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Search Results: 1 - 10 of 62623 matches for " Yea-Wen Lin "
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The causes, consequences, and mediating effects of job burnout among hospital employees in Taiwan
Yea-Wen Lin
Journal of Hospital Administration , 2012, DOI: 10.5430/jha.v2n1p15
Abstract: For the purpose of explaining the causes, consequences and mediating effects of burnout on relevant variables, the researcher conducted a cross-sectional survey of 371 hospital employees in Taiwan. Four principal findings are made. First, with respect to the three components of burnout experienced by hospital employees, the most frequently reported is emotional exhaustion, being also the most problematic among hospital employees compared with employees in other industries. Second, while increased workload coupled with role conflict increases the likelihood of burnout among hospital employees, improved work autonomy and social support reduce its likelihood. Next, the study finds a direct correlation between employees’ perceptions of low levels of emotional exhaustion and depersonalization and high levels of organizational commitment. In contrast, employees’ perceptions of high levels of emotional exhaustion and depersonalization lead to high turnover intention. Finally, the result of the hierarchical regression analysis demonstrates a partial mediating effect of burnout in the current study. These findings suggest the need for hospital management to improve their wellbeing and incentive strategies, to embark upon regular investigations into job burnout and to adopt appropriate measures to meet the professional development needs of hospital employees.
Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways
Ming-Yi Shen,Yu-Ping Lin,Bei-Chang Yang,Yu-Song Jang,Chih-Kang Chiang,Clément Mettling,Zeng-Weng Chen,Joen-Rong Sheu,Cicero L. Chang,Yea-Lih Lin,Wen-Chin Yang
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/982396
Abstract: Inflammation contributes to leukocyte migration, termed insulitis, and β-cell loss in type 1 diabetes (T1D). Naturally occurring anthraquinones are claimed as anti-inflammatory compounds; however, their actions are not clear. This study aimed to investigate the effect and mechanism of catenarin on the inflammatory disease, T1D. Catenarin and/or its anthraquinone analogs dose-dependently suppressed C-X-C chemokine receptor type 4 (CXCR4)- and C-C chemokine receptor type 5 (CCR5)-implicated chemotaxis in leukocytes. Catenarin, the most potent anthraquinone tested in the study, prevented T1D in nonobese diabetic mice. Mechanistic study showed that catenarin did not act on the expression of CCR5 and CXCR4. On the contrary, catenarin inhibited CCR5- and CXCR4-mediated chemotaxis via the reduction of the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Overall, the data demonstrate the preventive effect and molecular mechanism of action of catenarin on T1D, suggesting its novel use as a prophylactic agent in T1D.
Predicting Consumer Repurchase Intentions to Shop Online
Chwen-Yea Lin,Kwoting Fang,Chien-Chung Tu
Journal of Computers , 2010, DOI: 10.4304/jcp.5.10.1527-1533
Abstract: The World Wide Web (WWW) has rapidly evolved since its inception in 1990. The total value of purchased goods and online services reached 327 billion US dollars in 2002. Such exponential growth has influenced the establishment of electronic commerce. Understanding online consumers is important in today’s economy. However, online sales remain relatively low compared to traditional retailing. It is also important to understand buyer motivation and the satisfaction of online customers after making a purchase. We test this with a questionnaire-based empirical study. The practical and theoretical implications discussed may help Web designers, developers, and managers understand consumer online shopping habits.
Perceived Ease of Use, Trust, and Satisfaction as Determinants of Loyalty in e-Auction Marketplace
Chien-Chung Tu,Kwoting Fang,Chwen-Yea Lin
Journal of Computers , 2012, DOI: 10.4304/jcp.7.3.645-652
Abstract: —Commercial online services have increased dramatically over the last decade, especially in the field of electronic commerce (EC). The rapid development of electronic commerce has allowed people to access information and interact with global businesses. This, in combination with the advent of economical and efficient electronic capabilities, has led to the rising popularity of online auctioning. The purpose of this study is to explore from customers’ perspectives what attracts them to online auction sites, and keeps them coming back. Through the use of structural equation modeling (SEM), this article provides insight into online auction customer loyalty and online customer behavior. The ways in which consumer satisfaction interacts with auction website loyalty (the essence of the business-consumer relationship) are discussed. Furthermore, suggestions are made as to how online auction website managers can use these findings to implement and improve upon marketing strategies.
A Cognitive Approach to IS Requirement Analysis: Mental Model Building from Case Study
Chien-Chung Tu,Kwoting Fang,Chwen-Yea Lin
Journal of Software , 2011, DOI: 10.4304/jsw.6.4.643-650
Abstract: —Determination of requirements is critical for development of a new information system prior to the IS design. A good system design not only fulfills user needs, but is also a required concern for specific and future development in industry. Past researches show many tools have been introduced to generate information system requirements; however, they lack cause-effect relationships among factors. The purpose of this study is to identify system requirements and their cause-effect relationship determination process to serve emerging needs. The goal of this study is to assess potential organization needs in order to get a better foundation for system development and effectiveness. Case study and mental models approach were used to demonstrate the relationships between the requirements for a new system. The results indicate leading vendor effect, management support, and user needs are important for system development. These findings should heighten organization information systems selecting and investment decisions.
Combined Phytochemistry and Chemotaxis Assays for Identification and Mechanistic Analysis of Anti-Inflammatory Phytochemicals in Fallopia japonica
Ming-Yi Shen, Yan-Jun Liu, Ming-Jaw Don, Hsien-Yueh Liu, Zeng-Weng Chen, Clément Mettling, Pierre Corbeau, Chih-Kang Chiang, Yu-Song Jang, Tzu-Hsuan Li, Paul Young, Cicero L. T. Chang, Yea-Lih Lin, Wen-Chin Yang
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027480
Abstract: Plants provide a rich source of lead compounds for a variety of diseases. A novel approach combining phytochemistry and chemotaxis assays was developed and used to identify and study the mechanisms of action of the active compounds in F. japonica, a medicinal herb traditionally used to treat inflammation. Based on a bioactivity-guided purification strategy, two anthranoids, emodin and physcion, were identified from F. japonica. Spectroscopic techniques were used to characterize its crude extract, fractions and phytochemicals. The crude extract, chloroform fraction, and anthranoids of F. japonica significantly inhibited CXCR4-mediated chemotaxis. Mechanistic studies showed that emodin and physcion inhibited chemotaxis via inactivating the MEK/ERK pathway. Moreover, the crude extract and emodin could prevent or treat type 1 diabetes in non-obese diabetic (NOD) mice. This study illustrates the applicability of a combinational approach for the study of anti-inflammatory medicine and shows the potential of F. japonica and its anthranoids for anti-inflammatory therapy.
Paradox of Developing Country Foreign Direct Investments: A Case of the South Korean Electronics Industry
Sanghan Yea
Pakistan Journal of Social Sciences , 2012,
Abstract: Foreign direct investments have been done in the environment that wide international wage gaps still exit. On top of it, we see that worldwide regionalism has been proliferating. In this paper, we can reach the conclusion that these two factors are largely responsible for why many South Korean firms in capital-intensive industry have invested in developed countries to produce as much as or more valued goods than home. If the trend continues, such foreign direct investments will hollow out the South Korean economy not only quantitatively but also qualitatively. The companies may gain but the economy is to lose.
The excess mortality risk of diabetes associated with functional decline in older adults: Results from a 7-year follow-up of a nationwide cohort in Taiwan
Chia-Lin Li, Hsing-Yi Chang, Yea-Ing L Shyu
BMC Public Health , 2011, DOI: 10.1186/1471-2458-11-953
Abstract: We analyzed data from a nationally representative sample of people aged 65 years and over, participating in the 2001 National Health Interview Survey in Taiwan. A total of 1873 participants were followed through 2002-2008, of whom 286 (15.3%) had a history of diabetes confirmed by a medical professional. Participants were divided into three functional status groups: (1) high functioning-no limitations involving activities of daily living (ADLs), instrumental activities of daily living (IADLs), or physical functioning; (2) low functioning-limitations in one or more ADLs; (3) middle functioning-all participants in between groups 1 and 2.The crude mortality rate was 52.7 per 1,000 person-years in those with diabetes and 34.1 per 1,000 person-years in those without diabetes. After adjustment for other factors, diabetes alone was not associated with an increased mortality risk in those with high functioning. However, diabetes alone had a hazard ratio (HR) for mortality of 1.90 (95%CI = [1.02-3.53]) in those with middle functioning and 3.67 (95%CI = [1.55-8.69]) in those with low functioning. The presence of diabetes and one or more other chronic conditions was associated with a HR for mortality of 2.46 (95%CI = [1.61-3.77]) in those with middle functioning and 4.03 (95%CI = [2.31-7.03]) in those with low functioning.Our results indicate that diabetes is not associated with increased mortality in those with high functioning. There was a gradient effect of functional decline on mortality in individuals with diabetes. Additionally, among participants with other chronic conditions, functional decline was associated with a greater burden of mortality in older adults with diabetes. These findings highlight the critical importance of the prevention of cardiovascular disease morbidity and the maintenance of functional abilities in order to reduce mortality risk in older adults with diabetes.Most studies of health outcomes in older adult populations have consistently demonstrated
Ming-Hone Tsai,Yu-De Lin,Yea-Huey Su
International Journal of Electronic Business Management , 2011,
Abstract: Business is a system. When business is perceived as a system, business model could became a system configuration issue and designable. Business models are the creations of entrepreneurs or scholars of business schools. How to quickly design of new business model has become an important issue. If the academia can propose methodology about business model design principle, then practitioners or entrepreneurs are able to create their new business without burning huge money to try-and-error. One of the important issues for business model design is to understand the business model structure of a firm. The purpose of this research is to propose a new systematical method for identifying a specific company’s business model structure. We chose Google as our case to demonstrate our new systematical method. Google has run an innovative business model that is very different to traditional business model and thus Google is a case worth to investigate. Grounded theory qualitative research method with causal map, cognitive mapping, core element analysis, and social network analysis were imported to analyze various data of Google from 1996 to 2008 when businesses migrated from telephone age to network age but not yet to fully mobile age. By deeply exploring Google’s business model structure, we understood how Google do business from the perspectives of business system. This comprehensive would give researchers the industrial insights and contribute the practitioners with the way of understanding the business model structure of a company along with the business model design principle in a dynamic context. Once a company understands its business model structure, the company could design its business model to face the future challenges.
Eccrine Angiomatous Hamartoma: A Retrospective Study of 15 Cases
Yi-Ting Lin,Chien-Ming Chen,Chih-Hsun Yang,Yea-Huey Chuang
Chang Gung Medical Journal , 2012,
Abstract: Background: Eccrine angiomatous hamartoma (EAH) comprises a rare nevoid proliferation of normal eccrine glands and small blood vessels and occasionally otherelements in the middle and deep dermis with variable clinical manifestations.Case series have rarely been published except for case reports and literaturereviews. The aims of this article were to investigate the clinical and pathologic features of patients with EAH in Taiwan and to compare our resultswith the results of previous studies.Methods: A retrospective review of medical records and histopathological findings wasperformed on patients diagnosed with EAH in a medical center in Taiwanbetween 1994 and 2010.Results: Fifteen patients with pathologically diagnosed EAH were collected. Themean age at the time of diagnosis was 38.6 years (range, birth to 67 years).The male to female ratio was 3 to 2. In most cases, EAH arose as a singlelesion on a lower extremity. The symptoms and signs most commonly associated with EAH were pain (60%), hypertrichosis (13.3%), itching (13.3%)and hyperhidrosis (6.7%). Additional pathological findings included hemangioma (13.3%), verrucous hemangioma (6.7%), arteriovenous malformation(6.7%), and angiokeratoma (6.7%). None of the patients experienced spontaneous regression of the lesions before excision. Excisions were done in onepatient under general anesthesia, and ten patients with local anesthesia. Fourpatients were kept under observation. Tumor recurrences were noted in twoout of the eleven patients whose lesions were excised.Conclusion: Compared with cases in the literature, we found additional histopathologicalfindings and an increased tumor recurrence risk in our cohort. EAH remainsa benign and uncommon hamartomatous condition. Further multi-center, retrospective studies with larger case numbers are needed to better characterizethe disease presentation in Asian populations.
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