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Search Results: 1 - 10 of 326322 matches for " Yanelkys; Sánchez Segura "
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Enfermedad granulomatosa crónica: Aspectos actuales Chronic granulomatous disease: Current aspects
Yanelkys Cos Padrón,Vianed Marsán Suárez,Miriam Sánchez Segura,Consuelo Macías Abraham
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2004,
Abstract: La enfermedad granulomatosa crónica (EGC) es una inmunodeficiencia primaria causada por mutaciones en los genes que codifican para cualquiera de las 4 subunidades que conforman a la enzima adenina dinucleótido fosfato oxidasa (NADPH oxidasa), encargada de regular la producción de especies oxidantes microbicidas que constituyen la primera vía de defensa del organismo contra los microorganismos infecciosos. Esta es una deficiencia muy heterogénea clasificada en EGC ligada al cromosoma X (subunidad gp91-phox) y autosómica recesiva, donde puede estar afectada cualquiera de las siguientes subunidades de la enzima: p22-phox, p47-phox y p67-phox. Dentro de los hallazgos clínicos más frecuentes se encuentran entre otros la linfadenopatía, hepatoesplenomegalia, neumonía. Para el tratamiento de la enfermedad se utilizan antibióticos de amplio espectro y el interferón gamma para el tratamiento de infecciones severas en la EGC ligada al cromosoma X. Actualmente se están realizando estudios para utilizar la terapia génica somática como posible cura de la enfermedad Chronic granulomatous disease is a primary immunodeficiency caused by mutations in genes encoding any of the 4 subunits that make up adenine dinucleotide phosphate oxidase (NADPH oxidase), the enzyme that regulates the production of microbial oxidizing species that are the first defensive pathway of the body against infectious microorganisms. This is a very heterogeneous deficiency classified as X chromosome-linked CGD (gp91-phox subunit) and as autosomal recessive chronic granulomatous disease, where any of the subunits of the enzyme, that is, p22-phox, p47-phox and p67-phox, may be affected. The most frequent clinical findings include, among others, lymphadenopathy, splenohepatomegaly and pneumonia. Broad-spectrum antibiotics for the treatment of the disease and gamma interferon for the treatment of severe infections are used in X chromosome-linked chronic granulomatous disease. At present, studies are being carried out with a view to using somatic gene therapy as a likely disease cure
Caracterización biológica y clínica de pacientes pediátricos con leucemia linfoide aguda pro-B Biological and clinical characterization of pediatric patients with pro-B acute lymphocytic leukemia
Vianed Marsán Suárez,Yanelkys Cos Padrón,Bertha Beatriz Socarrás Ferrer,Miriam Sánchez Segura
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2006,
Abstract: Se estudiaron las características biológicas y clínicas de 19 ni os con leucemia linfoide aguda (LLA) pro-B en un periodo de 14 a os. El inmunofenotipaje celular se realizó mediante el ultramicrométodo inmunocitoquímico. Se observó una mayor incidencia en el grupo de 2-5 a os. La distribución por raza en este trabajo fue la misma que en la población normal. Los ni os varones de piel blanca fueron los más afectados. El 73,7 % de los pacientes mostró leucocitos < 20 x109 /L al inicio de la enfermedad y el 57,9 % mostró hepatomegalia y esplenomegalia. Se observaron adenopatías y manifestaciones hemorrágicas en el 47,4 % y en el 2 %, respectivamente. El antígeno CD19 se expresó en el 100 % de los pacientes, el CD22 citoplasmático en el 89,5 %, la enzima Tdt en el 68,4 % y el HLA-DR en el 57,9 %. Del total de pacientes estudiados, 4 (21 %) expresaron antígenos mieloides y fueron clasificados como LLA pro-B Mi+. Los antígenos mieloides expresados fueron, en un paciente el CD13 y CD33 (5,3 %), y el CD15 en 2 enfermos (10,5 %). Estos resultados demuestran que la LLA es una enfermedad heterogénea con subtipos biológicos y clínicos diferentes The biological and clinical characteristics of 19 children with pro-B acute lymphocytic leukemia were studied during 14 years. The cellular immunophenotyping was performed by the immunocytochemical ultramicrornethod. A higher incidence was observed in a group aged 2-5 years old. The distribution by race was the same as in the normal population. The white boys were the most affected. 73.7 % of the patients presented leukocytes < 20x10 9 /L at the onset of the disease, and 57.9 % had hepatomegaly and splenomegaly. Adenopathies and hemorrhagic manifestations were observed in 47.4 % and in 2 %, respectively. The CD19 antigen was expressed in 100 % of the patients, the CD22 plasmatic antigen in 89.5 %, the Tdt enzyme in 68.4 % and HLA-DR in 57.9 %. Of the total of studied patients, 4 (21 %) expressed myeloid antigens and were classified as pro-B LLA-Mi+. The expressed myeloid antigens were CD13 and CD33 (5.3 %) in a patient, and CD15 in 2 patients (10.5 %). These results show that LLA is a heterogenous disease with different biological and clinical subtypes
Relevancia biológica y clínica del inmunofenotipaje celular en la leucemia linfoide aguda del ni o Biological and clinical importance of the cellular immunophenotyping in acute lymphocytic leukemia in children
Vianed Marsán Suárez,Yanelkys Cos Padrón,Miriam Sánchez Segura,Bertha B. Socarrás Ferrer
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2008,
Abstract: Se estudiaron las características biológicas y clínicas de 238 ni os con leucemia linfoide aguda (LLA) en un período de 13 a os. El inmunofenotipaje celular de muestras procedentes de la médula ósea se realizó mediante un ultramicrométodo inmunocitoquímico. Del total de LLA estudiadas 81,4 % fueron de fenotipo B y 18,5 % de fenotipo T. El 48,4 % de los ni os con LLA de fenotipo B se encontraron en edades comprendidas entre 2-5 a os, mientras que el 65,9 % con LLA-T presentaron 6 o más a os de edad. No se encontraron diferencias estadísticamente significativas cuando se analizaron el sexo y el color de la piel en relación con el fenotipo celular leucémico. Al diagnóstico de la enfermedad, el 59,3 % de los pacientes con LLA-B mostraron cifras de leucocitos en sangre periférica < 20 x 10(9)/L y en el 61,4 % con LLA-T cifras superiores a 50 x 10(9)/L. Se observó una mayor incidencia de organomegalia, adenopatías mediastinales, manifestaciones hemorrágicas e infiltración inicial del sistema nervioso central en enfermos con LLA-T en relación con los de LLA-B, con diferencias altamente significativas. Estos resultados demuestran que el fenotipo leucémico en la LLA del ni o pudiera considerarse como un factor pronóstico positivo o negativo de la enfermedad. The biological and clinical characteristics of 238 children with acute lymphocytic leukemia (ALL) were studied for 13 years. The cellular immunophenotyping of samples from the bone marrow was performed by an immunocytochemical ultramicromethod. Of the total of studied ALL, 81.4 % were phenotype B and 18.5 % phenotype T. 48.4 % of the children with B-ALL were 2-5 years old, whereas 65.9 % with T-ALL were 6 or over. No statistically significant differences were found when sex and colour of the skin were analyzed in relation to the cellular leukemic phenotype. On diagnosing the disease, 59.3 % of the patients with B-ALL showed figures of leukocytes in peripheral blood < 20x109/L, whereas in 61.4 % with T-ALL, the figures were higher than 50x109/L. It was observed a greater incidence of organomegaly, mediastinal adenopathies, hemorrhagic manifestations and initial infiltration of the central nervous system in patients with T-ALL compared with those suffering B-ALL. The differences were highly significant. These results proved that the leukemic phenotype in ALL in children could be considered as a positive or negative prognostic factor of the disease.
Caracterización inmunofenotípica de la leucemia linfoide crónica-B Immunophenotypical characterization of B-cell chronic lymphocytic leukemia
Miriam Sánchez Segura,Vianed Marsán Suárez,Bertha Beatriz Socarrás Ferrer,Yanelkys Cos Padrón
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2007,
Abstract: Se realizó la caracterización inmunofenotípica de 115 pacientes con leucemia linfoide crónica de fenotipo B, de células procedentes de médula ósea y sangre periférica mediante un ultramicrométodo inmunocitoquímico en el Instituto de Hematología e Inmunología durante un período de 13 a os y medio. Los antígenos más frecuentemente expresados fueron: HLA-DR (98 %), CD5 (94 %), CD19 (93 %), CD20 (90 %), CD22 (84 %) e IgS (76 %). En 7 pacientes no se expresó el antígeno CD5. Se halló pobre expresión de antígenos mielomonocíticos como el CD11b (2/27) (7,4 %) y el CD11c (5/13) (38,4 %). Hubo baja expresión de IgS y de CD22 de membrana, ya que estos antígenos solo estuvieron sobreexpresados en 12,5 % y 32 % de los enfermos, respectivamente. Se encontró un predominio en la expresión de cadenas ligeras kappa. El comportamiento fenotípico de los pacientes con leucemia linfoide crónica B se correspondió con lo comunicado por otros autores para esta entidad. The immunophenotypical characterization of bone marrow cells and peripheral blood from 115 patients with B-cell chronic lymphocytic leukemia was performed by an immunocytochemical ultramicromethod at the Institute of Hematology and Immmunology during 13.5 years. The most frequently expressed antigens were: HLA-DR (98 %), CD5 (94 %), CD19 (93 %), CD20 (90 %), CD22 (84 %) and IgS (76 %). The CD-5 antigen was not present in 7 patients. It was found a poor expression of myelomonocytic antigens, such as CD11b (2/27) (7.4 %) and CD11c (5/13) (38.4 %). It was observed a low expression of IgS and of CD22 membrane, since these antigens were only overexpressed in 12.5 % and 32 % of the sick, respectively. There was a predominance in the expression of kappa light chains. The phenotypic behaviour of the patients with B-cell chronic lymphocytic leukemia corresponded with what has been reported by other authors about this entity.
Enfermedad granulomatosa crónica: Aspectos actuales
Cos Padrón,Yanelkys; Marsán Suárez,Vianed; Sánchez Segura,Miriam; Macías Abraham,Consuelo;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2004,
Abstract: chronic granulomatous disease is a primary immunodeficiency caused by mutations in genes encoding any of the 4 subunits that make up adenine dinucleotide phosphate oxidase (nadph oxidase), the enzyme that regulates the production of microbial oxidizing species that are the first defensive pathway of the body against infectious microorganisms. this is a very heterogeneous deficiency classified as x chromosome-linked cgd (gp91-phox subunit) and as autosomal recessive chronic granulomatous disease, where any of the subunits of the enzyme, that is, p22-phox, p47-phox and p67-phox, may be affected. the most frequent clinical findings include, among others, lymphadenopathy, splenohepatomegaly and pneumonia. broad-spectrum antibiotics for the treatment of the disease and gamma interferon for the treatment of severe infections are used in x chromosome-linked chronic granulomatous disease. at present, studies are being carried out with a view to using somatic gene therapy as a likely disease cure
Estrés y sistema inmune
Sánchez Segura,Miriam; González García,René Marcos; Cos Padrón,Yanelkys; Macías Abraham,Consuelo;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2007,
Abstract: in the last years, the study of the interaction among behaviour, neural and endocrine function and the immune processes, has developed an interdisciplinary research field. when the homeostatic balance in the living organisms is disturbed by deficiency or excess of stimuli, to which the organism is able to adjust, a generally multifactorial stress is produced. the interactions between the nervous system and the immune system, as well as the influences of psychological stress on immunity, both in animals and humans, are reviewed.
Estrés y sistema inmune Stress and immune system
Miriam Sánchez Segura,René Marcos González García,Yanelkys Cos Padrón,Consuelo Macías Abraham
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2007,
Abstract: En los últimos a os, el estudio de la interacción entre la conducta, función neural y endocrina, y los procesos inmunes, ha desarrollado un campo de investigación interdisciplinario. Cuando en los organismos vivientes se ve perturbado el equilibrio homeostático por deficiencia o por exceso de los estímulos a los que el organismo es capaz de ajustarse, se produce el estrés, el cual es, por lo general, multifactorial. Se revisan las interacciones entre el sistema nervioso y el sistema inmune, así como las influencias del estrés psicológico sobre la inmunidad tanto en los animales como en los humanos. In the last years, the study of the interaction among behaviour, neural and endocrine function and the immune processes, has developed an interdisciplinary research field. When the homeostatic balance in the living organisms is disturbed by deficiency or excess of stimuli, to which the organism is able to adjust, a generally multifactorial stress is produced. The interactions between the nervous system and the immune system, as well as the influences of psychological stress on immunity, both in animals and humans, are reviewed.
Caracterización biológica y clínica de pacientes pediátricos con leucemia linfoide aguda pro-B
Marsán Suárez,Vianed; Cos Padrón,Yanelkys; Socarrás Ferrer,Bertha Beatriz; Sánchez Segura,Miriam; Macías Abraham,Consuelo; del Valle Pérez,Lázaro O; Torres Leyva,Isabel; Nú?ez Quintana,Aramís; González Otero,Alejandro;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2006,
Abstract: the biological and clinical characteristics of 19 children with pro-b acute lymphocytic leukemia were studied during 14 years. the cellular immunophenotyping was performed by the immunocytochemical ultramicrornethod. a higher incidence was observed in a group aged 2-5 years old. the distribution by race was the same as in the normal population. the white boys were the most affected. 73.7 % of the patients presented leukocytes < 20x10 9 /l at the onset of the disease, and 57.9 % had hepatomegaly and splenomegaly. adenopathies and hemorrhagic manifestations were observed in 47.4 % and in 2 %, respectively. the cd19 antigen was expressed in 100 % of the patients, the cd22 plasmatic antigen in 89.5 %, the tdt enzyme in 68.4 % and hla-dr in 57.9 %. of the total of studied patients, 4 (21 %) expressed myeloid antigens and were classified as pro-b lla-mi+. the expressed myeloid antigens were cd13 and cd33 (5.3 %) in a patient, and cd15 in 2 patients (10.5 %). these results show that lla is a heterogenous disease with different biological and clinical subtypes
Efecto in vitro de la espirulina sobre los linfocitos humanos de donantes sanos y pacientes con inmunodeficiencia celular
del Valle Pérez,Lázaro O.; Socarrás Ferrer,Bertha B.; Marsán Suárez,Vianed; Torres Leyva,Isabel; Sánchez Segura,Miriam; Cos Padrón,Yanelkys; Macías Abraham,Consuelo; Hernández Ramírez,Porfirio; Ballester Santovenia,José M.;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2008,
Abstract: spirulina (spirulina spp) is a cyanophyceae alga used as a dietary supplement and for its medicinal properties. this paper was aimed at evaluating the in vitro effect of spirulina (spirel, génix, havana city, cuba) on 30 patients with diagnosis of cellular immunodeficiency and on 20 healthy donors from the institute of hematology and immunology by the lymphoblastic transformation tests with tritiated thymidine, expression of hla-dr and cd25 activation antigens by the immunocytochemical ultramicromethod, and the formation of active rosette. in the lymphoblastic transformation with criterion of tritiated thymidine, no statistically significant differences were found under the experimental conditions with and without spirulina, both in patients with cellular immunodeficiencies and in sound donors. statistically marked differences (p 0,001) were detected on applying the student's t test for matched samples between the experimental conditions with and without spirulina in the expression of the activation antigens and in the rosette formation in the analyzed groups. it was concluded that spirulina produced in cuba exerted a positive influence on the activation process of human lymphocytes.
Efecto in vitro de un extracto de Calendula officinalis L: sobre linfocitos humanos
del Valle Pérez,Lázaro O; Torres Leyva,Isabel; Sánchez Segura,Miriam; Socarrás Ferrer,Bertha B; Sagarra Veranes,Martha; Marsán Suárez,Vianed; Cos Padrón,Yanelkys; Macías Abraham,Consuelo;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2002,
Abstract: calendula officinalis l is an ornamental and medicinal plant to which many immunoestimulating properties are attributed by the traditional medicine. the effect in vitro of an extract from this plant(100 mg/ml) on human lymphocytes from 30 healthy donors and 30 patients diagnosed with cellular immunodeficiency was studied through lymphoblastic transformation following tritated thymidine and active rosette criteria. no statistically significant differences were found under experimental conditions without and with calendula officinalis l. dilutions (from 1:2 to 1:2048) in blastic transformation test. as to active rosette test, there was no difference between lymphocytes without and with incubated extract (dilution rate: 1:64) during the 24 hours before the rosette formation. it is concluded that calendula officinalis l extract in vitro does not bring about changes in human lymphocytes from both healthy donors and patients diagnosed with cellular immunodeficiency
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