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Search Results: 1 - 10 of 60408 matches for " Yang-Sae Moon "
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A fast divide-and-conquer algorithm for indexing human genome sequences
Woong-Kee Loh,Yang-Sae Moon,Wookey Lee
Computer Science , 2010, DOI: 10.1587/transinf.E94.D.1369
Abstract: Since the release of human genome sequences, one of the most important research issues is about indexing the genome sequences, and the suffix tree is most widely adopted for that purpose. The traditional suffix tree construction algorithms have severe performance degradation due to the memory bottleneck problem. The recent disk-based algorithms also have limited performance improvement due to random disk accesses. Moreover, they do not fully utilize the recent CPUs with multiple cores. In this paper, we propose a fast algorithm based on 'divide-and-conquer' strategy for indexing the human genome sequences. Our algorithm almost eliminates random disk accesses by accessing the disk in the unit of contiguous chunks. In addition, our algorithm fully utilizes the multi-core CPUs by dividing the genome sequences into multiple partitions and then assigning each partition to a different core for parallel processing. Experimental results show that our algorithm outperforms the previous fastest DIGEST algorithm by up to 3.5 times.
Linear Detrending Subsequence Matching in Time-Series Databases
Myeong-Seon Gil,Yang-Sae Moon,Bum-Soo Kim
Computer Science , 2010, DOI: 10.1587/transinf.E94.D.917
Abstract: Each time-series has its own linear trend, the directionality of a timeseries, and removing the linear trend is crucial to get the more intuitive matching results. Supporting the linear detrending in subsequence matching is a challenging problem due to a huge number of possible subsequences. In this paper we define this problem the linear detrending subsequence matching and propose its efficient index-based solution. To this end, we first present a notion of LD-windows (LD means linear detrending), which is obtained as follows: we eliminate the linear trend from a subsequence rather than each window itself and obtain LD-windows by dividing the subsequence into windows. Using the LD-windows we then present a lower bounding theorem for the index-based matching solution and formally prove its correctness. Based on the lower bounding theorem, we next propose the index building and subsequence matching algorithms for linear detrending subsequence matching.We finally show the superiority of our index-based solution through extensive experiments.
Efficient 2-Step Protocol and Its Discriminative Feature Selections in Secure Similar Document Detection
Sang-Pil Kim,Myeong-Sun Gil,Yang-Sae Moon,Hee-Sun Won
Computer Science , 2015,
Abstract: Secure similar document detection (SSDD) identifies similar documents of two parties while each party does not disclose its own sensitive documents to another party. In this paper, we propose an efficient 2-step protocol that exploits a feature selection as the lower-dimensional transformation and presents discriminative feature selections to maximize the performance of the protocol. For this, we first analyze that the existing 1-step protocol causes serious computation and communication overhead for high dimensional document vectors. To alleviate the overhead, we next present the feature selection-based 2-step protocol and formally prove its correctness. The proposed 2-step protocol works as follows: (1) in the filtering step, it uses low dimensional vectors obtained by the feature selection to filter out non-similar documents; (2) in the post-processing step, it identifies similar documents only from the non-filtered documents by using the 1-step protocol. As the feature selection, we first consider the simplest one, random projection (RP), and propose its 2-step solution SSDD-RP. We then present two discriminative feature selections and their solutions: SSDD-LF (local frequency) which selects a few dimensions locally frequent in the current querying vector and SSDD-GF (global frequency) which selects ones globally frequent in the set of all document vectors. We finally propose a hybrid one, SSDD-HF (hybrid frequency), that takes advantage of both SSDD-LF and SSDD-GF. We empirically show that the proposed 2-step protocol outperforms the 1-step protocol by three or four orders of magnitude.
A Data Cleansing Method for Clustering Large-scale Transaction Databases
Woong-Kee Loh,Yang-Sae Moon,Jun-Gyu Kang
Computer Science , 2010, DOI: 10.1587/transinf.E93.D.3120
Abstract: In this paper, we emphasize the need for data cleansing when clustering large-scale transaction databases and propose a new data cleansing method that improves clustering quality and performance. We evaluate our data cleansing method through a series of experiments. As a result, the clustering quality and performance were significantly improved by up to 165% and 330%, respectively.
Analyzing Spur-Distorted Impedance Spectra for the QCM
Sae Moon Yoon,Nam Joon Cho,Kay Kanazawa
Journal of Sensors , 2009, DOI: 10.1155/2009/259746
Abstract: The quartz crystal microbalance (QCM) is a sensitive device for determining the properties of materials loading it. One of the fundamental means of making these measurements is the so-called impedance (or admittance) spectra method. The resonant properties of the piezoelectric QCM sensor are measured over a spectral range in the neighborhood of a resonance, both with load and without load. The changes in the spectrum upon loading can be compared to models that describe the changes based on the mass density, the shear modulus, and the viscosity of the load. This comparison can be made with confidence so long as the spectrum corresponds to the model assumption of a single main resonance. Often, there exists a spurious resonance lying above the main resonance which is not included in the models. This can change the shape of the spectrum in ways not included in the model analysis. We describe a method we have used that separates the spur resonance from the main resonance, permitting the parameters of the main resonance to be isolated from that of the spur. These corrected parameters of the main resonance can then be used with confidence in model analyses.
A multi-center, randomized, clinical study to compare the effect and safety of autologous cultured osteoblast(Ossron?) injection to treat fractures
Seok-Jung Kim, Yong-Woon Shin, Kyu-Hyun Yang, Sang-Bum Kim, Moon-Jib Yoo, Suk-Ku Han, Soo-Ah Im, Yoo-Dong Won, Yerl-Bo Sung, Taek-Soo Jeon, Cheong-Ho Chang, Jae-Deog Jang, Sae-Bom Lee, Hyun-Cho Kim, Soo-Young Lee
BMC Musculoskeletal Disorders , 2009, DOI: 10.1186/1471-2474-10-20
Abstract: Sixty-four patients with long-bone fractures were randomly divided into two groups, i.e. those who received autologous cultured osteoblast injection and those who received no treatment. The sum of the difference in the callus formation scores after four and eight weeks, was used as the first efficacy variable.The autologous cultured osteoblast injection group showed fracture healing acceleration of statistical significance, and there were no specific patient complications when using this treatment.Autologous cultured osteoblast injection should therefore be considered as a successful treatment option for treating long-bone fracture.Current Controlled Trials ISRCTN10637905During the past few decades, various surgical instruments and external as well as internal metal fixators have been developed for the treatment of fractures; these instruments are constantly being improved in order to provide more effective fracture treatment. To accelerate fracture healing, ultrasound and other treatment methods have also recently been introduced[1]. In particular, cell therapy suggests a new treatment approach[2]. For articular cartilage defects, autologous chondrocyte implantation has become the major treatment[3], and even as a treatment for fracture, the use of autologous cultured osteoblasts has been suggested[4].When using bone grafts, problems may develop in the donor area in general autologous bone grafts and immunological problems, while the spread of disease may also develop in allografts. There may be faster patient recovery and an absence of these problems when autologous cultured osteoblasts are used[5]. However, as there are only a small number of cells within bone marrow which can be differentiated into osteoblasts[6,7], cell culture is essential for clinical applications. Therefore, it can be anticipated that osteoblasts obtained using cell culture methods may be helpful for healing fractures[8].Kim et al. showed in animal studies that transplanted autologous cultur
The Moderating Effects of Collectivistic Orientation on Psychological Ownership and Constructive Deviant Behavior
Yang Woon Chung,Hyoung Koo Moon
International Journal of Business and Management , 2011, DOI: 10.5539/ijbm.v6n12p65
Abstract: Psychological ownership has been theorized to result in positive organizational consequences because feelings of ownership can increase an individual’s sense of responsibility and prioritize organizational interests. Previous studies have found psychological ownership to be significantly related to job satisfaction, organizational commitment, and organizational citizenship behavior; therefore, this study proposes psychological ownership to be significantly related to constructive deviant behavior because it is considered to be functional behavior that is intended to improve the organization’s well-being. Furthermore, this study investigates the moderating effects of collectivistic orientation on psychological ownership and constructive deviant behavior. The study sampled 465 Korean employees and has found psychological ownership to be significantly related to innovative constructive deviant behavior and interpersonal constructive deviant behavior. For the moderating effects, collectivistic orientation moderated the relationships between psychological ownership and organizational constructive deviant behavior and interpersonal constructive deviant behavior.
The effects of pre-pregnancy body mass index and gestational weight gain on perinatal outcomes in Korean women: a retrospective cohort study
Sae-Kyung Choi, In-Yang Park, Jong-chul Shin
Reproductive Biology and Endocrinology , 2011, DOI: 10.1186/1477-7827-9-6
Abstract: We retrospectively reviewed the medical records of 2,454 women who had received antenatal care at Seoul St. Mary's Hospital from January 2007 to December 2009. We used World Health Organization definitions for Asian populations of underweight (BMI < 18.5), normal (BMI equal or higher 18.5 and < 23), overweight (BMI equal or higher 23 and < 25), and obese (BMI equal or higher 25). We analyzed perinatal outcomes according to the pre-pregnancy BMI and weight gain during pregnancy, and calculated the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) from multiple logistic regression models by considering maternal age, parity, number of fetuses, length of gestation, and medical history.Among obese women, the adjusted ORs for gestational diabetes, hypertensive disorder, and incompetent internal os of cervix were 4.46, 2.53, and 3.70 (95% CI = 2.63-7.59, 1.26-5.07, and 1.50-9.12), respectively, and the adjusted ORs for neonatal complications such as macrosomia and low Apgar score were 2.08 and 1.98 (95% CI = 1.34-3.22 and 1.19-3.29), respectively, compared with normal weight women. However, there was no positive linear association between gestational weight gain and obstetric outcomes. In normal weight women, maternal and neonatal complications were significantly increased with inadequate weight gain during pregnancy (p < 0.0001 and = 0.0180, respectively), and we observed similar results in underweight women (p = 0.0136 and 0.0004, respectively).This study shows that pre-pregnancy overweight and obesity are more closely related to the adverse obstetric outcomes than excess weight gain during pregnancy. In addition, inadequate weight gain during pregnancy can result in significant complications.Obesity has been frequently cited as a health problem in women of childbearing age. A recent report found that 25% of the adult population was obese. The obesity rate has rapidly increased in the general population and in women of childbearing age [1,2]. According to a s
Rapid and reliable extraction of genomic DNA from various wild-type and transgenic plants
Tae-Jin Kang, Moon-Sik Yang
BMC Biotechnology , 2004, DOI: 10.1186/1472-6750-4-20
Abstract: We developed new rapid and reliable genomic DNA extraction method. With our developed method, plant genomic DNA extraction could be performed within 30 min. The method was as follows. Plant tissue was homogenized with salt DNA extraction buffer using hand-operated homogenizer and extracted by phenol:chloroform:isoamyl alcohol (25:24:1). After centrifugation, the supernatant was directly used for DNA template for PCR, resulting in successful amplification for RAPD from various sources of plants and specific foreign genes from transgenic plants. After precipitating the supernatant, the DNA was completely digested by restriction enzymes.This DNA extraction procedure promises simplicity, speed, and efficiency, both in terms of time and the amount of plant sample required. In addition, this method does not require expensive facilities for plant genomic DNA extraction.Molecular biological studies of plants require high-quality DNA. Several DNA extraction procedures for isolating genomic DNA from various plant sources have been described, including the salt extraction method and the cetyltrimethyl ammonium bromide (CTAB) method [1] and its modifications [2,3]. The need for a rapid and simple procedure is urgent, especially when hundreds of samples need to be analyzed.Most methods require the use of liquid nitrogen [4] or freeze-drying (lyophilization) [5,6] of tissue for the initial grinding, and these processes are unavailable in many regions of the world. After grinding the tissues in various extraction buffers, DNA is extracted with phenol-chloroform, or the extract is dialyzed against EDTA and a buffered Tris-HCl solution [7]. After extraction, the aqueous phase is concentrated, either by ethanol or isopropanol precipitation [8,9], or with microconcentrators (e.g., the Wizard genomic DNA purification system; Promega, USA). However, these methods are not time efficient for consistently obtaining PCR-quality DNA from calluses and plants, since they require that the tissu
The Effects of Thinning on Fine Root Distribution and Litterfall in a Pinus koraiensis Plantation
Byung Bae Park,Im Kyun Lee,Hee Moon Yang
Journal of Ecology and Field Biology , 2009,
Abstract: The purpose of this study was to investigate the effects of thinning on fine root biomass andvertical distribution and litterfall amount in a 50 year old Pinus koraiensis plantation in Chuncheon, KangwonProvince. Fine root (< 2 mm in diameter) biomass (367 g/m2) in the site ‘OC_75’, thinning once in 1975, was68% of those in the site ‘CON’, no thinning after planting, and in the site ‘TC_00’, thinning twice in 1975 and2000. There were no significant differences of dead roots among treatments. Diameter 0~1 mm roots werevertically decreased only in the TC_00 site. The litterfall was very similar between OC_75 (5.2 Mg ha-1 yr-1)and TC_00 (4.7 Mg ha-1 yr-1), but the composition of litterfall was different: The proportion of leaves andbranches was 80% and 13% in OC_75 and 56% and 36% in TC_00, respectively. Reduction of P. koraiensisdensity by thinning decreased leaf litter as well as fine roots of P. koraiensis, but increased fine roots productionby neighboring understory plants offset the reduction of fine roots of P. koraiensis. We suggest that belowgroundas well as aboveground responses, including both over- and understory vegetation, should be considered tomeasure the responses of trees in thinned forest ecosystems.
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