OALib Journal期刊

ISSN: 2333-9721



匹配条件: “Yedluri Rupasree” ,找到相关结果约2条。
Clinical utility of polymorphisms in one-carbon metabolism for breast cancer risk prediction
Shaik Mohammad Naushad,Shree Divyya,Addepalli Pavani,Yedluri Rupasree
Journal of Medical and Allied Sciences , 2011,
Abstract: This study addresses the issues in translating the laboratory derived data obtained during discovery phase of research to a clinical setting using a breast cancer model. Laboratory-based risk assessment indi-cated that a family history of breast cancer, reduced folate carrier 1 (RFC1) G80A, thymidylate synthase (TYMS) 5’-UTR 28bp tandem repeat, methylene tetrahydrofolate reductase (MTHFR) C677T and catecholamine-O-methyl transferase (COMT) genetic polymorphisms in one-carbon metabolic pathway increase the risk for breast cancer. Glutamate carboxypeptidase II (GCPII) C1561T and cytosolic serine hydroxymethyl transferase (cSHMT) C1420T polymorphisms were found to decrease breast cancer risk. In order to test the clinical validity of this information in the risk prediction of breast cancer, data was stratified based on number of protective alleles into four categories and in each category sensitivity and 1-specificity values were obtained based on the distribution of number of risk alleles in cases and controls. Receiver operating characteristic (ROC) curves were plotted and the area under ROC curve (C) was used as a measure of discriminatory ability between cases and controls. In subjects without any protective allele, aberrations in one-carbon metabolism showed perfect prediction (C=0.93) while the predictability was lost in subjects with one protective allele (C=0.60). However, predictability increased steadily with increasing number of protective alleles (C=0.63 for 2 protective alleles and C=0.71 for 3 protective alleles). The cut-off point for discrimination was >4 alleles in all predictable combinations. Models of this kind can serve as valuable tools in translational re-search, especially in identifying high-risk individuals and reducing the disease risk either by life style modification or by medical intervention.
Role of Stress in Periodontal Disease
Rupasree G,Chava VK,Ramesh Reddy B V
Indian Journal of Dental Advancements , 2012,
Abstract: Psychological stress, if sustained over an extended period of time can have deleterious effects on the body representing an example of the mind-body interaction. Human and animal studies have shown that dental plaque bacteria are important for the development of gingivitis and periodontitis in both healthy and immunocompromised humans. As with many chronic infections the onset and progression of periodontal infections are clearly modified by local and systemic host conditions or risk factors that markedly affect the resistance of the host to infecting periodontal organisms. Psychological conditions, particularly psychological stress have been implicated as risk indicators for periodontal disease. This article reviews the current literature with emphasis on the potential role of psychological stress in periodontal disease progression.

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