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Search Results: 1 - 10 of 58165 matches for " Yi-Der Jiang "
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Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Han Chinese Population: A Replication Study and Meta-Analysis
Yi-Cheng Chang, Pi-Hua Liu, Yu-Hsiang Yu, Shan-Shan Kuo, Tien-Jyun Chang, Yi-Der Jiang, Jiun-Yi Nong, Juey-Jen Hwang, Lee-Ming Chuang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095045
Abstract: Background Several genome-wide association studies (GWAS) involving European populations have successfully identified risk genetic variants associated with type 2 diabetes mellitus (T2DM). However, the effects conferred by these variants in Han Chinese population have not yet been fully elucidated. Methods We analyzed the effects of 24 risk genetic variants with reported associations from European GWAS in 3,040 Han Chinese subjects in Taiwan (including 1,520 T2DM cases and 1,520 controls). The discriminative power of the prediction models with and without genotype scores was compared. We further meta-analyzed the association of these variants with T2DM by pooling all candidate-gene association studies conducted in Han Chinese. Results Five risk variants in IGF2BP2 (rs4402960, rs1470579), CDKAL1 (rs10946398), SLC30A8 (rs13266634), and HHEX (rs1111875) genes were nominally associated with T2DM in our samples. The odds ratio was 2.22 (95% confidence interval, 1.81-2.73, P<0.0001) for subjects with the highest genetic score quartile (score>34) as compared with subjects with the lowest quartile (score<29). The incoporation of genotype score into the predictive model increased the C-statistics from 0.627 to 0.657 (P<0.0001). These estimates are very close to those observed in European populations. Gene-environment interaction analysis showed a significant interaction between rs13266634 in SLC30A8 gene and age on T2DM risk (P<0.0001). Further meta-analysis pooling 20 studies in Han Chinese confirmed the association of 10 genetic variants in IGF2BP2, CDKAL1, JAZF1, SCL30A8, HHEX, TCF7L2, EXT2, and FTO genes with T2DM. The effect sizes conferred by these risk variants in Han Chinese were similar to those observed in Europeans but the allele frequencies differ substantially between two populations. Conclusion We confirmed the association of 10 variants identified by European GWAS with T2DM in Han Chinese population. The incorporation of genotype scores into the prediction model led to a small but significant improvement in T2DM prediction.
SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes
Yi-Der Jiang, Yi-Cheng Chang, Yen-Feng Chiu, Tien-Jyun Chang, Hung-Yuan Li, Wen-Hsing Lin, Hsiang-Yu Yuan, Yuan-Tsong Chen, Lee-Ming Chuang
BMC Medical Genetics , 2010, DOI: 10.1186/1471-2350-11-126
Abstract: We genotyped 10 single nucleotide polymorphisms and one microsatellite spanning 34 kb across the SLC2A10 gene in a prospective cohort of 372 diabetic patients. Their association with the development of peripheral arterial disease (PAD) in type 2 diabetic patients was analyzed.At baseline, several common SNPs of SLC2A10 gene were associated with PAD in type 2 diabetic patients. A common haplotype was associated with higher risk of PAD in type 2 diabetic patients (haplotype frequency: 6.3%, P = 0.03; odds ratio [OR]: 14.5; 95% confidence interval [CI]: 1.3- 160.7) at baseline. Over an average follow-up period of 5.7 years, carriers with the risk-conferring haplotype were more likely to develop PAD (P = 0.007; hazard ratio: 6.78; 95% CI: 1.66- 27.6) than were non-carriers. These associations remained significant after adjustment for other risk factors of PAD.Our data demonstrate that genetic polymorphism of the SLC2A10 gene is an independent risk factor for PAD in type 2 diabetes.Peripheral arterial disease (PAD), defined as lower extremity arterial atherosclerosis, is one of most common diseases of the arteries and is a major complication of type 2 diabetes [1]. Conventional cardiovascular risk factors such as aging, smoking, hyperglycemia, hypertension and dyslipidemia have been shown to be associated with PAD [1]. However, the increased risk for atherosclerotic diseases in diabetic patients can be only partially explained by the conventional risk factors [2]. In fact, a high heritability for ankle-brachial blood pressure index (ABI), an index of PAD, has been obtained in Twin studies in Caucasians [3], indicating that additional genetic factors might be involved in the pathogenesis of PAD. In this respect, the search for genetic causes of PAD remains limited [4].Recently, a genetic form of arterial tortuosity syndrome (ATS; OMIM 208050) was reported to be caused by loss-of-function mutations in the SLC2A10 gene encoding the facilitative glucose transporter GLUT10. A
Genetic Variation in the NOC Gene Is Associated with Body Mass Index in Chinese Subjects
Yi-Cheng Chang, Yen-Feng Chiu, Pi-Hua Liu, Siow Wei Hee, Tien-Jyun Chang, Yi-Der Jiang, Wei-Jei Lee, Po-Chu Lee, Hui-Yi Kao, Juey-Jen Hwang, Lee-Ming Chuang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069622
Abstract: Circadian clock genes are critical regulators of energy homeostasis and metabolism. However, whether variation in the circadian genes is associated with metabolic phenotypes in humans remains to be explored. In this study, we systemically genotyped 20 tag single nucleotide polymorphisms (SNPs) in 8 candidate genes involved in circadian clock, including CLOCK, BMAL1(ARNTL), PER1, PER2, CRY1, CRY2, CSNK1E,, and NOC(CCRN4L) in 1,510 non-diabetic Chinese subjects in Taipei and Yunlin populations in Taiwan. Their associations with metabolic phenotypes were analyzed. We found that genetic variation in the NOC gene, rs9684900 was associated with body mass index (BMI) (P = 0.0016, Bonferroni corrected P = 0.032). Another variant, rs135764 in the CSNK1E gene was associated with fasting glucose (P = 0.0023, Bonferroni corrected P = 0.046). These associations were consistent in both Taipei and Yunlin populations. Significant epistatic and joint effects between SNPs on BMI and related phenotypes were observed. Furthermore, NOC mRNA levels in human abdominal adipose tissue were significantly increased in obese subjects compared to non-obese controls. Conclusion Genetic variation in the NOC gene is associated with BMI in Chinese subjects.
Genetic Diversity of Salp15 in the Ixodes ricinus Complex (Acari: Ixodidae)
Xin Wang, Yong Huang, Si-bo Niu, Bao-Gui Jiang, Na Jia, Leo van der Geest, Xue-bing Ni, Yi Sun, Wu-Chun Cao
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094131
Abstract: Salp15, a 15-kDa tick salivary gland protein, is both essential for ticks to successfully obtain host blood and also facilitates transmission of Lyme borreliosis. To determine whether the Salp15 gene is expressed in Ixodes persulcatus and Ixodes sinensis, principle vectors of Lyme borreliosis in China, we studied transcriptions of this gene in semi-engorged larvae, nymph and adults of these two species. A total of eight Salp15 homologues, five in I. persulcatus and three in I. sinensis, were identified by reverse transcriptase–polymerase chain reaction (RT-PCR). Interestingly, the intra-species similarity of Salp15 is approximately equal to its interspecies similarity and more than one Salp15 protein is expressed in a certain tick developmental stage. Comparison of DNA and proteins with other available tick Salp15 homologues suggests that the Salp15 superfamily is genetically conserved and diverse in the Ixodes ricinus complex. These findings indicate that Salp15 proteins in the I. ricinus complex may play an essential role in interacting with the host immune system and transmission of Borrelia genospecies.
Regular Circle Actions on 2-connected 7-manifolds
Yi Jiang
Mathematics , 2013,
Abstract: We determine the homeomorphism (resp. diffeomorphism) types of those 2-connected 7-manifolds (resp. smooth 2-connected 7-manifolds) that admit regular circle actions (resp. smooth regular circle actions).
Topology of certain symplectic conifold transitions of $CP^{1}$-bundles
Yi Jiang
Mathematics , 2015,
Abstract: In this paper, we prove the existence of certain symplectic conifold transitions on all $CP^{1}$-bundles over symplectic 4--manifolds, which generalizes Smith, Thomas and Yau's examples of symplectic conifold transitions on trivial $CP^{1}$-bundles over K\"ahler surfaces. Our main result is to determine the diffeomorphism types of such symplectic conifold transitions of $CP^{1}$-bundles. In particular, this implies that in the case of trivial $CP^{1}$-bundles over projective surfaces, Smith, Thomas and Yau's examples of symplectic conifold transitions are diffeomorphic to K\"ahler 3--folds.
Polyprenol from the Whole Plants of Leucaena leucocephala  [PDF]
Chung-Yi Chen, Yau-Der Wang
Journal of Environmental Protection (JEP) , 2010, DOI: 10.4236/jep.2010.11009
Abstract: Ficaprenol-11 (polyprenol) (1), squalene (2), lupeol (3), ?-sitostenone (4), trans-coumaric acid (5), cis-coumaric acid (6) pheophytin-a (7), pheophorbide a methyl ester (8), methyl-132-hydroxy-(132-S)- pheophorbide-b (9) and aristo-phyll-C (10) were isolated from the whole plants of Leucaena leucocephala (Leguminosae). Among them, 1 and 2 was found for the first time from this species. The structure of these compounds were characterized and identified by spectra analyses.
Steroids from the Whole Plants of Leucaena Leucocephala  [PDF]
Chung-Yi Chen, Yau-Der Wang
American Journal of Analytical Chemistry (AJAC) , 2010, DOI: 10.4236/ajac.2010.11004
Abstract: Four steroids, 5α,8α-epidioxy-(24ξ)-ergosta-6,22-dien-3β-ol (1), β-sitosterol (2), β-sitostenone (3), and stigmastenone (4), along with 10 known compounds were isolated from the whole plants of Leucaena leucocephala (Leguminosae). 1, Lupeol (5), 1,3-dipalmitoyl-2-oleoylglycerol (6), methylparabene (8) and isovanillic acid (9) were found for the first time from the species. The structure of these compounds were characterized and identified by spectra analyses.
Recent developments in fiber optic spectral white-light interferometry
Yi Jiang,Wenhui Ding
Photonic Sensors , 2011, DOI: 10.1007/s13320-010-0014-z
Abstract: Recent developments in spectral white-light interferometry (WLI) are reviewed. Firstly, the techniques for obtaining optical spectrum are introduced. Secondly, some novel measurement techniques are reviewed, including the improved peak-to-peak WLI, improved wavelength-tracking WLI, Fourier transform WLI, and 3 × 3 coupler based WLI. Furthermore, a hybrid measurement for the intensity-type sensors, interferometric sensors, and fiber Bragg grating sensors is achieved. It is shown that these developments have assisted in the progress of WLI.
White Light Interferometry for the Measurement of Extrinsic Fabry-Perot Interferometer

Jiang Yi,

光子学报 , 2006,
Abstract: The white light interferometry for the measurement of low-finesse extrinsic Fabry-Perot interferometer(EFPI) is reported. A broadband light is injected into EFPI,and the reflected light is scanned by another high-finesse tunable Fabry-Perot filter,the periodic spectra of EFPI can be obtained.To measure the cavity length,the spectra are fast Fourier transformed,the absolute length of cavity can be calculated by using the periodic spectra. The measuring accuracy is limited by the length of cavity. The longer cavity has higher measuring accuracy. When the length of cavity are 200 μm,400 μm,and 600 μm respectively,the measured results are agree with the actual length of the cavity.
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