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Search Results: 1 - 10 of 66986 matches for " Yi-Cheng Chang "
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Contact Stress Analysis of Straight Concave Conical Involute Gear Pairs with Small Intersected Angles
Chia-Chang Liu,Yi-Cheng Chen,Shih-Hao Lin
Lecture Notes in Engineering and Computer Science , 2010,
Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: Gene-environmental interaction with alcohol consumption
Chang Yi-Cheng,Chiu Yen-Feng,Lee I-Te,Ho Low-Tone
BMC Cardiovascular Disorders , 2012, DOI: 10.1186/1471-2261-12-58
Abstract: Background Genetic variants near/within the ALDH2 gene encoding the mitochondrial aldehyde dehydrogenase 2 have been associated with blood pressure and hypertension in several case–control association studies in East Asian populations. Methods Three common tag single nucleotide polymorphisms (tagSNP) in the ALDH2 gene were genotyped in 1,134 subjects of Chinese origin from the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance (SAPPHIRe) family cohort. We examined whether the ALDH2 SNP genotypes predicted the development of hypertension in the prospective SAPPHIRe cohort. Results Over an average follow-up period of 5.7 years, carriers homozygous for the rs2238152 T allele in the ALDH2 gene were more likely to progress to hypertension than were non-carriers (hazard ratio [HR], 2.88, 95% confidence interval [CI], 1.06-7.84, P = 0.03), corresponding to a population attributable risk of ~7.1%. The risk associated with the rs2238152 T allele were strongest in heavy/moderate alcohol drinkers and was reduced in non-drinkers, indicating an interaction between ALDH2 genetic variants and alcohol intake on the risk of hypertension (P for interaction = 0.04). The risk allele was associated with significantly lower ALDH2 gene expression levels in human adipose tissue. Conclusion ALDH2 genetic variants were associated with progression to hypertension in a prospective Chinese cohort. The association was modified by alcohol consumption.
Correlation of Anaplastic Lymphoma Kinase Overexpression and the EML4-ALK Fusion Gene in Non-Small Cell Lung Cancer by Immunohistochemical Study
Tai-Di Chen,Il-Chi Chang,Hui-Ping Liu,Yi-Cheng Wu
Chang Gung Medical Journal , 2012,
Abstract: Background: Recently the echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene with transforming activity was identified in non-small cell lung cancer (NSCLC). In addition, NSCLC patients with the EML4-ALK fusion gene had a dramatic response and longer progression free survival after ALK inhibitor treatment than those without this fusion gene. However, the incidence and clinical and molecular characteristics of the EML4-ALK fusion gene in NSCLC patients of Taiwan are still unclear.Methods:Sixty-four fresh frozen tumor specimens were obtained from the tissue bank of Chang Gung Memorial Hospital for RNA extraction and EML4-ALK fusion gene detection. Paraffin sections of lung tumors from all of these patients were available and were analyzed for ALK protein expression by immunohistochemical (IHC) study. The results were correlated with clinical and molecular biomarkers.Results: Three of the 64 tumors (4.7%) had the EML4-ALK fusion gene. Two were adenocarcinomas, and one was adenosquamous carcinoma. Twenty patients with non-squamous cell carcinomas had epidermal growth factor receptor (EGFR) mutations, so the EML4-ALK fusion gene was found in 14.3% of EGFR wild type non-squamous cell carcinomas. Two tumors were variant 3 (3a+3b with 3b predominant) and had strong staining (3+) for ALK by IHC stains. One tumor was variant 1 and had moderate staining (2+) for ALK. None of the ALK wild type tumors had strong staining for ALK. When compared with other clinical and molecular features, only the IHC stain for ALK was significantly correlated with the EML4-ALK fusion gene (p = 0.0002).Conclusions: ALK overexpression detected by IHC study could be a promising detection method for the EML4-ALK fusion gene and is worth further confirmation with more samples.
Therapeutic effects of scalp-acupuncture in patients with vascular dementia induced by cerebral infarction: a randomized controlled trial
Yi-cheng LIU
Zhong Xi Yi Jie He Xue Bao , 2008,
Abstract: Objective: To investigate the effects of scalp-acupuncture on intelligence in patients with vascular dementia (VaD).Methods: A total of 108 VaD patients were randomly divided into two groups: scalp-acupuncture group and Western medicine group. The scores of Mini-Mental State Examination (MMSE), Blesse Dementia Scale (BDS), Hasegawa Dementia Scale (HDS), Ability of Daily Life (ADL) before and after treatment in the two groups were detected.Results: A total of 92 patients completed the treatment. The scores of MMSE, BDS and HDS in the two groups were significantly increased, and the ADL scores significantly declined (P<0.05). There was no difference in the scores of MMSE, BDS, HDS and ADL between the two groups before and after the treatment. There was no difference in the total effectiveness between the two groups (P>0.05).Conclusion: Scalp-acupuncture therapy could improve the clinical intelligence level of VaD patients.
Happier World with More Information
Yi-Cheng Zhang
Physics , 2001, DOI: 10.1016/S0378-4371(01)00278-3
Abstract: We explore the consequences of incomplete information in the stable marriage problem. When information capacity of the participants is increased, more favorable games are created and the quality of the matches are also better. The simple model serves as a metaphor for a world with ever more computing power that leads to more positive inter-personal interactions and of higher quality.
Modeling Market Mechanism with Evolutionary Games
Yi-Cheng Zhang
Physics , 1998,
Abstract: This is an essay solicited by Europhysics News, published in its March/April 1998 issue with slight modifications. We outline some highlights of the econophysics models, especially the so-called Minority model of competition and evolution. Even without the usual math, this essay offers an analytical solution to the Minority model, revealing some key features of the solution.
An Electroweak-like Theory from Four Fermion Interactions
Yi-Cheng Huang
Physics , 2014,
Abstract: An electroweak-like theory of a broken chiral symmetry that is constructed by the collective modes of fermion pairs from four fermion interactions of one lepton generation is presented. The products of Dirac spinors lead to the separation of the two chiral fermions to couple respectively with two different kinds of polarization states. Because of a broken vacuum, a fermion and an anti-fermion out of the four pair up to form vector bosons, which behave like gauge bosons, such as $W^\pm$, $Z$ and $\gamma$ in a group structure of $SU(2)_L\times U(1)_Y$. The pairing of spinors only allows left-handed fermions to interact with charged bosons to secure the gauge invariance, while, as desired, $Z$-like bosons mediate different weak forces for two chiral fermions and $\gamma$-like bosons interact freely with fermions.
Toward a Theory of Marginally Efficient Markets
Yi-Cheng Zhang
Quantitative Finance , 1999, DOI: 10.1016/S0378-4371(99)00077-1
Abstract: Empirical evidence suggests that even the most competitive markets are not strictly efficient. Price histories can be used to predict near future returns with a probability better than random chance. Many markets can be considered as {\it favorable games}, in the sense that there is a small probabilistic edge that smart speculators can exploit. We propose to identify this probability using conditional entropy concept. A perfect random walk has this entropy maximized, and departure from the maximal value represents a price history's predictability. We propose that market participants should be divided into two categories: producers and speculators. The former provides the negative entropy into the price, upon which the latter feed. We show that the residual negative entropy can never be arbitraged away: infinite arbitrage capital is needed to make the price a perfect random walk.
Why Financial Markets Will Remain Marginally Inefficient?
Yi-Cheng Zhang
Quantitative Finance , 2001,
Abstract: I summarize the recent work on market (in)efficiency, highlighting key elements why financial markets will never be made efficient. My approach is not by adding more empirical evidence, but giving plausible reasons as to where inefficiency arises and why it's not rational to arbitrage it away.
Long-term survival and prognostic implications of Chinese type 2 diabetic patients with coronary artery disease after coronary artery bypass grafting  [PDF]
Ming C Hsiung, Tao-Hsin Tung, Chung-Yi Chang, Yi-Cheng Chuang, Kuo-Chen Lee, Sung-How Sue, Yi-Pen Chou, Richard Hsiung, Chien-Ming Huang, Chang-Chyi Lin, Wei-Hsian Yin, Mason S Young, Jeng Wei
Health (Health) , 2009, DOI: 10.4236/health.2009.13023
Abstract: This study was conducted to determine the sur-vival rates of type 2 diabetic patients after coro-nary artery bypass grafting (CABG) surgery, and the prognostic factors related to all-cause mor-tality during a 7-year follow-up. The medical re-cords of 816 type 2 diabetic patients who un-derwent primary, isolated CABG surgery during 1997-2003 were studied. The Kaplan-Meier me- thod and Cox regression were used to estimate survival and the independence of prognostic factors associated with all-cause mortality. One hundred and five out of 816 patients expired during the 7-year period. The overall survival rate was 83.5% (95%CI: 78.7-88.3%). Associated prog- nostic factors varied by gender. For males, but not for females, smoking (RR=3.44, 95%CI: 1.01- 11.70), myocardial infarction (RR=4.77, 95% CI: 1.23-18.86), respiratory failure (RR=4.21, 95% CI: 1.48-7.99), cardiogenic shock (RR=12.58, 95% CI: 3.25-20.77), and congestive heart failure (RR= 3.77, 95%CI: 1.10-13.45) were significantly related to all-cause mortality. Older age at sur-gery (RR= 1.15, 95%CI: 1.04-1.27), emergent op-eration (RR= 21.29, 95%CI: 10.03-39.43), pul-monary ede-ma (RR=7.72, 95%CI: 1.89-15.59), and days of ICU stay (RR=1.05, 95%CI: 1.02-1.09) were significant- ly related to all-cause mortality in females only. In conclusion, several gen-der-related differences were noted pertaining to all-cause mortality and its relationship to smok- ing, myocardial infarction, respiratory failure, cardiogenic shock, congestive heart failure, older age at surgery, emergent operation, pul-monary edema, and days of ICU stay.
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