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Search Results: 1 - 10 of 49285 matches for " Yan Jia "
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Isoform Inference From RNA-Seq Samples Based on Gene Structures on Chromosomes  [PDF]
Yan Ji, Jia Wei
Journal of Biosciences and Medicines (JBM) , 2013, DOI: 10.4236/jbm.2013.11001
Abstract: The emerging RNA-Seq technology makes it possible to infer splicing variants from millions of short sequence reads. Here we present a method to identify isoforms by their specific signatures on chromosomes including both exons and junctions. By applying this method to a RNA-Seq dataset of gastric cancer, we showed that our method is more accurate and sensitive than other isoform inference tools such as RSEM and Cufflinks. By constructing a network from gene list identified by our method but missed by other tools, we found that some cancer-related genes enriched in network modules have significant implications for cancer drug discovery.
Evaluation of RNA-Seq software in gene expression quantification  [PDF]
Yan Ji, Ziliang Qian, Jia Wei
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.64059

High-throughput RNA sequencing (RNA-Seq) promises a complete annotation and quantification of all genes and their isoforms across samples. Because sequencing reads from this new technology are shorter than transcripts from which they are derived, expression estimation with RNA-Seq requires increasingly complex computational methods. In recent years, a number of expression quantification methods have been published from both public and commercial sources. Here we presented an overview of these attempts on quantifying gene expression. We then defined a set of criteria and compared the performance of several programs based on these criteria, and we further provided advices on selecting suitable tools for different biological applications.

On Wick product of generalized operators
Shunlong Luo,Jia’an Yan
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02884135
Abstract: Fundamental properties of Wick product of generalized operators are investigated. The annihilation and creation algebras are characterized from various points of view. Wick ordering widely used in quantum physics is interpreted as the Wick product of generalized operators.
Generalized Fourier-Mehler transforms on white noise functional spaces
Shunlong Luo,Jia’an Yan
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02883674
Abstract: A new (non-unitary) representation of the general linear group of white noise space on Hida’ s test and distribution spaces is presented. The relevant representative operators are natural generalization of Fourier-Mehler transforms.
The ungulates of northern China
Wu Jia-yan
Rangifer , 1994,
Abstract: Presently, thirty five species of ungulates occur in northern China. Some species are threatened or endangered. There are three species of Equidae (E. przewalskii, E. hemionus, E. kiang), one of Suidae (Sus scrofa), one of Camelidae (Camelus bactrianus), 14 species of Cervidae (with the genera Moschus, Elaphus, Cervus, Elaphurus, Alces, Rangifer, Capreolus) and 16 species of Bovidae (within the genera Bos, Gazella, Procapra, Pantholops, Saiga, Nemorhaedus, Capricornis, Budorcas, Capra, Pseudois, Ovis). They inhabit different biotopes, i.e. temperate mountain forest and steppe, temperate desert and semi-desert, and vast alpine ranges. Ungulate fossils are widespread in China evidencing that Asia was an evolutionary centre for some ungulates. Although new data have been gathered through research efforts in China since 1949 it is a fact that some ungulate species have suffered serious population set-backs and some have become endangered or even extinct. Detailed studies of ungulate populations and protection of habitats are now most important future research needs.
Epigenetic changes in colorectal cancer
Yan Jia,Mingzhou Guo
Chinese Journal of Cancer , 2013, DOI: 10.5732/cjc.011.10245
Abstract: Epigenetic changes frequently occur in human colorectal cancer. Genomic global hypomethylation, gene promoter region hypermethylation, histone modifications, and alteration of miRNA patterns are major epigenetic changes in colorectal cancer. Loss of imprinting(LOI) is associated with colorectal neoplasia. Folate deficiency may cause colorectal carcinogenesis by inducing gene-specific hypermethylation and genomic global hypomethylation. HDAC inhibitors and demethylating agents have been approved by the FDA for myelodysplastic syndrome and leukemia treatment. Non-coding RNA is regarded as another kind of epigenetic marker in colorectal cancer. This review is mainly focused on DNA methylation, histone modification, and microRNA changes in colorectal cancer.
A numeraire-free and original probability based framework for financial markets
Jia-An Yan
Mathematics , 2003,
Abstract: In this paper, we introduce a numeraire-free and original probability based framework for financial markets. We reformulate or characterize fair markets, the optional decomposition theorem, superhedging, attainable claims and complete markets in terms of martingale deflators, present a recent result of Kramkov and Schachermayer (1999, 2001) on portfolio optimization and give a review of utility-based approach to contingent claim pricing in incomplete markets.
Role of Xuesaitong in Amelioration of Neural Function and Alteration of Bax Expression in Rats with Brain Trauma  [PDF]
Wei Huang, Qi Yan, Jia Liu, Jintao Li, Tinghua Wang
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.69091
Abstract: Traumatic brain injury (TBI) is one of the most common diseases in clinical neurosurgery characterized with high incidence rate, mortality and many complications. Objectives: The purpose of this study is to explore the roles of Xuesaitong in the therapeutic effect of brain trauma and alteration of expression in Bax, a kind of promoting apoptosis factor. Methods: The rat traumatic brain injury models were established by using modified free falling body impact method. Thereafter, Xuesaitong was employed to be administered to TBI rats, and NSS Score Rating Scale was used to evaluate the effect of Xuesaitong. Moreover, real-time PCR was used to detect the Bax expression changes before and after the Xuesaitong administration. Results: Xuesaitong could accelerate the neurofunctional recovery of TBI rats, accompanied by NSS Scores significant decrease. Simultaneously, it also could inhibit the expression of Bax factor. Conclusions: Xusaitong could markedly ameliorate TBI restoration, in which it promotes the neurofunctional recovery, and at the same time it inhibits the expression of Bax.
Effects of Fillers on the Damping Property of Ethylene Vinyl-Acetate/Polylactic Acid Blends  [PDF]
Xinyan Shi, Lingyan Jia, Yan Ma, Chengliang Li
Journal of Materials Science and Chemical Engineering (MSCE) , 2016, DOI: 10.4236/msce.2016.42010
Abstract: New and high performance damping materials from ethylene vinyl-acetate copolymer (VA content over 40%, shorted as EVM) and polylactic acid (PLA) blends were prepared with dicumyl peroxide (DCP) as the curing agent and triallyl isocyanurate (TAIC) as the curing coagent. The effects of silica, mesoporous silica and glass beads on the damping of the EVM/PLA blends were examined using a dynamic mechanical analyzer (DMA). The microstructures of the silica, mesoporous silica and glass beads were observed by transmission electron microscope (TEM). The dispersion of the fillers in the matrix was studied using a Rubber Process Analyzer (RPA). The results showed that silica filled blend had an effective damping temperature range (EDTR, tan δ > 0.3) of 81, while the mesoporous silica/silica and glass beads/silica filled blends had EDTR of 86 and 85, respectively. Mixtures of mesoporous silica and silica as well as glass beads and silica exhibited a more improved dispersion in the blends than silica alone. Blends filled with mesoporous silica and glass beads retained good mechanical properties as well as improved damping performance.
Numerical Modelling of Radiation-Convection Coupling of Greenhouse Using Underfloor Heating  [PDF]
Yan Jia, Can Wang, Chi Zhang, Wenxiong Li
Open Journal of Fluid Dynamics (OJFD) , 2017, DOI: 10.4236/ojfd.2017.73030
Greenhouse is an important place for crop growth, and it is necessary to control the temperature of growing environment in winter. In addition, the root temperature underground also plays a decisive role for plants growth. Adopting underground heating to increase the temperature can effectively improve the yield of crops. The objective of our study was to model the heat transfer of greenhouse underfloor heating which is analyzed and simplified based on the FLUENT software by changing the several important factors that affect the temperature distribution: pipe diameter, pipe spacing, laying depth, supplied water temperature and flow rate, as boundary conditions to simulate the changes of the soil temperature field around the winter night environment. Researching the temperature distribution of the greenhouse, the soil surface and the plant root layer under the different parameters and the basic rules of the heating system are summarized. The results show that the water supply temperature, pipe spacing and diameter of the pipe has a greater impact on the ground and room temperature, and the laying depth has greater impact on the temperature uniformity of the ground, the velocity of water in pipe has little impact on the uniformity of ground temperature.
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