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Search Results: 1 - 10 of 62424 matches for " Yen Kuang Yang "
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Clinical impact of multidetector computed tomography before double-balloon enteroscopy for obscure gastrointestinal bleeding
Hsu-Heng Yen,Yang-Yuan Chen,Chia-Wei Yang,Chi-Kuang Liu
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i7.692
Abstract: AIM: To evaluate the clinical impact of multidetector computed tomography (MDCT) before double-balloon endoscopy (DBE) for patients with obscure gastrointestinal bleeding (OGIB). METHODS: A retrospective analysis of prospectively collected cases with DBE and MDCT for overt OGIB was conducted from April 2004 to April 2010 at Changhua Christian Hospital. We evaluated the clinical impact of MDCT on the subsequent DBE examinations and the diagnostic yields of both MDCT and DBE respectively. RESULTS: From April 2004 to April 2010, a total of 75 patients underwent DBE for overt OGIB. Thirty one cases received MDCT followed by DBE for OGIB. The overall diagnostic yields of DBE and MDCT was 93.5% and 45.2%. The MDCT had a high diagnostic yield of tumor vs non-tumor etiology of OGIB (85.7% vs 33.3%, P = 0.014). Additionally, the choice of initial route of DBE was correct in those with a positive MDCT vs negative MDCT (100% vs 52.9%, P = 0.003). CONCLUSION: This study suggests MDCT as a triage tool may identify patients who will benefit from DBE and aid the endoscopist in choosing the most efficient route.
Long-Acting Injectable Antipsychotics for First-Episode Schizophrenia: The Pros and Cons
Borah Kim,Sang-Hyuk Lee,Yen Kuang Yang,Jong-Il Park,Young-Chul Chung
Schizophrenia Research and Treatment , 2012, DOI: 10.1155/2012/560836
Abstract: Clinical and psychosocial deterioration associated with schizophrenia occurs within the first few years following the onset of the illness. Therefore, to improve the long-term prognosis, it is important to provide schizophrenia patients with intensive treatment following their first episode. Relapse is highly associated with partial medication adherence or nonadherence in patients with first-episode schizophrenia. Recent studies suggest that long-acting injectable (LAI) antipsychotics compared with oral antipsychotics are more effective for medication adherence and relapse prevention. Moreover, some clinical guidelines for the treatment of schizophrenia suggested that LAI antipsychotics should be considered when patients are nonadherent “at any stage.” Decreased compliance is a common cause of relapse during the initial stages of the disease. Therefore, LAI antipsychotics should be highly considered when treating patients with first-episode schizophrenia. In the present paper, clinical trial data and current guidelines on the use of LAI antipsychotics for first-episode schizophrenia are discussed as well as the pros and cons of this treatment option.
Long-Acting Injectable Antipsychotics for First-Episode Schizophrenia: The Pros and Cons
Borah Kim,Sang-Hyuk Lee,Yen Kuang Yang,Jong-Il Park,Young-Chul Chung
Schizophrenia Research and Treatment , 2012, DOI: 10.1155/2012/560836
Abstract: Clinical and psychosocial deterioration associated with schizophrenia occurs within the first few years following the onset of the illness. Therefore, to improve the long-term prognosis, it is important to provide schizophrenia patients with intensive treatment following their first episode. Relapse is highly associated with partial medication adherence or nonadherence in patients with first-episode schizophrenia. Recent studies suggest that long-acting injectable (LAI) antipsychotics compared with oral antipsychotics are more effective for medication adherence and relapse prevention. Moreover, some clinical guidelines for the treatment of schizophrenia suggested that LAI antipsychotics should be considered when patients are nonadherent “at any stage.” Decreased compliance is a common cause of relapse during the initial stages of the disease. Therefore, LAI antipsychotics should be highly considered when treating patients with first-episode schizophrenia. In the present paper, clinical trial data and current guidelines on the use of LAI antipsychotics for first-episode schizophrenia are discussed as well as the pros and cons of this treatment option. 1. Introduction Schizophrenia is a chronic disorder characterized by periods of illness alternating with periods of full or partial remission. Previous studies [1, 2] suggest that schizophrenia is a neurodegenerative disease associated with frequent relapses. This alternating nature of the illness causes neurotoxicity in the brain, thereby resulting in structural abnormalities, including ventricular enlargement and cortical atrophy. Recent evidence further suggests that progressive structural changes in the brain occur within the initial years following a diagnosis [3–5]. Moreover, with each subsequent relapse after the first episode, it usually takes longer time to reach remission [6]. The primary clinical and psychosocial deterioration associated with schizophrenia occurs within the first 5 years following the onset of the illness, called the critical period [7, 8]. Therefore, it is important to provide intensive biopsychosocial interventions during the critical period in an effort to improve the long-term prognosis. The primary goal of treatment during the critical period is to prevent a subsequent relapse and to restore socio-occupational functioning to the premorbid level. The relapse rate in patients with first-episode schizophrenia is relatively low during the first year of the illness but substantially rises to rates of 53.7% and 74%–81.9% after 2 and 5 years, respectively [9, 10]. The most common
Application and comparison of scoring indices to predict outcomes in patients with healthcare-associated pneumonia
Wen-Feng Fang, Kuang-Yao Yang, Chieh-Liang Wu, Chong-Jen Yu, Chang-Wen Chen, Chih-Yen Tu, Meng-Chih Lin
Critical Care , 2011, DOI: 10.1186/cc9979
Abstract: We conducted a retrospective cohort study based on an inpatient database from six medical centers, recruiting a total of 444 patients with HCAP between 1 January 2007 and 31 December 2007. Pneumonia severity scoring indices including PSI (pneumonia severity index), CURB 65 (confusion, urea, respiratory rate, blood pressure, age 65), IDSA/ATS (Infectious Diseases Society of America/American Thoracic Society), modified ATS rule, SCAP (severe community acquired pneumonia), SMART-COP (systolic blood pressure, multilobar involvement, albumin, respiratory rate, tachycardia, confusion, oxygenation, pH), SMRT-CO (systolic blood pressure, multilobar involvement, respiratory rate, tachycardia, confusion, oxygenation), and SOAR (systolic blood pressure, oxygenation, age, respiratory rate) were calculated for each patient. Patient characteristics, co-morbidities, pneumonia pathogen culture results, length of hospital stay (LOS), and length of ICU stay were also recorded.PSI (>90) has the highest sensitivity in predicting mortality, followed by CURB-65 (≥2) and SCAP (>9) (SCAP score (area under the curve (AUC): 0.71), PSI (AUC: 0.70) and CURB-65 (AUC: 0.66)). Compared to PSI, modified ATS, IDSA/ATS, SCAP, and SMART-COP were easy to calculate. For predicting ICU admission (Day 3 and Day 14), modified ATS (AUC: 0.84, 0.82), SMART-COP (AUC: 0.84, 0.82), SCAP (AUC: 0.82, 0.80) and IDSA/ATS (AUC: 0.80, 0.79) performed better (statistically significant difference) than PSI, CURB-65, SOAR and SMRT-CO.The utility of the scoring indices for risk assessment in patients with healthcare-associated pneumonia shows that the scoring indices originally designed for CAP can be applied to HCAP.Healthcare-associated pneumonia (HCAP), a relatively new category of pneumonia, refers to infections that occur prior to hospital admission in patients with contact or exposure to a healthcare environment [1]. Compared to community-acquired pneumonia (CAP), HCAP is a distinct type of pneumonia with unique m
Enriching the Symmetry of Maxwell Equations through Unprecedented Magnetic Responses of Artificial Metamaterials and Their Revolutionary Applications
Yueh-Chun Lai,Cheng-Kuang Chen,Tsung-Yu Huang,Ieng-Wai Un,Yu-Hang Yang,Ta-Jen Yen
Symmetry , 2011, DOI: 10.3390/sym3020283
Abstract: The major issue regarding magnetic response in nature—“negative values for the permeability μ of material parameters, especially in terahertz or optical region” makes the electromagnetic properties of natural materials asymmetric. Recently, research in metamaterials has grown in significance because these artificial materials can demonstrate special and, indeed, extraordinary electromagnetic phenomena such as the inverse of Snell’s law and novel applications. A critical topic in metamaterials is the artificial negative magnetic response, which can be designed in the higher frequency regime (from microwave to optical range). Artificial magnetism illustrates new physics and new applications, which have been demonstrated over the past few years. In this review, we present recent developments in research on artificial magnetic metamaterials including split-ring resonator structures, sandwich structures, and high permittivity-based dielectric composites. Engineering applications such as invisibility cloaking, negative refractive index medium, and slowing light fall into this category. We also discuss the possibility that metamaterials can be suitable for realizing new and exotic electromagnetic properties.
Functional interaction between Env oncogene from Jaagsiekte sheep retrovirus and tumor suppressor Sprouty2
Ebenezer Chitra, Yi-Wen Lin, Fabian Davamani, Kuang-Nan Hsiao, Charles Sia, Shih-Yang Hsieh, Olivia L Wei, Jen-Hao Chen, Yen-Hung Chow
Retrovirology , 2010, DOI: 10.1186/1742-4690-7-62
Abstract: JSRV Env-mediated transformation of a lung adenocarcinoma cell line induced rapid proliferation, anchorage-independent growth and tumor formation, but completely abrogated the migration ability. An analysis of the signaling scenario in the transformed cells suggested the involvement of the ERK pathway regulated by Sprouty2 in cell migration, and the PI3K-Akt and STAT3 pathways in proliferation and anchorage-independence. On the other hand, in a normal lung epithelial cell line, Env-mediated transformation only decreased the migration potential while the other functions remained unaltered. We observed that Env induced the expression of a tumor suppressor, Sprouty2, suggesting a correlation between Env-effect and Sprouty2 expression. Overexpression of Sprouty2 per se not only decreased the migratory potential and tumor formation potential of the target cells but also made them resistant to subsequent Env-mediated transformation. On the other hand, over expression of the functional mutants of Sprouty2 had no inhibitory effect, confirming the role of Sprouty2 as a tumor suppressor.Our studies demonstrate that Env and Sprouty2 have a functional relationship, probably through shared signaling network. Sprouty2 functions as a tumor suppressor regulating oncogenic transformation of cells, and it therefore has the potential to be exploited as a therapeutic anti-cancer agent.The Envelope proteins of many retroviruses have been identified to be directly involved in oncogenic transformation of cells leading to the evolution of a new paradigm. Friend Spleen Focus Forming Virus (SFFV) was the first virus to be identified to be linked to oncogenesis induced by a retroviral Env protein [1]. Tumor formation by SFFV was reported to involve the mitogen-activated protein kinase (MAPK) and the phosphatidylinositol 3-kinase (PI3K) pathways, with a number of host factors governing the susceptibility to tumor formation [1]. Structural proteins of Avian Hemangioma Virus (AHV) and Mouse Mamm
High Peritoneal KT/V and Peritonitis Rates Are Associated with Peritoneal Calcification
Jenq-Wen Huang, Yu-Chung Lien, Chung-Yi Yang, Kao-Lang Liu, Cheng-Chung Fang, Cho-Kai Wu, Jen-Kuang Lee, Hon-Yen Wu, Chih-Kang Chiang, Hui-Teng Cheng, Chung-Jen Yen, Kuan-Yu Hung
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071636
Abstract: Background Peritoneal calcification (PC) is a specific finding in patients undergoing peritoneal dialysis (PD), but its prevalence, risk factors, and impacts in PD patients remain unclear. The present study investigated these issues and provided information useful for the management of PC. Methods The study included 183 PD patients. The severity of PC was determined using abdominal computed tomography (CT), and we summed up all scores from slices obtained from the diaphragm to the pelvic floor normalized to body surface area. We analyzed the associations between PC and demographic and clinical characteristics, and between PC and levels of biomarkers, including C-reactive protein (CRP), osteoprotegrin and fetuin-A. The determinants of PC were examined using multiple regression analysis. Results Patients were categorized into group 1 (without PC, n = 133) and group 2 (with PC, n = 50). Group 2 patients showed different degrees of PC with a mean of 160±769 mm2/m2. Group 1 patients had higher fetuin-A levels than group 2 patients (861±309 vs. 760±210 μg/mL; p = 0.021). The independent risk factors for the presence of PC included male gender, previous peritonitis, and PD adequacy (KT/V). Further analysis performed in group 2 patients showed that the dosage of vitamin D, serum levels of CRP, and dialysate calcium load were the independent determinants of PC. However, the presence of PC did not affect patients’ technique survival, peritonitis incidence, or mortality in the mean follow up period of 28±12 months. Conclusions The presence and severity of PC were associated with inflammation, peritoneal KT/V, and mineral metabolism. The impact of PC on the outcomes of PD patients requires further study with a longer follow-up.
Identification of miR-27b as a Novel Signature from the mRNA Profiles of Adipose-Derived Mesenchymal Stem Cells Involved in the Tolerogenic Response
Kuang-Den Chen, Shigeru Goto, Li-Wen Hsu, Tzu-Yang Lin, Toshiaki Nakano, Chia-Yun Lai, Yen-Chen Chang, Wei-Teng Weng, Yur-Ren Kuo, Chih-Chi Wang, Yu-Fan Cheng, Yen-Ying Ma, Chih-Che Lin, Chao-Long Chen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060492
Abstract: Adipose-derived mesenchymal stem cells (adipose-derived MSCs, ASCs) possess the ability to differentiate into multiple tissue types and have immune-modulatory properties similar to those of MSCs from other origins. However, the regulation of the MSC-elicited immune-modulatory activity by specific microRNA (miRNA) mechanisms remains unexplored. Gene expression profiling with knowledge-based functional enrichment analysis is an appropriate approach for unraveling these mechanisms. This tool can be used to examine the transcripts and miRNA regulators that differentiate the rat tolerogenic orthotopic liver transplantation (OLT; DA liver into PVG) and rejection OLT (DA liver into LEW) models. In both models, the rejection reaction was observed on postoperative day 7~14 (rejection phase) but was overcome only by the PVG recipients. Thus, the global gene expression patterns of ASCs from spontaneously tolerant (PVG) and acute rejecting (LEW) rats in response to LPS activation were compared. In this study, we performed miRNA enrichment analysis based on the analysis of pathway, gene ontology (GO) terms and transcription factor binding site (TFBS) motif annotations. We found that the top candidate, miR-27, was specifically enriched and had the highest predicted frequency. We also identified a greater than 3-fold increase of miR-27b expression in the ASCs of tolerant recipients (DA to PVG) compared to those of rejecting recipients (DA to LEW) during the rejection phase in the rat OLT model. Furthermore, our data showed that miR-27b knockdown has a positive influence on the allosuppressive activity that inhibits T-cell proliferation. We found that miR-27 knockdown significantly induced the expression of CXCL12 in cultured ASCs and the expression of CXCL12 was responsible for the miR-27b antagomir-mediated inhibition of T-cell proliferation. These results, which through a series of comprehensive miRNA enrichment analyses, might be relevant for stem cell-based therapeutic applications in immunosuppressive function using ASCs.
Identification of Two Cold Water-Soluble Polysaccharides from the Stems of Ephedra sinica Stapf  [PDF]
Yonggang Xia, Jun Liang, Bingyou Yang, Qiuhong Wang, Haixue Kuang
Chinese Medicine (CM) , 2010, DOI: 10.4236/cm.2010.13013
Abstract: Two polysaccharides (ESP-A1 and ESP-A2) were isolated from the cold water extract of Ephedra sinica Stapf and purified through ethanol precipitation, deproteinization and by ion exchange and gel-filtration chromatography. Their molecular weight was determined using high performance size exclusion chromatog-raphy and evaporative light scattering detector (HPSEC-ELSD) and their monosaccharide composition was analyzed by high performance capillary electrophoresis (HPCE) based on pre-column derivatization with 1-phenyl-3-methyl-5-pyrazolone (PMP). It was shown that ESP-A1 consisted of xylose, arabinose, glucose, mannose and galactose and ESP-A2 consisted of xylose, arabinose, rhamnose and galactose, in a molar ratio (%) of 3.2: 61.1: 11.1: 12.9: 11.6 and 20.6: 67.7: 5.0: 6.7, respectively. The molecular weights (Mw) of ESP-A1 and ESP-A2 were 5.83 × 104 Da and more than 200 × 104 Da, respectively. To the best of our knowledge, two neutral polysaccharides are now being reported for the first time in this study.
Impact of Consumers’ Self-Construal, Empathy, and Moral Identity on Purchase Intention toward Cause-Related Marketing Goods: A Perspective of the Moderated Mediation Model  [PDF]
Hsin-Ti Yang, Ghi-Feng Yen
Psychology (PSYCH) , 2018, DOI: 10.4236/psych.2018.92017
Abstract: This study examined whether the impact of consumers’ self-construal on purchase intention toward cause-related marketing (CRM) goods was indirectly affected by empathy and moral identity. A total of 524 valid samples were collected, after which the moderated mediation hypotheses were tested using Process software. The research data were segmented into three score groups to compare the differences between the high score and low score groups. The empirical results revealed the following findings. 1) Moral identity internalization and symbolization resulted in positive moderation effects on the direct impact of interdependent self-construal on purchase intention toward CRM products. However, under the mediating effect of empathy, the “low/low” and “high/high” groups from moral identity internalization and symbolization each produced positive and negative moderation effects. 2) Regarding the direct impact of moral identity internalization and symbolization on independent self-construal toward purchase intention toward CRM products, the “low/low” and “low/high” groups from internalization and symbolization produced positive moderation effects. However, under the mediating effect of empathy, only the “low/low” groups from internalization and symbolization produced significant positive mediating effects. Within the consumers’ self-construal and its impact on purchase intention toward CRM products, the mediation role of empathy and moderated mediation role of the two moral identity dimensions in the influence relationship were constructed. In terms of practical aspects, companies are recommended to conduct market segmentation based on consumers’ moral identities and develop distinct marketing strategies accordingly. Future studies are recommended to explore the factors behind the impact of these two groups from moral identity on purchase intention toward CRM products.
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