-interpretable protein localization maps that quantitatively describe the similarities in the localization patterns of proteins and major subcellular compartments, without requiring manual assignment or supervised learning of these compartments. Using the budding yeast Saccharomyces cerevisiae as a model system, we show that PLAST is more accurate than existing, qualitative protein localization annotations in identifying known co-localized proteins. Furthermore, we demonstrate that PLAST can reveal protein localization-function relationships that are not obvious from these annotations. First, we identified proteins that have similar localization patterns and participate in closely-related biological processes, but do not necessarily form stable complexes with each other or localize at the same organelles. Second, we found an association between spatial and functional divergences of proteins during evolution. Surprisingly, as proteins with common ancestors evolve, they tend to develop more diverged subcellular localization patterns, but still occupy similar numbers of compartments. This suggests that divergence of protein localization might be more frequently due to the development of more specific localization patterns over ancestral compartments than the occupation of new compartments. PLAST enables systematic and quantitative analyses of protein localization-function relationships, and will be useful to elucidate protein functions and how these functions were acquired in cells from different organisms or species. A public web interface of PLAST is available at http://plast.bii.a-star.edu.sg.
Behavioral and Synaptic Circuit Features in a Zebrafish Model of Fragile X Syndrome
Ming-Chong Ng, Yi-Ling Yang, Kwok-Tung Lu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0051456
Abstract: Fragile X syndrome (FXS) is the most frequent inherited form of human mental retardation. It is characterized by cognitive impairment and physical and behavioral problems and is caused by the silencing of fmr1 transcription and the absence of the fmr1 protein (FMRP). Recently, animal models of FXS have greatly facilitated the investigation of the molecular and cellular mechanisms of this loss-of-function disorder. The present study was aimed to further characterize the role of FMRP in behavior and synaptic function by using fmr1 knockout zebrafish. In adult zebrafish, we found that fmr1 knockout produces the anxiolytic-like responses of increased exploratory behavior in light/dark and open-field tests and avoidance learning impairment. Furthermore, electrophysiological recordings from telencephalic slice preparations of knockout fish displayed markedly reduced long-term potentiation and enhanced long-term depression compared to wild-type fish; however, basal glutamatergic transmission and presynaptic function at the lateral (Dl) and medial (Dm) division of the dorsal telencephalon synapse remained normal. Taken together, our study not only evaluates the mechanism of FRMP but also suggests that zebrafish have valuable potential as a complementary vertebrate model in studying the molecular pathogenesis of human fragile X syndrome.
Trends of System Management Software Development in the Context of Data Center Management Automation
Yi-Ling Wei
International Journal of Automation and Smart Technology , 2013, DOI: 10.5875/ausmt.v3i2.206
Abstract: In the past, data centers were designed as independent hardware system and management software. With the shift from cloud-computing architecture to integrated system management and with continuing requests for lower costs, data centers are developing in the direction of automated management, which has made data center system management software increasingly important. System management software mainly provides functions like environmental monitoring, automatic control, energy monitoring, which can help data centers with integrated management and maintenance conveniently.
Resveratrol Protects Rats from Aβ-induced Neurotoxicity by the Reduction of iNOS Expression and Lipid Peroxidation
Tai-Chun Huang, Kwok-Tung Lu, Yu-Yuan Peter Wo, Yao-Ju Wu, Yi-Ling Yang
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0029102
Abstract: Alzheimer disease (AD) is an age-dependent neurodegenerative disease characterized by the formation of β–amyloid (Aβ)-containing senile plaque. The disease could be induced by the administration of Aβ peptide, which was also known to upregulate inducible nitric oxide synthase (iNOS) and stimulate neuronal apoptosis. The present study is aimed to elucidate the cellular effect of resveratrol, a natural phytoestrogen with neuroprotective activities, on Aβ-induced hippocampal neuron loss and memory impairment. On adult Sprague-Dawley rats, we found the injection of Aβ could result in a significant impairment in spatial memory, a marked increase in the cellular level of iNOS and lipid peroxidation, and an apparent decrease in the expression of heme oxygenase-1 (HO-1). By combining the treatment with Aβ, resveratrol was able to confer a significant improvement in spatial memory, and protect animals from Aβ-induced neurotoxicity. These neurological protection effects of resveratrol were associated with a reduction in the cellular levels of iNOS and lipid peroxidation and an increase in the production of HO-1. Moreover, the similar neurological and cellular response were also observed when Aβ treatment was combined with the administration of a NOS inhibitor, N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME). These findings strongly implicate that iNOS is involved in the Aβ-induced lipid peroxidation and HO-1 downregulation, and resveratrol protects animals from Aβ-induced neurotoxicity by suppressing iNOS production.
Two New Species of Doronicum Linn. (Compositae) from China

CHEN Yi-Ling,

中国科学院研究生院学报 , 1998,
Eight New Species of the Tribe Senecioneae (Compositae) from China

Chen Yi-Ling,

中国科学院研究生院学报 , 1988,
New Plants from the Hengduan Mountains

Chen Yi-Ling,

中国科学院研究生院学报 , 1990,
Abstract: Two new species of Impatiens (Balsaminaceae) and two new species of Compositae from the Hengduan Mountains of China are described and illustrated.They are I. muliensis, I. hengduanensis, Aster zayuensis and Anaphalis batangensis.
The New Species of the Tribe Senecioneae (Compositae) from China (II)

Chen Yi-ling,

中国科学院研究生院学报 , 1996,
Sinoleontopodium, a New Genus of Compositae from China

Chen Yi-Ling,

中国科学院研究生院学报 , 1985,
The New Speciets of the Tribe Senecioneae (Compositae) from China

Chen Yi-ling,

中国科学院研究生院学报 , 1995,
Page 1 /40246
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.