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Search Results: 1 - 10 of 14833 matches for " YaLin Tang "
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Does Salary Gap Really Have Incentive Effect  [PDF]
Yalin Wang
Modern Economy (ME) , 2015, DOI: 10.4236/me.2015.69097
Abstract: The salary gap is an important content in the design of salary system inside enterprises. The effect of salary gap on recipients and performances can totally be explained by the tournament theory and the behavioral theory. This paper concludes relative theories and previous empirical studies so that we hope it will make a contribution to prospective researches and salary practice in our country.
Novel sintering behavior of polystyrene nano-latex particles in filming process
Xiaozhong Qu,Yalin Tang,Liusheng Chen,Xigao Jin
Chinese Science Bulletin , 2001, DOI: 10.1007/BF03183542
Abstract: Filming process of polystyrene nano-latex (NPS) particles was studied by a combination of various methods. For a constant annealing time of 1 h, the AFM images showed that the deformation and sintering temperatures for NPS particles were ca. 90°C and 100°C respectively. In spin-lattice relaxation measurements of solid state NMR, it is found that T1L, T1S and I1I/I0 increased significantly after annealing at 90°C and above. DSC results showed that there was an exothermic peak near Tg after annealing for 1 h at the selected temperatures below 95°C; otherwise, the exothermic peak disappeared after annealing at 100°C or above. The apparent density of NPS increased suddenly in the temperature range. The results implied that the macromolecules in NPS particles are in a confined state with higher conformational energy and less cohensional interactions which are the drive force for the sintering at a lower temperature compared with the multichain PS particles and the bulk polymer.
Novel sintering behavior of polystyrene nano-latex particles in filming process

QU Xiaozhong,TANG Yalin,CHEN Liusheng,JIN Xigao,

科学通报(英文版) , 2001,
Abstract:
The Effect of Polyhydroxylated Alkaloids on Maltase-Glucoamylase
Qian Shang, Junfeng Xiang, Hong Zhang, Qian Li, Yalin Tang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070841
Abstract: One of the most important carbohydrate-splitting enzymes is themaltase-glucoamylase which catalyzes the hydrolysis of alpha-glucosidic linkages. Maltase-glucoamylase inhibitors during the last few years have aroused medical interests in the treatment of diabetes. They contribute to a better understanding of the mechanism of maltase-glucoamylase. At present there are many different classes of maltase-glucoamylase inhibitors. This paper focuses on alkaloidal inhibitors of maltase-glucoamylase and structure-activity relationship (SAR) studies between them in order to discover some drugs with better efficiency and lower toxicity for treating diabetes.
Screen Anti-influenza Lead Compounds That Target the PAC Subunit of H5N1 Viral RNA Polymerase
Lin Li, Shenghai Chang, Junfeng Xiang, Qian Li, Huanhuan Liang, Yalin Tang, Yingfang Liu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035234
Abstract: The avian influenza (H5N1) viral RNA polymerase protein PAC was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PAC ligands, and four inhibited influenza RNA polymerase activity. These results aid in the design of anti-influenza agents based on caffeoylquinic acid.
A Network-Based Multi-Target Computational Estimation Scheme for Anticoagulant Activities of Compounds
Qian Li,Xudong Li,Canghai Li,Lirong Chen,Jun Song,Yalin Tang,Xiaojie Xu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0014774
Abstract: Traditional virtual screening method pays more attention on predicted binding affinity between drug molecule and target related to a certain disease instead of phenotypic data of drug molecule against disease system, as is often less effective on discovery of the drug which is used to treat many types of complex diseases. Virtual screening against a complex disease by general network estimation has become feasible with the development of network biology and system biology. More effective methods of computational estimation for the whole efficacy of a compound in a complex disease system are needed, given the distinct weightiness of the different target in a biological process and the standpoint that partial inhibition of several targets can be more efficient than the complete inhibition of a single target.
Metabonomics analysis of the urine of rats with Qi deficiency and blood stasis syndrome based on NMR techniques
Lin Li,JianNong Wang,JianXun Ren,JunFeng Xiang,YaLin Tang,JianXun Liu,Ding Han
Chinese Science Bulletin , 2007, DOI: 10.1007/s11434-007-0389-4
Abstract: Metabonomics analysis of the urine of rats with Qi deficiency and blood stasis syndrome has been performed by comparison with those of normal rats based on NMR techniques. The relative contents of formate, creatinine, 2-oxoglutarate (2-OG), citrate, taurine, trimethylamine-N-oxide(TMAO), succinate and hippurate in the urine of the rats with Qi deficiency and blood stasis syndrome have been changed. These results have provided evidence for understanding the mechanism and the therapy of Qi deficiency and blood stasis syndrome.
An important functional group, benzo[1,3]dioxole, of alkaloids induces the formation of the human telomeric DNA G-quadruplex
Shu Yang,JunFeng Xiang,QianFan Yang,QiuJu Zhou,XiuFeng Zhang,Qian Li,YaLin Tang,GuangZhi Xu
Chinese Science Bulletin , 2011, DOI: 10.1007/s11434-010-4257-2
Abstract: Over the past few decades, numerous molecules have been discovered or designed to interact efficiently and selectively with a peculiar DNA structure named G-quadruplex. Some of these molecules have been developed as anticancer agents. To aid the design of anticancer agents, the ability of alkaloids possessing Protoberberine and Benzophenanthridine groups to induce the formation of G-quadruplexes were studied using CD spectroscopy. By careful examination of their structures, we found that a benzo[1,3]dioxole group plays an important role in influencing their inductive properties. The more functional groups the alkaloids have, the stronger their G-quadruplex inductive ability.
Spectroscopic studies of the interaction between methylene blue and G-quadruplex
Hongxia Sun,Junfeng Xiang,Yazhou Zhang,Guangzhi Xu,Lianghua Xu,Yalin Tang
Chinese Science Bulletin , 2006, DOI: 10.1007/s11434-006-2025-0
Abstract: G-rich single-stranged DNA (5′-TTAG-GG-3′) adopted a G-quadruplex structure in buffer containing potassium ions. The spectroscopic feature and the interaction between methylene blue and G-qadruplex have been investigated by circular dichroism, and nuclear magnetic resonance spectroscopy. The UV-Vis absorption and fluorescence spectral results show that the fluorescence behavior of MB by single-stranded DNA fits Stern-Volmer static quenching equation very well and they formed 1: 1 complexes; dimeric G-quadruplexes were bound to MB with 1: 1 or 2: 1, and their equilibrium constants were 1.047×105 and 8.79×104 L/mol, respectively. Based on the above results and 1H-NMR spectral data, one may conclude that MB stacked either the terminal tetrads to form 1: 1 complexes or between two terminal tetrads of G-quadruplexes to form 1: 2 sandwich complexes with G-qudruplexes.
Association between Regulated upon Activation, Normal T Cells Expressed and Secreted (RANTES) -28C/G Polymorphism and Susceptibility to HIV-1 Infection: A Meta-Analysis
Zhenghua Gong, Jialin Tang, Tianxin Xiang, Lunli Zhang, Qinghua Liao, Wei Liu, Yalin Wang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060683
Abstract: Background Many studies have investigated the distributions of RANTES genotypes between HIV-1 infected patients and uninfected individuals. However, no definite results have been put forward about whether the RANTES ?28C/G polymorphism can affect HIV-1 susceptibility. Methods We performed a meta-analysis of 12 studies including 7473 subjects for whom the RANTES ?28C/G polymorphism was genotyped. Odds ratios (ORs) with 95% confidence intervals (CIs) were employed to assess the association of the polymorphism with HIV-1 susceptibility. By dividing the controls into healthy controls and HIV-1 exposed but seronegative (HESN) controls, we explored the both allelic and dominant genetic models. Results By using the healthy controls, we found a marginally significant association between the ?28C/G polymorphism and susceptibility to HIV-1 infection in the allelic model (OR = 0.82, 95%CI = 0.70–0.97). But sensitivity analysis suggested that the association was driven by one study. We further performed stratified analysis according to ethnicity. The ?28G allele decreased susceptibility to HIV-1 infection in the allelic model among Asians (OR = 0.79, 95%CI = 0.66–0.94). By using the HESN controls, no association between the polymorphism ?28C/G and the susceptibility to HIV-1 infection was revealed in either the allelic model (OR = 0.84, 95%CI = 0.60–1.17) or the dominant model (OR = 0.77, 95%CI = 0.54–1.10). Conclusions Our findings suggested that the RANTES ?28G allele might play a role in resistance to HIV-1 infection among Asians. Additional well-designed studies were required for the validation of this association.
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