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Search Results: 1 - 10 of 55228 matches for " Yi-Chung Lee "
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Gabapentin for complex regional pain syndrome in Machado-Joseph disease: a case report
Yang-Ching Lo, Kwong-Kum Liao, Yi-Chung Lee, Bing-Wen Soong
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-268
Abstract: A 29-year-old man (Han Chinese, Hoklo) with Machado-Joseph disease experienced severe chronic pain in both feet, cutaneous thermal change, thermal hypersensitivity, focal edema, and sweating and had a history of bone fracture. These symptoms were compatible with a diagnosis of complex regional pain syndrome. After common analgesics failed to relieve his pain, gabapentin was added and titrated to 2000 mg/day (500 mg every six hours) in less than two weeks. This relieved 40% of his pain and led to significant clinical improvement.The pathophysiology of complex regional pain syndrome includes peripheral and central sensitizations, the latter of which might be associated with the neurodegeneration in Machado-Joseph disease. In this report, we suggest that gabapentin could inhibit central sensitization as an adjunct for complex regional pain syndrome in patients with Machado-Joseph disease.Machado-Joseph disease (MJD), also called spinocerebellar ataxia type 3, is the most common subtype of spinocerebellar ataxias worldwide and is caused by a CAG trinucleotide repeat expansion in the coding region of the MJD1 gene. The main features of MJD are ataxia and ophthalmoparesis and pyramidal, extrapyramidal, and amyotrophic signs [1]. Chronic pain is one of the most disabling symptoms of MJD. Nearly 80% of the chronic pain in MJD has been reported to be of musculoskeletal origin [2]. To the best of our knowledge, no previous case report has mentioned complex regional pain syndrome (CRPS) in patients with MJD. In the case reported here, a patient with MJD experienced symptoms of CRPS, which were relieved by gabapentin.A 29-year-old man (Han Chinese, Hoklo) with a diagnosis of MJD and CAG repeat numbers of 14 and 70 in the MJD1 gene had been confined to a wheelchair for three years. He had a history of left humeral bone fracture as a result of an accidental fall one year earlier. Three months prior to his stay in the hospital, he began to have severe regional pain in his feet. Hi
Vertical Externalities in a Tax Setting in a System of Hierarchical Governments  [PDF]
Chao-Lan Wang, Yi-Chung Hsu
Theoretical Economics Letters (TEL) , 2013, DOI: 10.4236/tel.2013.33021

This paper focuses on the overlap in the tax bases between two levels of government. This overlap leads to vertical fiscal externalities that arise when several different commodities are in the tax base and the tax bases of the two levels of government may not be identical. In the unified government’s case, if it is supposed that the marginal utilities of income for the two states are the same, the tax policy in state i not only considers the price elasticity and cross elasticity of each state, but also the shares of expenditure on commodities x1 and x2 in the different states. When the cross elasticity is zero, the tax rates on the same commodity sold in the different states and the price elasticity should be inversely related. If the cross elasticity of the commodities is zero, the higher the marginal utility of income of state i, the lower should be the tax rate set by the unified government in state i.

Online Maximum Loadability Monitoring Scheme for Smart Grid  [PDF]
Heng-Yi Su, Yi-Chung Chen, Jia-Chuan Lin
Journal of Power and Energy Engineering (JPEE) , 2015, DOI: 10.4236/jpee.2015.34024

This paper presents an algorithm based on Thevenin equivalent network for voltage stability evaluation. The proposed algorithm provides a technique for online predicting the largest possible margin to voltage collapse of an electrical power system. An online maximum loadability determination algorithm is developed by transforming the impedance margin, obtained from the Thevenin equivalent network, into the loading margin at each of the load buses in a power system. Furthermore, the proposed algorithm also takes system load trends into account for practical applications. The effectiveness of the proposed algorithm is tested on the IEEE 14 and 57 bus test systems. Simulation results have shown that the proposed algorithm is useful and practical for online voltage instability monitoring.

PRRT2 Mutations in Paroxysmal Kinesigenic Dyskinesia with Infantile Convulsions in a Taiwanese Cohort
Yi-Chung Lee, Ming-Jen Lee, Hsiang-Yu Yu, Chien Chen, Chang-Hung Hsu, Kon-Ping Lin, Kwong-Kum Liao, Ming-Hong Chang, Yi-Chu Liao, Bing-Wen Soong
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038543
Abstract: Background Mutations in the PRRT2 gene have recently been identified in patients with familial paroxysmal kinesigenic dyskinesia with infantile convulsions (PKD/IC) and patients with sporadic PKD/IC from several ethnic groups. To extend these recent genetic reports, we investigated the frequency and identities of PRRT2 mutations in a cohort of Taiwanese patients with PKD/IC. Methodology and Principal Findings We screened all 3 coding exons of PRRT2 for mutations in 28 Taiwanese patients with PKD/IC. Among them, 13 had familial PKD/IC and 15 were apparently sporadic cases. In total, 7 disparate mutations were identified in 13 patients, including 8 familial cases and 5 apparently sporadic cases. The mutations were not present in 500 healthy controls. Four mutations were novel. One patient had a missense mutation and all other patients carried PRRT2 mutations putatively resulting in a protein truncation. Haplotype analysis revealed that 5 of the 7 patients with the PRRT2 p.R217Pfs*8 mutation shared the same haplotype linked to the mutation. Conclusions and Significance PRRT2 mutations account for 61.5% (8 out of 13) of familial PKD/IC and 33.3% (5 out of 15) of apparently sporadic PKD/IC in the Taiwanese cohort. Most patients with the PRRT2 p.R217Pfs*8 mutation in Taiwan likely descend from a single common ancestor. This study expands the spectrum of PKD/IC-associated PRRT2 mutations, highlights the pathogenic role of PRRT2 mutations in PKD/IC, and suggests genetic heterogeneity within idiopathic PKD.
The Mutational Spectrum in a Cohort of Charcot-Marie-Tooth Disease Type 2 among the Han Chinese in Taiwan
Kon-Ping Lin, Bing-Wen Soong, Chih-Chao Yang, Li-Wen Huang, Ming-Hong Chang, I-Hui Lee, Antony Antonellis, Yi-Chung Lee
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0029393
Abstract: Background Charcot-Marie-Tooth disease type 2 (CMT2) is a clinically and genetically heterogeneous group of inherited axonal neuropathies. The aim of this study was to extensively investigate the mutational spectrum of CMT2 in a cohort of patients of Han Chinese. Methodology and Principal Findings Genomic DNA from 36 unrelated Taiwanese CMT2 patients of Han Chinese descent was screened for mutations in the coding regions of the MFN2, RAB7, TRPV4, GARS, NEFL, HSPB1, MPZ, GDAP1, HSPB8, DNM2, AARS and YARS genes. Ten disparate mutations were identified in 14 patients (38.9% of the cohort), including p.N71Y in AARS (2.8%), p.T164A in HSPB1 (2.8%), and p.[H256R]+[R282H] in GDAP1 (2.8%) in one patient each, three NEFL mutations in six patients (16.7%) and four MFN2 mutations in five patients (13.9%). The following six mutations were novel: the individual AARS, HSPB1 and GDAP1 mutations and c.475-1G>T, p.L233V and p.E744M mutations in MFN2. An in vitro splicing assay revealed that the MFN2 c.475-1G>T mutation causes a 4 amino acid deletion (p.T159_Q162del). Despite an extensive survey, the genetic causes of CMT2 remained elusive in the remaining 22 CMT2 patients (61.1%). Conclusions and Significance This study illustrates the spectrum of CMT2 mutations in a Taiwanese CMT2 cohort and expands the number of CMT2-associated mutations. The relevance of the AARS and HSPB1 mutations in the pathogenesis of CMT2 is further highlighted. Moreover, the frequency of the NEFL mutations in this study cohort was unexpectedly high. Genetic testing for NEFL and MFN2 mutations should, therefore, be the first step in the molecular diagnosis of CMT2 in ethnic Chinese.
Connectivity Features for Identifying Cognitive Impairment in Presymptomatic Carotid Stenosis
Chun-Jen Lin, Pei-Chi Tu, Chang-Ming Chern, Fu-Jung Hsiao, Feng-Chi Chang, Hsien-Lin Cheng, Chih-Wei Tang, Yi-Chung Lee, Wei-Ta Chen, I-Hui Lee
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0085441
Abstract: Severe asymptomatic stenosis of the internal carotid artery (ICA) leads to increased incidence of mild cognitive impairment (MCI) likely through silent embolic infarcts and/or chronic hypoperfusion, but the brain dysfunction is poorly understood and difficult to diagnose. Thirty cognitively intact subjects with asymptomatic, severe (≧70%), unilateral stenosis of the ICA were compared with 30 healthy controls, matched for age, sex, cardiovascular risk factors and education level, on a battery of neuropsychiatric tests, voxel-based morphometry of magnetic resonance imaging (MRI), diffusion tensor imaging and brain-wise, seed-based analysis of resting-state functional MRI. Multivariate regression models and multivariate pattern classification (support vector machines) were computed to assess the relationship between connectivity measures and neurocognitive performance. The patients had worse dizziness scores and poorer verbal memory, executive function and complex visuo-spatial performance than controls. Twelve out of the 30 patients (40%) were considered to have MCI. Nonetheless, the leukoaraiosis Sheltens scores, hippocampal and brain volumes were not different between groups. Their whole-brain mean fractional anisotropy (FA) was significantly reduced and regional functional connectivity (Fc) was significantly impaired in the dorsal attention network (DAN), frontoparietal network, sensorimotor network and default mode network. In particular, the Fc strength at the insula of the DAN and the mean FA were linearly related with attention performance and dizziness severity, respectively. The multivariate pattern classification gave over 90% predictive accuracy of individuals with MCI or severe dizziness. Cognitive decline in stroke-free individuals with severe carotid stenosis may arise from nonselective widespread disconnections of long-range, predominantly interhemispheric non-hippocampal pathways. Connectivity measures may serve as both predictors for cases at risk and therapeutic targets for mitigating vascular cognitive impairment.
An Ultra-Broadband, Coplanar-Waveguide FED Circular Monopole Antenna with Improved Radiation Characteristics
Nan-Wei Chen;Yi-Chung Liang
PIER C , 2009, DOI: 10.2528/PIERC09071610
Abstract: A planar, circular monopole antenna (PCMA) with satisfactory radiation characteristics over an ultra-broadband is demonstrated. Compared to the classical coplanar-waveguide (CPW) fed PCMA, the radiation characteristics of the proposed CPW-fed PCMA are significantly improved, particularly at the frequencies around the higher band edge. This improvement is achieved by exploiting a tapered and periodically corrugated edge design to the CPW ground plane. The tapered and corrugated ground-plane edge design, in essence, modifies the current distribution on the circular disc as well as along the edges of the ground plane. With this design, the cross polarization radiation is remarkably reduced, and the pattern deterioration, especially at the planes perpendicular to the plane of the antenna, is greatly alleviated. The demonstrated CPW-fed PCMA features an over 150 % VSWR=2 fractional bandwidth (0.81-5.87 GHz) and promises satisfactory radiation characteristics over the entire band. The proposed PCMA is poised for applications in wideband/ultra-wideband communication systems.
Applying Backpropagation Neural Networks to Bankruptcy Prediction
Yi-Chung Hu,Fang-Mei Tseng
International Journal of Electronic Business Management , 2005,
Abstract: Bankruptcy prediction is an important classification problem for a business, and has become a major concern of managers. In this paper, two well-known backpropagation neural network models serving as data mining tools for classification problems are employed to perform bankruptcy forecasting: one is the backpropagation multi-layer perceptron, and the other is the radial basis function network. In particular, the radial basis function network can be treated as a fuzzy neural network. Through examining their classification generalization abilities, the empirical results from the data resources consisting of bankrupt and nonbankrupt firms in England, demonstrated that the radial basis function network outperforms the other classification methods, including the multi-layer perceptron, the multivariate discriminant analysis, and the probit method.
Genetic Variants of LRRK2 in Taiwanese Parkinson’s Disease
Yih-Ru Wu, Kuo-Hsuan Chang, Wen-Teng Chang, Ya-Chin Hsiao, Hsuan-Chu Hsu, Pei-Ru Jiang, Yi-Chun Chen, Chih-Ying Chao, Yi-Chung Chang, Bo-Hsun Lee, Fen-Ju Hu, Wan-Ling Chen, Guey-Jen Lee-Chen, Chiung-Mei Chen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0082001
Abstract: Genetic variants of leucine-rich repeat kinase 2 (LRRK2) were reported to alter the risk for Parkinson’s disease (PD). However, the genetic spectrum of LRRK2 variants has not been clearly disclosed yet in Taiwanese population. Herein, we sequenced LRRK2 coding region in 70 Taiwanese early onset PD patients (age at onset ≤ 50), and found six amino acid-changing single nucleotide polymorphisms (SNPs, N551K, R1398H, R1628P, S1647T, G2385R and M2397T), one reported (R1441H) and 2 novel missense (R767H and S885N) mutations. We examined the frequency of identified LRRK2 variants by genotyping 573 Taiwanese patients with PD and 503 age-matched control subjects. The results showed that PD patients demonstrated a higher frequency of G2385R A allele (4.6%) than control subjects (2.1%; odds ratio = 2.27, 95% confidence interval: 1.38–3.88, P = 0.0017). Fewer PD patients (27.7%) carried the 1647T-2397T haplotype as compared with the control subjects (33.0%; odds ratio = 0.80, 95% confidence interval: 0.65–0.97, P = 0.0215). However, the frequency of 1647T-2385R-2397T haplotype (4.3%) in PD patients was still higher than in control subjects (1.9%, odds ratio: 2.15, 95% confidence interval: 1.27–3.78, P = 0.0058). While no additional subject was found to carry R767H and R1441H, one more patient was observed to carry the S885N variant. Our results indicate a robust risk association regarding G2385R and a new possible protective haplotype (1647T-2397T). Gene-environmental interaction and a larger cohort study are warranted to validate our findings. Additionally, two new missense mutations (R767H and S885N) regarding LRRK2 in PD patients were identified. Functional studies are needed to elucidate the effects of these LRRK2 variants on protein function.
Erratum to “Ethanol Extracts of Fruiting Bodies of Antrodia cinnamomea Suppress CL1-5 Human Lung Adenocarcinoma Cells Migration by Inhibiting Matrix Metalloproteinase-2/9 through ERK, JNK, p38, and PI3K/Akt Signaling Pathways”
Ying-Yi Chen,Fon-Chang Liu,Pei-Yu Chou,Yi-Chung Chien
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/423987
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