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Search Results: 1 - 10 of 6872 matches for " Yali Hou "
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Applications of High-Efficiency Abrasive Process with CBN Grinding Wheel  [PDF]
Yali Hou, Changhe Li, Yan Zhou
Engineering (ENG) , 2010, DOI: 10.4236/eng.2010.23026
Abstract: High-efficiency abrasive process with CBN grinding wheel is one of the important techniques of advanced manufacture. Combined with raw and finishing machining, it can attain high material removal rate like turning, milling and planning. The difficult-to-grinding materials can also be ground by means of this method with high performance. In the present paper, development status and latest progresses on high-efficiency abrasive machining technologies with CBN grinding wheel relate to high speed and super-high speed grinding, quick point-grinding, high efficiency deep-cut grinding, creep feed deep grinding, heavy-duty snagging and abrasive belt grinding were summarized. The efficiency and parameters range of these abrasive machining processes were compared. The key technologies of high efficiency abrasive machining, including grinding wheel, spindle and bearing, grinder, coolant supplying, installation and orientation of wheel and workpiece and safety defended, as well as intelligent monitor and NC grinding were investigated. It is concluded that high efficiency abrasive machining is a promising technology in the future.
Fine mapping of copy number variations on two cattle genome assemblies using high density SNP array
Hou Yali,Bickhart Derek M,Hvinden Miranda L,Li Congjun
BMC Genomics , 2012, DOI: 10.1186/1471-2164-13-376
Abstract: Background Btau_4.0 and UMD3.1 are two distinct cattle reference genome assemblies. In our previous study using the low density BovineSNP50 array, we reported a copy number variation (CNV) analysis on Btau_4.0 with 521 animals of 21 cattle breeds, yielding 682 CNV regions with a total length of 139.8 megabases. Results In this study using the high density BovineHD SNP array, we performed high resolution CNV analyses on both Btau_4.0 and UMD3.1 with 674 animals of 27 cattle breeds. We first compared CNV results derived from these two different SNP array platforms on Btau_4.0. With two thirds of the animals shared between studies, on Btau_4.0 we identified 3,346 candidate CNV regions representing 142.7 megabases (~4.70%) of the genome. With a similar total length but 5 times more event counts, the average CNVR length of current Btau_4.0 dataset is significantly shorter than the previous one (42.7 kb vs. 205 kb). Although subsets of these two results overlapped, 64% (91.6 megabases) of current dataset was not present in the previous study. We also performed similar analyses on UMD3.1 using these BovineHD SNP array results. Approximately 50% more and 20% longer CNVs were called on UMD3.1 as compared to those on Btau_4.0. However, a comparable result of CNVRs (3,438 regions with a total length 146.9 megabases) was obtained. We suspect that these results are due to the UMD3.1 assembly's efforts of placing unplaced contigs and removing unmerged alleles. Selected CNVs were further experimentally validated, achieving a 73% PCR validation rate, which is considerably higher than the previous validation rate. About 20-45% of CNV regions overlapped with cattle RefSeq genes and Ensembl genes. Panther and IPA analyses indicated that these genes provide a wide spectrum of biological processes involving immune system, lipid metabolism, cell, organism and system development. Conclusion We present a comprehensive result of cattle CNVs at a higher resolution and sensitivity. We identified over 3,000 candidate CNV regions on both Btau_4.0 and UMD3.1, further compared current datasets with previous results, and examined the impacts of genome assemblies on CNV calling.
Study on the Problems in Special-Contracted Teachers’ Professional Development  [PDF]
Yali Zhang
Creative Education (CE) , 2015, DOI: 10.4236/ce.2015.614164
Abstract: Special-contracted teachers’ scheme, conducted by the central government, is a policy which aims to supply teachers for compulsory education in western China. A large number of special-contracted teachers are recruited in Guizhou province. Research method of investigation is used in this study. The purpose is finding the problems of professional development of special-contracted teachers and looking for the suggestions for the professional development of special-contracted teachers.
Can Supervisor Support Mitigate the Impact of Colleague Exclusion on Silence Behavior?—A Moderated Mediating Model  [PDF]
Yali Chen
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.610011
Abstract: In this study, we explored the generation and influence mechanism of employees’ silence behavior from the perspectives of different relationship with colleagues and leaders. A questionnaire survey was conducted among 226 employees to investigate the possibility of employees’ silence behavior in organizational situations. The results of regression analysis show that: 1) Colleagues’ exclusion has a significant positive effect on employees’ silence behavior; 2) Psychological security has a significant negative effect on employee silence behavior, and psychological security plays a part mediating role between colleagues exclusion and silence behavior; 3) Supervisor support has a significant negative moderating effect on the relationship between colleague exclusion and psychological security.
Driver Cognitive Distraction Detection Using Driving Performance Measures
Lisheng Jin,Qingning Niu,Haijing Hou,Huacai Xian,Yali Wang,Dongdong Shi
Discrete Dynamics in Nature and Society , 2012, DOI: 10.1155/2012/432634
Abstract: Driver cognitive distraction is a hazard state, which can easily lead to traffic accidents. This study focuses on detecting the driver cognitive distraction state based on driving performance measures. Characteristic parameters could be directly extracted from Controller Area Network-(CAN-)Bus data, without depending on other sensors, which improves real-time and robustness performance. Three cognitive distraction states (no cognitive distraction, low cognitive distraction, and high cognitive distraction) were defined using different secondary tasks. NLModel, NHModel, LHModel, and NLHModel were developed using SVMs according to different states. The developed system shows promising results, which can correctly classify the driver’s states in approximately 74%. Although the sensitivity for these models is low, it is acceptable because in this situation the driver could control the car sufficiently. Thus, driving performance measures could be used alone to detect driver cognitive state. 1. Introduction Driver distraction is a major factor in traffic accidents, and it is estimated that up to 23 percent of crashes and near-crashes are caused by driver distraction. As the use of in-vehicle information systems (IVISs) such as cell phones, navigation systems, and satellite radios, will increase these figures will likely increase [1–6]. Thus enabling drivers to benefit from IVISs without diminishing safety is an important challenge [7]. One way to solve this problem is to detect the driver state in real time, and when distraction occurs, the corresponding warning system works to mitigate the effects of distraction [8]. Obviously, measuring driver state in real time is the core function in such systems. There has been an explosion research on these topics including the definition, classification, and detection of distraction. Donmez et al. [8] proposed a general definition that is “driver distraction is a diversion of attention away from activities critical for safe driving toward a competing activity.” Generally, visual distraction and cognitive distraction are the two major types. Visual distraction can be described as “eye-off-road” and cognitive distraction as “mind-off-road” [9]. Both of them can undermine drivers’ performance. Visual distraction is straightforward, occurring when drivers look away from the roadway (e.g., to adjust a radio), which can be reasonably measured by the length and frequency of glances away from the road [10]. Unlike visual distraction, cognitive distraction occurs when drivers think about something not directly related to the
Retrospective Analysis for Genetic Improvement of Hip Joints of Cohort Labrador Retrievers in the United States: 1970–2007
Yali Hou,Yachun Wang,George Lust,Lan Zhu,Zhiwu Zhang,Rory J. Todhunter
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009410
Abstract: Canine Hip Dysplasia (CHD) is a common inherited disease that affects dog wellbeing and causes a heavy financial and emotional burden to dog owners and breeders due to secondary hip osteoarthritis. The Orthopedic Foundation for Animals (OFA) initiated a program in the 1960's to radiograph hip and elbow joints and release the OFA scores to the public for breeding dogs against CHD. Over last four decades, more than one million radiographic scores have been released.
Changes in the Ratio of Tc1/Tc2 and Th1/Th2 Cells but Not in Subtypes of NK-Cells in Preeclampsia
Yali Hu,Jianjun Zhou,Sha Hao,Zhiqun Wang,Yiming Dai,Jingxian Ling,Yayi Hou
International Journal of Molecular Sciences , 2007, DOI: 10.3390/i8060492
Abstract: It has been suggested that natural killer (NK) cell activity and Th1 immunitymay be involved in the pathogenesis of preeclampsia. This study aimed to investigate theimmunophenotypes of NK cells and type 1/type 2 immunity in both decidua and maternalperipheral blood between normal (n=11) and preeclamptic pregnant women (n=20) by flowcytometry. The results showed that no significant difference was observed between patientsand controls by detecting CD56+ CD69+ and CD56+ CD94+ NK cells in both peripheralblood and decidua. Moreover, in preeclamptic patients, decreased percentages of Tc2 andTh2 cells and the increased ratios of Tc1/Tc2 were determined in both decidua andmaternal peripheral blood. In addition, the ratio of Th1/Th2 in peripheral blood alsoincreased. There was no significant difference of immunophenotypes of uNK cells betweenpreeclampsia and normal pregnancy. Local decidua and systematic immunity did notcorrelate with each other. These results suggest that the type 1/type 2 immunity shifted totype 1 immunity including Th1 and Tc1 cells may contribute to the patho-genesis ofpreeclampsia.
Assessment of genome integrity with array CGH in cattle transgenic cell lines produced by homologous recombination and somatic cell cloning
George E Liu, Yali Hou, James M Robl, Yoshimi Kuroiwa, Zhongde Wang
Genome Integrity , 2011, DOI: 10.1186/2041-9414-2-6
Abstract: We detected similar amounts of differences between the control hybridizations (8, 13 and 39 differences) and the comparative analyses of both "high" and "low" cell lines (ranging from 7 to 57 with a mean of ~20). Almost 75% of the large differences (>10 kb) and about 45% of all differences shared the same type (loss or gain) and were located in nearby genomic regions across hybridizations. Therefore, it is likely that they were not true differences but caused by systematic factors associated with local genomic features (e.g. GC contents).Our findings reveal that large copy number variations are less likely to arise during genetic targeting and serial rounds of cloning, fortifying the notion that epigenetic errors introduced from serial cloning may be responsible for the cloning efficiency decline.As embryonic stem cells are not available in the bovine species, somatic cells have been used for genetic modifications, and transgenic cattle have been produced from such genetically modified somatic cells by animal cloning. However, because primary somatic cells have limited life span and inevitably become senescent following DNA transfection and selection in cell culture, it is impossible to perform any further genetic modifications in these cells. Because of such, transgenic cattle with a desired genotype that requires more than one genetic targeting event, such as homozygous deletion of the two alleles of a gene, cannot be produced. To overcome such limitations, a novel sequential genetic modification strategy in bovine somatic cells, for producing extensively genetically modified cattle, has been developed [1]. This process involves a serial round of genetic targeting events, each followed by cloning to rejuvenate the genetically modified somatic cells (to rescue them from senescence) for the next round of genetic targeting. Such genetically modified somatic cells are then subjected to a final round of cloning for producing transgenic animals with the desired genotype
The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma
Hong Shi, Jie Wang, Fusheng Dong, Xu Wang, Hexiang Li, Yali Hou
BMC Cancer , 2009, DOI: 10.1186/1471-2407-9-456
Abstract: In this study, human xylosyltransferase-I (XTLY-I) gene, which catalyzes the rate-limited step of proteoglycans biosynthesis, was knocked down by RNA interference (RNAi) to inhibit the proteoglycans biosynthesis in SACC cell line with high tendency of lung metastasis (SACC-M). The impact of down-regulated proteoglycans on the metastasis characters of SACC-M cells was analyzed and discussed. This research could provide a new idea for the clinical treatment of SACC.The eukaryotic expression vector of short hairpin RNA (shRNA) targeting XTLY-I gene was constructed and transfected into SACC-M cells. A stably transfectant cell line named SACC-M-WJ4 was isolated. The XTLY-I expression was measured by real-time PCR and Western blot; the reduction of proteoglycans was measured. The invasion and metastasis of SACC-M-WJ4 cells were detected; the effect of down-regulated proteoglycans on the potential lung metastasis of nude mice was observed, respectively.The shRNA plasmid targeting XTLY-I gene showed powerful efficiency of RNAi. The mRNA level of target gene decreased by 86.81%, the protein level was decreased by 80.10%, respectively. The silence of XTLY-I gene resulted in the reduction of proteoglycans significantly in SACC-M-WJ4 cells. The inhibitory rate of proteoglycans was 58.17% (24 h), 66.06% (48 h), 57.91% (72 h), 59.36% (96 h), and 55.65% (120 h), respectively. The reduction of proteoglycans suppressed the adhesion, invasion and metastasis properties of SACC-M cells, and decreased the lung metastasis of SACC-M cells markedly either.The data suggested that the silence of XTLY-I gene in SACC-M cells could suppress proteoglycans biosynthesis and secretion significantly. The reduction of proteoglycans inhibited cell adhesion, invasion and metastasis of SACC-M cells. There is a close relationship between proteoglycans and the biological behavior of SACC.Proteoglycans are important macromolecules, which show the largest and most complex molecular structures in human body.
THz spectra of five borates crystals
BiHui Hou,YaLi Wang,YiCheng Wu,Hua Chen,Li Wang,PengZhen Fu,FengYan Liu
Chinese Science Bulletin , 2008, DOI: 10.1007/s11434-007-0411-x
Abstract: Terahertz spectral responses have been studied for five borate crystals Na5[B2P3O13] (NBP), Zn3BPO (ZBP), SrB4O7 (SBO), Na3La9O3(BO3)8 (NLBO) and PbB4O7 (PBO). It is found that the samples had good transmission in 0.25–1.5 THz region. Both SBO and NLBO have an absorption coefficient less than 10 cm 1. Among them, SBO has not only the smallest absorption coefficient but also a very flat dispersion in the frequency region under investigation. Distinct resonance absorption peaks are observed for ZBP at v 1 = 1.4 THz, v 2 = 2.0 THz and SBO at v = 2.4 THz. In the spectrum of PBO, two abnormal dispersions appear in the frequency regions 1.44–1.74 and 2.2–2.5 THz. The absorption coefficients and refraction indices of the five crystals are extracted from the THz time-domain (THz-TDS) spectra in 0.25–2.5 THz region. The properties and origins of the spectral responses are addressed.
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