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Search Results: 1 - 10 of 1278 matches for " Yasuhiro Arisuda "
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Improvement of die life in high speed injection die casting
Yasuhiro Arisuda,Akihito Hasuno,Junji Yoshida
China Foundry , 2008,
Abstract: High-speed injection die casting is an effi cient manufacturing technology for upgrading aluminum die-cast products. However, defi ciencies (such as die damage in early period) due to larger load on the molding die compared with conventional technology have brought new challenges. In this study, the cause of damage generated in super high-speed injection was investigated by the combination of experimental observation of the dies and CAE simulation (e.g. die emperature analysis, fl ow analysis and thermal stress analysis). The potential countermeasures to solve the above problems were also proposed.
Working Memory in Patients with Major Depressive Disorder  [PDF]
Yasuhiro Kaneda
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.329115
Abstract: Objective: Patients with major depressive disorder (MDD) have been reported to perform less well in neurocognitive tests than normal control subjects. The author tested the hypotheses that verbal working memory (WM) is predictive of the functional outcome in patients with MDD. Methods: In this naturalistic longitudinal study, the subjects consisted of 22 adult outpatients receiving paroxetine as antidepressant therapy. Functional outcome was rated on a scale of 0 (non-impaired) to 3 (severely impaired). Results: 1) At 12 weeks, nine of the 22 patients currently experiencing MDD exhibited full remission; 2) significantly decreased 7-item Hamilton Rating Scale for Depression (HAM-D7) scores were observed during the 12-week study period, while Digit Sequencing Task (DST) scores increased significantly; 3) at baseline, functional outcomes correlated significantly with HAM-D7 scores, but, at 12 weeks, correlated significantly with both HAM-D7 and DST scores. Furthermore, when looking at only patients in full or partial remission (mild depression), functional outcome correlated more strongly with DST than with HAM-D7 scores. Conclusions: A deficit of verbal WM correlated with the functional outcome after treatment in pa- tients with MDD. Antidepressant therapy with paroxetine might contribute to improvement of verbal WM.
Clinical and pathobiological heterogeneity of asthma—Mechanisms of severe and glucocorticoid-resistant asthma  [PDF]
Yasuhiro Matsumura
Health (Health) , 2013, DOI: 10.4236/health.2013.52A046
Abstract:

It is increasingly recognized that asthma represents a syndrome, and there is clinical and pathobiological heterogeneity. Many genes are reported to be associated with asthma, and may be involved in the disease heterogeneity. Diverse cells, such as T helper 1 (Th1)-cells, Th2-cells, Th17-cells, airway epithelial cells, and innate and adaptive immunity associated cells, contribute to the pathobiology of asthma independently of each other or they can also coexist and interact. Although, generally, Th2 immunity is important in most asthma endotypes, non- Th2-driven inflammation tends to be difficult to manage. Recently, increased attention has been focused on severe asthma and glucocorticoid (GC)-resistant (GC-R) asthma, in which diverse inflammatory processes may be involved. Treatment approaches should take into account pathological differences.

A Critical Review of Selye’s Stress Theory: The Statistical Analyses of Selye’s Own Experimental Data Disprove It  [PDF]
Yasuhiro Nageishi
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.614175
Abstract: Selye’s article (Selye, 1936a) published in “Nature” has been enormously cited and markedly affected the entire field of “stress”, until today. The key concept of Selye’s stress theory was “the principle of nonspecificity”. Selye defined stress as the nonspecific responses of the body to various noxious agents. He gave various noxious stimuli to rats, and reported the results in his paper (Selye, 1936b). However, he described only raw data (thymus, and adrenal weights in individual rats), without even the mean values. This study analyzed those data statistically. Among his data, the result pattern most frequently observed was the both occurrences of thymus involution and adrenal enlargement. It appeared to give a conclusive evidence for Selye’s theory. However, there were also other two result patterns. The second pattern was a significant decrease in the thymus weight without changes in the adrenal weight (fasting for 24 - 96 hours in 3-month-old rats, morphine injections, and skin lesions). The third pattern was no change in either the thymus or adrenal weight (exposure to heat and bone fractures). These results disproved Selye’s theory of nonspecificity and they forsook it. And moreover, it was suggested that Selye’s results themselves supported Mason’s proposal that all stress responses were elicited through psychological emotional reactions (Mason, 1971), which were very compatible with the recent psychological stress theories.
Parallel Computing of Discrete Element Method on GPU  [PDF]
Teruyoshi Washizawa, Yasuhiro Nakahara
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.41A037
Abstract:

General purpose computing on GPU for scientific computing has been rapidly growing in recent years. We investigate the applicability of GPU to discrete element method (DEM) often used in particle motion simulation. NVIDIA provides a sample code for this type of simulation, which obtained superior performance than CPU in computational time. A computational model of the contact force in NVIDIA’s sample code is, however, too simple to use in practice. This paper modifies the NVIDIA’s simple model by replacing it with the practical model. The computing speed of the practical model on GPU is compared with the simple one on GPU and with the practical one on CPU in numerical experiments. The result shows that the practical model on GPU obtains the computing speed 6 times faster than the practical one on CPU while 7 times slower than that of the simple one on GPU. The effects of the GPU architectures on the computing speed are analyzed.

Cardiac Arrest Cases and Automated External Defibrillator Use in Railroad Stations in Tokyo  [PDF]
Satoko Fukuike, Yasuhiro Otomo
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.520170
Abstract: Objective: Nationwide dissemination of public-access defibrillation (PAD) contributed to an increase of survival rate in Japan. We analysed cardiac arrests (CAs) that occurred in railroad stations in Tokyo to evaluate PAD in the metropolis. Methods: We collected Utstein data from the Tokyo Fire Department (TFD) and analysed CA cases that occurred in stations. In total, 245 non-traumatic CAs from January 1, 2007 to March 31, 2008 were analysed; CAs in children under 8 years were excluded. Results: The rates of pre-hospital return of spontaneous circulation (ROSC) were 41 out of 145 witnessed CA patients (28.3%) and 12 ROSC out of 100 unwitnessed CA patients (12%). Of 245 CA cases, bystander cardiopulmonary resuscitation (CPR) performed in 156 (63.7%), automated external defibrillator (AED) used in 117 (47.8%) and shock delivered in 65 (26.5%). Rates of ROSC were 31.6% (37/117) with AED use significantly higher than those of 12.5% (16/128) without AED use (P < 0.001). Most CAs occurred on platforms; the use of AEDs on platforms increased from 18/31 (58.1%) in 2007 to 32/43 (74.4%) in 2008 and ROSC rates increased from 8 (25.8%) to 14 (32.6%), respectively. On train CAs: ROSC cases were very few, 1 case each year (8.3%; 7.7%) while the use of AED increased from 8/12 (66.7%) in 2007 to 10/13 (76.9%) in 2008. Conclusion: Bystander CPR and the use of AED at railroad stations improved ROSC for out-of-hospital cardiac arrest (OHCA) patients. AED location and strategies for dealing with CAs on trains should be re-evaluated.
Visualization of a Laminar Necklace Vortex System in Front of a Vertical Rectangular Plate on a Ground Wall  [PDF]
Yasuhiro Nakahara, Hidemi Yamada
Journal of Flow Control, Measurement & Visualization (JFCMV) , 2015, DOI: 10.4236/jfcmv.2015.32008
Abstract: Various properties of a necklace vortex system formed around a rectangular plate standing vertically on a flat ground wall were investigated by visualizations produced by injecting fluorescent dye into a water channel flow. As a result, it was found that the necklace vortex pattern had three steady systems depending on the Reynolds number Reh, the relative height h/δ of the rectangular plate compared with the laminar boundary layer thickness and the aspect ratio w/h. As it is expected that the aspect ratio of the rectangular plate will typify the projected area configuration of various three-dimensional bodies, the aspect ratio is varied widely from 0.5 to 7.0. The transitional boundaries of Reh and h/δ in the 2-vortex, 4-vortex and 6-vortex systems for each aspect ratio decreased when w/h < 3.0, and increased when w/h ≥ 3.0 as w/h increased. The x-direction length of the main vortex position XV1/h was almost constant when w/h < 3.0, and decreased when w/h ≥ 3.0 as Reh increased. Then, the separation length r1/h increased when w/h < 3.0 and Reh < 1000, and became almost constant when w/h ≥ 3.0 and Reh ≥ 1000 as w/h and Reh increased. Moreover, the increase of r1/h is notably rapid when w/h < 3.0.
The Changes in the Neck Meridian Test Scores Induced by Self-Administered Acupressure: A Secondary Analysis of Data from a Randomized Controlled Trial of Self-Administered Acupressure  [PDF]
Satoshi Horiuchi, Yasuhiro Honda
Chinese Medicine (CM) , 2017, DOI: 10.4236/cm.2017.81002
Abstract: In the neck meridian test, the examinee stretches his or her neck in four directions and rates the intensity of pain and/or symptoms on a four point Likert scale. The four responses are summed to calculate the test score. This study conducted secondary analyses of data from a randomized controlled trial of self-administered acupressure. The study aimed to examine the change of the neck meridian test score induced by self-administered acupressure. The data of 54 (male, n = 34; female, n = 20) students, who were randomly assigned to an intervention group (IG) and a control group (CG), were subjected to secondary analyses. The IG participants were asked to complete a self-administered acupressure intervention for two weeks; the CG participants were not. In the IG, the perceived stress decreased significantly over time, while the neck meridian test score decreased significantly; in contrast, this score increased in the CG. A significant positive correlation was found between the changes in the perceived stress and neck meridian test scores. These results supported validity of the neck meridian test as a tool for assessing perceived stress.
Role of Allergen Source-Derived Proteases in Sensitization via Airway Epithelial Cells
Yasuhiro Matsumura
Journal of Allergy , 2012, DOI: 10.1155/2012/903659
Abstract: Protease activity is a characteristic common to many allergens. Allergen source-derived proteases interact with lung epithelial cells, which are now thought to play vital roles in both innate and adaptive immune responses. Allergen source-derived proteases act on airway epithelial cells to induce disruption of the tight junctions between epithelial cells, activation of protease-activated receptor-2, and the production of thymic stromal lymphopoietin. These facilitate allergen delivery across epithelial layers and enhance allergenicity or directly activate the immune system through a nonallergic mechanism. Furthermore, they cleave regulatory cell surface molecules involved in allergic reactions. Thus, allergen source-derived proteases are a potentially critical factor in the development of allergic sensitization and appear to be strongly associated with heightened allergenicity. 1. Introduction Asthma is regarded as an inflammatory disorder of the airways and has generally been recognized as being driven by T helper 2- (Th2-) skewed Th cell differentiation. Th2-driven cytokines, interleukin (IL)-4 and IL-13, trigger B cells to synthesize IgE, while IL-5 plays a role in eosinophil maturation and survival, and IL-13 regulates airway hyperresponsiveness and mucus hyperplasia. Epithelial cells clearly play important roles in the initiation of Th2 cell responses to allergens. The epithelial cell layer also acts as a molecular sieve that excludes invaders and plays an important role in homeostasis. Barrier function disorder due to filaggrin (FLG) mutations is critical in the pathogenesis of atopic dermatitis [1]. Although FLG is not expressed in the lower airway respiratory epithelium [2], barrier function of the airway epithelium is impaired in asthma, showing shared common underlying pathogenic mechanisms. Taking these findings together, asthma can be viewed as a disease of both excessive activation and impairment of airway epithelial barrier function [3–5]. Sources of allergens, such as pollen, house dust mites (HDMs), cockroaches, and fungi, may produce or contain proteases and thereby activate and disrupt the epithelial barrier, causing greater sensitization. This paper focuses on the importance of allergen source-derived proteases as a factor contributing to primary sensitization to allergens and to exacerbation of allergic disorders secondary to impaired epithelial barrier function. 2. Allergen Source-Derived Proteases Environmental exposure to allergens is an important determinant of the prevalence of asthma. Allergen source-derived proteases act not
Organic Zeolite Analogues Based on Multi-Component Liquid Crystals: Recognition and Transformation of Molecules within Constrained Environments
Yasuhiro Ishida
Materials , 2011, DOI: 10.3390/ma4010183
Abstract: In liquid crystals (LCs), molecules are confined in peculiar environments, where ordered alignment and certain mobility are realized at the same time. Considering these characteristics, the idea of “controlling molecular events within LC media” seems reasonable. As a suitable system for investigating this challenge, we have recently developed a new class of ionic LCs; the salts of amphiphilic carboxylic acids with 2-amino alcohols, or those of carboxylic acids with amphiphilic 2-amino alcohols, have a strong tendency to exhibit thermotropic LC phases. Because of the noncovalent nature of the interaction between molecules, one of the two components can easily be exchanged with, or transformed into, another molecule, without distorting the original LC architecture. In addition, both components are common organic molecules, and a variety of compounds are easily available. Taking advantage of these characteristics, we have succeeded in applying two?component LCs as chiral media for molecular recognition and reactions. This review presents an overview of our recent studies, together with notable reports related to this field.
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