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Search Results: 1 - 10 of 83 matches for " Yacubian "
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Apert syndrome: skull abnormalities, brain malformations, neuropsychological evaluation and timing for surgery
YACUBIAN-FERNANDES A
Arquivos de Neuro-Psiquiatria , 2002,
Abstract:
Tratamento da epilepsia na infancia
Yacubian, Elza Márcia Targas;
Jornal de Pediatria , 2002, DOI: 10.1590/S0021-75572002000700005
Abstract: objective: due to the development of new antiepileptic drugs, epilepsy treatment has presented substantial progress in the last decade. in spite of presenting more adequate profile, these drugs have not shown better efficiency in seizure control than the traditional drugs. the objective of this revision is to provide up-to-date data for the treatment of epilepsy in childhood and the role of the new antiepileptic drugs. sources: bibliographic review has been performed at medline for the last 10 years, and the most pertinent papers and abstracts presented in international epilepsy meetings were selected. summary of the findings: the new antiepileptic drugs could be indicated in the treatment of some specific epileptic syndromes. serious side effects have been described with the use of these drugs. conclusions: the traditional drugs must be considered as the primary choice in the treatment of ordinary epilepsy.
Medicamentos genéricos no tratamento das epilepsias: uma reflex?o
Yacubian, Elza Márcia T.;
Journal of Epilepsy and Clinical Neurophysiology , 2007, DOI: 10.1590/S1676-26492007000300007
Abstract: objective: we discuss some controversial aspects with prescription of generic drugs (gd) and the problems concerning bioequivalence in the treatment of epilepsy. some antiepileptic drugs (aed) are poorly soluble in water, have nonlinear kinetics and a narrow therapeutic range, implying that problems with bioequivalence are likely to occur. there are clearly advantages (cost saving) and disadvantages (loss of seizure control or drug toxicity) in prescribing generics aed. methods: review of literature. results and conclusion: the main information is about classical aed (phenytoin, carbamazepine and valproate). regarding the new aed we found only one poster presentation related to lamotrigine substitution. the level of evidence is, generally, weak, based on case-series and expert opinion without explicit critical appraisal (except in phenytoin with level of evidence moderate, based on some analytical studies). we may allow the use of generics for epilepsy treatment. however, this opens the possibility of successive substitution of different formulations which may even be life threatening.
When epilepsy may have changed history: Ant?nio Moreira César as the commander of the third expedition in the war of Canudos
Yacubian, Elza Márcia Targas;
Arquivos de Neuro-Psiquiatria , 2003, DOI: 10.1590/S0004-282X2003000300035
Abstract: colonel ant?nio moreira césar, the commander of the third expedition against canudos (1896-1897), nicknamed "head-chopper", was considered an implacable military man, a synonym of ferocity and extreme brutality against his adversaries. therefore, he was nominated the commander of an expedition considered almost invincible. since his 30's he presented epileptic seizures, which increased in frequency and severity on his way to canudos. after several well-documented episodes and probably considering himself the winner in anticipation, he ordered a premature and almost ingenuous attack against canudos. his misjudging is attributed to the effect of successive seizures. he was shot and killed on the very first day of that battle and his expedition had a horrible and unexpected end. based on the descriptions of his biographer we discuss the nature of his disease probably characterized by focal seizures with elementary and complex visual hallucinations followed by language deficits and episodes of complex partial seizures and secondary generalization and its role in this episode of brazilian history.
When epilepsy may have changed history: Ant nio Moreira César as the commander of the third expedition in the war of Canudos
Yacubian Elza Márcia Targas
Arquivos de Neuro-Psiquiatria , 2003,
Abstract: Colonel Ant nio Moreira César, the Commander of the third Expedition against Canudos (1896-1897), nicknamed "head-chopper", was considered an implacable military man, a synonym of ferocity and extreme brutality against his adversaries. Therefore, he was nominated the Commander of an expedition considered almost invincible. Since his 30's he presented epileptic seizures, which increased in frequency and severity on his way to Canudos. After several well-documented episodes and probably considering himself the winner in anticipation, he ordered a premature and almost ingenuous attack against Canudos. His misjudging is attributed to the effect of successive seizures. He was shot and killed on the very first day of that battle and his expedition had a horrible and unexpected end. Based on the descriptions of his biographer we discuss the nature of his disease probably characterized by focal seizures with elementary and complex visual hallucinations followed by language deficits and episodes of complex partial seizures and secondary generalization and its role in this episode of Brazilian history.
Curso em comemora o ao dia internacional da mulher
Elza Márcia Targas Yacubian
Journal of Epilepsy and Clinical Neurophysiology , 2005, DOI: 10.1590/s1676-26492005000200006
Abstract:
Reuni o do Grupo Lusof nico em Mo ambique
Elza Márcia Targas Yacubian
Journal of Epilepsy and Clinical Neurophysiology , 2008, DOI: 10.1590/s1676-26492008000200009
Abstract:
IV Escola Latino-Americana de Ver?o em Epilepsia: chamada especial aos epileptologistas brasileiros
Scorza, Fulvio A.;Yacubian, Elza M.;Cavalheiro, Esper A.;
Journal of Epilepsy and Clinical Neurophysiology , 2009, DOI: 10.1590/S1676-26492009000400006
Abstract: introduction: the development of new treatments and effective means to prevent the epilepsies, the most prevalent neurological disorder and that affects around 1% of worldwide population, must be the main goal of the health systems of a nation. objetives: following these reasoning, the goal of our article is to promote the iv latin-american summer school on epilepsy (lasse) among brazilian epileptologists.
The role of mirror focus in the surgical outcome of patients with indolent temporal lobe tumors
Sampaio, Leticia;Yacubian, Elza Marcia;Manreza, Maria Luiza;
Arquivos de Neuro-Psiquiatria , 2004, DOI: 10.1590/S0004-282X2004000100002
Abstract: purpose: to review the clinical and neurophysiological data of 21 patients with epilepsy due to temporal lobe tumors and who had undergone evaluation and surgery at the hospital das clínicas da universidade de s?o paulo. the aim of this study was to investigate whether the occurrence of a mirror focus was influenced either by certain clinical factors or if the surgical outcome was influenced by the presence of a mirror focus. method: we included these 21 patients who had undergone at least one interictal electroencephalogram in the pre- and post-surgical periods. they had had a minimum follow-up of one year. results: eight patients had mirror focus (group 1) and 13 did not (group 2). the mean age at seizure onset, duration of epilepsy disorder and total number of seizures did not vary statistically between the two groups of patients. generalized tonic-clonic seizures occurred more frequently in the mirror focus group. all, but one patient, with a mirror focus were seizure free at follow- up. the mirror focus disappeared in all eight patients in the post-surgical electroencephalogram. in this group, the patient who was not seizure - free had a seizure recorded in his post-surgical electroencephalogram with seizure onset ipsilateral to the resected tumor. the patients who were not seizure-free had either been submitted to an incomplete resection of the tumor or showed evidence of associated cortical dysplasia. conclusion: the occurrence of mirror focus is not a contraindication to surgery even when interictal epileptiform activity predominates contralaterally to the tumor and neither when seizures appear to arise from the mirror focus on scalp eeg. good surgical outcome is expected despite eeg findings that may conflict with tumor location.
The role of mirror focus in the surgical outcome of patients with indolent temporal lobe tumors
Sampaio Leticia,Yacubian Elza Marcia,Manreza Maria Luiza
Arquivos de Neuro-Psiquiatria , 2004,
Abstract: PURPOSE: To review the clinical and neurophysiological data of 21 patients with epilepsy due to temporal lobe tumors and who had undergone evaluation and surgery at the Hospital das Clínicas da Universidade de S o Paulo. The aim of this study was to investigate whether the occurrence of a mirror focus was influenced either by certain clinical factors or if the surgical outcome was influenced by the presence of a mirror focus. METHOD: We included these 21 patients who had undergone at least one interictal electroencephalogram in the pre- and post-surgical periods. They had had a minimum follow-up of one year. RESULTS: Eight patients had mirror focus (Group 1) and 13 did not (Group 2). The mean age at seizure onset, duration of epilepsy disorder and total number of seizures did not vary statistically between the two groups of patients. Generalized tonic-clonic seizures occurred more frequently in the mirror focus group. All, but one patient, with a mirror focus were seizure free at follow- up. The mirror focus disappeared in all eight patients in the post-surgical electroencephalogram. In this group, the patient who was not seizure - free had a seizure recorded in his post-surgical electroencephalogram with seizure onset ipsilateral to the resected tumor. The patients who were not seizure-free had either been submitted to an incomplete resection of the tumor or showed evidence of associated cortical dysplasia. CONCLUSION: The occurrence of mirror focus is not a contraindication to surgery even when interictal epileptiform activity predominates contralaterally to the tumor and neither when seizures appear to arise from the mirror focus on scalp EEG. Good surgical outcome is expected despite EEG findings that may conflict with tumor location.
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