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Search Results: 1 - 10 of 510 matches for " Yasunao Hattori "
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Special metrics
Yasunao Hattori
Mathematics , 2002,
Abstract: This is a survey on special metrics. We shall present some results and open questions on special metrics mainly appeared in the last 10 years
Delivery of Plasmid DNA into Tumors by Intravenous Injection of PEGylated Cationic Lipoplexes into Tumor-Bearing Mice  [PDF]
Yoshiyuki Hattori
Pharmacology & Pharmacy (PP) , 2016, DOI: 10.4236/pp.2016.77034
Abstract: For systemic injection of cationic liposome/plasmid DNA (pDNA) complexes (cationic lipoplexes), polyethylene glycol (PEG)-modification (PEGylation) of lipoplexes can enhance their systemic stability. In this study, we examined whether intravenous injection of PEGylated cationic lipoplexes into tumor-bearing mice could deliver pDNA into tumor tissues and induce transgene expression. PEGylation of cationic liposomes could prevent their agglutination with erythrocytes. However, when PEGylated cationic lipoplexes were injected intravenously into tumor-bearing mice, they accumulated in tumor vascular vessels and did not exhibit transgene expression in tumors with both poor and well-developed vascularization. Furthermore, PEGylated cationic lipoplexes of CpG- free pDNA could not increase transgene expression in tumors after intravenous injection. These results suggested that PEGylation could not extravasate cationic lipoplexes from vascular vessels in tumors and abolished transgene expression although it enhanced the systemic stability of cationic lipoplexes by avoiding interactions with blood components such as erythrocytes. Successful delivery of pDNA to tumors by PEGylated cationic liposomes will require a rational strategy and the design of liposomal delivery systems to overcome the issue associated with the use of PEG.
Equation of motion for incompressible mixed fluid driven by evaporation and its application to online rankings
Kumiko Hattori,Tetsuya Hattori
Physics , 2008,
Abstract: We give a unique classical solution to initial value problem for a system of partial differential equations for the densities of components of one dimensional incompressible fluid mixture driven by evaporation. Motivated by the known fact that the solution appears as an infinite particle limit of stochastic ranking processes, which is a simple stochastic model of time evolutions of e.g., Amazon Sales Ranks, we collected data from the web and performed statistical fits to our formula. The results suggest that the fluid equations and solutions may have an application in the analysis of online rankings.
Existence of an infinite particle limit of stochastic ranking process
Kumiko Hattori,Tetsuya Hattori
Mathematics , 2008, DOI: 10.1016/j.spa.2008.05.006
Abstract: We study a stochastic particle system which models the time evolution of the ranking of books by online bookstores (e.g., Amazon). In this system, particles are lined in a queue. Each particle jumps at random jump times to the top of the queue, and otherwise stays in the queue, being pushed toward the tail every time another particle jumps to the top. In an infinite particle limit, the random motion of each particle between its jumps converges to a deterministic trajectory. (This trajectory is actually observed in the ranking data on web sites.) We prove that the (random) empirical distribution of this particle system converges to a deterministic space-time dependent distribution. A core of the proof is the law of large numbers for {\it dependent} random variables.
Hydrodynamic limit of move-to-front rules and search cost probabilities
Kumiko Hattori,Tetsuya Hattori
Mathematics , 2009,
Abstract: We study a hydrodynamic limit approach to move-to-front rules, namely, a scaling limit as the number of items tends to infinity, of the joint distribution of jump rate and position of items. As an application of the limit formula, we present asymptotic formulas on search cost probability distributions, applicable for general jump rate distributions.
Mathematical analysis of long tail economy using stochastic ranking processes
Kumiko Hattori,Tetsuya Hattori
Quantitative Finance , 2008,
Abstract: We present a new method of estimating the distribution of sales rates of, e.g., book titles at an online bookstore, from the time evolution of ranking data found at websites of the store. The method is based on new mathematical results on an infinite particle limit of the stochastic ranking process, and is suitable for quantitative studies of the long tail structure of online retails. We give an example of a fit to the actual data obtained from Amazon.co.jp, which gives the Pareto slope parameter of the distribution of sales rates of the book titles in the store.
Head and Neck Cancer with Dermatomyositis: A Report of Two Clinical Cases
Kohichi Yamauchi,Yasunao Kogashiwa,Hiroshi Nagafuji,Naoyuki Kohno
International Journal of Otolaryngology , 2010, DOI: 10.1155/2010/401825
Abstract: Dermatomyositis is well known to be associated with several types of malignancy and patients with dermatomyositis have higher rates of mortality from cancer. Although rare in Japan, head and neck cancer, especially nasopharyngeal cancer, is the predominant type of cancer associated with dermatomyositis in several areas in Asia, including Hong Kong and Singapore. Here we report two cases of head and neck cancer with dermatomyositis as well as a literature review. Both cases were treated with chemotherapy and radiotherapy. Although the patients were immunosuppressed due to dermatomyositis treatment, no grade 3 or 4 adverse events occurred.
Head and Neck Cancer with Dermatomyositis: A Report of Two Clinical Cases
Kohichi Yamauchi,Yasunao Kogashiwa,Hiroshi Nagafuji,Naoyuki Kohno
International Journal of Otolaryngology , 2010, DOI: 10.1155/2010/401825
Abstract: Dermatomyositis is well known to be associated with several types of malignancy and patients with dermatomyositis have higher rates of mortality from cancer. Although rare in Japan, head and neck cancer, especially nasopharyngeal cancer, is the predominant type of cancer associated with dermatomyositis in several areas in Asia, including Hong Kong and Singapore. Here we report two cases of head and neck cancer with dermatomyositis as well as a literature review. Both cases were treated with chemotherapy and radiotherapy. Although the patients were immunosuppressed due to dermatomyositis treatment, no grade 3 or 4 adverse events occurred. 1. Introduction Dermatomyositis is a connective tissue disease with characteristic cutaneous manifestations and it is well known that dermatomyositis is associated with various types of cancer. The first suggestion that dermatomyositis was associated with cancer was made by Sterz in 1916 [1] and numerous cases have since been reported. In this paper, two cases of patients with head and neck cancer along with dermatomyositis are reported. 2. Case Reports 2.1. Case 1 A 79-year-old man was admitted to our hospital with nasal bleeding and left cheek swelling suggestive of maxillary sinus carcinoma. A solid mass with aggressive bone destruction was detected in the left maxillary sinus on contrast-enhanced computed tomography images. For 1 month, the patient had noticed a systemic rash, the typical heliotrope coloration of the upper eyelids, Gottron’s sign on the dorsal surface of his proximal interphalangeal joints, erythematous areas at the bases of the fingernails (Figure 1), dysphagia, and proximal muscle weakness of both extremities, but he and his family did not think that the symptoms were serious. On the second day of hospitalization, his respiratory dysfunction progressed rapidly. His chest X-ray was normal and initial investigations revealed a normal complete blood count and negative antinuclear antibody and anti Jo-1 antibody levels. However, there were several abnormal laboratory test results, including increases in aspartate aminotransferase (AST) (451?IU/L; normal range, 8–33?IU/L), alanine aminotransferase (ALT) (90?IU/L; normal range, 3–30?IU/L), creatine kinase (CK) (8,800?IU/L; normal range, 15–166?IU/L), lactate dehydrogenase (LDH) (973?IU/L; normal range, 118–226?IU/L), and aldolase (ALD) (23.3?IU/L; normal range, 0.60–7.60?IU/L). His clinical symptoms fulfilled the criteria for the diagnosis of dermatomyositis and it was thought that his respiratory dysfunction was caused by acute interstitial pneumonia
Rikkunshito and Ghrelin
Tomohisa Hattori
International Journal of Peptides , 2010, DOI: 10.1155/2010/283549
Abstract: Rikkunshito is a popular Japanese traditional medicine that is prescribed in Japan to treat various gastrointestinal tract disorders. In a double-blind controlled study, rikkunshito significantly ameliorated dysmotility-like dyspepsia and brought about a generalized improvement in upper gastric symptoms such as nausea and anorexia when compared with a control group. Several studies in rats have shown enhanced gastric emptying and a protective effect on gastric mucosa injury with rikkunshito administration. In addition, rikkunshito in combination with an anti-emetic drug is effective against anorexia and vomiting that occur as adverse reactions to chemotherapy in patients with advanced breast cancer. However, the mechanism by which rikkunshito alleviates gastrointestinal disorders induced by anticancer agents remains unclear. It has recently been shown that rikkunshito ameliorates cisplatin-induced anorexia by mediating an increase in the circulating ghrelin concentration. Moreover, Fujitsuka et al. found that decreased contractions of the antrum and duodenum in rats treated with a selective serotonin reuptake inhibitor were reversed by rikkunshito via enhancement of the circulating ghrelin concentration. These findings show that rikkunshito may be useful for treatment of anorexia and may provide a new strategy for improvement of upper gastrointestinal dysfunction. Rikkunshito is one of the few traditional Japanese medicines for which a double-blind study has been conducted. This trial was performed in patients with dysmotility-like dyspepsia [1, 2] based on a report that rikkunshito showed efficacy against non-ulcer dyspepsia, which is an old diagnostic classification. In a subsequent comparative clinical study, rikkunshito was found to be more effective than cisapride against undefined gastrointestinal complaints such as chronic gastritis [3]. Rikkunshito is prepared by compounding eight herbal medicines listed in the Japanese Pharmacopoeia: Atractylodis Lanceae Rhizoma, Ginseng Radix, Pinelliae Tuber, Hoelen, Zizyphi Fructus, Aurantii Nobilis Pericarpium, Glycyrrhizae Radix and Zingiberis Rhizoma. It has recently been shown that oral administration of rikkunshito stimulates secretion of the orexigenic peptide, ghrelin, from the stomach [4, 5]. In this section, the effects of rikkunshito are introduced, with main focus on the action of rikkunshito as an enhancer of ghrelin secretion. Anorexia is commonly seen in gastrointestinal diseases, although it is not a specific symptom. Anorexia is particularly common in chronic gastritis and gastric cancer but
Critical Nature of Non-Fermi Liquid in Spin 3/2 Multipolar Kondo Model
Kazumasa Hattori
Physics , 2005, DOI: 10.1143/JPSJ.74.3135
Abstract: A multipolar Kondo model of an impurity spin S_I=3/2 interacting with conduction electrons with spin s_c=3/2 is investigated using boundary conformal field theory. A two-channel Kondo (2CK) -like non-Fermi liquid (NFL) under the particle-hole symmetry is derived explicitly using a ``superspin absorption'' in the sector of a hidden symmetry, SO(5). We discuss the difference between the usual spin-1/2 2CK NFL fixed point and the present one. In particular, we find that, unlike the usual 2CK model, the low temperature impurity specific heat is proportional to temperature.
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